EGF Suppresses the Initiation and Drives the Reversion of TGF-β1-induced Transition in Hepatic Oval Cells Showing the Plasticity of Progenitor Cells

Journal of Cellular Physiology

Volumn 230, Issue 10, 2015, Pages 2362-2370

  Wang, Ping ^a,b   Yang, Ai Ting ^a   Cong, Min ^a   Liu, Tian Hui ^a   Zhang, Dong ^a   Huang, Jian ^a   Tong, Xiao Fei ^a   Zhu, Sheng Tao ^a   Xu, Yong ^a   Tang, Shu Zhen ^a   Wang, Bao En ^a   Ma, Hong ^a   Jia, Ji Dong ^a   You, Hong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; CADHERIN;

ADULT; ANIMAL CELL; ARTICLE; EPITHELIAL MESENCHYMAL TRANSITION; HEPATIC OVAL CELL; INTRACELLULAR SIGNALING; LIVER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STEM CELL; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CELL MOTION; CYTOLOGY; EPITHELIUM CELL; METABOLISM; PHYSIOLOGY;

RATTUS;

ANIMALS; CADHERINS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCYTES; RATS; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84932598569     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24962     Document Type: Article

References (31)

1. Bird TG, Lorenzini S, Forbes SJ. 2008. Activation of stem cells in hepatic diseases. Cell Tissue Res 331:283-300.
2. Caja L, Bertran E, Campbell J, Fausto N, Fabregat I. 2011. The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol 226:1214-1223.
3. Dolle L, Best J, Mei J, Al Battah F, Reynaert H, van Grunsven LA, Geerts A. 2010. The quest for liver progenitor cells: a practical point of view. J Hepatol 52:117-129.
4. Fabregat I, Sanchez A, Alvarez AM, Nakamura T, Benito M. 1996. Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture. FEBS Lett 384:14-18.
5. Friedman SL. 2008. Mechanisms of hepatic fibrogenesis. Gastroenterology 134:1655-1669.
6. Hinz B, Phan SH, Thannickal VJ, Prunotto M, Desmouliere A, Varga J, De Wever O, Mareel M, Gabbiani G. 2012. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 180:1340-1355.
7. Huang G, Besner GE, Brigstock DR. 2012. Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. Lab Invest; J Tech Methods Pathol 92:703-712.
8. Martinez-Palacian A, del Castillo G, Herrera B, Fernandez M, Roncero C, Fabregat I, Sanchez A. 2012. EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells. Cell signalling 24:505-513.
9. Massague J. 2008. TGFbeta in Cancer. Cell 134:215-230.
10. Meng F, Francis H, Glaser S, Han Y, DeMorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G. 2012. Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology 55:209-221.
11. Nguyen LN, Furuya MH, Wolfraim LA, Nguyen AP, Holdren MS, Campbell JS, Knight B, Yeoh GC, Fausto N, Parks WT. 2007. Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology 45:31-41.
12. Pinzani M. 2011. Epithelial-mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death ?. J Hepatol 55:459-465.
13. Reichl P, Haider C, Grubinger M, Mikulits W. 2012. TGF-beta in epithelial to mesenchymal transition and metastasis of liver carcinoma. Curr Pharm Des 18:4135-4147.
14. Roberts RA, James NH, Cosulich SC. 2000. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Hepatology 31:420-427.
15. Roskams T. 2003. Progenitor cell involvement in cirrhotic human liver diseases: From controversy to consensus. J Hepatol 39:431-434.
16. Roskams T, Katoonizadeh A, Komuta M. 2010. Hepatic progenitor cells: An update. Clin Liver Dis 14:705-718.
17. Rountree CB, Mishra L, Willenbring H. 2012. Stem cells in liver diseases and cancer: Recent advances on the path to new therapies. Hepatology 55:298-306.
18. Russo FP, Parola M. 2011. Stem and progenitor cells in liver regeneration and repair. Cytotherapy 13:135-144.
19. Russo FP, Parola M. 2012. Stem cells in liver failure. Best Pract Res Clin Gastroenterol 26:35-45.
20. Sam R, Wanna L, Gudehithlu KP, Garber SL, Dunea G, Arruda JA, Singh AK. 2006. Glomerular epithelial cells transform to myofibroblasts: early but not late removal of TGF-beta1 reverses transformation. Transl Res: J lab Clin Med 148:142-148.
21. Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M. 2010. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology 52:966-974.
22. Shafritz DA, Oertel M, Menthena A, Nierhoff D, Dabeva MD. 2006. Liver stem cells and prospects for liver reconstitution by transplanted cells. Hepatology 43:S89-S98.
23. Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T. 2013. Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. Biochem Biophys Res Commun 437:185-191.
24. Tian YC, Chen YC, Chang CT, Hung CC, Wu MS, Phillips A, Yang CW. 2007. Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Expe Cell Res 313:2367-2377.
25. Uttamsingh S, Bao X, Nguyen KT, Bhanot M, Gong J, Chan JL, Liu F, Chu TT, Wang LH. 2008. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27:2626-2634.
26. Wang P, Cong M, Liu TH, Yang AT, Cong R, Wu P, Tang SZ, Xu Y, Wang H, Wang BE, Jia JD, You H. 2010a. Primary isolated hepatic oval cells maintain progenitor cell phenotypes after two-year prolonged cultivation. J Hepatol 53:863-871.
27. Wang P, Liu T, Cong M, Wu X, Bai Y, Yin C, An W, Wang B, Jia J, You H. 2009. Expression of extracellular matrix genes in cultured hepatic oval cells: An origin of hepatic stellate cells through transforming growth factor beta?. Liver int : Off Int Assoc Stud Liver 29:575-584.
28. Wang Z, Yao T, Song Z. 2010b. Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: A potential mechanism for liver injury in methionine-choline deficient-diet-fed mice. Exp Bio Med 235:1347-1355.
29. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. 2008. Cadherin switching. J Cell Sci 121:727-735.
30. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. 2012. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology 56:2255-2267.
31. Xu Z, Jiang Y, Steed H, Davidge S, Fu Y. 2010. TGFbeta and EGF synergistically induce a more invasive phenotype of epithelial ovarian cancer cells. Biochem Biophys Res Commun 401:376-381.