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Volumn 47, Issue 2, 2015, Pages 222-228

Pharmacogenetics of isoniazid-induced hepatotoxicity

Author keywords

Genetic; Hepatotoxicity; Oral antituberculosis; Polymorphism; Tuberculosis

Indexed keywords

ACYLTRANSFERASE; CYTOCHROME P450 2E1; GLUCURONOSYLTRANSFERASE 1A1; GLUTATHIONE TRANSFERASE; ISONIAZID; LEUCINE ZIPPER PROTEIN; NITRIC OXIDE SYNTHASE; URIDINE DIPHOSPHATE; ARYLAMINE ACETYLTRANSFERASE; GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE S-TRANSFERASE T1; NAT2 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; TUBERCULOSTATIC AGENT;

EID: 84932108291     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2014.984070     Document Type: Review
Times cited : (45)

References (49)
  • 1
    • 84861678115 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients
    • An HR, Wu XQ, Wang ZY, et al. (2012). NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients. Clin Exp Pharmacol Physiol 39: 535-543.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , pp. 535-543
    • An, H.R.1    Wu, X.Q.2    Wang, Z.Y.3
  • 2
    • 84932149963 scopus 로고    scopus 로고
    • Anonymous. Available from last accessed 3 May 2014]
    • Anonymous. (2014). World TB day: Reach the 3 Million. Available from: http://www.who.int/campaigns/tb-day/2014/en/[last accessed 3 May 2014].
    • (2014) World TB Day: Reach the 3 Million
  • 3
    • 84863938811 scopus 로고    scopus 로고
    • Management of and risk factors related to hepatotoxicity during tuberculosis treatment
    • Babalik A, Arda H, Bakirci N, et al. (2012). Management of and risk factors related to hepatotoxicity during tuberculosis treatment. Tuberk Toraks 60:136-144.
    • (2012) Tuberk Toraks , vol.60 , pp. 136-144
    • Babalik, A.1    Arda, H.2    Bakirci, N.3
  • 4
    • 1542357580 scopus 로고    scopus 로고
    • Human leukocyte antigen class i supertypes influence susceptibility and severity of tuberculosis
    • Balamurugan A, Sharma SK, Mehra NK. (2004). Human leukocyte antigen class I supertypes influence susceptibility and severity of tuberculosis. J Infect Dis 189:805-811.
    • (2004) J Infect Dis , vol.189 , pp. 805-811
    • Balamurugan, A.1    Sharma, S.K.2    Mehra, N.K.3
  • 5
    • 77952836903 scopus 로고    scopus 로고
    • Isoniazid-induced apoptosis in HepG2 cells: Generation of oxidative stress and Bcl-2 down-regulation
    • Bhadauria S, Mishra R, Kanchan R, et al. (2010). Isoniazid-induced apoptosis in HepG2 cells: Generation of oxidative stress and Bcl-2 down-regulation. Toxicol Mech Methods 20:242-251.
    • (2010) Toxicol Mech Methods , vol.20 , pp. 242-251
    • Bhadauria, S.1    Mishra, R.2    Kanchan, R.3
  • 6
    • 34249083462 scopus 로고    scopus 로고
    • Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells
    • Bhadauria S, Singh G, Sinha N, Srivastava S. (2007). Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells. Cell Mol Biol (Noisy-le-grand) 53:102-114.
    • (2007) Cell Mol Biol (Noisy-le-grand) , vol.53 , pp. 102-114
    • Bhadauria, S.1    Singh, G.2    Sinha, N.3    Srivastava, S.4
  • 7
    • 84896364866 scopus 로고    scopus 로고
    • Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress
    • Boelsterli UA, Lee KK. (2014). Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress. J Gastroenterol Hepatol 29:678-687.
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 678-687
    • Boelsterli, U.A.1    Lee, K.K.2
  • 8
    • 0038278508 scopus 로고    scopus 로고
    • An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons
    • Brandon EF, Raap CD, Meijerman I, et al. (2003). An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons. Toxicol Appl Pharmacol 189:233-246.
    • (2003) Toxicol Appl Pharmacol , vol.189 , pp. 233-246
    • Brandon, E.F.1    Raap, C.D.2    Meijerman, I.3
  • 9
    • 84867650304 scopus 로고    scopus 로고
    • Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of anti-Tuberculosis drug-induced liver injury: A meta-Analysis
    • Cai Y, Yi J, Zhou C, Shen X. (2012). Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of anti-Tuberculosis drug-induced liver injury: A meta-Analysis. PLoS One 7:e47769.
    • (2012) PLoS One , vol.7 , pp. e47769
    • Cai, Y.1    Yi, J.2    Zhou, C.3    Shen, X.4
  • 10
    • 84863172644 scopus 로고    scopus 로고
    • UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-Tuberculosis medications
    • Chang JC, Liu EH, Lee CN, et al. (2012). UGT1A1 polymorphisms associated with risk of induced liver disorders by anti-Tuberculosis medications. Int J Tuberc Lung Dis 16:376-378.
    • (2012) Int J Tuberc Lung Dis , vol.16 , pp. 376-378
    • Chang, J.C.1    Liu, E.H.2    Lee, C.N.3
  • 11
    • 33744935289 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice
    • Chowdhury A, Santra A, Bhattacharjee K, et al. (2006). Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice. J Hepatol 45:117-126.
    • (2006) J Hepatol , vol.45 , pp. 117-126
    • Chowdhury, A.1    Santra, A.2    Bhattacharjee, K.3
  • 12
    • 0021080920 scopus 로고
    • The mitochondrial metabolism of 1, 2-disubstituted hydrazines, procarbazine and 1, 2-dimethylhydrazine
    • Coomes MW, Prough RA. (1983). The mitochondrial metabolism of 1, 2-disubstituted hydrazines, procarbazine and 1, 2-dimethylhydrazine. Drug Metab Dispos 11:550-555.
    • (1983) Drug Metab Dispos , vol.11 , pp. 550-555
    • Coomes, M.W.1    Prough, R.A.2
  • 13
    • 84878471770 scopus 로고    scopus 로고
    • The binding characteristics of isoniazid with copper-zinc superoxide dismutase and its effect on enzymatic activity
    • Du N, Sheng L, Liu Z, et al. (2013). The binding characteristics of isoniazid with copper-zinc superoxide dismutase and its effect on enzymatic activity. Chem Cent J 7:97.
    • (2013) Chem Cent J , vol.7 , pp. 97
    • Du, N.1    Sheng, L.2    Liu, Z.3
  • 14
    • 0022672080 scopus 로고
    • Oxidative metabolism of some hydrazine derivatives by rat liver and lung tissue fractions
    • Erikson JM, Prough RA. (1986). Oxidative metabolism of some hydrazine derivatives by rat liver and lung tissue fractions. J Biochem Toxicol 1:41-52.
    • (1986) J Biochem Toxicol , vol.1 , pp. 41-52
    • Erikson, J.M.1    Prough, R.A.2
  • 15
    • 84880673426 scopus 로고    scopus 로고
    • Association of Nacetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India
    • Gupta VH, Amarapurkar DN, Singh M, et al. (2013). Association of Nacetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India. J Gastroenterol Hepatol 28:1368-1374.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 1368-1374
    • Gupta, V.H.1    Amarapurkar, D.N.2    Singh, M.3
  • 16
    • 34249304028 scopus 로고    scopus 로고
    • Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury
    • Huang YS. (2007). Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury. Expert Opin Drug Metab Toxicol 3:1-8.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 1-8
    • Huang, Y.S.1
  • 17
    • 84897571138 scopus 로고    scopus 로고
    • Recent progress in genetic variation and risk of antituberculosis drug-induced liver injury
    • Huang YS. (2014). Recent progress in genetic variation and risk of antituberculosis drug-induced liver injury. J Chin Med Assoc 77: 169-173.
    • (2014) J Chin Med Assoc , vol.77 , pp. 169-173
    • Huang, Y.S.1
  • 18
    • 0037380862 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    • Huang YS, Chern HD, Su WJ, et al. (2003). Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology 37:924-930.
    • (2003) Hepatology , vol.37 , pp. 924-930
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3
  • 19
    • 34249284163 scopus 로고    scopus 로고
    • Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H: Quinone oxidoreductase, glutathione S-Transferase M1 and T1, and the susceptibility to drug-induced liver injury
    • Huang YS, Su WJ, Huang YH, et al. (2007). Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H: Quinone oxidoreductase, glutathione S-Transferase M1 and T1, and the susceptibility to drug-induced liver injury. J Hepatol 47:128-134.
    • (2007) J Hepatol , vol.47 , pp. 128-134
    • Huang, Y.S.1    Su, W.J.2    Huang, Y.H.3
  • 20
    • 0242711669 scopus 로고    scopus 로고
    • Antituberculosis drug-induced hepatitis: Risk factors, prevention and management
    • Hussain Z, Kar P, Husain SA. (2003). Antituberculosis drug-induced hepatitis: Risk factors, prevention and management. Indian J Exp Biol 41:1226-1232.
    • (2003) Indian J Exp Biol , vol.41 , pp. 1226-1232
    • Hussain, Z.1    Kar, P.2    Husain, S.A.3
  • 21
    • 0043135016 scopus 로고    scopus 로고
    • The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
    • Jaeschke H, Knight TR, Bajt ML. (2003). The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 144:279-288.
    • (2003) Toxicol Lett , vol.144 , pp. 279-288
    • Jaeschke, H.1    Knight, T.R.2    Bajt, M.L.3
  • 22
    • 0022406554 scopus 로고
    • Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans
    • Lauterburg BH, Smith CV, Todd EL, Mitchell JR. (1985). Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans. J Pharmacol Exp Ther 235:566-570.
    • (1985) J Pharmacol Exp Ther , vol.235 , pp. 566-570
    • Lauterburg, B.H.1    Smith, C.V.2    Todd, E.L.3    Mitchell, J.R.4
  • 23
    • 77950881900 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-Tuberculosis druginduced hepatitis
    • Lee SW, Chung LS, Huang HH, et al. (2010). NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-Tuberculosis druginduced hepatitis. Int J Tuberc Lung Dis 14:622-626.
    • (2010) Int J Tuberc Lung Dis , vol.14 , pp. 622-626
    • Lee, S.W.1    Chung, L.S.2    Huang, H.H.3
  • 24
    • 0028817867 scopus 로고
    • Drug-induced hepatotoxicity
    • Lee WM. (1995). Drug-induced hepatotoxicity. N Engl J Med 333: 1118-1127.
    • (1995) N Engl J Med , vol.333 , pp. 1118-1127
    • Lee, W.M.1
  • 25
    • 84879171907 scopus 로고    scopus 로고
    • GSTM1 and GSTT1 genetic polymorphisms and risk of anti-Tuberculosis drug-induced hepatotoxicity: An updated meta-Analysis
    • Li C, Long J, Hu X, Zhou Y. (2013). GSTM1 and GSTT1 genetic polymorphisms and risk of anti-Tuberculosis drug-induced hepatotoxicity: An updated meta-Analysis. Eur J Clin Microbiol Infect Dis 32: 859-868.
    • (2013) Eur J Clin Microbiol Infect Dis , vol.32 , pp. 859-868
    • Li, C.1    Long, J.2    Hu, X.3    Zhou, Y.4
  • 26
    • 84455161882 scopus 로고    scopus 로고
    • A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct
    • Mahapatra S, Woolhiser LK, Lenaerts AJ, et al. (2012). A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct. Antimicrob Agents Chemother 56:28-35.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 28-35
    • Mahapatra, S.1    Woolhiser, L.K.2    Lenaerts, A.J.3
  • 27
    • 79956313436 scopus 로고    scopus 로고
    • A fresh look at the mechanism of isoniazid-induced hepatotoxicity
    • Metushi IG, Cai P, Zhu X, et al. (2011). A fresh look at the mechanism of isoniazid-induced hepatotoxicity. Clin Pharmacol Ther 89:911-914.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 911-914
    • Metushi, I.G.1    Cai, P.2    Zhu, X.3
  • 28
    • 84896690558 scopus 로고    scopus 로고
    • Detection of antiisoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure
    • Metushi IG, Sanders C, Lee WM, Uetrecht J. (2014). Detection of antiisoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure. Hepatology 59:1084-1093.
    • (2014) Hepatology , vol.59 , pp. 1084-1093
    • Metushi, I.G.1    Sanders, C.2    Lee, W.M.3    Uetrecht, J.4
  • 29
    • 0021804094 scopus 로고
    • Propane and propylene formation during the microsomal metabolism of iproniazid and isopropylhydrazine
    • Moloney SJ, Guengerich FP, Prough RA. (1985). Propane and propylene formation during the microsomal metabolism of iproniazid and isopropylhydrazine. Life Sci 36:947-954.
    • (1985) Life Sci , vol.36 , pp. 947-954
    • Moloney, S.J.1    Guengerich, F.P.2    Prough, R.A.3
  • 30
    • 84859496757 scopus 로고    scopus 로고
    • Genetic variants in antioxidant pathway: Risk factors for hepatotoxicity in tuberculosis patients
    • Nanashima K, Mawatari T, Tahara N, et al. (2012). Genetic variants in antioxidant pathway: Risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis (Edinb) 92:253-259.
    • (2012) Tuberculosis (Edinb) , vol.92 , pp. 253-259
    • Nanashima, K.1    Mawatari, T.2    Tahara, N.3
  • 31
    • 0029805130 scopus 로고    scopus 로고
    • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    • Oyake T, Itoh K, Motohashi H, et al. (1996). Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol 16:6083-6095.
    • (1996) Mol Cell Biol , vol.16 , pp. 6083-6095
    • Oyake, T.1    Itoh, K.2    Motohashi, H.3
  • 32
    • 0023502310 scopus 로고
    • Acetylation of acetylhydrazine, the toxic metabolite of isoniazid, in humans. Inhibition by concomitant administration of isoniazid
    • Peretti E, Karlaganis G, Lauterburg BH. (1987). Acetylation of acetylhydrazine, the toxic metabolite of isoniazid, in humans. Inhibition by concomitant administration of isoniazid. J Pharmacol Exp Ther 243:686-689.
    • (1987) J Pharmacol Exp Ther , vol.243 , pp. 686-689
    • Peretti, E.1    Karlaganis, G.2    Lauterburg, B.H.3
  • 33
    • 0014516713 scopus 로고
    • Evidence for the hepatic metabolism of some monoalkylhydrazines
    • Prough RA, Wittkop JA, Reed DJ. (1969). Evidence for the hepatic metabolism of some monoalkylhydrazines. Arch Biochem Biophys 131:369-373.
    • (1969) Arch Biochem Biophys , vol.131 , pp. 369-373
    • Prough, R.A.1    Wittkop, J.A.2    Reed, D.J.3
  • 34
    • 42449142373 scopus 로고    scopus 로고
    • Pharmacogenomics of anti-TB drugs-related hepatotoxicity
    • Roy PD, Majumder M, Roy B. (2008). Pharmacogenomics of anti-TB drugs-related hepatotoxicity. Pharmacogenomics 9:311-321.
    • (2008) Pharmacogenomics , vol.9 , pp. 311-321
    • Roy, P.D.1    Majumder, M.2    Roy, B.3
  • 35
    • 0036796798 scopus 로고    scopus 로고
    • Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment
    • Sharma SK, Balamurugan A, Saha PK, et al. (2002). Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med 166:916-919.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 916-919
    • Sharma, S.K.1    Balamurugan, A.2    Saha, P.K.3
  • 36
    • 84900792342 scopus 로고    scopus 로고
    • Association of NAT2, GST and CYP2E1 polymorphisms and anti-Tuberculosis drug-induced hepatotoxicity
    • Singla N, Gupta D, Birbian N, Singh J. (2014). Association of NAT2, GST and CYP2E1 polymorphisms and anti-Tuberculosis drug-induced hepatotoxicity. Tuberculosis (Edinb) 94:293-298.
    • (2014) Tuberculosis (Edinb) , Issue.94 , pp. 293-298
    • Singla, N.1    Gupta, D.2    Birbian, N.3    Singh, J.4
  • 37
    • 84930542317 scopus 로고    scopus 로고
    • Facing multi-drug resistant tuberculosis
    • Epub ahead of print]
    • Sotgiu G, Migliori GB. (2014). Facing multi-drug resistant tuberculosis. Pulm Pharmacol Ther [Epub ahead of print].
    • (2014) Pulm Pharmacol Ther
    • Sotgiu, G.1    Migliori, G.B.2
  • 38
    • 0021645980 scopus 로고
    • Effect of cytosolic components on the metabolism of the hydrazide iproniazid
    • Spearman ME, Moloney SJ, Prough RA. (1984). Effect of cytosolic components on the metabolism of the hydrazide iproniazid. Mol Pharmacol 26:566-573.
    • (1984) Mol Pharmacol , vol.26 , pp. 566-573
    • Spearman, M.E.1    Moloney, S.J.2    Prough, R.A.3
  • 39
    • 0025969396 scopus 로고
    • Toxic hepatitis with isoniazid and rifampin. A meta-Analysis
    • Steele MA, Burk RF, DesPrez RM. (1991). Toxic hepatitis with isoniazid and rifampin. A meta-Analysis. Chest 99:465-471.
    • (1991) Chest , vol.99 , pp. 465-471
    • Steele, M.A.1    Burk, R.F.2    Desprez, R.M.3
  • 41
    • 35348938570 scopus 로고    scopus 로고
    • Genetic profile of the arylamine N-Acetyltransferase 2 coding gene among individuals from two different regions of Brazil
    • Teixeira RL, Miranda AB, Pacheco AG, et al. (2007). Genetic profile of the arylamine N-Acetyltransferase 2 coding gene among individuals from two different regions of Brazil. Mutat Res 624:31-40.
    • (2007) Mutat Res , vol.624 , pp. 31-40
    • Teixeira, R.L.1    Miranda, A.B.2    Pacheco, A.G.3
  • 42
    • 0018909078 scopus 로고
    • Isoniazid hepatoxicity: The relationship between covalent binding and metabolism in vivo
    • Timbrell JA, Mitchell JR, Snodgrass WR, Nelson SD. (1980). Isoniazid hepatoxicity: The relationship between covalent binding and metabolism in vivo. J Pharmacol Exp Ther 213:364-369.
    • (1980) J Pharmacol Exp Ther , vol.213 , pp. 364-369
    • Timbrell, J.A.1    Mitchell, J.R.2    Snodgrass, W.R.3    Nelson, S.D.4
  • 43
    • 27944444088 scopus 로고    scopus 로고
    • Hydrazide derivatives produce active oxygen species as hydrazine
    • Timperio AM, Rinalducci S, Zolla L. (2005). Hydrazide derivatives produce active oxygen species as hydrazine. Bioorg Chem 33:459-469.
    • (2005) Bioorg Chem , vol.33 , pp. 459-469
    • Timperio, A.M.1    Rinalducci, S.2    Zolla, L.3
  • 44
    • 0034495943 scopus 로고    scopus 로고
    • Effectiveness and problems of PZA-containing 6-month regimen for the treatment of new pulmonary tuberculosis patients
    • Wada M. (2001). Effectiveness and problems of PZA-containing 6-month regimen for the treatment of new pulmonary tuberculosis patients. Kekkaku 76:33-43.
    • (2001) Kekkaku , vol.76 , pp. 33-43
    • Wada, M.1
  • 45
    • 0019945685 scopus 로고
    • Inhibition of metabolismmediated cytotoxicity by 1, 1-disubstituted hydrazines in mouse mastocytoma (line P815) cells
    • Wiebkin P, Sieg MS, Nelson RE, et al. (1982). Inhibition of metabolismmediated cytotoxicity by 1, 1-disubstituted hydrazines in mouse mastocytoma (line P815) cells. Biochem Pharmacol 31:2921-2928.
    • (1982) Biochem Pharmacol , vol.31 , pp. 2921-2928
    • Wiebkin, P.1    Sieg, M.S.2    Nelson, R.E.3
  • 46
    • 84899870732 scopus 로고    scopus 로고
    • The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1
    • Xiang Y, Ma L, Wu W, et al. (2014). The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. PLoS One 9:e85905.
    • (2014) PLoS One , vol.9 , pp. e85905
    • Xiang, Y.1    Ma, L.2    Wu, W.3
  • 47
    • 0022646242 scopus 로고
    • Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype
    • Yamamoto T, Suou T, Hirayama C. (1986). Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype. Hepatology 6:295-298.
    • (1986) Hepatology , vol.6 , pp. 295-298
    • Yamamoto, T.1    Suou, T.2    Hirayama, C.3
  • 48
    • 33846631743 scopus 로고    scopus 로고
    • Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-Acetyltransferase 2
    • Zang Y, Zhao S, Doll MA, et al. (2007). Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-Acetyltransferase 2. Pharmacogenet Genomics 17:37-45.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 37-45
    • Zang, Y.1    Zhao, S.2    Doll, M.A.3
  • 49
    • 0035940414 scopus 로고    scopus 로고
    • Mechanism of indinavirinduced hyperbilirubinemia
    • Zucker SD, Qin X, Rouster SD, et al. (2001). Mechanism of indinavirinduced hyperbilirubinemia. Proc Natl Acad Sci USA 98: 12671-12676.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12671-12676
    • Zucker, S.D.1    Qin, X.2    Rouster, S.D.3


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