Increasing the Permeability of the Blood-brain Barrier in Three Different Models in vivo

CNS Neuroscience and Therapeutics

Volumn 21, Issue 7, 2015, Pages 568-574

  Liu, Wei Ye ^a   Wang, Zhi Bin ^a   Wang, Yue ^b   Tong, Ling Chang ^a   Li, Ya ^a   Wei, Xin ^a   Luan, Ping ^c   Li, Ling ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c SHENZHEN UNIVERSITY   (China)

Author keywords

Animal model; Blood brain barrier; Tight junction; Vascular permeability

Indexed keywords

CAVEOLIN 1; CLAUDIN 5; VASCULAR ENDOTHELIAL CADHERIN; CADHERIN; EVANS BLUE; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COLD INJURY; COMPARATIVE STUDY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE; IN VIVO STUDY; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CHEMICALLY INDUCED; DISEASE MODEL; ENCEPHALITIS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; SPINAL CORD INJURY;

ANIMALS; ANTIGENS, CD; BLOOD-BRAIN BARRIER; CADHERINS; CAVEOLIN 1; CLAUDIN-5; DISEASE MODELS, ANIMAL; ENCEPHALITIS; EVANS BLUE; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; PERMEABILITY; SPINAL CORD INJURIES;

EID: 84931578910     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12405     Document Type: Article

References (26)

1. Liu WY, Su DF. Blood-brain barrier is not a barrier in the development of new drugs for ischemic stroke. CNS Neurosci Ther 2014;20:1013-1014.
2. Obermeier B, Daneman R, Ransohoff RM. Development, maintenance and disruption of the blood-brain barrier. Nat Med 2013;19:1584-1596.
3. Tam SJ, Watts RJ. Connecting vascular and nervous system development: Angiogenesis and the blood-brain barrier. Annu Rev Neurosci 2010;33:379-408.
4. Huang JY, Li LT, Wang H, et al. In vivo two-photon fluorescence microscopy reveals disturbed cerebral capillary blood flow and increased susceptibility to ischemic insults in diabetic mice. CNS Neurosci Ther 2014;20:816-822.
5. Krol S, Macrez R, Docagne F, et al. Therapeutic benefits from nanoparticles: The potential significance of nanoscience in diseases with compromise to the blood brain barrier. Chem Rev 2013;113:1877-1903.
6. Schoknecht K, Prager O, Vazana U, et al. Monitoring stroke progression: In vivo imaging of cortical perfusion, blood-brain barrier permeability and cellular damage in the rat photothrombosis model. J Cerebr Blood F Met 2014;34:1791-1801.
7. Lee H, Pienaar IS. Disruption of the blood-brain barrier in Parkinson's disease: Curse or route to a cure? Front Biosci 2014;19:272-280.
8. Marques F, Sousa JC, Sousa N, Palha JA. Blood-brain-barriers in aging and in Alzheimer's disease. Mol Neurodegener 2013;8:38.
9. Lok J, Wang XS, Xing CH, et al. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther 2015;21:304-308.
10. Chan PH, Longar S, Fishman RA. Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema. Ann Neurol 1987;21:540-547.
11. Hama H, Kasuya Y, Sakurai T, et al. Role of endothelin-1 in astrocyte responses after acute brain damage. J Neurosci Res 1997;47:590-602.
12. Kakinuma Y, Hama H, Sugiyama F, et al. Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat Med 1998;4:1078-1080.
13. Nag S, Venugopalan R, Stewart DJ. Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown. Acta Neuropathol 2007;114:459-469.
14. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet 2008;371:1612-1623.
15. Moretti R, Pansiot J, Bettati D, et al. Blood-brain barrier dysfunction in disorders of the developing brain. Front Neurosci 2015;9:40.
16. Ansari S, Azari H, McConnell DJ, Afzal A, Mocco J. Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser doppler flowmetry guidance in mice. J Vis Exp 2011;51:2879.
17. Denes A, Ferenczi S, Kovacs KJ. Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size. J Neuroinflammation 2011;8:164.
18. Guo JM, Liu AJ, Zang P, et al. ALDH2 protects against stroke by clearing 4-HNE. Cell Res 2013;23:915-930.
19. Walchli T, Mateos JM, Weinman O, et al. Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain. Nat Protoc 2015;10:53-74.
20. Dejana E, Tournier-Lasserve E, Weinstein BM. The control of vascular integrity by endothelial cell junctions: Molecular basis and pathological implications. Dev Cell 2009;16:209-221.
21. Matter K, Balda MS. Holey barrier: Claudins and the regulation of brain endothelial permeability. J Cell Biol 2003;161:459-460.
22. Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003;161:653-660.
23. Harris ES, Nelson WJ. VE-cadherin: At the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol 2010;22:651-658.
24. Gavard J. Endothelial permeability and VE-cadherin: A wacky comradeship. Cell Adh Migr 2013;7:455-461.
25. Virgintino D, Robertson D, Errede M, et al. Expression of caveolin-1 in human brain microvessels. Neuroscience 2002;115:145-152.
26. Shin T, Kim H, Jin JK, et al. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J Neuroimmunol 2005;165:11-20.