Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-γ2 and leptin gene polymorphisms in a pedigree of subjects with bipolar disorder

Revista Brasileira de Psiquiatria

Volumn 37, Issue 2, 2015, Pages 106-112

  Baptista, Trino ^a   Sandia, Ignacio ^a   Fernandez, Erika ^b   Balzán, Ligia ^b   Connell, Lissette ^b   Uzcátegui, Euderruh ^a   Serrano, Ana ^a   Pabón, Albis ^a   Angeles, Félix ^a   Araque, Yarira ^a   Delgado, Heidy ^a   González, Alexy ^a   Alviare, Yonathan ^a   Piñero, Jose ^a   De Baptista, Enma A ^c  

^a Universidad De Los Andes Facultad de Medicina   (Venezuela)

^b UNIVERSIDAD DEL ZULIA   (Venezuela)

^c UNIVERSIDAD DE LOS ANDES   (Venezuela)

Author keywords

Bipolar disorder; Familiar hypercholesterolemia; Insulin sensitivity; Leptin; Metabolic syndrome

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRIACYLGLYCEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ARTICLE; BIPOLAR DISORDER; BODY MASS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN RESISTANCE; INTERVIEW; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE; ADOLESCENT; BLOOD; CROSS-SECTIONAL STUDY; GENETICS; MIDDLE AGED; PEDIGREE; PSYCHOLOGY; RURAL POPULATION; VENEZUELA; YOUNG ADULT;

ADOLESCENT; ADULT; BIPOLAR DISORDER; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PEDIGREE; POLYMORPHISM, GENETIC; PPAR GAMMA; RURAL POPULATION; VENEZUELA; YOUNG ADULT;

EID: 84931435928     PISSN: 15164446     EISSN: None     Source Type: Journal    
DOI: 10.1590/1516-4446-2014-1425     Document Type: Article

References (41)

1. Gomes FA, Almeida KM, Magalhães PV, Caetano SC, Kauer- Sant’Anna M, Lafer B, et al. Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder. Rev Bras Psiquiatr. 2013;35:126-30.
2. Smith DJ, Martin D, McLean G, Langan J, Guthrie B, Mercer SW. Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study. BMC Med. 2013;11:263.
3. Crump C, Sundquist K, Winkleby MA, Sundquist J. Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. JAMA Psychiatry. 2013;70:931-9.
4. Czepielewski L, Daruy Filho L, Brietzke E, Grassi-Oliveira R. Bipolar disorder and metabolic syndrome: a systematic review. Rev Bras Psiquiatr. 2013;35:88-93.
5. Baptista T, Uzcátegui E, Arapé Y, Serrano A, Mazarella X, Quiroz S, et al. Migraine lifetime prevalence in mental disorders: concurrent comparisons with first-degree relatives and the general population. Invest Clin. 2012;53:38-51.
6. McIntyre RS, Alsuwaidan M, Goldstein BI, Taylor VH, Schaffer A, Beaulieu S, et al. The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid metabolic disorders. Ann Clin Psychiatry. 2012;24:69-81.
7. Baptista T, Serrano A, Uzcátegui E, ElFakih Y, Rangel N, Carrizo E, et al. The metabolic syndrome and its constituting variables in atypical antipsychotic-treated subjects: comparison with other drug treatments, drug-free psychiatric patients, first-degree relatives and the general population in Venezuela. Schizophr Res. 2011;126:93-102.
8. Sicras A, Rejas J, Navarro R, Serrat J, Blanca M. Metabolic syndrome in bipolar disorder: a cross-sectional assessment of a Health Management Organization database. Bipolar Disord. 2008;10:607-16.
9. Baskaran A, Cha DS, Powell AM, Jalil D, McIntyre RS. Sex differences in rates of obesity in bipolar disorder: postulated mechanisms. Bipolar Disord. 2014;16:83-92.
10. Baptista T, De Mendoza S, Beaulieu S, Bermúdez A, Martinez M. The metabolic syndrome during antipsychotic drug treatment: mechanisms and management. Metab Syndr Relat Disord. 2004;2:290-307.
11. Vancampfort D, Vansteelandt K, Correll CU, Mitchell AJ, De Herdt A, Sienaert P, et al. Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators. Am J Psychiatry. 2013;170:265-74.
12. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-78.
13. Chagnon YC, Merette C, Bouchard RH, Emond C, Roy MA, Maziade M. A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses. Mol Psychiatry. 2004;9:1067-74.
14. Carrizo E, Fernandez V, Quintero J, Connell L, Rodriguez Z, Mosquera M, et al. Coagulation and inflammation markers during atypical or typical antipsychotic treatment in schizophrenia patients and drug-free first-degree relatives. Schizophr Res. 2008;103:83-93.
15. U.S. National Library of Medicine. Genetics Home Reference. Glossary [Internet]. 2014 [cited May 21, 2014]. http://ghr.nlm.nih. gov/glossary=firstdegreerelative
16. Paoli M, Uzcátegui L, Zerpa J, Gomez-Perez R, Camacho N, Molina Z, et al.: [Obesity in schoolchildren from Merida, Venezuela: association with cardiovascular risk factors]. Endocrinol Nutr. 2009;56:218-26.
17. Consenso Latinoamericano de la Asociación Latinoamericana de Diabetes (ALAD). Epidemiologia, diagnóstico, control, prevención y tratamiento del síndrome metabólico en adultos. Rev Asoc Latinoam Diab. 2010;18:25-44.
18. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DMS-IV Axis I Disorders - Clinician Version (SCID-CV) (Spanish Version). Washington: American Psychiatric Press; 1997.
19. Ulloa RE, Ortiz S, Higuera F, Nogales I, Fresan A, Apiquian R, et al. [Interrater reliability of the Spanish version of Schedule for Affective Disorders and Schizophrenia for School-Age Children–Present and Lifetime version (K-SADS-PL)]. Actas Esp Psiquiatr. 2006;34:36-40.
20. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extraction DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215.
21. Ausubel F, Brent R, Kingston R, Moore D, Seidman J, Smith J, et al. Preparation of genomic DNA. Phenol extraction and concentrationof DNA from aqueous solutions. In: Short protocols in molecular biology. Current protocols in molecular biology. New York: Reene Publishing associates and Wiley-Interscience; 1989. p. 114.1-5.4.
22. Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN, Chouchane L. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer. 2006;6:38.
23. Quijada Z, Paoli M, Zerpa Y, Camacho N, Cichetti R, Villarroel V, et al. The triglyceride/HDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors. Pediatr Diabetes. 2008;9:464-71.
24. Marquina D, Peña R, Fernández E, Baptista T. Abnormal correlation between serum leptin levels and body mass index may predict metabolic dysfunction irrespective of the psychopharmacological treatment. Int Clin Psychopharmacol. 2011;26:169-72.
25. Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J 2013;34:3478-90a.
26. Margari F, Lozupone M, Pisani R, Pastore A, Todarello O, Zagaria G, et al. Metabolic syndrome: differences between psychiatric and internal medicine patients. Int J Psychiatry Med. 2013;45:203-26.
27. Glasziou PP, Irwig L, Kirby AC, Tonkin AM, Simes RJ. Which lipid measurement should we monitor? An analysis of the LIPID study. BMJ Open. 2014;4:e003512.
28. De Berardis D, Conti CM, Serroni N, Moschetta FS, Carano A, Salerno RM, et al. The role of cholesterol levels in mood disorders and suicide. J Biol Regul Homeost Agents. 2009;23:133-40.
29. D’Ambrosio V, Salvi V, Bogetto F, Maina G. Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2012;37:136-40.
30. Liao PJ, Chen CH, Chan HY, Tan HK, Hsu KH. Serum lipid profile could predict the inception and impacts of violent behaviors among acute psychiatric inpatients. Chang Gung Med J. 2012;35:382-91.
31. Fiedorowicz JG, Palagummi NM, Behrendtsen O, Coryell WH. Cholesterol and affective morbidity. Psychiatry Res. 2010;175:78-81.
32. Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Bayik Y. Serum leptin and cholesterol levels in patients with bipolar disorder. Neuropsychobiology. 2002;46:176-9.
33. Ghaemi SN, Shields GS, Hegarty JD, Goodwin FK. Cholesterol levels in mood disorders: high or low? Bipolar Disord. 2000;2:60-4.
34. Fernández E, Morales LM, Vargas R, Sandrea L, Molero-Conejo E, Fernández V, et al. Polimorfismo Pro12Ala del gen PPAR-c2 y síndrome metabólico: Estudio preliminar. Acta Bioquim Clin Latinoam. 2009;43:3-9.
35. Fernández EI, Carrizo E, Fernández V, Connell L, Sandia I, Prieto D, et al. Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin. Schizophr Res. 2010;121:213-7.
36. Fernandez E, Carrizo E, Connell L, Baptista T. Pro12Ala polymorphism in PPARg2 gene, the metabolic syndrome and response to metformin in clozapine-treated patients. Schizophr Res. 2012;137:262-3.
37. Costa V, Gallo MA, Letizia F, Aprile M, Casamassimi A, Ciccodicola A. PPARG: gene expression regulation and next-generation sequencing for unsolved issues. PPAR Res. 2010;pii:409168.
38. Jermendy A, Korner A, Kovacs M, Madacsy L, Cseh K. PPARgamma2 pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity. J Pediatr Endocrinol Metab. 2011;24:55-9.
39. Templeman LA, Reynolds GP, Arranz B, San L. Polymorphisms of the 5-HT2Creceptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a firstepisode psychosis. Pharmacogenet Genomics. 2005;15:195-200.
40. Suriyaprom K, Tungtrongchitr R, Thawnasom K. Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome. Diabetol Metab Syndr. 2014;6:6.
41. Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ouedrani A, Ben Rejeb N, et al. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genet Test Mol Biomarkers. 2012;16:726-33.