메뉴 건너뛰기




Volumn 21, Issue 21, 2015, Pages 2993-3001

New molecules as drug candidates for the treatment of upper and lower GI tract Ulcers

Author keywords

Angiogenic growth factors; Angiogenic steroids; Angiostatic steroids; Angiosteroids; BFGF; Crohn s disease; Dopamine; Gastric and duodenal ulcers; Inflammatory bowel diseases; PDGF; Pyrazole derivatives; Ulcerative colitis; VEGF

Indexed keywords

ALCOHOL; ANTIULCER AGENT; DOPAMINE; ENEMA; FIBROBLAST GROWTH FACTOR 2; NONSTEROID ANTIINFLAMMATORY AGENT; PLATELET DERIVED GROWTH FACTOR; PYRAZOLE; STEROID; VASCULOTROPIN; ANGIOGENIC PROTEIN; PYRAZOLE DERIVATIVE;

EID: 84931846557     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150514105026     Document Type: Article
Times cited : (7)

References (102)
  • 2
    • 0002210727 scopus 로고
    • A syndrome produced by diverse nocuous agents
    • Selye H. A syndrome produced by diverse nocuous agents. Nature 1936; 138: 132.
    • (1936) Nature , vol.138 , pp. 132
    • Selye, H.1
  • 4
    • 84865513832 scopus 로고    scopus 로고
    • The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief "Letter" to the Editor of Nature
    • Szabo S, Tache Y, Somogyi A. The legacy of Hans Selye and the origins of stress research: a retrospective 75 years after his landmark brief "Letter" to the Editor of Nature. Stress 2012; 15: 472-8.
    • (2012) Stress , vol.15 , pp. 472-478
    • Szabo, S.1    Tache, Y.2    Somogyi, A.3
  • 5
    • 50349133528 scopus 로고
    • Perforated peptic ulcer during air-raid
    • Selye H. Perforated peptic ulcer during air-raid. Lancet 1943; 20: 252.
    • (1943) Lancet , vol.20 , pp. 252
    • Selye, H.1
  • 7
    • 0347531789 scopus 로고
    • Perforated peptic ulcer during the period of heavy air-raids
    • Spicer CC, Stewart DN, Winser DMdeR. Perforated peptic ulcer during the period of heavy air-raids. Lancet 1944; 1: 14-5.
    • (1944) Lancet , vol.1 , pp. 14-15
    • Spicer, C.C.1    Stewart, D.N.2    deWinser, D.M.R.3
  • 8
    • 77952841800 scopus 로고    scopus 로고
    • Identification of NSAID users at risk for gastrointestinal complications: A systematic review of current guidelines and consensus agreements
    • Tielemans MM, Eikendal T, Jansen JB, van Oijen MG. Identification of NSAID users at risk for gastrointestinal complications: a systematic review of current guidelines and consensus agreements. Drug Saf 2010; 33: 443-53.
    • (2010) Drug Saf , vol.33 , pp. 443-453
    • Tielemans, M.M.1    Eikendal, T.2    Jansen, J.B.3    van Oijen, M.G.4
  • 9
    • 77952478071 scopus 로고    scopus 로고
    • Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events
    • Scheiman JM, Hindley CE. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther 2010; 32: 667-77.
    • (2010) Clin Ther , vol.32 , pp. 667-677
    • Scheiman, J.M.1    Hindley, C.E.2
  • 10
    • 84920247287 scopus 로고
    • Unidentified curved bacilli on gastric epithelium in active chronic gastritis
    • Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; 321: 1273-5.
    • (1983) Lancet , vol.321 , pp. 1273-1275
    • Warren, J.R.1    Marshall, B.2
  • 11
    • 84931832840 scopus 로고    scopus 로고
    • Hans Selye 70 years later: Steroids, stress ulcers and H. pylori
    • Szabo S. Hans Selye 70 years later: Steroids, stress ulcers and H. pylori. Arch Neurosci [Ideggyogy Szemle] 2014; 67: 85-8.
    • (2014) Arch Neurosci [Ideggyogy Szemle] , vol.67 , pp. 85-88
    • Szabo, S.1
  • 12
    • 79953703986 scopus 로고    scopus 로고
    • The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxity
    • Liu Z, Yadav PK, Xu X, et al. The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxity. J Leukoc Biol 2011; 89: 597-606.
    • (2011) J Leukoc Biol , vol.89 , pp. 597-606
    • Liu, Z.1    Yadav, P.K.2    Xu, X.3
  • 13
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 14
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 15
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456: 259-63.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 16
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008; 40: 1319-23.
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 17
    • 84855215371 scopus 로고    scopus 로고
    • Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice
    • Tolstanova G, Deng XM, French S, et al. Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice. Lab Invest 2012; 92: 9-21.
    • (2012) Lab Invest , vol.92 , pp. 9-21
    • Tolstanova, G.1    Deng, X.M.2    French, S.3
  • 21
    • 33749058959 scopus 로고    scopus 로고
    • Szabo S. Altered angiogenic balance in ulcerative colitis: A key to impaired healing?
    • Sandor Z, Deng XM, Khomenko T, Tarnawski AS, Szabo S. Altered angiogenic balance in ulcerative colitis: a key to impaired healing? Biochem Biophys Res Commun 2006; 350: 147-50.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 147-150
    • Sandor, Z.1    Deng, X.M.2    Khomenko, T.3    Tarnawski, A.S.4
  • 24
    • 84931833026 scopus 로고    scopus 로고
    • Why gastrointestinal ulcers develop and do not heal? From New Ulcerogenic Chemicals to Novel Molecular Mediators and Ulcer Genes
    • Mozsik G, Ed. Budapest: Akademiai Kiado
    • Szabo S, Chen L, Deng X, et al. Why gastrointestinal ulcers develop and do not heal? From New Ulcerogenic Chemicals to Novel Molecular Mediators and Ulcer Genes In: Mozsik G, Ed. Discoveries in Gastroenterology: From Basic Research to Clinical Perspectives 1960-2005. Budapest: Akademiai Kiado 2006; pp. 399-443.
    • (2006) Discoveries in Gastroenterology: From Basic Research to Clinical Perspectives 1960-2005 , pp. 399-443
    • Szabo, S.1    Chen, L.2    Deng, X.3
  • 25
    • 79959960475 scopus 로고    scopus 로고
    • Angiogenic and antiangiogenic therapy for gastrointestinal ulcers: New challenges for rational therapeutic predictions and drug design
    • Szabo S, Deng XM, Tolstanova G, et al. Angiogenic and antiangiogenic therapy for gastrointestinal ulcers: New challenges for rational therapeutic predictions and drug design. Curr Pharm Des 2011; 17: 1633-42.
    • (2011) Curr Pharm Des , vol.17 , pp. 1633-1642
    • Szabo, S.1    Deng, X.M.2    Tolstanova, G.3
  • 26
    • 0018292487 scopus 로고
    • Cytoprotection by prostaglandins
    • Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761-7.
    • (1979) Gastroenterology , vol.77 , pp. 761-767
    • Robert, A.1
  • 27
    • 0018350772 scopus 로고
    • Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine and probanthine
    • Guth PH, Aures D, Paulsen G: Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine and probanthine. Gastroenterology 1979; 76: 88-93.
    • (1979) Gastroenterology , vol.76 , pp. 88-93
    • Guth, P.H.1    Aures, D.2    Paulsen, G.3
  • 28
    • 0021057636 scopus 로고
    • Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls and cimetidine in the rat
    • Szabo S, Gallagher G, Horner HC, et al. Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls and cimetidine in the rat. Gastroenterology 1983; 85: 1384-90.
    • (1983) Gastroenterology , vol.85 , pp. 1384-1390
    • Szabo, S.1    Gallagher, G.2    Horner, H.C.3
  • 29
    • 0019825246 scopus 로고
    • Sulfhydryl compounds may mediate cytoprotection
    • Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate cytoprotection. Science 1981; 214: 200-2.
    • (1981) Science , vol.214 , pp. 200-202
    • Szabo, S.1    Trier, J.S.2    Frankel, P.W.3
  • 30
    • 0021236780 scopus 로고
    • Peptides, sulfhydryls, and glucocorticoids in gastric mucosal defense: Coincidence or connection?
    • Szabo S. Peptides, sulfhydryls, and glucocorticoids in gastric mucosal defense: coincidence or connection? Gastroenterology 1984; 87: 228-9.
    • (1984) Gastroenterology , vol.87 , pp. 228-229
    • Szabo, S.1
  • 31
    • 0021680862 scopus 로고
    • Rapid epithelial restitution of the rat gastric mucosa after ethanol injury
    • Lacy ER, Ito S. Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 1984; 51: 573-83.
    • (1984) Lab Invest , vol.51 , pp. 573-583
    • Lacy, E.R.1    Ito, S.2
  • 32
    • 0022006479 scopus 로고
    • Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat
    • Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88: 228-36.
    • (1985) Gastroenterology , vol.88 , pp. 228-236
    • Szabo, S.1    Trier, J.S.2    Brown, A.3    Schnoor, J.4
  • 33
    • 0023035825 scopus 로고
    • Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16, 16-dimethyl prostaglandin E2 or sodium thiosulfate
    • Pihan G, Majzoubi D, Haudenschild C, Trier JS, Szabo S. Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16, 16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 1986; 91: 1415-26.
    • (1986) Gastroenterology , vol.91 , pp. 1415-1426
    • Pihan, G.1    Majzoubi, D.2    Haudenschild, C.3    Trier, J.S.4    Szabo, S.5
  • 35
    • 0026064386 scopus 로고
    • Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury
    • Hauser J, Szabo S. Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury. J Pharmacol Exp Ther 1991; 256: 592-8.
    • (1991) J Pharmacol Exp Ther , vol.256 , pp. 592-598
    • Hauser, J.1    Szabo, S.2
  • 37
    • 84919421114 scopus 로고    scopus 로고
    • "Gastric cytoprotection" is still relevant
    • Szabo S. "Gastric cytoprotection" is still relevant. J Gastroenterol Hepatol 2014; 29(Suppl. 4): 124-32.
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 124-132
    • Szabo, S.1
  • 38
    • 70349199435 scopus 로고    scopus 로고
    • Helicobacter pylori-negative duodenal ulcer disease
    • Gisbert JP, Calvet X. Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther 2009; 30: 791-815.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 791-815
    • Gisbert, J.P.1    Calvet, X.2
  • 39
    • 84876563514 scopus 로고    scopus 로고
    • Is Helicobacter pylori infection the primary cause of duodenal ulceration or a secondary factor? A review of the evidence
    • Kate V, Ananthakrishnan N, Tovey FI. Is Helicobacter pylori infection the primary cause of duodenal ulceration or a secondary factor? A review of the evidence. Gastroenterol Res Pract 2013, Article ID 425840, 8 pages.
    • (2013) Gastroenterol Res Pract
    • Kate, V.1    Ananthakrishnan, N.2    Tovey, F.I.3
  • 41
    • 0030670231 scopus 로고    scopus 로고
    • Substantial production of dopamine in the human gastrointestinal tract
    • Eisenhofer G, Aneman A, Friberg P, et al. Substantial production of dopamine in the human gastrointestinal tract. J Clin Endocrinol Metab 1997; 82: 3864-71.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3864-3871
    • Eisenhofer, G.1    Aneman, A.2    Friberg, P.3
  • 42
    • 0027230374 scopus 로고
    • Soares-da-Silva P Dopamine formation, from its immediate precursor 3, 4-dihydroxyphenylalanine, along the rat digestive tract
    • Vieira-Coelho MA, Soares-da-Silva P Dopamine formation, from its immediate precursor 3, 4-dihydroxyphenylalanine, along the rat digestive tract. Fundam Clin Pharmacol 1993; 7: 235-43.
    • (1993) Fundam Clin Pharmacol , vol.7 , pp. 235-243
    • Vieira-Coelho, M.A.1
  • 43
    • 0001077810 scopus 로고
    • Dopamine and dopamine receptors in the gut: Their possible role in duodenal ulceration
    • Kohasaka M, Shohmori J, Tsukada Y, Woodruff GN, Eds. Oxford: Pergamon Press
    • Szabo S, Sandrock AW, Nafradi J, Maull EA, Gallagher GT, Blyzniuk A. Dopamine and dopamine receptors in the gut: Their possible role in duodenal ulceration. In: Kohasaka M, Shohmori J, Tsukada Y, Woodruff GN, Eds. Advances in Dopamine Research. Oxford: Pergamon Press 1982; pp. 165-70.
    • (1982) Advances in Dopamine Research , pp. 165-170
    • Szabo, S.1    Sandrock, A.W.2    Nafradi, J.3    Maull, E.A.4    Gallagher, G.T.5    Blyzniuk, A.6
  • 44
    • 33644829284 scopus 로고    scopus 로고
    • Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: Analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice
    • Li ZS, Schmauss C, Cuenca A, Ratcliffe E, Gershon MD. Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: Analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. J Neurosci 2006; 26: 2798-807.
    • (2006) J Neurosci , vol.26 , pp. 2798-2807
    • Li, Z.S.1    Schmauss, C.2    Cuenca, A.3    Ratcliffe, E.4    Gershon, M.D.5
  • 45
    • 0019989665 scopus 로고
    • Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis
    • Szabo S, Reynolds ES, Unger SH. Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. J Pharmacol Exp Ther 1982; 223: 68-76.
    • (1982) J Pharmacol Exp Ther , vol.223 , pp. 68-76
    • Szabo, S.1    Reynolds, E.S.2    Unger, S.H.3
  • 46
    • 0023116726 scopus 로고
    • Effect of dopamine-related drugs on duodenal ulcer induced by cysteamine or propionitrile: Prevention and aggravation may not be mediated by gastrointestinal secretory change in the rat
    • Gallagher G, Brown A, Szabo S. Effect of dopamine-related drugs on duodenal ulcer induced by cysteamine or propionitrile: Prevention and aggravation may not be mediated by gastrointestinal secretory change in the rat. J Pharmacol Exp Ther 1987; 240: 883-9.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 883-889
    • Gallagher, G.1    Brown, A.2    Szabo, S.3
  • 47
    • 0345699369 scopus 로고
    • Drug-induced duodenal ulcer: Structure-activity correlations and pathogenesis
    • Pfeiffer CJ, Ed. Boca Raton: CRC Press
    • Szabo S, Horner HC, Gallagher GT. Drug-induced duodenal ulcer: Structure-activity correlations and pathogenesis. In: Pfeiffer CJ, Ed. Drugs and Peptic Ulcer. Boca Raton: CRC Press 1982; vol.2: pp. 55-74.
    • (1982) Drugs and Peptic Ulcer , vol.2 , pp. 55-74
    • Szabo, S.1    Horner, H.C.2    Gallagher, G.T.3
  • 48
    • 0018597201 scopus 로고
    • Dopamine disorder in duodenal ulceration
    • Szabo S. Dopamine disorder in duodenal ulceration. Lancet 1979; 2: 880-2.
    • (1979) Lancet , vol.2 , pp. 880-882
    • Szabo, S.1
  • 49
    • 0022297111 scopus 로고
    • Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine)
    • Szabo S, Brown A, Pihan G, Dali H, Neumeyer JL. Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine). Proc Soc Exp Biol Med 1985; 180: 567-71.
    • (1985) Proc Soc Exp Biol Med , vol.180 , pp. 567-571
    • Szabo, S.1    Brown, A.2    Pihan, G.3    Dali, H.4    Neumeyer, J.L.5
  • 51
    • 0023112793 scopus 로고
    • Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat
    • Szabo S, Horner HC, Maull H, Schnoor J, Chieuh CC, Palkovits M. Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat. J Pharmacol Exp Ther 1987; 240: 871-8.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 871-878
    • Szabo, S.1    Horner, H.C.2    Maull, H.3    Schnoor, J.4    Chieuh, C.C.5    Palkovits, M.6
  • 52
    • 0019836385 scopus 로고
    • Differential effect of changing central and peripheral catecholamine levels in cysteamine-induced duodenal ulcer in the rat
    • Horner HC, Szabo S. Differential effect of changing central and peripheral catecholamine levels in cysteamine-induced duodenal ulcer in the rat. Life Sci 1981; 29: 2437-43.
    • (1981) Life Sci , vol.29 , pp. 2437-2443
    • Horner, H.C.1    Szabo, S.2
  • 53
    • 36749020653 scopus 로고    scopus 로고
    • Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: Revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis
    • Ozdemir V, Jamal MM, Osapay K, et al. Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: Revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis. Investig Med 2007; 55: 315-20.
    • (2007) Investig Med , vol.55 , pp. 315-320
    • Ozdemir, V.1    Jamal, M.M.2    Osapay, K.3
  • 54
    • 0021301919 scopus 로고
    • Role of dopamine receptors in the mechanism of formation of stress-induced stomach lesions
    • Groĭsman SD, Karevina TG, Khokholia VP. Role of dopamine receptors in the mechanism of formation of stress-induced stomach lesions. Bull Eksp Biol Med 1984; 97(1): 57-60.
    • (1984) Bull Eksp Biol Med , vol.97 , Issue.1 , pp. 57-60
    • Groĭsman, S.D.1    Karevina, T.G.2    Khokholia, V.P.3
  • 55
    • 35348865434 scopus 로고    scopus 로고
    • The effect of sulpirid in treatment of patients with gastric and duodenal erosions and ulcers
    • Belova EV. The effect of sulpirid in treatment of patients with gastric and duodenal erosions and ulcers. [Article in Russian]. Klin Med (Mosk) 2007; 85(7): 70-3.
    • (2007) [Article in Russian]. Klin Med (Mosk) , vol.85 , Issue.7 , pp. 70-73
    • Belova, E.V.1
  • 56
    • 0036149120 scopus 로고    scopus 로고
    • Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5- hydroxytryptamine in human inflammatory bowel disease
    • Magro F, Vieira-Coelho MA, Fraga S, et al. Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5- hydroxytryptamine in human inflammatory bowel disease. Dig Dis Sci 2002; 47: 216-24.
    • (2002) Dig Dis Sci , vol.47 , pp. 216-224
    • Magro, F.1    Vieira-Coelho, M.A.2    Fraga, S.3
  • 57
    • 1942534113 scopus 로고    scopus 로고
    • Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake
    • Magro F, Fraga S, Ribeiro T, et al. Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake. Acta Physiol Scand 2004; 180: 379-86.
    • (2004) Acta Physiol Scand , vol.180 , pp. 379-386
    • Magro, F.1    Fraga, S.2    Ribeiro, T.3
  • 58
    • 33751531923 scopus 로고    scopus 로고
    • Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment
    • Magro F, Cunha E, Araujo F, et al. Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment. Dig Dis Sci 2006; 51: 2039-44.
    • (2006) Dig Dis Sci , vol.51 , pp. 2039-2044
    • Magro, F.1    Cunha, E.2    Araujo, F.3
  • 59
    • 46349111790 scopus 로고    scopus 로고
    • Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation
    • Straub RH, Grum F, Strauch U, et al. Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Gut 2008; 57: 911-21.
    • (2008) Gut , vol.57 , pp. 911-921
    • Straub, R.H.1    Grum, F.2    Strauch, U.3
  • 60
    • 84867823011 scopus 로고    scopus 로고
    • Colonic inflammation in Parkinson's disease
    • Devos D, Lebouvier T, Lardeux B, et al. Colonic inflammation in Parkinson's disease. Neurobiol Dis 2013; 50: 42-8.
    • (2013) Neurobiol Dis , vol.50 , pp. 42-48
    • Devos, D.1    Lebouvier, T.2    Lardeux, B.3
  • 61
    • 84857540888 scopus 로고    scopus 로고
    • Suchowersky O. Increased intestinal permeability and Parkinson disease patients: Chicken or egg?
    • Salat-Foix D, Tran K, Ranawaya R, Meddings J, Suchowersky O. Increased intestinal permeability and Parkinson disease patients: chicken or egg? Can J Neurol Sci 2012; 39: 185-8.
    • (2012) Can J Neurol Sci , vol.39 , pp. 185-188
    • Salat-Foix, D.1    Tran, K.2    Ranawaya, R.3    Meddings, J.4
  • 62
    • 82455206282 scopus 로고    scopus 로고
    • Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease
    • Forsyth CB, Shannon KM, Kordower JH, et al. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PLoS One 2011; 6(12): e28032.
    • (2011) PLoS One , vol.6 , Issue.12
    • Forsyth, C.B.1    Shannon, K.M.2    Kordower, J.H.3
  • 63
    • 0014872848 scopus 로고
    • A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis
    • Brahme F, Lindstrom C. A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis. Gut 1970; 11: 928-40.
    • (1970) Gut , vol.11 , pp. 928-940
    • Brahme, F.1    Lindstrom, C.2
  • 64
    • 34249822849 scopus 로고    scopus 로고
    • Differential angiogenic regulation of experimental colitis
    • Chidlow JH Jr, Langston W, Greer JJM, et al. Differential angiogenic regulation of experimental colitis. Am J Pathol 2006; 169: 2014-30.
    • (2006) Am J Pathol , vol.169 , pp. 2014-2030
    • Chidlow, J.H.1    Langston, W.2    Greer, J.J.M.3
  • 65
    • 33744510694 scopus 로고    scopus 로고
    • Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
    • Danese S, Sans M, Motte CDL, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroeneterology 2006; 130: 2060-73.
    • (2006) Gastroeneterology , vol.130 , pp. 2060-2073
    • Danese, S.1    Sans, M.2    Motte, C.D.L.3
  • 66
    • 62449300644 scopus 로고    scopus 로고
    • Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: Direct evidence for the pathogenic role of VEGF
    • Tolstanova G, Khomenko T, Deng X, et al. Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: direct evidence for the pathogenic role of VEGF. J Pharmacol Exp Ther 2009; 328: 749- 57.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 57-749
    • Tolstanova, G.1    Khomenko, T.2    Deng, X.3
  • 67
    • 78249232956 scopus 로고    scopus 로고
    • Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice
    • Jerkic M, Peter M, Ardelean D, et al. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice. Inflamm Bowel Dis 2010; 16: 1859-70.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1859-1870
    • Jerkic, M.1    Peter, M.2    Ardelean, D.3
  • 68
    • 58649111743 scopus 로고    scopus 로고
    • VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
    • Scaldaferri F, Vetrano S, Sans M, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 2009; 136: 585-95.
    • (2009) Gastroenterology , vol.136 , pp. 585-595
    • Scaldaferri, F.1    Vetrano, S.2    Sans, M.3
  • 69
    • 79958842222 scopus 로고    scopus 로고
    • Feasibility of anti-VEGF agent bevacizumab in patients with Crohn's disease
    • Coriat R, Mir O, Leblanc S, et al. Feasibility of anti-VEGF agent bevacizumab in patients with Crohn's disease. Inflamm Bowel Dis 2011; 17: 1632.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1632
    • Coriat, R.1    Mir, O.2    Leblanc, S.3
  • 70
    • 0035026748 scopus 로고    scopus 로고
    • The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/ vascular endothelial growth factor
    • Basu S, Nagy JA, Pal S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/ vascular endothelial growth factor. Nat Med 2001; 7: 569-74.
    • (2001) Nat Med , vol.7 , pp. 569-574
    • Basu, S.1    Nagy, J.A.2    Pal, S.3
  • 71
    • 42249112993 scopus 로고    scopus 로고
    • Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models
    • Sarkar C, Chakroborty D, Chowdhury UR, et al. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin Cancer Res 2008; 14: 2502-10.
    • (2008) Clin Cancer Res , vol.14 , pp. 2502-2510
    • Sarkar, C.1    Chakroborty, D.2    Chowdhury, U.R.3
  • 72
    • 4143067127 scopus 로고    scopus 로고
    • Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factormediated angiogenesis
    • Basu S, Sarkar C, Chakroborty D, et al. Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factormediated angiogenesis. Cancer Res 2004; 64: 5551-5.
    • (2004) Cancer Res , vol.64 , pp. 5551-5555
    • Basu, S.1    Sarkar, C.2    Chakroborty, D.3
  • 73
    • 49949092565 scopus 로고    scopus 로고
    • The neurotransmitter dopamine modulates vascular permeability in the endothelium
    • Bhattacharya R, Sinha S, Yang SP, et al. The neurotransmitter dopamine modulates vascular permeability in the endothelium. J Mol Signal 2008; 3: 14.
    • (2008) J Mol Signal , vol.3 , pp. 14
    • Bhattacharya, R.1    Sinha, S.2    Yang, S.P.3
  • 74
    • 78649579140 scopus 로고    scopus 로고
    • Novel highly effective medical treatment of severe treatment refractory Crohn's disease using sympathomimetic amines: Case report
    • Check JH, Katsoff B, Cohen R. Novel highly effective medical treatment of severe treatment refractory Crohn's disease using sympathomimetic amines: case report. Inflamm Bowel Dis 2010; 16: 1999-2000.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1999-2000
    • Check, J.H.1    Katsoff, B.2    Cohen, R.3
  • 75
    • 79951654282 scopus 로고    scopus 로고
    • Case report showing that a woman with ulcerative colitis refractory to standard therapy responded well to the sympathomimetic amine dextroamphetamine sulfate
    • Check JH, Katsoff B, Cohen R. Case report showing that a woman with ulcerative colitis refractory to standard therapy responded well to the sympathomimetic amine dextroamphetamine sulfate. Inflamm Bowel Dis 2011; 17: 870-1.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 870-871
    • Check, J.H.1    Katsoff, B.2    Cohen, R.3
  • 76
    • 33750943987 scopus 로고    scopus 로고
    • The treatment of idiopathic edema, a cause of chronic pelvic pain in women: Effectively controlled chronic refractory urticaria--case reports
    • Check JH, Amadi C, Kaplan H, Katsoff D. The treatment of idiopathic edema, a cause of chronic pelvic pain in women: effectively controlled chronic refractory urticaria--case reports. Clin Exp Obstet Gynecol 2006; 33: 183-4.
    • (2006) Clin Exp Obstet Gynecol , vol.33 , pp. 183-184
    • Check, J.H.1    Amadi, C.2    Kaplan, H.3    Katsoff, D.4
  • 77
    • 0025142652 scopus 로고
    • Dopamine in gastrointestinal disease
    • Glavin GB, Szabo S. Dopamine in gastrointestinal disease. Dig Dis Sci 1990; 35: 1153-61.
    • (1990) Dig Dis Sci , vol.35 , pp. 1153-1161
    • Glavin, G.B.1    Szabo, S.2
  • 78
  • 79
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-80.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 80
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocrinol Rev 1997; 18: 4-25.
    • (1997) Endocrinol Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 82
    • 0028270417 scopus 로고
    • Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats
    • Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology 1994; 106: 1106-11.
    • (1994) Gastroenterology , vol.106 , pp. 1106-1111
    • Szabo, S.1    Folkman, J.2    Vattay, P.3    Morales, R.E.4    Pinkus, G.S.5    Kato, K.6
  • 83
    • 0026070033 scopus 로고
    • Duodenal ulcer: Discovery of a new mechanism and development of angiogenic therapy that accelerates healing
    • Folkman J, Szabo S, Stovroff M. McNeil P, Li W, Shing Y. Duodenal ulcer: Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann Surg 1991; 214: 414-26.
    • (1991) Ann Surg , vol.214 , pp. 414-426
    • Folkman, J.1    Szabo, S.2    Stovroff, M.3    McNeil, P.4    Li, W.5    Shing, Y.6
  • 84
    • 0001358972 scopus 로고
    • Effect of rhbFGF mutein CS23 (TGP-580) on the healing of gastric ulcers induced by acetic acid in rats
    • Satoh H, Shino A, Inatomi N, et al. Effect of rhbFGF mutein CS23 (TGP-580) on the healing of gastric ulcers induced by acetic acid in rats. Gastroenterology 1991; 100: A155.
    • (1991) Gastroenterology , vol.100
    • Satoh, H.1    Shino, A.2    Inatomi, N.3
  • 85
    • 0028822763 scopus 로고
    • Different molecular forms of basic fibroblast growth factor (bFGF) accelerate duodenal ulcer healing in rats
    • Kusstatscher S, Sandor Z, Szabo S, et al. Different molecular forms of basic fibroblast growth factor (bFGF) accelerate duodenal ulcer healing in rats. J Pharmacol Exp Ther 1995; 275: 456-61.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 456-461
    • Kusstatscher, S.1    Sandor, Z.2    Szabo, S.3
  • 86
    • 0029919577 scopus 로고    scopus 로고
    • Basic fibroblast growth factor and PDGF in GI diseases
    • Szabo S, Sandor Z. Basic fibroblast growth factor and PDGF in GI diseases. Baillere's Clin Gastroenterol 1996; 10: 97-112.
    • (1996) Baillere's Clin Gastroenterol , vol.10 , pp. 97-112
    • Szabo, S.1    Sandor, Z.2
  • 90
    • 0028869030 scopus 로고
    • Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration
    • Hull MA, Cullen DJ, Hudson N, et al. Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration. Gut 1995; 37: 610-2.
    • (1995) Gut , vol.37 , pp. 610-612
    • Hull, M.A.1    Cullen, D.J.2    Hudson, N.3
  • 92
    • 10044253117 scopus 로고    scopus 로고
    • Gene therapy with adenoviral plasmids or naked DNA of vascular endothelial growth factor and platelet-derived growth factor accelerates healing of duodenal ulcer in rats
    • Deng X, Szabo S, Khomenko T, Jadus MR, Yoshida M. Gene therapy with adenoviral plasmids or naked DNA of vascular endothelial growth factor and platelet-derived growth factor accelerates healing of duodenal ulcer in rats. J Pharmacol Exp Ther 2004; 311: 982-8.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 982-988
    • Deng, X.1    Szabo, S.2    Khomenko, T.3    Jadus, M.R.4    Yoshida, M.5
  • 93
    • 0009620657 scopus 로고
    • Platelet-derived growth factor (PDGF) accelerates the healing of experimental ulcerative colitis in rats
    • Sandor Z, Szeli D, Charette M, Szabo S. Platelet-derived growth factor (PDGF) accelerates the healing of experimental ulcerative colitis in rats. Gastroenterology 1995; 108(4): A887.
    • (1995) Gastroenterology , vol.108 , Issue.4
    • Sandor, Z.1    Szeli, D.2    Charette, M.3    Szabo, S.4
  • 94
    • 0029643432 scopus 로고
    • Effect of plateletderived growth factor in experimental colitis in rats
    • Sandor Z, Kusstatscher S, Szeli D, Szabo S. Effect of plateletderived growth factor in experimental colitis in rats. Orvosi Hetilap 1995; 136: 1059-61.
    • (1995) Orvosi Hetilap , vol.136 , pp. 1059-1061
    • Sandor, Z.1    Kusstatscher, S.2    Szeli, D.3    Szabo, S.4
  • 95
    • 80054788701 scopus 로고    scopus 로고
    • Molecular mechanisms of bFGF effect on healing of ulcerative colitis in rats
    • Paunovic B, Deng XM, Khomenko T, et al. Molecular mechanisms of bFGF effect on healing of ulcerative colitis in rats. J Pharmacol Exp Ther 2011; 339: 430-7.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 430-437
    • Paunovic, B.1    Deng, X.M.2    Khomenko, T.3
  • 96
    • 15144350829 scopus 로고    scopus 로고
    • Role of endogenous basic fibroblast growth factor in the healing of gastric ulcers in rats
    • Satoh H, Shino A, Sato F, et al. Role of endogenous basic fibroblast growth factor in the healing of gastric ulcers in rats. Jpn J Pharmacol 1997; 73: 59-71.
    • (1997) Jpn J Pharmacol , vol.73 , pp. 59-71
    • Satoh, H.1    Shino, A.2    Sato, F.3
  • 97
    • 79960023963 scopus 로고    scopus 로고
    • Angiogenesis and growth factors in ulcer healing
    • Tai-Ping D. Fan, Elise C. Kohn, Eds. Totowa, New Jersey: Humana Press
    • Szabo S, Shing Y, Folkman J, et al. Angiogenesis and growth factors in ulcer healing. In: Tai-Ping D. Fan, Elise C. Kohn, Eds. The New Angiotherapy, Totowa, New Jersey: Humana Press 2001, pp. 199-211.
    • (2001) The New Angiotherapy , pp. 199-211
    • Szabo, S.1    Shing, Y.2    Folkman, J.3
  • 98
    • 0022366074 scopus 로고
    • A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment
    • Crum R, Szabo S, Folkman J. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment. Science 1985; 230: 1375-8.
    • (1985) Science , vol.230 , pp. 1375-1378
    • Crum, R.1    Szabo, S.2    Folkman, J.3
  • 99
    • 51149210512 scopus 로고
    • An attempt at a natural classification of the steroids
    • Selye H. An attempt at a natural classification of the steroids. Nature 1943; 151: 662.
    • (1943) Nature , vol.151 , pp. 662
    • Selye, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.