Bystander immunotherapy as a strategy to control allergen-driven airway inflammation

Mucosal Immunology

Volumn 8, Issue 4, 2015, Pages 841-851

  Navarro, S ^a,c   Lazzari, A ^a   Kanda, A ^b   Fleury, S ^b   Dombrowicz, D ^b   Glaichenhaus, N ^a   Julia, V ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c JAMES COOK UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDUCIBLE T CELL COSTIMULATOR; ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 2 RECEPTOR ALPHA; LACK ANTIGEN, LEISHMANIA; OVALBUMIN; PARASITE ANTIGEN; PROTOZOAL PROTEIN;

ALLERGEN SPECIFIC IMMUNOTHERAPY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE CONTROL; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH2 CELL; ANIMAL; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DESENSITIZATION; DISEASE MODEL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PROCEDURES; RESPIRATORY HYPERSENSITIVITY; TRANSGENIC MOUSE;

ALLERGENS; ANIMALS; ANTIGENS, PROTOZOAN; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CTLA-4 ANTIGEN; DESENSITIZATION, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN E; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; OVALBUMIN; PROTOZOAN PROTEINS; RESPIRATORY HYPERSENSITIVITY; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 84932602593     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.115     Document Type: Article

References (44)

1. Casale T.B. & Stokes J.R. Immunotherapy: what lies beyond. J. Allergy Clin. Immunol. 133, 612-619. quiz 620 (2014
2. Akdis C.A., et al. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J. Clin. Invest. 98, 1676-1683 (1996
3. Akdis C.A., Blesken T., Wymann D., Akdis M. & Blaser K. Differential regulation of human Tcell cytokine patterns and IgE and IgG4 responses by conformational antigen variants. Eur. J. Immunol. 28, 914-925 (1998
4. Jutel M., et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur. J. Immunol. 33, 1205-1214 (2003
5. Francis J.N., Till S.J. & Durham S.R. Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J. Allergy Clin. Immunol. 111, 1255-1261 (2003
6. Ostroukhova M., et al. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J. Clin. Invest. 114, 28-38 (2004
7. Seymour B.W.P., Gershwin L.J. & Coffman R.L. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not requireCD8(+) or Tcell receptor (TCR)-gamma/delta(+) Tcells or interferon (IFN)-gamma in a murine model of allergen sensitization. J. Exp. Med. 187, 721-731 (1998
8. Akbari O., DeKruyff R.H. & Umetsu D.T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2, 725-731 (2001
9. Akbari O., et al. Antigen-specific regulatory T cells develop via the ICOSICOS- ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8, 1024-1032 (2002
10. Stock P., Akbari O., DeKruyff R.H. & Umetsu D.T. Respiratory tolerance is inhibited by the administration of corticosteroids. J. Immunol. 175, 7380-7387 (2005
11. Chen W., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003
12. Des Roches A., et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI.Specific immunotherapy prevents the onset ofnewsensitizations inchildren. J. AllergyClin. Immunol.99, 450-453 (1997
13. Pajno G.B., Barberio G., De Luca F., Morabito L. & Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin. Exp. Allergy 31, 1392-1397 (2001
14. Bullock W.W., Katz D.H. & Benacerraf B. Induction of T-lymphocyte responses to a small molecular weight antigen. II. specific tolerance induced in azebenzenearsonate (ABA)-specific T cells in Guniea pigs by administration of low doses of an ABA conjugate of chloroacetyl tyrosine in incomplete Freund's adjuvant. J. Exp. Med. 142, 261-274 (1975
15. Smith C.E. & Miller S.D. Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities. J. Autoimmun. 27, 218-231 (2006
16. Turley D.M. & Miller S.D. Peripheral tolerance induction using ethylenecarbodiimide- fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis. J. Immunol. 178, 2212-2220 (2007
17. Kendal A.R. & Waldmann H. Infectious tolerance: therapeutic potential. Curr. Opin. Immunol. 22, 560-565 (2010
18. Qin S., et al. Infectious transplantation tolerance. Science 259, 974-976 (1993
19. Miller A., Hafler D.A.& Weiner H.L. Tolerance and suppressormechanisms in experimentalautoimmuneencephalomyelitis: implications for immunotherapy of human autoimmune diseases. FASEB J. 5, 2560-2566 (1991
20. Miller A., Lider O., al-Sabbagh A. & Weiner H.L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. J. Neuroimmunol. 39, 243-250 (1992
21. Homann D., et al. Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity 11, 463-472 (1999
22. Al-Sabbagh A., Miller A., Santos L.M. & Weiner H.L. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur. J. Immunol. 24, 2104-2109 (1994
23. Aharoni R., Teitelbaum D., Sela M. & Arnon R. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 94, 10821-10826 (1997
24. Miska J., et al. Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. J. Exp. Med. 211, 441-456 (2014
25. Mionnet C., et al. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat. Med. 16, 1305-1312 (2010
26. Navarro S., et al. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol. 4, 53-65 (2011
27. Verhasselt V., et al. Breast milk-mediated transfer of an antigen induces tolerance and protection fromallergic asthma. Nat.Med. 14, 170-175 (2008
28. Yamaguchi T., Wing J.B. & Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or noninflammatory conditions. Semin. Immunol. 23, 424-430 (2011
29. Busse M., Krech M., Meyer-Bahlburg A., Hennig C. & Hansen G. ICOS mediates the generation and function ofCD4+CD25+Foxp3+ regulatory Tcells conveying respiratory tolerance. J. Immunol. 189, 1975-1982 (2012
30. Cohn L., Homer R.J., Marinov A., Rankin J.& Bottomly K. Inductionof airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186, 1737-1747 (1997
31. Mahnke K., Qian Y., Knop J. & Enk A.H. Induction of CD4+/CD25+ regulatory Tcells by targeting of antigens to immature dendritic cells. Blood 101, 4862-4869 (2003
32. Chai J.G., James E., Dewchand H., Simpson E. & Scott D. Transplantation tolerance induced by intranasal administration of HY peptides. Blood 103, 3951-3959 (2004
33. Apostolou I. & von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004
34. Campbell J.D., et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J. Exp. Med. 206, 1535-1547 (2009
35. Wing K., Yamaguchi T. & Sakaguchi S. Cell-autonomous and -nonautonomous roles of CTLA-4 in immune regulation. Trends Immunol. 32, 428-433 (2011
36. Shevach E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2, 389-400 (2002
37. Strickland D.H., et al. Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthmacontrol.Mucosal Immunol.4, 43-52 (2010
38. Tang Q. & Krummel M.F. Imaging the function of regulatory Tcells in vivo. Curr. Opin. Immunol. 18, 496-502 (2006
39. Tadokoro C.E., et al. Regulatory T cells inhibit stable contacts between CD4+ Tcells and dendritic cells in vivo. J. Exp. Med. 203, 505-511 (2006
40. Derks R.A., Jankowska-Gan E., Xu Q. & Burlingham W.J. Dendriticcell type determines themechanism of bystander suppression by adaptive Tregulatory cells specific for the minor antigen HA-1. J. Immunol. 179, 3443-3451 (2007
41. Inal A., et al. Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/or asthma monosensitized to house dust mite. J. Investig. Allergol. Clin. Immunol. 17, 85-91 (2007
42. Wang Q., et al. CD4 promotes breadth in the TCR repertoire. J. Immunol. 167, 4311-4320 (2001
43. Mougneau E., et al. A Leishmania protective T-cell antigen identified using a new expression cloning strategy. Vaccines 95: (CSH, eds) 51-56 (1995
44. Hamelmann E., et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156, 766-775 (1997