Determination of methotrexate and its metabolite 7-hydroxymethotrexate by direct injection of human plasma into a column-switching liquid chromatographic system using post-column photochemical reaction with fluorimetric detection

Journal of Chromatography B: Biomedical Applications

Volumn 689, Issue 2, 1997, Pages 379-386

  Yu, Zuoxiang ^a   Westerlund, Douglas ^a   Boos, Karl Siegfried ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

4 Amino 10 methylfolic acid; 7 Hydroxymethotrexate; Methotrexate

Indexed keywords

7 HYDROXYMETHOTREXATE; DRUG METABOLITE; METHOTREXATE;

ARTICLE; AUTOMATION; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; PHOTOCHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; STORAGE; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTIRHEUMATIC AGENTS; CHROMATOGRAPHY, LIQUID; FLUOROMETRY; HUMANS; METHOTREXATE; MOLECULAR STRUCTURE; PHOTOCHEMISTRY;

EID: 0031581915     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00357-X     Document Type: Article

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