-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309-314.
-
(1956)
Science
, vol.123
, Issue.3191
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
84880876347
-
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
-
Fendt SM, Bell EL, Keibler MA, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res. 2013;73(14):4429-4438.
-
(2013)
Cancer Res
, vol.73
, Issue.14
, pp. 4429-4438
-
-
Fendt, S.M.1
Bell, E.L.2
Keibler, M.A.3
-
3
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
Michelakis ED, Webster L, Mackey JR. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer. 2008;99(7):989-994.
-
(2008)
Br J Cancer
, vol.99
, Issue.7
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
Mackey, J.R.3
-
4
-
-
33745728461
-
Fatty acid synthase and cancer: new application of an old pathway
-
Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res. 2006;66(12):5977-5980.
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 5977-5980
-
-
Kuhajda, F.P.1
-
5
-
-
78649302320
-
Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
-
Decensi A, Puntoni M, Goodwin P, et al. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila). 2010;3(11):1451-1461.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, Issue.11
, pp. 1451-1461
-
-
Decensi, A.1
Puntoni, M.2
Goodwin, P.3
-
6
-
-
68449094325
-
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
-
Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 2009;52(9):1766-1777.
-
(2009)
Diabetologia
, vol.52
, Issue.9
, pp. 1766-1777
-
-
Currie, C.J.1
Poole, C.D.2
Gale, E.A.3
-
7
-
-
67650945180
-
Antidiabetic therapies affect risk of pancreatic cancer
-
Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology. 2009;137(2):482-488.
-
(2009)
Gastroenterology
, vol.137
, Issue.2
, pp. 482-488
-
-
Li, D.1
Yeung, S.C.2
Hassan, M.M.3
Konopleva, M.4
Abbruzzese, J.L.5
-
8
-
-
77951006620
-
Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
-
Hassan MM, Curley SA, Li D, et al. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer. 2010;116(8):1938-1946.
-
(2010)
Cancer
, vol.116
, Issue.8
, pp. 1938-1946
-
-
Hassan, M.M.1
Curley, S.A.2
Li, D.3
-
9
-
-
67650169923
-
Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease
-
Donadon V, Balbi M, Ghersetti M, et al. Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease. World J Gastroenterol. 2009;15(20):2506-2511.
-
(2009)
World J Gastroenterol
, vol.15
, Issue.20
, pp. 2506-2511
-
-
Donadon, V.1
Balbi, M.2
Ghersetti, M.3
-
10
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
Jiralerspong S, Palla SL, Giordano SH, et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009;27(20):3297-3302.
-
(2009)
J Clin Oncol
, vol.27
, Issue.20
, pp. 3297-3302
-
-
Jiralerspong, S.1
Palla, S.L.2
Giordano, S.H.3
-
11
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009;69(19):7507-7511.
-
(2009)
Cancer Res
, vol.69
, Issue.19
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
12
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben Sahra I, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene. 2008;27(25):3576-3586.
-
(2008)
Oncogene
, vol.27
, Issue.25
, pp. 3576-3586
-
-
Ben Sahra, I.1
Laurent, K.2
Loubat, A.3
-
13
-
-
47249088612
-
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
-
Gotlieb WH, Saumet J, Beauchamp MC, et al. In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol Oncol. 2008;110(2):246-250.
-
(2008)
Gynecol Oncol
, vol.110
, Issue.2
, pp. 246-250
-
-
Gotlieb, W.H.1
Saumet, J.2
Beauchamp, M.C.3
-
14
-
-
70749106139
-
Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy
-
Cantrell LA, Zhou C, Mendivil A, Malloy KM, Gehrig PA, Bae-Jump VL. Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy. Gynecol Oncol. 2010;116(1):92-98.
-
(2010)
Gynecol Oncol
, vol.116
, Issue.1
, pp. 92-98
-
-
Cantrell, L.A.1
Zhou, C.2
Mendivil, A.3
Malloy, K.M.4
Gehrig, P.A.5
Bae-Jump, V.L.6
-
15
-
-
34249069215
-
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis
-
Isakovic A, Harhaji L, Stevanovic D, et al. Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci. 2007;64(10):1290-1302.
-
(2007)
Cell Mol Life Sci
, vol.64
, Issue.10
, pp. 1290-1302
-
-
Isakovic, A.1
Harhaji, L.2
Stevanovic, D.3
-
16
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
-
El-Mir MY, Nogueira V, Fontaine E, Avéret N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 2000;275(1):223-228.
-
(2000)
J Biol Chem
, vol.275
, Issue.1
, pp. 223-228
-
-
El-Mir, M.Y.1
Nogueira, V.2
Fontaine, E.3
Avéret, N.4
Rigoulet, M.5
Leverve, X.6
-
17
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008;8(12):915-928.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.12
, pp. 915-928
-
-
Pollak, M.1
-
18
-
-
77954933558
-
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
-
Foretz M, Hébrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 2010;120(7):2355-2369.
-
(2010)
J Clin Invest
, vol.120
, Issue.7
, pp. 2355-2369
-
-
Foretz, M.1
Hébrard, S.2
Leclerc, J.3
-
19
-
-
84932613054
-
-
Clinicaltrials.gov Web site. Updated April 10, 2015. Accessed April 17, 2015
-
A phase III randomized trial of metformin vs placebo in early stage breast cancer. Clinicaltrials.gov Web site. https://clinicaltrials.gov/ct2/show/NCT01101438?term=metformin+breast+cancer&rank=8. Updated April 10, 2015. Accessed April 17, 2015.
-
A phase III randomized trial of metformin vs placebo in early stage breast cancer
-
-
-
20
-
-
84855167770
-
Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles
-
Mehta S, Hughes NP, Buffa FM, et al. Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles. J Natl Cancer Inst Monogr. 2011;2011(43):71-74.
-
(2011)
J Natl Cancer Inst Monogr
, vol.2011
, Issue.43
, pp. 71-74
-
-
Mehta, S.1
Hughes, N.P.2
Buffa, F.M.3
-
21
-
-
84864075329
-
Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial
-
Bonanni B, Puntoni M, Cazzaniga M, et al. Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial. J Clin Oncol. 2012;30(21):2593-2600.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2593-2600
-
-
Bonanni, B.1
Puntoni, M.2
Cazzaniga, M.3
-
22
-
-
85058723176
-
Effect of metformin on apoptosis in a presurgical trial in non-diabetic patients with breast cancer
-
Cazzaniga M, Decensi A, Pruneri G. Effect of metformin on apoptosis in a presurgical trial in non-diabetic patients with breast cancer. Cancer Res. 2012;72(24 suppl):116s.
-
(2012)
Cancer Res
, vol.72
, Issue.24
, pp. 116s
-
-
Cazzaniga, M.1
Decensi, A.2
Pruneri, G.3
-
23
-
-
79960845901
-
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
-
Hadad S, Iwamoto T, Jordan L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat. 2011;128(3):783-794.
-
(2011)
Breast Cancer Res Treat
, vol.128
, Issue.3
, pp. 783-794
-
-
Hadad, S.1
Iwamoto, T.2
Jordan, L.3
-
24
-
-
85058723501
-
Pre-surgical trial of metformin in overweight and obese, multi-ethnic patients with newly diagnosed breast cancer
-
Kalinsky K, Crew KD, Refice S. Pre-surgical trial of metformin in overweight and obese, multi-ethnic patients with newly diagnosed breast cancer. Cancer Res. 2012;72(24 suppl):117s.
-
(2012)
Cancer Res
, vol.72
, Issue.24
, pp. 117s
-
-
Kalinsky, K.1
Crew, K.D.2
Refice, S.3
-
25
-
-
84866538325
-
Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
-
Niraula S, Dowling RJ, Ennis M, et al. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat. 2012;135(3):821-830.
-
(2012)
Breast Cancer Res Treat
, vol.135
, Issue.3
, pp. 821-830
-
-
Niraula, S.1
Dowling, R.J.2
Ennis, M.3
-
26
-
-
58249119446
-
18F-FDG PET and PET/CT in the evaluation of cancer treatment response
-
Ben-Haim S, Ell P. 18F-FDG PET and PET/CT in the evaluation of cancer treatment response. J Nucl Med. 2009;50(1):88-99.
-
(2009)
J Nucl Med
, vol.50
, Issue.1
, pp. 88-99
-
-
Ben-Haim, S.1
Ell, P.2
-
27
-
-
84873547281
-
Metformin-an adjunct antineoplastic therapy-divergently modulates tumor metabolism and proliferation, interfering with early response prediction by 18F-FDG PET imaging
-
Habibollahi P, van den Berg NS, Kuruppu D, Loda M, Mahmood U. Metformin-an adjunct antineoplastic therapy-divergently modulates tumor metabolism and proliferation, interfering with early response prediction by 18F-FDG PET imaging. J Nucl Med. 2013;54(2):252-258.
-
(2013)
J Nucl Med
, vol.54
, Issue.2
, pp. 252-258
-
-
Habibollahi, P.1
van den Berg, N.S.2
Kuruppu, D.3
Loda, M.4
Mahmood, U.5
-
28
-
-
0025845450
-
The applications of PET in clinical oncology
-
discussion 649
-
Strauss LG, Conti PS. The applications of PET in clinical oncology. J Nucl Med. 1991;32(4):623-48; discussion 649.
-
(1991)
J Nucl Med
, vol.32
, Issue.4
, pp. 623-648
-
-
Strauss, L.G.1
Conti, P.S.2
-
29
-
-
33746098219
-
Comparison of image-derived and arterial input functions for estimating the rate of glucose metabolism in therapy-monitoring 18F-FDG PET studies
-
de Geus-Oei LF, Visser EP, Krabbe PF, et al. Comparison of image-derived and arterial input functions for estimating the rate of glucose metabolism in therapy-monitoring 18F-FDG PET studies. J Nucl Med. 2006;47(6): 945-949.
-
(2006)
J Nucl Med
, vol.47
, Issue.6
, pp. 945-949
-
-
de Geus-Oei, L.F.1
Visser, E.P.2
Krabbe, P.F.3
-
30
-
-
75649117850
-
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
-
Buffa FM, Harris AL, West CM, Miller CJ. Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. Br J Cancer. 2010;102(2):428-435.
-
(2010)
Br J Cancer
, vol.102
, Issue.2
, pp. 428-435
-
-
Buffa, F.M.1
Harris, A.L.2
West, C.M.3
Miller, C.J.4
-
31
-
-
51349088017
-
Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
-
Desmedt C, Haibe-Kains B, Wirapati P, et al. Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res. 2008;14(16):5158-5165.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.16
, pp. 5158-5165
-
-
Desmedt, C.1
Haibe-Kains, B.2
Wirapati, P.3
-
32
-
-
0037080449
-
Biologic correlates of (18) fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography
-
Bos R, van Der Hoeven JJ, van Der Wall E, et al. Biologic correlates of (18) fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol. 2002;20(2):379-387.
-
(2002)
J Clin Oncol
, vol.20
, Issue.2
, pp. 379-387
-
-
Bos, R.1
van Der Hoeven, J.J.2
van Der Wall, E.3
-
33
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012;13(4):251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, Issue.4
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
34
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012;481(7381):385-388.
-
(2012)
Nature
, vol.481
, Issue.7381
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
-
35
-
-
34248156160
-
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
-
Shu Y, Sheardown SA, Brown C, et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007;117(5):1422-1431.
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1422-1431
-
-
Shu, Y.1
Sheardown, S.A.2
Brown, C.3
-
36
-
-
0031033070
-
Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques
-
Diraison F, Pachiaudi C, Beylot M. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques. J Mass Spectrom. 1997;32(1): 81-86.
-
(1997)
J Mass Spectrom
, vol.32
, Issue.1
, pp. 81-86
-
-
Diraison, F.1
Pachiaudi, C.2
Beylot, M.3
-
37
-
-
0344874201
-
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
-
Diraison F, Moulin P, Beylot M. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 2003;29(5):478-485.
-
(2003)
Diabetes Metab
, vol.29
, Issue.5
, pp. 478-485
-
-
Diraison, F.1
Moulin, P.2
Beylot, M.3
-
38
-
-
0036723743
-
Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle
-
Evans K, Burdge GC, Wootton SA, Clark ML, Frayn KN. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes. 2002;51(9):2684-2690.
-
(2002)
Diabetes
, vol.51
, Issue.9
, pp. 2684-2690
-
-
Evans, K.1
Burdge, G.C.2
Wootton, S.A.3
Clark, M.L.4
Frayn, K.N.5
-
39
-
-
78650922427
-
Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer
-
Pinhel IF, Macneill FA, Hills MJ, et al. Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer. Breast Cancer Res. 2010;12(5):R76.
-
(2010)
Breast Cancer Res
, vol.12
, Issue.5
, pp. R76
-
-
Pinhel, I.F.1
Macneill, F.A.2
Hills, M.J.3
|