메뉴 건너뛰기




Volumn 141, Issue 5, 2015, Pages 909-921

Efficacy and safety of angiogenesis inhibitors in advanced non-small cell lung cancer: a systematic review and meta-analysis

Author keywords

Angiogenesis; Antibody; Non small cell lung cancer; Tyrosine kinase inhibitor

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBANILAMIDE DERIVATIVE; CEDIRANIB; INDOLE DERIVATIVE; MONOCLONAL ANTIBODY; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; NICOTINAMIDE; PAZOPANIB; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; RAMUCIRUMAB; SORAFENIB; SULFONAMIDE; SUNITINIB; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VEGFA PROTEIN, HUMAN;

EID: 84931457947     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1862-5     Document Type: Article
Times cited : (52)

References (59)
  • 1
    • 84887617202 scopus 로고    scopus 로고
    • A randomized, phase II study of vandetanib maintenance for advanced or metastatic non-small-cell lung cancer following first-line platinum-doublet chemotherapy
    • PID: 24075125
    • Ahn JS et al (2013) A randomized, phase II study of vandetanib maintenance for advanced or metastatic non-small-cell lung cancer following first-line platinum-doublet chemotherapy. Lung Cancer 82:455–460
    • (2013) Lung Cancer , vol.82 , pp. 455-460
    • Ahn, J.S.1
  • 2
    • 84880923313 scopus 로고    scopus 로고
    • Vandetanib plus chemotherapy for induction followed by vandetanib or placebo as maintenance for patients with advanced non-small-cell lung cancer: a randomized phase 2 PrECOG study (PrE0501)
    • COI: 1:CAS:528:DC%2BC3sXhtFeksrbF, PID: 23689430
    • Aisner J, Manola JB, Dakhil SR, Stella PJ, Sovak MA, Schiller JH (2013) Vandetanib plus chemotherapy for induction followed by vandetanib or placebo as maintenance for patients with advanced non-small-cell lung cancer: a randomized phase 2 PrECOG study (PrE0501). J Thorac Oncol 8:1075–1083
    • (2013) J Thorac Oncol , vol.8 , pp. 1075-1083
    • Aisner, J.1    Manola, J.B.2    Dakhil, S.R.3    Stella, P.J.4    Sovak, M.A.5    Schiller, J.H.6
  • 3
    • 50549083648 scopus 로고    scopus 로고
    • Secondary erythrocytosis produced by the tyrosine kinase inhibitors sunitinib and sorafenib
    • PID: 18711201
    • Alexandrescu DT, McClure R, Farzanmehr H, Dasanu CA (2008) Secondary erythrocytosis produced by the tyrosine kinase inhibitors sunitinib and sorafenib. J Clin Oncol 26:4047–4048
    • (2008) J Clin Oncol , vol.26 , pp. 4047-4048
    • Alexandrescu, D.T.1    McClure, R.2    Farzanmehr, H.3    Dasanu, C.A.4
  • 4
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • COI: 1:CAS:528:DC%2BD1cXovV2lsrk%3D, PID: 18650835
    • Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592–603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 5
    • 84875008449 scopus 로고    scopus 로고
    • Docetaxel-carboplatin in combination with erlotinib and/or bevacizumab in patients with non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3sXkt1Wltr4%3D
    • Boutsikou E et al (2013) Docetaxel-carboplatin in combination with erlotinib and/or bevacizumab in patients with non-small cell lung cancer. OncoTargets Ther 6:125–134. doi:10.2147/OTT.S42245
    • (2013) OncoTargets Ther , vol.6 , pp. 125-134
    • Boutsikou, E.1
  • 6
    • 84891060305 scopus 로고    scopus 로고
    • Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents
    • PID: 24102047
    • Cesca M, Bizzaro F, Zucchetti M, Giavazzi R (2013) Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents. Front Oncol 3:259
    • (2013) Front Oncol , vol.3 , pp. 259
    • Cesca, M.1    Bizzaro, F.2    Zucchetti, M.3    Giavazzi, R.4
  • 7
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial
    • PID: 21282537
    • de Boer RH et al (2011) Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. J Clin Oncol 29:1067–1074
    • (2011) J Clin Oncol , vol.29 , pp. 1067-1074
    • de Boer, R.H.1
  • 8
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab—an Eastern Cooperative Oncology Group Study
    • COI: 1:CAS:528:DC%2BD1cXislSrs7c%3D, PID: 18316562
    • Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH (2008) Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab—an Eastern Cooperative Oncology Group Study. Clin Cancer Res 14:1407–1412
    • (2008) Clin Cancer Res , vol.14 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 9
    • 84871977845 scopus 로고    scopus 로고
    • A randomized phase II study of gemcitabine and carboplatin with or without cediranib as first-line therapy in advanced non-small-cell lung cancer: north Central Cancer Treatment Group Study N0528
    • COI: 1:CAS:528:DC%2BC38XhvVCqtLfI, PID: 23232491
    • Dy GK et al (2013) A randomized phase II study of gemcitabine and carboplatin with or without cediranib as first-line therapy in advanced non-small-cell lung cancer: north Central Cancer Treatment Group Study N0528. J Thorac Oncol 8:79–88
    • (2013) J Thorac Oncol , vol.8 , pp. 79-88
    • Dy, G.K.1
  • 10
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
    • Garon EB et al (2014) Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384:665–673
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1
  • 11
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study
    • COI: 1:CAS:528:DC%2BC3cXhtF2ku7Y%3D, PID: 19917841
    • Goss GD et al (2010) Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. J Clin Oncol 28:49–55
    • (2010) J Clin Oncol , vol.28 , pp. 49-55
    • Goss, G.D.1
  • 12
    • 84883360843 scopus 로고    scopus 로고
    • A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC)
    • COI: 1:STN:280:DC%2BC3sjkslGquw%3D%3D, PID: 23788751
    • Groen HJ et al (2013) A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC). Ann Oncol 24:2382–2389
    • (2013) Ann Oncol , vol.24 , pp. 2382-2389
    • Groen, H.J.1
  • 13
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC3cXjtVSqt78%3D, PID: 19949019
    • Hanrahan EO et al (2010) Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 28:193–201
    • (2010) J Clin Oncol , vol.28 , pp. 193-201
    • Hanrahan, E.O.1
  • 14
    • 84893413347 scopus 로고    scopus 로고
    • CALGB 30704 (Alliance): a randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2cXpvVemuw%3D%3D, PID: 24419419
    • Heist RS et al (2014) CALGB 30704 (Alliance): a randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer. J Thorac Oncol 9:214–221
    • (2014) J Thorac Oncol , vol.9 , pp. 214-221
    • Heist, R.S.1
  • 15
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD2sXhtlCgsLnP, PID: 17909199
    • Herbst RS et al (2007) Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 25:4743–4750
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1
  • 16
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
    • COI: 1:CAS:528:DC%2BC3cXotVWqu78%3D, PID: 20570559
    • Herbst RS et al (2010) Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 11:619–626
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1
  • 17
    • 79957823572 scopus 로고    scopus 로고
    • Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial
    • COI: 1:CAS:528:DC%2BC3MXmslKnu7Y%3D, PID: 21621716
    • Herbst RS et al (2011) Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial. Lancet 377:1846–1854
    • (2011) Lancet , vol.377 , pp. 1846-1854
    • Herbst, R.S.1
  • 18
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD2sXhtFyis7jN, PID: 17878479
    • Heymach JV et al (2007) Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 25:4270–4277
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1
  • 19
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD1MXhslClsg%3D%3D, PID: 18936474
    • Heymach JV et al (2008) Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 26:5407–5415
    • (2008) J Clin Oncol , vol.26 , pp. 5407-5415
    • Heymach, J.V.1
  • 21
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD2cXpsVWltrg%3D, PID: 15169807
    • Johnson DH et al (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22:2184–2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1
  • 22
    • 84863867875 scopus 로고    scopus 로고
    • Tumor angiogenesis and anti-angiogenic therapy
    • COI: 1:CAS:528:DC%2BC38XhsVehsLrN, PID: 22760023
    • Kubota Y (2012) Tumor angiogenesis and anti-angiogenic therapy. Keio J Med 61:47–56
    • (2012) Keio J Med , vol.61 , pp. 47-56
    • Kubota, Y.1
  • 23
    • 84894041073 scopus 로고    scopus 로고
    • Randomised, double-blind trial of carboplatin and paclitaxel with daily oral cediranib or placebo in patients with advanced non-small cell lung cancer: NCIC Clinical Trials Group study BR29
    • COI: 1:CAS:528:DC%2BC3sXitVShtLzO, PID: 24360368
    • Laurie SA et al (2014) Randomised, double-blind trial of carboplatin and paclitaxel with daily oral cediranib or placebo in patients with advanced non-small cell lung cancer: NCIC Clinical Trials Group study BR29. Eur J Cancer 50:706–712
    • (2014) Eur J Cancer , vol.50 , pp. 706-712
    • Laurie, S.A.1
  • 24
    • 84902297551 scopus 로고    scopus 로고
    • The use of bevacizumab in non-small cell lung cancer: an update
    • COI: 1:CAS:528:DC%2BC2cXptFymsr4%3D, PID: 24692680
    • Lauro S, Onesti CE, Righini R, Marchetti P (2014) The use of bevacizumab in non-small cell lung cancer: an update. Anticancer Res 34:1537–1545
    • (2014) Anticancer Res , vol.34 , pp. 1537-1545
    • Lauro, S.1    Onesti, C.E.2    Righini, R.3    Marchetti, P.4
  • 25
    • 84861720010 scopus 로고    scopus 로고
    • Vandetanib Versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR)
    • COI: 1:CAS:528:DC%2BC38XntVOqtbo%3D, PID: 22370318
    • Lee JS et al (2012) Vandetanib Versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol 30:1114–1121
    • (2012) J Clin Oncol , vol.30 , pp. 1114-1121
    • Lee, J.S.1
  • 26
    • 68549140332 scopus 로고    scopus 로고
    • Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC
    • COI: 1:CAS:528:DC%2BD1MXms12gtLc%3D, PID: 19483740
    • Linardou H, Dahabreh IJ, Bafaloukos D, Kosmidis P, Murray S (2009) Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC. Nat Rev Clin Oncol 6:352–366
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 352-366
    • Linardou, H.1    Dahabreh, I.J.2    Bafaloukos, D.3    Kosmidis, P.4    Murray, S.5
  • 27
    • 84870931206 scopus 로고    scopus 로고
    • Hypertension as a biomarker in patients with recurrent glioblastoma treated with antiangiogenic drugs: a single-center experience and a critical review of the literature
    • COI: 1:CAS:528:DC%2BC38Xhslantb7O, PID: 23075631
    • Lombardi G et al (2013) Hypertension as a biomarker in patients with recurrent glioblastoma treated with antiangiogenic drugs: a single-center experience and a critical review of the literature. Anticancer Drugs 24:90–97
    • (2013) Anticancer Drugs , vol.24 , pp. 90-97
    • Lombardi, G.1
  • 28
    • 80052199468 scopus 로고    scopus 로고
    • Emerging targeted therapies in metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhtlKitr7N, PID: 21827388
    • Matrana MR, Atkinson B, Jonasch E, Tannir NM (2011) Emerging targeted therapies in metastatic renal cell carcinoma. Curr Clin Pharmacol 6:189–198
    • (2011) Curr Clin Pharmacol , vol.6 , pp. 189-198
    • Matrana, M.R.1    Atkinson, B.2    Jonasch, E.3    Tannir, N.M.4
  • 29
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • PID: 19631508
    • Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006–1012
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4    Group, P.5
  • 30
    • 84977772902 scopus 로고    scopus 로고
    • Nasser H. Hanna RK, Richard N. Sullivan, Osvaldo Rudy Aren, Myung-Ju Ahn, Beatrice Tiangco, Zanete Zvirbule, Carlos H. Barrios, Ahmet Demirkazik, Birgit Gaschler-Markefski, Isabelle Voccia, Jose Barrueco, Joo-Hang Kim Lume-lung 2: A multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. J Clin Oncol 31, 2013 (suppl; abstr 8034)
    • Nasser H. Hanna RK, Richard N. Sullivan, Osvaldo Rudy Aren, Myung-Ju Ahn, Beatrice Tiangco, Zanete Zvirbule, Carlos H. Barrios, Ahmet Demirkazik, Birgit Gaschler-Markefski, Isabelle Voccia, Jose Barrueco, Joo-Hang Kim Lume-lung 2: A multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. J Clin Oncol 31, 2013 (suppl; abstr 8034)
  • 31
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase II study
    • COI: 1:CAS:528:DC%2BD1MXmvVOhsbw%3D, PID: 19332730
    • Natale RB et al (2009) Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase II study. J Clin Oncol 27:2523–2529
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1
  • 32
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC3MXkslOhsLc%3D, PID: 21282542
    • Natale RB et al (2011) Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 29:1059–1066
    • (2011) J Clin Oncol , vol.29 , pp. 1059-1066
    • Natale, R.B.1
  • 33
    • 84860505684 scopus 로고    scopus 로고
    • Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer
    • PID: 22244743
    • Niho S et al (2012) Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer. Lung Cancer 76:362–367
    • (2012) Lung Cancer , vol.76 , pp. 362-367
    • Niho, S.1
  • 34
    • 77950243445 scopus 로고    scopus 로고
    • Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib
    • COI: 1:CAS:528:DC%2BC3cXjtFygtrs%3D, PID: 20215520
    • Nikolinakos PG et al (2010) Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib. Cancer Res 70:2171–2179
    • (2010) Cancer Res , vol.70 , pp. 2171-2179
    • Nikolinakos, P.G.1
  • 35
    • 77954601010 scopus 로고    scopus 로고
    • Targeted therapies for non-small cell lung cancer: an evolving landscape
    • COI: 1:CAS:528:DC%2BC3cXhtFertbnJ, PID: 20571071
    • Pal SK, Figlin RA, Reckamp K (2010) Targeted therapies for non-small cell lung cancer: an evolving landscape. Mol Cancer Ther 9:1931–1944
    • (2010) Mol Cancer Ther , vol.9 , pp. 1931-1944
    • Pal, S.K.1    Figlin, R.A.2    Reckamp, K.3
  • 36
    • 85047687980 scopus 로고    scopus 로고
    • Current status of targeted therapy in non-small cell lung cancer
    • COI: 1:STN:280:DC%2BC2cbpslOktQ%3D%3D
    • Parums DV (2014) Current status of targeted therapy in non-small cell lung cancer. Drugs Today (Barc) 50:503–525
    • (2014) Drugs Today (Barc) , vol.50 , pp. 503-525
    • Parums, D.V.1
  • 37
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC38XhsVKlsLnO, PID: 22851564
    • Paz-Ares LG et al (2012) Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol 30:3084–3092
    • (2012) J Clin Oncol , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1
  • 38
    • 84867602821 scopus 로고    scopus 로고
    • Aflibercept and Docetaxel versus Docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled phase III trial
    • COI: 1:CAS:528:DC%2BC38XhslSkur3E, PID: 22965962
    • Ramlau R et al (2012) Aflibercept and Docetaxel versus Docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled phase III trial. J Clin Oncol 30:3640–3647
    • (2012) J Clin Oncol , vol.30 , pp. 3640-3647
    • Ramlau, R.1
  • 39
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • COI: 1:CAS:528:DC%2BD1MXktFKhsL0%3D, PID: 19188680
    • Reck M et al (2009) Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 27:1227–1234
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1
  • 40
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
    • COI: 1:STN:280:DC%2BC3cjmtleltw%3D%3D, PID: 20150572
    • Reck M et al (2010) Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 21:1804–1809
    • (2010) Ann Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1
  • 41
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2cXns1Sjtg%3D%3D, PID: 24411639
    • Reck M et al (2014) Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol 15:143–155
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1
  • 42
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD28XhtlWqsbzI, PID: 17167137
    • Sandler A et al (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542–2550
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1
  • 43
    • 12444304260 scopus 로고    scopus 로고
    • Angiogenic growth factors and hypertension
    • COI: 1:CAS:528:DC%2BD2MXht1KjsbY%3D, PID: 15609074
    • Sane DC, Anton L, Brosnihan KB (2004) Angiogenic growth factors and hypertension. Angiogenesis 7:193–201
    • (2004) Angiogenesis , vol.7 , pp. 193-201
    • Sane, D.C.1    Anton, L.2    Brosnihan, K.B.3
  • 44
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC3cXmsFyitL0%3D, PID: 20212250
    • Scagliotti G et al (2010) Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 28:1835–1842
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1
  • 45
    • 84863936062 scopus 로고    scopus 로고
    • Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: a phase III trial
    • COI: 1:CAS:528:DC%2BC38XhtVynsbvK, PID: 22564989
    • Scagliotti GV et al (2012a) Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: a phase III trial. J Clin Oncol 30:2070–2078
    • (2012) J Clin Oncol , vol.30 , pp. 2070-2078
    • Scagliotti, G.V.1
  • 46
    • 84865095318 scopus 로고    scopus 로고
    • International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1
    • COI: 1:CAS:528:DC%2BC38Xhtlygu7zI, PID: 22753922
    • Scagliotti GV et al (2012b) International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J Clin Oncol 30:2829–2836
    • (2012) J Clin Oncol , vol.30 , pp. 2829-2836
    • Scagliotti, G.V.1
  • 47
    • 84892165925 scopus 로고    scopus 로고
    • An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2cXktFWrtA%3D%3D, PID: 24389434
    • Scagliotti GV et al (2013) An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancer. J Thorac Oncol 8:1529–1537
    • (2013) J Thorac Oncol , vol.8 , pp. 1529-1537
    • Scagliotti, G.V.1
  • 48
    • 84862502742 scopus 로고    scopus 로고
    • Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension
    • COI: 1:CAS:528:DC%2BC38XptFaltbs%3D, PID: 22719881
    • Schuster C et al (2012) Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLoS ONE 7:e38364
    • (2012) PLoS ONE , vol.7 , pp. e38364
    • Schuster, C.1
  • 49
    • 84864879887 scopus 로고    scopus 로고
    • Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
    • PID: 22460450
    • Shang B, Cao Z, Zhou Q (2012) Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives. Front Med 6:67–78
    • (2012) Front Med , vol.6 , pp. 67-78
    • Shang, B.1    Cao, Z.2    Zhou, Q.3
  • 51
    • 79959306917 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC3MXpsVyqtrY%3D, PID: 21576636
    • Spigel DR et al (2011) Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer. J Clin Oncol 29:2582–2589
    • (2011) J Clin Oncol , vol.29 , pp. 2582-2589
    • Spigel, D.R.1
  • 52
    • 84866155376 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone and carboplatin with or without bevacizumab in patients with previously untreated advanced non-small-cell lung cancer
    • PID: 22947511
    • Spigel DR et al (2012) Phase II trial of ixabepilone and carboplatin with or without bevacizumab in patients with previously untreated advanced non-small-cell lung cancer. Lung Cancer 78:70–75
    • (2012) Lung Cancer , vol.78 , pp. 70-75
    • Spigel, D.R.1
  • 53
    • 50349101200 scopus 로고    scopus 로고
    • Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    • COI: 1:CAS:528:DC%2BD1cXmslygtr8%3D, PID: 18519779
    • Steeghs N et al (2008) Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res 14:3470–3476
    • (2008) Clin Cancer Res , vol.14 , pp. 3470-3476
    • Steeghs, N.1
  • 54
    • 65349124698 scopus 로고    scopus 로고
    • Current treatments for advanced stage non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BD1MXltlOqtLY%3D, PID: 19349493
    • Stinchcombe TE, Socinski MA (2009) Current treatments for advanced stage non-small cell lung cancer. Proc Am Thorac Soc 6:233–241
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 233-241
    • Stinchcombe, T.E.1    Socinski, M.A.2
  • 55
    • 84859958002 scopus 로고    scopus 로고
    • Effect of angiogenesis inhibitor bevacizumab on survival in patients with cancer: a meta-analysis of the published literature
    • COI: 1:CAS:528:DC%2BC38Xms1ClsLc%3D, PID: 22539986
    • Su Y, Yang WB, Li S, Ye ZJ, Shi HZ, Zhou Q (2012) Effect of angiogenesis inhibitor bevacizumab on survival in patients with cancer: a meta-analysis of the published literature. PLoS ONE 7:e35629
    • (2012) PLoS ONE , vol.7 , pp. e35629
    • Su, Y.1    Yang, W.B.2    Li, S.3    Ye, Z.J.4    Shi, H.Z.5    Zhou, Q.6
  • 56
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • PID: 17555582
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8:16
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 57
    • 84866625336 scopus 로고    scopus 로고
    • A double-blind randomized discontinuation phase-II study of sorafenib (BAY 43-9006) in previously treated non-small-cell lung cancer patients: eastern cooperative oncology group study E2501
    • COI: 1:CAS:528:DC%2BC38XhsVKhu7bL, PID: 22982658
    • Wakelee HA, Lee JW, Hanna NH, Traynor AM, Carbone DP, Schiller JH (2012) A double-blind randomized discontinuation phase-II study of sorafenib (BAY 43-9006) in previously treated non-small-cell lung cancer patients: eastern cooperative oncology group study E2501. J Thorac Oncol 7:1574–1582
    • (2012) J Thorac Oncol , vol.7 , pp. 1574-1582
    • Wakelee, H.A.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5    Schiller, J.H.6
  • 58
    • 84873713565 scopus 로고    scopus 로고
    • Chemotherapy plus multitargeted antiangiogenic tyrosine kinase inhibitors or chemotherapy alone in advanced NSCLC: a meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC3sXht1Ojtrc%3D, PID: 22729611
    • Xiao YY, Zhan P, Yuan DM, Liu HB, Lv TF, Song Y, Shi Y (2013) Chemotherapy plus multitargeted antiangiogenic tyrosine kinase inhibitors or chemotherapy alone in advanced NSCLC: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol 69:151–159
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 151-159
    • Xiao, Y.Y.1    Zhan, P.2    Yuan, D.M.3    Liu, H.B.4    Lv, T.F.5    Song, Y.6    Shi, Y.7
  • 59
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • COI: 1:CAS:528:DyaK1cXhtFKqt70%3D, PID: 9509272
    • Zetter BR (1998) Angiogenesis and tumor metastasis. Annu Rev Med 49:407–424
    • (1998) Annu Rev Med , vol.49 , pp. 407-424
    • Zetter, B.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.