Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients

Journal of Molecular Neuroscience

Volumn 56, Issue 3, 2015, Pages 681-687

  Milanesi, Elena ^a   Hadar, Adva ^a   Maffioletti, Elisabetta ^b   Werner, Haim ^a   Shomron, Noam ^a   Gennarelli, Massimo ^b,c   Schulze, Thomas G ^d   Costa, Marta ^e   Del Zompo, Maria ^e,f   Squassina, Alessio ^e   Gurwitz, David ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF CAGLIARI   (Italy)

^f DEPARTMENT OF RADIOLOGY   (Italy)

Author keywords

Bipolar disorder; Insulin like growth factor 1 (IGF 1); Let 7c; Lithium; Lymphoblastoid cell lines (LCLs); Somatomedin C

Indexed keywords

BIOLOGICAL MARKER; LITHIUM; MESSENGER RNA; MICRORNA; MICRORNA LET 7C; SOMATOMEDIN C; UNCLASSIFIED DRUG; MIRNLET7 MICRORNA, HUMAN;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; DRUG RESPONSE; DRUG SENSITIVITY; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; PROTEIN EXPRESSION; SERUM; CELL LINE; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; LYMPHOCYTE; METABOLISM;

BIOMARKERS; BIPOLAR DISORDER; CELL LINE; DRUG RESISTANCE; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LITHIUM; LYMPHOCYTES; MICRORNAS;

EID: 84931578076     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0523-8     Document Type: Article

References (31)

1. Åberg MAI, Åberg ND, Hedba H et al (2000) Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. Endocrinology 20:2896–2903
2. Ambros V (2004) The functions of animal microRNAs. Nature 431:350–355
3. Bezchlibnyk YB, Xu L, Wang J-F, Young LT (2007) Decreased expression of insulin-like growth factor binding protein 2 in the prefrontal cortex of subjects with bipolar disorder and its regulation by lithium treatment. Brain Res 1147:213–217. doi:10.1016/j.brainres.2007.01.147
4. Carro E, Trejo JL, Busiguina S, Torres-aleman I (2001) Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 21:5678–5684
5. Corrada D, Viti F, Merelli I et al (2011) myMIR: a genome-wide microRNA targets identification and annotation tool. Brief Bioinform 12:588–600. doi:10.1093/bib/bbr062
6. Grof P, Ph D, Duffy A et al (2002) Is response to prophylactic lithium a familial trait? J Clin Psychiatry 63:942–947
7. Honegger A, Humbel RE (1986) Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities. J Biol Chem 261:569–575
8. Hornstein E, Shomron N (2006) Canalization of development by microRNAs. Nat Genet 38(Suppl):S20–S24. doi:10.1038/ng1803
9. Kim Y-K, Na K-S, Hwang J-A et al (2013) High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker? J Affect Disord 151:738–743. doi:10.1016/j.jad.2013.07.041
10. Liu X, Zhang T, He S et al (2014) Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder. Psychiatry Res 218:54–60. doi:10.1016/j.psychres.2014.03.042
11. Maffioletti E, Tardito D, Gennarelli M, Bocchio-Chiavetto L (2014) Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders. Front Cell Neurosci 8:75. doi:10.3389/fncel.2014.00075
12. Manchia M, Adli M, Akula N et al (2013) Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) Report. PLoS One 8(6):e65636
13. Martin EC, Bratton MR, Zhu Y et al (2012) Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line. PLoS One 7:e49067. doi:10.1371/journal.pone.0049067
14. Merikangas KR, Akiskal HS, Angst J et al (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 64:543–552. doi:10.1001/archpsyc.64.5.543
15. Morag A, Kirchheiner J, Rehavi M, Gurwitz D (2010) Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways. Pharmacogenomics 11:327–340
16. Morag A, Pasmanik-Chor M, Oron-Karni V (2011) Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. Pharmacogenomics 171–184
17. Orengo AM, Di Carlo E, Comes A et al (2014) Tumor cells engineered with IL-12 and IL-15 genes induce protective antibody responses in nude mice. J Immunol 171:569–575. doi:10.4049/jimmunol.171.2.569
18. Oved K, Morag A, Pasmanik-Chor M et al (2013) Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants. Transl Psychiatry 3:e313. doi:10.1038/tp.2013.86
19. Palomino A, González-pinto A, Martinez-cengotitabengoa M et al (2013) Progress in neuro-psychopharmacology & biological psychiatry relationship between negative symptoms and plasma levels of insulin-like growth factor 1 in first-episode schizophrenia and bipolar disorder patients. Prog Neuropsychopharmacol Biol Psychiatry 44:29–33. doi:10.1016/j.pnpbp.2013.01.008
20. Pereira ACP, McQuillin A, Puri V et al (2011) Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 156:177–187. doi:10.1002/ajmg.b.31153
21. Roush S, Slack FJ (2008) The let-7 family of microRNAs. Trends Cell Biol 18:505–516. doi:10.1016/j.tcb.2008.07.007
22. Rukov JL, Shomron N (2011) MicroRNA pharmacogenomics: post-transcriptional regulation of drug response. Trends Mol Med 17:412–423. doi:10.1016/j.molmed.2011.04.003
23. Sarkissyan S, Sarkissyan M, Wu Y et al (2014) IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. PLoS One 9:e103534. doi:10.1371/journal.pone.0103534
24. Sciacca L, Le Moli R, Vigneri R (2012) Insulin analogs and cancer. Front Endocrinol (Lausanne) 3:21. doi:10.3389/fendo.2012.00021
25. Singh B, Armstrong DT (1997) Insulin-like growth factor-1, a component of serum that enables porcine cumulus cells to expand in response to follicle-stimulating hormone in vitro. Biol Reprod 1375:1370–1375
26. Squassina A, Manchia M, Borg J et al (2011) Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder. Pharmacogenomics 12:1559–1569
27. Squassina A, Costa M, Congiu D et al (2013) Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients. Pharmacol Res 73:1–7. doi:10.1016/j.phrs.2013.04.004
28. Werner H, Leroith D (2014) Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects. Eur Neuropsychopharmacol 1–7. doi: 10.1016/j.euroneuro.2014.01.020
29. Wulczyn FG, Smirnova L, Rybak A et al (2007) Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J 21:415–426. doi:10.1096/fj.06-6130com
30. Yildiz A, Vieta E, Leucht S, Baldessarini RJ (2011) Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials. Neuropsychopharmacology 36:375–389. doi:10.1038/npp.2010.192
31. Zhou R, Yuan P, Wang Y et al (2009) NIH Public Access 34:1395–1405. doi:10.1038/npp.2008.131.Evidence