Co-delivery of doxorubicin and tumor-suppressing p53 gene using aPOSS-based star-shaped polymer for cancer therapy

Biomaterials

Volumn 55, Issue , 2015, Pages 12-23

  Li, Yongmao ^a   Xu, Bing ^a   Bai, Tao ^a   Liu, Wenguang ^a  

^a TIANJIN UNIVERSITY   (China)

Author keywords

Amphiphilic micelles; Cancer therapy; Co delivery; Doxorubicin; P53; POSS

Indexed keywords

AMMONIUM HYDROXIDE; BIOCOMPATIBILITY; CATIONIC POLYMERIZATION; DISEASES; GENE TRANSFER; GENES; MICELLES; ONCOLOGY; POLYMERS; SOLUTIONS; TUMORS;

AMPHIPHILICS; CANCER THERAPY; CO DELIVERIES; DOXORUBICIN; P53; POSS;

GENE THERAPY;

DOXORUBICIN; POLYMER; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; POLY[N [3 (METHACRYLOYLAMINO)PROPYL]N,N DIMETHYL N(3 SULFOPROPYL)AMMONIUM HYDROXIDE]; PROTEIN P53; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CATION; DRUG CARRIER; METHACRYLIC ACID DERIVATIVE; MICELLE; NYLON; ORGANOSILICON DERIVATIVE; POLY(2-(DIMETHYLAMINO)ETHYL METHACRYLATE); POLYHEDRALOLIGOSILSESQUIOXANE; POLYMETHACRYLIC ACID DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; ATOMIC TRANSFER RADICAL POLYMERIZATION; BIOCOMPATIBILITY; CANCER GENE THERAPY; CANCER INHIBITION; CELL CYCLE ASSAY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; INVESTIGATIVE PROCEDURES; MICELLE; MICELLIZATION; MOUSE; NEOPLASM; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SERUM; TUMOR CELL; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; CHO CELL LINE; COS 1 CELL LINE; CRICETULUS; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; HAMSTER; MCF 7 CELL LINE; NEOPLASMS; NUDE MOUSE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CATIONS; CELL CYCLE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DOXORUBICIN; DRUG CARRIERS; FEMALE; HUMANS; MCF-7 CELLS; METHACRYLATES; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NYLONS; ORGANOSILICON COMPOUNDS; POLYMETHACRYLIC ACIDS; QUATERNARY AMMONIUM COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84932603696     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.03.034     Document Type: Article

References (38)

1. Davis M.E., Chen Z.G., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008, 7:771-782.
2. Cho K., Wang X., Nie S., Chen Z.G., Shin D.M. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008, 14:1310-1316.
3. Wiradharma N., Tong Y.W., Yang Y.Y. Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect. Biomaterials 2009, 30:3100-3109.
4. Wang Y., Gao S., Ye W.H., Yoon H.S., Yang Y.Y. Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nat Mater 2006, 5:791-796.
5. Janát-Amsbury M.M., Yockman J.W., Lee M., Kern S., Furgeson D.Y., Bikram M., et al. Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Mol Ther 2004, 9:829-836.
6. Xu F.J., Zhang Z.X., Ping Y., Li J., Kang E.T., Neoh K.G. Star-shaped cationic polymers by atom transfer radical polymerization from beta-cyclodextrin cores for nonviral gene delivery. Biomacromolecules 2009, 10:285-293.
7. Qiu L.Y., Wang R.J., Zheng C., Jin Y., Jin L.Q. Beta-cyclodextrin-centered star-shaped amphiphilic polymers for doxorubicin delivery. Nanomedicine 2010, 5:193-208.
8. Jia MH, Ren TB, Wang A, Yuan WZ, Ren J. Amphiphilic star-shaped poly(ε-caprolactone)-block-poly(l-lysine) copolymers with porphyrin core: synthesis, self-assembly, and cell viability assay. J Appl Polym Sci. http://dx.doi.org/10.1002/APP.40097.
9. Wang F., Bronich T.K., Kabanov A.V., Rauh R.D., Roovers J. Synthesis and evaluation of a star amphiphilic block copolymer from poly(epsilon-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier. Bioconjug Chem 2005, 16:397-405.
10. Yang Y., Wang X., Hu Y., Hu H., Wu D., Xu F. Bioreducible POSS-cored star-shaped polycation for efficient gene delivery. ACS Appl Mater Interfaces 2014, 6:1044-1052.
11. Kuo S.W., Chang F.C. POSS related polymer nanocomposites. Prog Polym Sci 2011, 36:1649-1696.
12. Cordes D.B., Lickiss P.D., Rataboul F. Recent developments in the chemistry of cubic polyhedral oligosilsesquioxanes. Chem Rev 2010, 110:2081-2173.
13. Kannan R.Y., Salacinski H.J., Butler P.E., Seifalian A.M. Polyhedral oligomeric silsesquioxane nanocomposites: the next generation material for biomedical applications. Acc Chem Res 2005, 38:879-884.
14. Knop K., Hoogenboom R., Fischer D., Schubert U.S. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl 2010, 49:6288-6308.
15. Lee H., Jeong J.H., Park T.G. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. JControl Release 2002, 79:283-291.
16. Deshpande M.C., Davies M.C., Garnett M.C., Williams P.M., Armitage D., Bailey L., et al. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. JControl Release 2004, 97:143-156.
17. Jiang S., Cao Z. Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications. Adv Mater 2010, 22:920-932.
18. Cao Z., Yu Q., Xue H., Cheng G., Jiang S. Nanoparticles for drug delivery prepared from amphiphilic PLGA zwitterionic block copolymers with sharp contrast in polarity between two blocks. Angew Chem Int Ed Engl 2010, 49:3771-3776.
19. Yang W., Liu S., Bai T., Keefe A.J., Zhang L., Ella-Menye J., et al. Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production. Nano Today 2014, 9:10-16.
20. Liu Y., Yang X., Zhang W., Zheng S. Star-shaped poly(ε-caprolactone) with polyhedral oligomeric silsesquioxane core. Polymer 2006, 47:6814-6825.
21. Dai F., Sun P., Liu Y., Liu W. Redox-cleavable star cationic PDMAEMA by arm-first approach of ATRP as a nonviral vector for gene delivery. Biomaterials 2010, 31:559-569.
22. Qian X., Long L., Shi Z., Liu C., Qiu M., Sheng J., et al. Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. Biomaterials 2014, 35:2322-2335.
23. Hu Y., Yuan W., Zhao N.N., Ma J., Yang W.T., Xu F.J. Supramolecular pseudo-block gene carriers based on bioreducible star polycations. Biomaterials 2013, 34:5411-5422.
24. Costa R.O.R., Vasconcelos W.L., Tamaki R., Laine R.M. Organic/inorganic nanocomposite star polymers via atom transfer radical polymerization of methyl methacrylate using octafunctional silsesquioxane cores. Macromolecules 2001, 34:5398-5407.
25. Chang Y., Lee S.C., Him K.T., Him C., Reeves S.D., Allcock H.R. Synthesis and micellar characterization of an amphiphilic diblock copolyphosphazene. Macromolecules 2001, 34:269-274.
26. Luo X., Huang F., Qin S., Wang H., Feng J., Zhang X., et al. Astrategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation. Biomaterials 2011, 32:9925-9939.
27. Risbud M., Saheb D.N., Jog J., Bhonde R. Preparation, characterization and invitro biocompatibility evaluation of poly(butylene terephthalate)/wollastonite composites. Biomaterials 2001, 22:1591-1597.
28. Ventura A., Kirsch D.G., McLaughlin M.E., Tuveson D.A., Grimm J., Lintault L., et al. Restoration of p53 function leads to tumour regression invivo. Nature 2007, 445:661-665.
29. Zhao F., Yin H., Li J. Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug. Biomaterials 2014, 35:1050-1062.
30. Mehra N.K., Verma A.K., Mishra P.R., Jain N.K. The cancer targeting potential of D-α-tocopheryl polyethylene glycol 1000 succinate tethered multi walled carbon nanotubes. Biomaterials 2014, 35:4573-4588.
31. Duan X., Xiao J., Yin Q., Zhang Z., Yu H., Mao S., et al. Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS Nano 2013, 7:5858-5869.
32. Wen Y., Zhang Z., Li J. Highly efficient multifunctional supramolecular gene carrier system self-assembled from redox-sensitive and zwitterionic polymer blocks. Adv Funct Mater 2014, 24:3874-3884.
33. Dai F., Liu W. Enhanced gene transfection and serum stability of polyplexes by PDMAEMA-polysulfobetaine diblock copolymers. Biomaterials 2011, 32:628-638.
34. Zhai X., Wang W., Wang C., Wang Q., Liu W. PDMAEMA-b-polysulfobetaine brushes-modified ε-polylysine as a serum-resistant vector for highly efficient gene delivery. JMater Chem 2012, 22:23576-23586.
35. Han L., Zhao J., Liu J., Duan X., Li L., Wei X., et al. Auniversal gene carrier platform for treatment of human prostatic carcinoma by p53 transfection. Biomaterials 2014, 35:3110-3120.
36. Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. JBiol Chem 1998, 273:9357-9360.
37. Mikata K., Uemura H., Ohuchi H., Ohta S., Nagashima Y., Kubota Y. Inhibition of growth of human prostate cancer xenograft by transfection of p53 gene: gene transfer by electroporation. Mol Cancer Ther 2002, 1:247-252.
38. Dow S.W., Fradkin L.G., Liggitt D.H., Willson A.P., Heath T.D., Potter T.A. Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously. JImmunol 1999, 163:1552-1561.