Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation

Expert Opinion on Drug Delivery

Volumn 12, Issue 7, 2015, Pages 1059-1069

  Taudorf, Elisabeth Hjardem ^a   Lerche, Catharina Margrethe ^a   Vissing, Anne Cathrine ^a   Philipsen, Peter Alshede ^a   Hannibal, Jens ^a   D'alvise, Janina ^b   Hansen, Steen Honore ^b   Janfelt, Christian ^b   Paasch, Uwe ^c   Anderson, Richard Rox ^d   Haedersdal, Merete ^a,d  

^a BISPEBJERG HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Desorption electro spray ionization mass spectrometry imaging; Fluorescence microscopy; Fractional erbium laser; Franz skin permeability cells; High performance liquid chromatography; Laser assisted drug delivery

Indexed keywords

METHOTREXATE;

ANIMAL TISSUE; ARTICLE; DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ELECTROSPRAY MASS SPECTROMETRY; ERBIUM YAG LASER; EXPERIMENTAL PIG; FLUORESCENCE MICROSCOPY; FRACTIONAL LASER ABLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LASER SURGERY; NONHUMAN; SKIN PERMEABILITY; TRANSDERMAL DRUG DELIVERY SYSTEM; TRANSPORT KINETICS; ULTRAVIOLET C RADIATION; ANIMAL; FEMALE; INTRADERMAL DRUG ADMINISTRATION; LOW LEVEL LASER THERAPY; METABOLISM; PIG; SKIN; SKIN ABSORPTION; SOLID STATE LASER; TISSUE DISTRIBUTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; FEMALE; LASER THERAPY; LASERS, SOLID-STATE; METHOTREXATE; MICROSCOPY, FLUORESCENCE; SKIN; SKIN ABSORPTION; SWINE; TISSUE DISTRIBUTION;

EID: 84931839541     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2015.1031216     Document Type: Article

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