BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety

Journal of Anxiety Disorders

Volumn 34, Issue , 2015, Pages 68-75

  Chen, Jie ^a   Yu, Jing ^b   Liu, Yujie ^c   Zhang, Leilei ^c   Zhang, Jianxin ^a  

^a INSTITUTE OF PSYCHOLOGY   (China)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Adolescent anxiety; BDNF Val66Met polymorphism; Differential susceptibility; Gene environment interaction; Positive parenting; Stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GENOMIC DNA; METHIONINE; VALINE; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADOLESCENT; ADOLESCENT TRAIT ANXIETY; ALLELE; ANXIETY; ANXIETY DISORDER; ARTICLE; BDNF GENE; CHILD; CHINESE; ENVIRONMENTAL FACTOR; FEMALE; GENE FUNCTION; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HUMAN; LIFE EVENT; LIFE STRESS; MALE; MOTHER CHILD RELATION; MOTHER WARMTH REASONING; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM; CHILD PARENT RELATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MATERNAL BEHAVIOR; MOTHER; PHYSIOLOGY; PSYCHOLOGY; QUESTIONNAIRE;

ADOLESCENT; ALLELES; ANXIETY; ANXIETY DISORDERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; MATERNAL BEHAVIOR; MOTHER-CHILD RELATIONS; MOTHERS; PARENTING; POLYMORPHISM, GENETIC; SURVEYS AND QUESTIONNAIRES;

EID: 84932631584     PISSN: 08876185     EISSN: 18737897     Source Type: Journal    
DOI: 10.1016/j.janxdis.2015.06.001     Document Type: Article

References (77)

1. Alexander N., Osinsky R., Schmitz A., Mueller E., Kuepper Y., Hennig J. The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress. Psychoneuroendocrinology 2010, 35:949-953. 10.1016/j.psyneuen.2009.12.008.
2. Allen J.L., Rapee R.M., Sandberg S. Severe life events and chronic adversities as antecedents to anxiety in children a matched control study. Journal of Abnormal Child Psychology 2008, 36:1047-1056. 10.1007/s10802-008-9240-x.
3. Andero R., Ressler K.J. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, Brain and Behavior 2012, 11:503-512. 10.1111/j.1601-183X.2012.00801.x.
4. Bögels S.M., Brechman-Toussaint M.L. Family issues in child anxiety: attachment, family functioning, parental rearing and beliefs. Clinical Psychology Review 2006, 26:834-856. 10.1016/j.cpr.2005.08.001.
5. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Differential susceptibility to rearing environment depending on dopamine-related genes: new evidence and a meta-analysis. Development and Psychopathology 2011, 23:39-52. 10.1017/S0954579410000635.
6. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. The hidden efficacy of interventions: gene×environmental experiments from a differential susceptibility perspective. Annual Review of Psychology 2015, 66:381-409. 10.1146/annurev-psych-010814-015407.
7. Balazs J., Miklósi M., Kereszteny A., Hoven C.W., Carli V., Wasserman C., et al. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. Journal of Child Psychology Psychiatry 2013, 54:670-677. 10.1111/jcpp.12016.
8. Beesdo K., Knappe S., Pine D.S. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatric Clinics of North America 2009, 32:483-524. 10.1016/j.psc.2009.06.002.
9. Belsky J., Bakermans-Kranenburg M.J., Van IJzendoorn M.H. For better and for worse differential susceptibility to environmental influences. Current Directions in Psychological Science 2007, 16:300-304. 10.1111/j.1467-8721.2007.00525.x.
10. Belsky J., Hartman S. Gene-environment interaction in evolutionary perspective: differential susceptibility to environmental influences. World Psychiatry 2014, 13:87-89. 10.1002/wps.20092.
11. Belsky J., Jonassaint C., Pluess M., Stanton M., Brummett B., Williams R. Vulnerability genes or plasticity genes?. Molecular Psychiatry 2009, 14:746-754. 10.1038/mp.2009.44.
12. Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin 2009, 135:885-908. 10.1037/a0017376.
13. Belsky J., Pluess M. Beyond risk, resilience, and dysregulation: phenotypic plasticity and human development. Development and Psychopathology 2013, 25:1243-1261. 10.1017/s095457941300059x.
14. Belsky J., Pluess M., Widaman K.F. Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses. Journal of Child Psychology Psychiatry 2013, 54:1135-1143. 10.1111/jcpp.12075.
15. Boyce W.T., Ellis B.J. Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Developement and Psychopathology 2005, 17:271-301.10.1017/S0954579405050145.
16. Bresin K., Finy M.S., Verona E. Childhood emotional environment and self-injurious behaviors: the moderating role of the BDNF Val66Met polymorphism. Journal of Affective Disorders 2013, 150:594-600.10.1016/j.jad.2013.01.050.
17. Broeren S., Newall C., Dodd H.F., Locker R., Hudson J.L. Longitudinal investigation of the role of temperament and stressful life events in childhood anxiety. Devlopment and Psychopathology 2014, 26:437-449. 10.1017/S0954579413000989.
18. Brumariu L.E., Kerns K.A. Mother-child emotion communication and childhood anxiety symptoms. Cognition & Emotion 2014, 3:1-16.10.1080/02699931.2014.917070.
19. Chambers J.A., Power K.G., Durham R.C. The relationship between trait vulnerability and anxiety and depressive diagnoses at long-term follow-up of generalized anxiety disorder. Journal of Affective Disorders 2004, 18:587-607. 10.1016/j.janxdis.2003.09.001.
20. Chen J., Li X., Zhang J., Natsuaki M.N., Leve L.D., Harold G.T., et al. The Beijing Twin Study (BeTwiSt): a longitudinal study of child and adolescent development. Twin Research and Human Genetics 2013, 16:91-97. 10.1017/thg.2012.115.
21. Cowansage K.K., LeDoux J.E., Monfils M.-H. Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Current Molecular Pharmacology 2010, 3:12-29. 10.2174/1874-470211003010012.
22. Dick D.M. Gene-environment interaction in psychological traits and disorders. Annual Review of Clinical Psychology 2011, 7:383. 10.1146/annurev-clinpsy-032210-104518.
23. Drake K.L., Ginsburg G.S. Family factors in the development, treatment, and prevention of childhood anxiety disorders. Clinical Child and Family Psychology Review 2012, 15:144-162. 10.1007/s10567-011-0109-0.
24. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biological Psychiatry 2006, 59:1116-1127. 10.1016/j.biopsych.2006.02.013.
25. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269. 10.1016/S0092-8674(03)00035-7.
26. Eley T.C. The future of therapygenetics: where will studies predicting psychological treatment response from genomic markers lead?. Depression and Anxiety 2014, 31:617-620. 10.1002/da.22292.
27. Eley T.C., Hudson J.L., Creswell C., Tropeano M., Lester K.J., Cooper P., et al. Therapygenetics: the 5HTTLPR and response to psychological therapy. Molecular Psychiatry 2012, 17:236-237. 10.1038/mp.2012.92.
28. Ellis B.J., Bjorklund D.F. Beyond mental health: an evolutionary analysis of development under risky and supportive environmental conditions: an introduction to the special section. Developmental Psychology 2012, 48:591-597. 10.1037/a0027651.
29. Ellis B.J., Boyce W.T. Differential susceptibility to the environment: toward an understanding of sensitivity to developmental experiences and context. Development and Psychopathology 2011, 23:1-5. 10.1017/s095457941000060x.
30. Ellis B.J., Boyce W.T., Belsky J., Bakermans-Kranenburg M.J., Van IJzendoorn M.H. Differential susceptibility to the environment: an evolutionary - neurodevelopmental theory. Development and Psychopathology 2011, 23:7-28. 10.1017/s0954579410000611.
31. Felmingham K.L., Dobson-Stone C., Schofield P.R., Quirk G.J., Bryant R.A. The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biological Psychiatry 2013, 73:1059-1063. 10.1016/j.biopsych.2012.10.033.
32. Frustaci A., Pozzi G., Gianfagna F., Manzoli L., Boccia S. Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology 2008, 58:163-170. 10.1159/000182892.
33. Fullana M., Alonso P., Gratacos M., Jaurrieta N., Jimenez-Murcia S., Segalas C., et al. Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. European Psychiatry 2012, 27:386-390. 10.1016/j.eurpsy.2011.09.005.
34. Gatt J.M., Nemeroff C.B., Dobson-Stone C., Paul R.H., Bryant R.A., Schofield P.R., et al. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry 2009, 14:681-695. 10.1038/mp.2008.143.
35. Garcia S.E., Tully E.C., Tarantino N., South S., Iacono W.G., McGue M. Changes in genetic and environmental influences on trait anxiety from middle adolescence to early adulthood. Journal of Affective Disorders 2013, 151:46-53. 10.1016/j.jad.2013.05.046.
36. Graham J.W. Missing data analysis: making it work in the real world. Annual Review of Psychology 2009, 60:549-576. 10.1146/annurev.psych.58.110405.085530.
37. Hajcak G., Castille C., Olvet D., Dunning J., Roohi J., Hatchwell E. Genetic variation in brain-derived neurotrophic factor and human fear conditioning. Genes Brain Behaviour 2009, 8:80-85. 10.1111/j.1601-183x.2008.00447.x.
38. Hankin B., Nederhof E., Oppenheimer C., Jenness J., Young J., Abela J., et al. Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'. Translational Psychiatry 2011, 1:e44. 10.1038/tp.2011.44.
39. Heldt S.A., Zimmermann K., Parker K., Gaval M., Ressler K.J. BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning. Journal of Neuroscience 2014, 34:2444-2450.
40. Hofmann S.G., Sawyer A.T., Witt A.A., Oh D. The effect of mindfulness-based therapy on anxiety and depression: a meta-analytic review. Journal of Consulting and Clinical Psychology 2010, 78:169-183. 10.1037/a0018555.
41. Hong E.J., McCord A.E., Greenberg M.E. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 2008, 60:610-624. 10.1016/j.neuron.2008.09.024.
42. Hudson J.L., Lester K.J., Lewis C.M., Tropeano M., Creswell C., Collier D.A., et al. Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information. Journal of Child Psychology and Psychiatry 2013, 54:1086-1094. 10.1111/jcpp.12092.
43. Johnson J.H., McCutcheon S.M. Assessing life stress in older children and adolescents: preliminary findings with the life events checklist. Stress and anxiety 1980, 111-125. Hemisphere, Washington, DC. I.G. Sarason, C.D. Spielberge (Eds.).
44. Karpova N.N. Role of BDNF epigenetics in activity-dependent neuonal plasticity. Neuropharmcology 2014, 76:709-718.
45. Kim I.J., Ge X., Brody G.H., Conger R.D., Gibbons F.X., Simons R.L. Parenting behaviors and the occurrence and co-occurrence of depressive symptoms and conduct problems among African American children. Journal Family Psychology 2003, 17:571-583. 10.1037/0893-3200.17.4.571.
46. Kim S., Misra A. SNP genotyping: technologies and biomedical applications. Annual Review of Biomedical Engineering 2007, 9:289-320. 10.1146/annurev.bioeng.9.060906.152037.
47. Kuczewski N., Porcher C., Gaiarsa J.L. Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity. European Journal of Neuroscience 2010, 32:1239-1244. 10.1111/j.1460-9568.2010.07378.x.
48. Lau J.Y., Gregory A.M., Goldwin M.A., Pine D.S., Eley T.C. Assessing gene-environment interactions on anxiety symptom subtypes across childhood and adolescence. Development and Psychopathology 2007, 19:1129-1146. 10.1017/s0954579407000582.
49. Lester K., Hudson J., Tropeano M., Creswell C., Collier D., Farmer A., et al. Neurotrophic gene polymorphisms and response to psychological therapy. Translational Psychiatry 2012, 2:e108. 10.1038/tp.2012.33.
50. Letcher P., Sanson A., Smart D., Toumbourou J.W. Precursors and correlates of anxiety trajectories from late childhood to late adolescence. Journal of Clinical Child Adolescent Psychology 2012, 41:417-432. 10.1080/15374416.2012.680189.
51. Li H.C.W., Lopez V. The reliability and validity of the Chinese version of the Trait Anxiety Scale for Children. Research in Nursing & Health 2004, 27:426-434. 10.1002/nur.20045.
52. Little R.J.A., Rubin D.B. Statistical analysis with missing data 1987, Wiley, New York.
53. Lonsdorf T.B., Weike A.I., Golkar A., Schalling M., Hamm A.O., Öhman A. Amygdala-dependent fear conditioning in humans is modulated by the BDNF val66met polymorphism. Behavioral Neuroscience 2010, 124:9-15. 10.1037/a0018261.
54. Manuck S.B., McCaffery J.M. Gene-environment interaction. Annual Review of Psychology 2014, 65:41-70. 10.1146/annurev-psych-010213-115100.
55. Marks I.M., Nesse R.M. Fear and fitness: an evolutionary analysis of anxiety disorders. Ethology and Sociobiology 1994, 15:247-261. 10.1016/0162-3095(94)90002-7.
56. Martinowich K., Manji H., Lu B. New insights into BDNF function in depression and anxiety. Natural Neuroscience 2007, 10:1089-1093. 10.1038/nn1971.
57. McLaughlin K.A., Hatzenbuehler M.L. Stressful life events, anxiety sensitivity, and internalizing symptoms in adolescents. Journal of Abnormal Psychology 2009, 118:659-669. 10.1037/a0016499.
58. McLeod B.D., Wood J.J., Weisz J.R. Examining the association between parenting and childhood anxiety: a meta-analysis. Clinical Psychology Review 2007, 27:155-172. 10.1016/j.cpr.2006.09.002.
59. Monroe S.M., Simons A.D. Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychological Bulletin 1991, 110:406-425. 10.1037//0033-2909.110.3.406.
60. Park H., Poo M.M. Neurotrophin regulation of neural circuit development and function. Natural Review Neuroscience 2013, 14:7-23. 10.1038/nrn3379.
61. Peters J., Dieppa-Perea L.M., Melendez L.M., Quirk G.J. Induction of fear extinction with hippocampal-infralimbic BDNF. Science 2010, 328:1288-1290. 10.1126/science.1186909.
62. Petryshen T.L., Sabeti P.C., Aldinger K.A., Fry B., Fan J.B., Schaffner S., et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry 2009, 15:810-815. 10.1038/mp.2009.24.
63. Pluess M., Belsky J. Vantage sensitivity: individual differences in response to positive experiences. Psychological Bulletin 2013, 139:901-916. 10.1037/a0030196.
64. Rapee R.M., Schniering C.A., Hudson J.L. Anxiety disorders during childhood and adolescence: origins and treatment. Annual Review of Clinical Psychology 2009, 5:311-341. 10.1146/annurev.clinpsy.032408.153628.
65. Sakata K., Martinowich K., Woo N.H., Schloesser R.J., Jimenez D.V., Ji Y., et al. Role of activity-dependent BDNF expression in hippocampal - prefrontal cortical regulation of behavioral perseverance. Proceedings of National Academic Science 2013, 110:15103-15108. 10.1073/pnas.1222872110.
66. Shalev I., Lerer E., Israel S., Uzefovsky F., Gritsenko I., Mankuta D., et al. BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. Psychoneuroendocrinology 2009, 34:382-388. 10.1016/j.psyneuen.2008.09.017.
67. Simons R.L., Whitbeck L.B., Beaman J., Conger R.D. The impact of mothers' parenting, involvement by nonresidential fathers, and parental conflict on the adjustment of adolescent children. Journal of Marriage and Family 1994, 56:356-374. 10.2307/353105.
68. Soliman F., Glatt C.E., Bath K.G., Levita L., Jones R.M., Pattwell S.S., et al. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 2010, 327:863-866. 10.1126/science.1181886.
69. Spielberger C.D. Understanding stress and anxiety 1979, Harper and Row, London.
70. Spielberger C.D. Manual for the state-trait anxiety inventory STAI (form Y) 1983, Consulting Psychologists Press, Palo Alto, CA.
71. Stefanaki C., Bacopoulou F., Livadas S., Kandaraki A., Karachalios A., Chrousos G.P., et al. Impact of a mindfullness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial. Stress 2014, (in press). 10.3109/10253890.2014.974030.
72. Van Ijzendoorn M., Belsky J., Bakermans-Kranenburg M. Serotonin transporter genotype 5-HTTLPR as a marker of differential susceptibility? a meta-analysis of child and adolescent gene-by-environment studies. Translational Psychiatry 2012, 2:e147. 10.1038/tp.2012.73.
73. Vendlinski M.K., Lemery-Chalfant K., Essex M.J., Goldsmith H.H. Genetic risk by experience interaction for childhood internalizing problems: converging evidence across multiple methods. Journal of Child Psychology and Psychiatry 2011, 52:607-618. 10.1111/j.1469-7610.2010.02343.x.
74. Verhagen M., Van Der Meij A., Van Deurzen P., Janzing J., Arias-Vasquez A., Buitelaar J., et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Molecular Psychiatry 2008, 15:260-271. 10.1038/mp.2008.109.
75. Waterhouse E.G., An J.J., Orefice L.L., Baydyuk M., Liao G.-Y., Zheng K., et al. BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. Journal of Neuroscience 2012, 32:14318-14330.10.1523/jneurosci.0709-12.2012.
76. Widaman K.F., Helm J.L., Castro-Schilo L., Pluess M., Stallings M.C., Belsky J. Distinguishing ordinal and disordinal interactions. Psychological Methods 2012, 17:615-622. 10.1037/a0030003.
77. Yap M.B.H., Pilkington P.D., Ryan S.M., Jorm A.F. Parental factors associated with depression and anxiety in young people: a systematic review and meta-analysis. Journal of Affective Disorders 2014, 156:8-23.10. 1016/j.jad.2013.11.007.