-
1
-
-
81855227611
-
Motility and segregation of Hsp104-associated protein aggregates in budding yeast
-
Zhou C, Slaughter BD, Unruh JR, Eldakak A. et al. 2011. Motility and segregation of Hsp104-associated protein aggregates in budding yeast. Cell 147: 1186-1196.
-
(2011)
Cell
, vol.147
, pp. 1186-1196
-
-
Zhou, C.1
Slaughter, B.D.2
Unruh, J.R.3
Eldakak, A.4
-
2
-
-
0344466781
-
Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera
-
Garcia-Mata R, Bebok Z, Sorscher EJ, Sztul ES. 1999. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J Cell Biol 146: 1239-1254.
-
(1999)
J Cell Biol
, vol.146
, pp. 1239-1254
-
-
Garcia-Mata, R.1
Bebok, Z.2
Sorscher, E.J.3
Sztul, E.S.4
-
3
-
-
0032576605
-
Aggresomes: a cellular response to misfolded proteins
-
Johnston JA, Ward CL, Kopito RR. 1998. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143: 1883-1898.
-
(1998)
J Cell Biol
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
4
-
-
74549184412
-
The polarisome is required for segregation and retrograde transport of protein aggregates
-
Liu B, Larsson L, Caballero A, Hao X. et al. 2010. The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140: 257-267.
-
(2010)
Cell
, vol.140
, pp. 257-267
-
-
Liu, B.1
Larsson, L.2
Caballero, A.3
Hao, X.4
-
5
-
-
50649116818
-
Misfolded proteins partition between two distinct quality control compartments
-
Kaganovich D, Kopito R, Frydman J. 2008. Misfolded proteins partition between two distinct quality control compartments. Nature 454: 1088-1095.
-
(2008)
Nature
, vol.454
, pp. 1088-1095
-
-
Kaganovich, D.1
Kopito, R.2
Frydman, J.3
-
6
-
-
81855218130
-
Segregation of protein aggregates involves actin and the polarity machinery
-
Liu B, Larsson L, Franssens V, Hao X. et al. 2011. Segregation of protein aggregates involves actin and the polarity machinery. Cell 147: 959-961.
-
(2011)
Cell
, vol.147
, pp. 959-961
-
-
Liu, B.1
Larsson, L.2
Franssens, V.3
Hao, X.4
-
7
-
-
84865277422
-
Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates
-
Malinovska L, Kroschwald S, Munder MC, Richter D. et al. 2012. Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell 23: 3041-3056.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 3041-3056
-
-
Malinovska, L.1
Kroschwald, S.2
Munder, M.C.3
Richter, D.4
-
8
-
-
84901856381
-
Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin
-
Ogrodnik M, Salmonowicz H, Brown R, Turkowska J. et al. 2014. Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin. Proc Natl Acad Sci USA 111: 8049-8054.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 8049-8054
-
-
Ogrodnik, M.1
Salmonowicz, H.2
Brown, R.3
Turkowska, J.4
-
9
-
-
81355149538
-
Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae
-
Specht S, Miller SB, Mogk A, Bukau B. 2011. Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae. J Cell Biol 195: 617-629.
-
(2011)
J Cell Biol
, vol.195
, pp. 617-629
-
-
Specht, S.1
Miller, S.B.2
Mogk, A.3
Bukau, B.4
-
10
-
-
84868149498
-
Confinement to organelle-associated inclusion structures mediates asymmetric inheritance of aggregated protein in budding yeast
-
Spokoini R, Moldavski O, Nahmias Y, England JL. et al. 2012. Confinement to organelle-associated inclusion structures mediates asymmetric inheritance of aggregated protein in budding yeast. Cell Rep 2: 738-747.
-
(2012)
Cell Rep
, vol.2
, pp. 738-747
-
-
Spokoini, R.1
Moldavski, O.2
Nahmias, Y.3
England, J.L.4
-
11
-
-
84866883258
-
Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity
-
Weisberg SJ, Lyakhovetsky R, Werdiger AC, Gitler AD. et al. 2012. Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity. Proc Natl Acad Sci USA 109: 15811-15816.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 15811-15816
-
-
Weisberg, S.J.1
Lyakhovetsky, R.2
Werdiger, A.C.3
Gitler, A.D.4
-
12
-
-
84885223714
-
Fission yeast does not age under favorable conditions, but does so after stress
-
Coelho M, Dereli A, Haese A, Kuhn S. et al. 2013. Fission yeast does not age under favorable conditions, but does so after stress. Curr Biol 23: 1844-1852.
-
(2013)
Curr Biol
, vol.23
, pp. 1844-1852
-
-
Coelho, M.1
Dereli, A.2
Haese, A.3
Kuhn, S.4
-
13
-
-
84903316264
-
Fusion of protein aggregates facilitates asymmetric damage segregation
-
Coelho M, Lade SJ, Alberti S, Gross T. et al. 2014. Fusion of protein aggregates facilitates asymmetric damage segregation. PLoS Biol 12: e1001886.
-
(2014)
PLoS Biol
, vol.12
, pp. e1001886
-
-
Coelho, M.1
Lade, S.J.2
Alberti, S.3
Gross, T.4
-
14
-
-
84876897280
-
Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect
-
Coquel AS, Jacob JP, Primet M, Demarez A. et al. 2013. Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect. PLoS Comput Biol 9: e1003038.
-
(2013)
PLoS Comput Biol
, vol.9
, pp. e1003038
-
-
Coquel, A.S.1
Jacob, J.P.2
Primet, M.3
Demarez, A.4
-
15
-
-
84885095437
-
Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress
-
Escusa-Toret S, Vonk WI, Frydman J. 2013. Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress. Nat Cell Biol 15: 1231-1243.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1231-1243
-
-
Escusa-Toret, S.1
Vonk, W.I.2
Frydman, J.3
-
16
-
-
45549098712
-
Asymmetric mitosis: Unequal segregation of proteins destined for degradation
-
Fuentealba LC, Eivers E, Geissert D, Taelman V. et al. 2008. Asymmetric mitosis: Unequal segregation of proteins destined for degradation. Proc Natl Acad Sci USA 105: 7732-7737.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7732-7737
-
-
Fuentealba, L.C.1
Eivers, E.2
Geissert, D.3
Taelman, V.4
-
17
-
-
42949100420
-
Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation
-
Lindner AB, Madden R, Demarez A, Stewart EJ. et al. 2008. Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation. Proc Natl Acad Sci USA 105: 3076-3081.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3076-3081
-
-
Lindner, A.B.1
Madden, R.2
Demarez, A.3
Stewart, E.J.4
-
18
-
-
33845491748
-
Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes
-
Rujano MA, Bosveld F, Salomons FA, Dijk F. et al. 2006. Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes. PLoS Biol 4: e417.
-
(2006)
PLoS Biol
, vol.4
, pp. e417
-
-
Rujano, M.A.1
Bosveld, F.2
Salomons, F.A.3
Dijk, F.4
-
19
-
-
84908269537
-
Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells
-
Zhou C, Slaughter Brian D, Unruh Jay R, Guo F, et al. 2014. Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells. Cell 159: 530-542.
-
(2014)
Cell
, vol.159
, pp. 530-542
-
-
Zhou, C.1
Slaughter Brian, D.2
Unruh Jay, R.3
Guo, F.4
-
20
-
-
57749089780
-
Selective benefits of damage partitioning in unicellular systems and its effects on aging
-
Erjavec N, Cvijovic M, Klipp E, Nystrom T. 2008. Selective benefits of damage partitioning in unicellular systems and its effects on aging. Proc Natl Acad Sci USA 105: 18764-18769.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18764-18769
-
-
Erjavec, N.1
Cvijovic, M.2
Klipp, E.3
Nystrom, T.4
-
21
-
-
34547410267
-
Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae
-
Erjavec N, Nystrom T. 2007. Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104: 10877-10881.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10877-10881
-
-
Erjavec, N.1
Nystrom, T.2
-
22
-
-
77649293067
-
Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing
-
Winkler J, Seybert A, Konig L, Pruggnaller S. et al. 2010. Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing. EMBO J 29: 910-923.
-
(2010)
EMBO J
, vol.29
, pp. 910-923
-
-
Winkler, J.1
Seybert, A.2
Konig, L.3
Pruggnaller, S.4
-
23
-
-
0242585476
-
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
-
Aguilaniu H, Gustafsson L, Rigoulet M, Nystrom T. 2003. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299: 1751-1753.
-
(2003)
Science
, vol.299
, pp. 1751-1753
-
-
Aguilaniu, H.1
Gustafsson, L.2
Rigoulet, M.3
Nystrom, T.4
-
24
-
-
84903363791
-
The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress
-
Weids AJ, Grant CM. 2014. The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress. J Cell Sci 127: 1327-1335.
-
(2014)
J Cell Sci
, vol.127
, pp. 1327-1335
-
-
Weids, A.J.1
Grant, C.M.2
-
25
-
-
84859091769
-
Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans
-
Burkewitz K, Choe KP, Lee EC, Deonarine A. et al. 2012. Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans. PLoS One 7: e34153.
-
(2012)
PLoS One
, vol.7
, pp. e34153
-
-
Burkewitz, K.1
Choe, K.P.2
Lee, E.C.3
Deonarine, A.4
-
26
-
-
34047179973
-
Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy
-
Kaniuk NA, Kiraly M, Bates H, Vranic M. et al. 2007. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56: 930-939.
-
(2007)
Diabetes
, vol.56
, pp. 930-939
-
-
Kaniuk, N.A.1
Kiraly, M.2
Bates, H.3
Vranic, M.4
-
27
-
-
84860361727
-
Segregation of molecules at cell division reveals native protein localization
-
Landgraf D, Okumus B, Chien P, Baker TA. et al. 2012. Segregation of molecules at cell division reveals native protein localization. Nat Methods 9: 480-482.
-
(2012)
Nat Methods
, vol.9
, pp. 480-482
-
-
Landgraf, D.1
Okumus, B.2
Chien, P.3
Baker, T.A.4
-
28
-
-
84860387931
-
Tracking protein aggregation and mislocalization in cells with flow cytometry
-
Ramdzan YM, Polling S, Chia CP, Ng IH, et al. 2012. Tracking protein aggregation and mislocalization in cells with flow cytometry. Nat Methods 9: 467-470.
-
(2012)
Nat Methods
, vol.9
, pp. 467-470
-
-
Ramdzan, Y.M.1
Polling, S.2
Chia, C.P.3
Ng, I.H.4
-
29
-
-
84878589158
-
The asymmetric segregation of damaged proteins is stem cell-type dependent
-
Bufalino MR, DeVeale B, van der Kooy D. 2013. The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol 201: 523-530.
-
(2013)
J Cell Biol
, vol.201
, pp. 523-530
-
-
Bufalino, M.R.1
DeVeale, B.2
van der Kooy, D.3
-
30
-
-
84871011474
-
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
-
Hughes AL, Gottschling DE. 2012. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492: 261-265.
-
(2012)
Nature
, vol.492
, pp. 261-265
-
-
Hughes, A.L.1
Gottschling, D.E.2
-
31
-
-
84889583055
-
Actin dynamics affect mitochondrial quality control and aging in budding yeast
-
Higuchi R, Vevea JD, Swayne TC, Chojnowski R. et al. 2013. Actin dynamics affect mitochondrial quality control and aging in budding yeast. Curr Biol 23: 2417-2422.
-
(2013)
Curr Biol
, vol.23
, pp. 2417-2422
-
-
Higuchi, R.1
Vevea, J.D.2
Swayne, T.C.3
Chojnowski, R.4
-
32
-
-
84905484568
-
Essential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregates
-
Song J, Yang Q, Yang J, Larsson L. et al. 2014. Essential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregates. PLoS Genet 10: e1004539.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004539
-
-
Song, J.1
Yang, Q.2
Yang, J.3
Larsson, L.4
-
33
-
-
33845876643
-
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
-
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A. et al. 2007. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol 9: 99-105.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 99-105
-
-
Scheckhuber, C.Q.1
Erjavec, N.2
Tinazli, A.3
Hamann, A.4
-
34
-
-
84909607974
-
Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling
-
Jan CH, Williams CC, Weissman JS. 2014. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science 346: 1257521.
-
(2014)
Science
, vol.346
, pp. 1257521
-
-
Jan, C.H.1
Williams, C.C.2
Weissman, J.S.3
-
35
-
-
84909606778
-
Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling
-
Williams CC, Jan CH, Weissman JS. 2014. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Science 346: 748-751.
-
(2014)
Science
, vol.346
, pp. 748-751
-
-
Williams, C.C.1
Jan, C.H.2
Weissman, J.S.3
-
36
-
-
77956795163
-
Widespread protein aggregation as an inherent part of aging in C. elegans
-
David DC, Ollikainen N, Trinidad JC, Cary MP. et al. 2010. Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol 8: e1000450.
-
(2010)
PLoS Biol
, vol.8
, pp. e1000450
-
-
David, D.C.1
Ollikainen, N.2
Trinidad, J.C.3
Cary, M.P.4
-
37
-
-
84916922050
-
Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast
-
Henderson KA, Hughes AL, Gottschling DE. 2014. Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast. Elife 3: e03504.
-
(2014)
Elife
, vol.3
, pp. e03504
-
-
Henderson, K.A.1
Hughes, A.L.2
Gottschling, D.E.3
|