Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice

Biochemical and Biophysical Research Communications

Volumn 437, Issue 2, 2013, Pages 185-191

  Takemura, Takayo ^a   Yoshida, Yuichi ^a   Kiso, Shinichi ^a   Kizu, Takashi ^a   Furuta, Kunimaro ^a   Ezaki, Hisao ^a   Hamano, Mina ^a   Egawa, Mayumi ^a   Chatani, Norihiro ^a   Kamada, Yoshihiro ^a   Imai, Yasuharu ^b   Higashiyama, Shigeki ^c   Iwamoto, Ryo ^d   Mekada, Eisuke ^d   Takehara, Tetsuo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b IKEDA MUNICIPAL HOSPITAL   (Japan)

^c EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Bile duct ligation; Heparin binding EGF like growth factor; Hepatic stellate cells; Liver fibrosis; Transforming growth factor

Indexed keywords

COLLAGEN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL ACTIVATION; CHOLESTASIS; CONTROLLED STUDY; FIBROGENESIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STELLATE CELL;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALP; ALT; BDL; BILE DUCT LIGATION; EGF; EPIDERMAL GROWTH FACTOR; H&E; HB-EGF; HEMATOXYLIN AND EOSIN; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; HEPATIC STELLATE CELLS; HSCS; KNOCKOUT; KO; LIVER FIBROSIS; POLY I:C; POLYINOSINIC:POLYCYTIDYLIC ACID; REVERSE-TRANSCRIPTION POLYMERASE CHAIN REACTION; RT-PCR; T.BIL; TGF-Β; TNF-Α; TOTAL BILIRUBIN; TRANSFORMING GROWTH FACTOR-Β; TUMOR NECROSIS FACTOR-Α; WILD TYPE; WT;

ANIMALS; BILE DUCTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION;

MUS;

EID: 84880747065     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.097     Document Type: Article

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