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Volumn 7, Issue 4, 2015, Pages 206-218

Vintafolide: A novel targeted therapy for the treatment of folate receptor expressing tumors

Author keywords

Folate receptor; Lung neoplasms; Neoplasms; Ovarian neoplasms; Small molecule drug conjugate; Vintafolide

Indexed keywords

FOLATE RECEPTOR; FOLATE RECEPTOR 1; VINTAFOLIDE;

EID: 84931327042     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834015584763     Document Type: Review
Times cited : (90)

References (68)
  • 1
    • 84867874739 scopus 로고    scopus 로고
    • IMGN853, an anti-folate receptor I antibody-maytansinoid conjugate for targeted cancer therapy
    • Ab O. Bartle L. Rui L. Coccia J. Johnson H. Whiteman K. et al. (2011) IMGN853, an anti-folate receptor I antibody-maytansinoid conjugate for targeted cancer therapy. Cancer Res 71: 4576.
    • (2011) Cancer Res , vol.71 , pp. 4576
    • Ab, O.1    Bartle, L.2    Rui, L.3    Coccia, J.4    Johnson, H.5    Whiteman, K.6
  • 2
    • 34648832104 scopus 로고    scopus 로고
    • Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas
    • Allard J. Risinger J. Morrison C. Young G. Rose G. Fowler J. et al. (2007) Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas. Gynecol Oncol 107: 52–57.
    • (2007) Gynecol Oncol , vol.107 , pp. 52-57
    • Allard, J.1    Risinger, J.2    Morrison, C.3    Young, G.4    Rose, G.5    Fowler, J.6
  • 3
    • 0029818146 scopus 로고    scopus 로고
    • Folate receptors
    • Antony A. (1996) Folate receptors. Annu Rev Nutr 16: 501–521.
    • (1996) Annu Rev Nutr , vol.16 , pp. 501-521
    • Antony, A.1
  • 4
    • 84877579319 scopus 로고    scopus 로고
    • Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer
    • Armstrong D. White A. Weil S. Phillips M. Coleman R. (2013) Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer. Gynecol Oncol. 129: 452–458.
    • (2013) Gynecol Oncol , vol.129 , pp. 452-458
    • Armstrong, D.1    White, A.2    Weil, S.3    Phillips, M.4    Coleman, R.5
  • 5
    • 84869797748 scopus 로고    scopus 로고
    • Fourth World Antibody-Drug Conjugate Summit Frankfurt
    • Germany MAbs
    • Beck A. Lambert J. Sun M. Lin K. (2012) Fourth World Antibody-Drug Conjugate Summit: February 29 – March 1, 2012, Frankfurt, Germany. MAbs 4: 637–647.
    • (2012) , vol.4 , pp. 637-647
    • Beck, A.1    Lambert, J.2    Sun, M.3    Lin, K.4
  • 6
    • 21244490748 scopus 로고    scopus 로고
    • The realisation of targeted antitumour therapy
    • Bicknell R. (2005) The realisation of targeted antitumour therapy. Br J Cancer 92(Suppl. 1): S2–S5.
    • (2005) Br J Cancer , vol.92 , pp. S2-S5
    • Bicknell, R.1
  • 7
    • 84869407359 scopus 로고    scopus 로고
    • Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
    • Bottsford-Miller J. Coleman R. Sood A. (2012) Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol 30: 4026–4034.
    • (2012) J Clin Oncol , vol.30 , pp. 4026-4034
    • Bottsford-Miller, J.1    Coleman, R.2    Sood, A.3
  • 8
    • 50549085621 scopus 로고    scopus 로고
    • Rationale for folate receptor alpha targeted therapy in “high risk” endometrial carcinomas
    • Brown J. Neuper C. Clayton A. Mariani A. Konecny G. Thomas M. et al. (2008) Rationale for folate receptor alpha targeted therapy in “high risk” endometrial carcinomas. Int J Cancer 123: 1699–1703.
    • (2008) Int J Cancer , vol.123 , pp. 1699-1703
    • Brown, J.1    Neuper, C.2    Clayton, A.3    Mariani, A.4    Konecny, G.5    Thomas, M.6
  • 9
    • 84871950953 scopus 로고    scopus 로고
    • Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed
    • Christoph D. Asuncion B. Hassan B. Tran C. Maltzman J. O'Shannessy D. et al. (2013) Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed. J Thorac Oncol 8: 19–30.
    • (2013) J Thorac Oncol , vol.8 , pp. 19-30
    • Christoph, D.1    Asuncion, B.2    Hassan, B.3    Tran, C.4    Maltzman, J.5    O'Shannessy, D.6
  • 10
    • 84866144174 scopus 로고    scopus 로고
    • The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer
    • Crane L. Arts H. van Oosten M. Low P. van der Zee A. van Dam G. et al. (2012) The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer. Cell Oncol 35: 9–18.
    • (2012) Cell Oncol , vol.35 , pp. 9-18
    • Crane, L.1    Arts, H.2    van Oosten, M.3    Low, P.4    van der Zee, A.5    van Dam, G.6
  • 11
    • 84879073124 scopus 로고    scopus 로고
    • Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy
    • Despierre E. Lambrechts S. Leunen K. Berteloot P. Neven P. Amant F. et al. (2013) Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy. Gynecol Oncol 130: 192–199.
    • (2013) Gynecol Oncol , vol.130 , pp. 192-199
    • Despierre, E.1    Lambrechts, S.2    Leunen, K.3    Berteloot, P.4    Neven, P.5    Amant, F.6
  • 12
    • 55349136976 scopus 로고    scopus 로고
    • A history of cancer chemotherapy
    • de Vita V. Jr Chu E. (2008) A history of cancer chemotherapy. Cancer Res 68: 8643–8653.
    • (2008) Cancer Res , vol.68 , pp. 8643-8653
    • de Vita, V.1    Chu, E.2
  • 13
    • 79952746215 scopus 로고    scopus 로고
    • EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers
    • Dosio F. Milla P. Cattel L. (2010) EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers. Curr Opin Investig Drugs 11: 1424–1433.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1424-1433
    • Dosio, F.1    Milla, P.2    Cattel, L.3
  • 14
    • 84914163404 scopus 로고    scopus 로고
    • The co-development of a folate receptor targeted drug conjugate vintafolide (EC145) and a folate receptor targeted imaging agent 99mTc-etarfolatide (EC20) in the treatment of advanced adenocarcinoma NSCLC
    • Edelman M. Bonomi P. Harb W. Pal S. Boccia R. Kraut M. et al. (2012 a) The co-development of a folate receptor targeted drug conjugate vintafolide (EC145) and a folate receptor targeted imaging agent 99mTc-etarfolatide (EC20) in the treatment of advanced adenocarcinoma NSCLC. J Thorac Oncol 7(Suppl. 1): S63.
    • (2012) J Thorac Oncol , vol.7 , pp. S63
    • Edelman, M.1    Bonomi, P.2    Harb, W.3    Pal, S.4    Boccia, R.5    Kraut, M.6
  • 15
    • 84866625235 scopus 로고    scopus 로고
    • Multicenter trial of EC 145 in advanced, folate-receptor positive adenocarcinoma of the lung
    • Edelman M. Harb W. Pal S. Boccia R. Kraut M. Bonomi P. et al. (2012 b) Multicenter trial of EC 145 in advanced, folate-receptor positive adenocarcinoma of the lung. J Thorac Oncol 7: 1618–1621.
    • (2012) J Thorac Oncol , vol.7 , pp. 1618-1621
    • Edelman, M.1    Harb, W.2    Pal, S.3    Boccia, R.4    Kraut, M.5    Bonomi, P.6
  • 16
    • 1942503303 scopus 로고    scopus 로고
    • Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy
    • Elnakat H. Ratnam M. (2004) Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 56: 1067–1084.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1067-1084
    • Elnakat, H.1    Ratnam, M.2
  • 17
    • 32944463897 scopus 로고    scopus 로고
    • Role of folate receptor genes in reproduction and related cancers
    • Elnakat H. Ratnam M. (2006) Role of folate receptor genes in reproduction and related cancers. Front Biosci 11: 506–519.
    • (2006) Front Biosci , vol.11 , pp. 506-519
    • Elnakat, H.1    Ratnam, M.2
  • 18
    • 84871180236 scopus 로고    scopus 로고
    • Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer
    • Farrell C. Schweizer C. Wustner J. Weil S. Namiki M. Nakano T. et al. (2012) Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer. Cancer Chemother Pharmacol 70: 727–734.
    • (2012) Cancer Chemother Pharmacol , vol.70 , pp. 727-734
    • Farrell, C.1    Schweizer, C.2    Wustner, J.3    Weil, S.4    Namiki, M.5    Nakano, T.6
  • 19
    • 84874612774 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy in the era of personalized medicine
    • Feliz L. Tsimberidou A. (2013) Anti-vascular endothelial growth factor therapy in the era of personalized medicine. Cancer Chemother Pharmacol 72: 1–12.
    • (2013) Cancer Chemother Pharmacol , vol.72 , pp. 1-12
    • Feliz, L.1    Tsimberidou, A.2
  • 20
    • 84877755368 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-angiogenesis therapies
    • Giuliano S. Pages G. (2013) Mechanisms of resistance to anti-angiogenesis therapies. Biochimie 95: 1110–1119.
    • (2013) Biochimie , vol.95 , pp. 1110-1119
    • Giuliano, S.1    Pages, G.2
  • 21
    • 84881136041 scopus 로고    scopus 로고
    • Degradation of BMS-753493, a novel epothilone folate conjugate anticancer agent
    • Gokhale M. Thakur A. Rinaldi F. (2012) Degradation of BMS-753493, a novel epothilone folate conjugate anticancer agent. Drug Dev Ind Pharm 39: 1315–1327.
    • (2012) Drug Dev Ind Pharm , vol.39 , pp. 1315-1327
    • Gokhale, M.1    Thakur, A.2    Rinaldi, F.3
  • 22
    • 84865992002 scopus 로고    scopus 로고
    • Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
    • Gonen N. Assaraf Y. (2012) Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat 15: 183–210.
    • (2012) Drug Resist Updat , vol.15 , pp. 183-210
    • Gonen, N.1    Assaraf, Y.2
  • 23
    • 84931395636 scopus 로고    scopus 로고
    • TARGET: a randomized phase II trial comparing vintafolide versus vintafolide plus docetaxel, versus docetaxel alone in second-line treatment of folate-receptor-positive nonsmall cell lung cancer (NSCLC) patients
    • abstract LBA40_PR.
    • Hanna N. Juhasz E. Cainap C. Gladkov O. Ramlau R. Juan-Vidal O. et al. (2014) TARGET: a randomized phase II trial comparing vintafolide versus vintafolide plus docetaxel, versus docetaxel alone in second-line treatment of folate-receptor-positive nonsmall cell lung cancer (NSCLC) patients. Ann Oncol 25(Suppl. 5): v1–v41; abstract LBA40_PR.
    • (2014) Ann Oncol , vol.25 , pp. v1-v41
    • Hanna, N.1    Juhasz, E.2    Cainap, C.3    Gladkov, O.4    Ramlau, R.5    Juan-Vidal, O.6
  • 25
    • 52049094603 scopus 로고    scopus 로고
    • Molecular mechanisms of adaptation to folate deficiency
    • Ifergan I. Assaraf Y. (2008) Molecular mechanisms of adaptation to folate deficiency. Vitam Horm 79: 99–143.
    • (2008) Vitam Horm , vol.79 , pp. 99-143
    • Ifergan, I.1    Assaraf, Y.2
  • 26
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K. Takaoka A. (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6: 714–727.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 27
    • 84867500287 scopus 로고    scopus 로고
    • Role of farletuzumab in epithelial ovarian carcinoma
    • Jelovac D. Armstrong D. (2012) Role of farletuzumab in epithelial ovarian carcinoma. Curr Pharm Des 18: 3812–3815.
    • (2012) Curr Pharm Des , vol.18 , pp. 3812-3815
    • Jelovac, D.1    Armstrong, D.2
  • 29
    • 0344401038 scopus 로고
    • Receptor-mediated folate accumulation is regulated by the cellular folate content
    • Kamen B. Capdevila A. (1986) Receptor-mediated folate accumulation is regulated by the cellular folate content. Proc Natl Acad Sci U S A 83: 5983–5987.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 5983-5987
    • Kamen, B.1    Capdevila, A.2
  • 30
    • 84863483737 scopus 로고    scopus 로고
    • Farletuzumab, an anti-folate receptor alpha antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro
    • Kamen B. Smith A. (2012) Farletuzumab, an anti-folate receptor alpha antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro. Cancer Chemother Pharmacol 70: 113–120.
    • (2012) Cancer Chemother Pharmacol , vol.70 , pp. 113-120
    • Kamen, B.1    Smith, A.2
  • 31
    • 84903154260 scopus 로고    scopus 로고
    • A phase I., first-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of IMGN 853 in patients (Pts) with epithelial ovarian cancer (EOC) and other FOLR1-positive solid tumors
    • abstract 2573.
    • Kirkjian C. LoRusso P. Sankhala K. Birrer M. Kirby M. Ladd S. et al. (2013) A phase I, first-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of IMGN 853 in patients (Pts) with epithelial ovarian cancer (EOC) and other FOLR1-positive solid tumors. J Clin Oncol 31(Suppl.): abstract 2573.
    • (2013) J Clin Oncol , vol.31
    • Kirkjian, C.1    LoRusso, P.2    Sankhala, K.3    Birrer, M.4    Kirby, M.5    Ladd, S.6
  • 32
    • 78049476593 scopus 로고    scopus 로고
    • Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study
    • Konner J. Bell-McGuinn K. Sabbatini P. Hensley M. Tew W. Pandit-Taskar N. et al. (2010) Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study. Clin Cancer Res 16:5288–5295.
    • (2010) Clin Cancer Res , vol.16 , pp. 5288-5295
    • Konner, J.1    Bell-McGuinn, K.2    Sabbatini, P.3    Hensley, M.4    Tew, W.5    Pandit-Taskar, N.6
  • 33
    • 35548957255 scopus 로고    scopus 로고
    • Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
    • Leamon C. Reddy J. Vlahov I. Westrick E. Dawson A. Dorton R. et al. (2007 a) Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Mol Pharmacol 4: 659–667.
    • (2007) Mol Pharmacol , vol.4 , pp. 659-667
    • Leamon, C.1    Reddy, J.2    Vlahov, I.3    Westrick, E.4    Dawson, A.5    Dorton, R.6
  • 34
    • 84914179824 scopus 로고    scopus 로고
    • Predicting response to EC 145 therapy using the folate receptor-specific radiodiagnostic imaging agent, 99mTc-EC20
    • Leamon C. Reddy J. Bloomfield A. Dorton R. Nelson M. Klein P. et al. (2012) Predicting response to EC 145 therapy using the folate receptor-specific radiodiagnostic imaging agent, 99mTc-EC20. Cancer Res 72(Suppl. 1): 3622.
    • (2012) Cancer Res , vol.72 , pp. 3622
    • Leamon, C.1    Reddy, J.2    Bloomfield, A.3    Dorton, R.4    Nelson, M.5    Klein, P.6
  • 35
    • 34447131647 scopus 로고    scopus 로고
    • Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC 140 and EC145
    • Leamon C. Reddy J. Vlahov I. Westrick E. Parker N. Nicoson J. et al. (2007 b) Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC 140 and EC145. Int J Cancer 121: 1585–1592.
    • (2007) Int J Cancer , vol.121 , pp. 1585-1592
    • Leamon, C.1    Reddy, J.2    Vlahov, I.3    Westrick, E.4    Parker, N.5    Nicoson, J.6
  • 36
    • 71449112911 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC 145 in cancer patients
    • Li J. Sausville E. Klein P. Morgenstern D. Leamon C. Messmann R. et al. (2009) Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC 145 in cancer patients. J Clin Pharmacol 49: 1467–1476.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1467-1476
    • Li, J.1    Sausville, E.2    Klein, P.3    Morgenstern, D.4    Leamon, C.5    Messmann, R.6
  • 37
    • 84869444058 scopus 로고    scopus 로고
    • Phase I study of folate conjugate EC 145 (vintafolide) in patients with refractory solid tumors
    • LoRusso P. Edelman M. Bever S. Forman K. Pilat M. Quinn M. et al. (2012) Phase I study of folate conjugate EC 145 (vintafolide) in patients with refractory solid tumors. J Clin Oncol 30: 4011–4016.
    • (2012) J Clin Oncol , vol.30 , pp. 4011-4016
    • LoRusso, P.1    Edelman, M.2    Bever, S.3    Forman, K.4    Pilat, M.5    Quinn, M.6
  • 38
    • 84886315269 scopus 로고    scopus 로고
    • Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics
    • Miller M. Foy K. Kaumaya P. (2013) Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics. Discov Med 15: 166–176.
    • (2013) Discov Med , vol.15 , pp. 166-176
    • Miller, M.1    Foy, K.2    Kaumaya, P.3
  • 39
    • 84906269444 scopus 로고    scopus 로고
    • Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors
    • abstract 5571.
    • Moore K. Ponte J. LoRusso P. Birrer M. Bauer T. Borghaei H. et al. (2014) Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors. J Clin Oncol 32(Suppl.): abstract 5571.
    • (2014) J Clin Oncol , vol.32
    • Moore, K.1    Ponte, J.2    LoRusso, P.3    Birrer, M.4    Bauer, T.5    Borghaei, H.6
  • 40
    • 84897043920 scopus 로고    scopus 로고
    • Phase 2 study of treatment of advanced ovarian cancer with folate receptor targeted therapeutic (vintafolide) and companion SPECT based imaging agent (99mTc-etarfolatide)
    • Morris R. Naumann R. Shah N. Mauer A. Strauss H. Uszler M. et al. (2014) Phase 2 study of treatment of advanced ovarian cancer with folate receptor targeted therapeutic (vintafolide) and companion SPECT based imaging agent (99mTc-etarfolatide). Ann Oncol 25: 852–858.
    • (2014) Ann Oncol , vol.25 , pp. 852-858
    • Morris, R.1    Naumann, R.2    Shah, N.3    Mauer, A.4    Strauss, H.5    Uszler, M.6
  • 41
    • 84891854386 scopus 로고    scopus 로고
    • Precedent: a randomized phase II trial comparing EC 145 (vintafolide) and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in patients with platinum-resistant ovarian cancer
    • Naumann R. Coleman R. Burger R. Sausville E. Kutarska E. Ghamande S. et al. (2013) Precedent: a randomized phase II trial comparing EC 145 (vintafolide) and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in patients with platinum-resistant ovarian cancer. J Clin Oncol 31: 4400–4406.
    • (2013) J Clin Oncol , vol.31 , pp. 4400-4406
    • Naumann, R.1    Coleman, R.2    Burger, R.3    Sausville, E.4    Kutarska, E.5    Ghamande, S.6
  • 42
    • 84861325993 scopus 로고    scopus 로고
    • High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation
    • Nunez M. Behrens C. Woods D. Lin H. Suraokar M. Kadara H. et al. (2012) High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation. J Thorac Oncol 7: 833–840.
    • (2012) J Thorac Oncol , vol.7 , pp. 833-840
    • Nunez, M.1    Behrens, C.2    Woods, D.3    Lin, H.4    Suraokar, M.5    Kadara, H.6
  • 43
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker N. Turk M. Westrick E. Lewis J. Low P. Leamon C. (2005) Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 338: 284–293.
    • (2005) Anal Biochem , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.2    Westrick, E.3    Lewis, J.4    Low, P.5    Leamon, C.6
  • 44
    • 9444279605 scopus 로고    scopus 로고
    • Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery
    • Paulos C. Reddy J. Leamon C. Turk M. Low P. (2004) Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Mol Pharmacol 66:1406–1414.
    • (2004) Mol Pharmacol , vol.66 , pp. 1406-1414
    • Paulos, C.1    Reddy, J.2    Leamon, C.3    Turk, M.4    Low, P.5
  • 45
    • 84859727702 scopus 로고    scopus 로고
    • EC145: a novel targeted agent for adenocarcinoma of the lung
    • Pribble P. Edelman M. (2012) EC145: a novel targeted agent for adenocarcinoma of the lung. Expert Opin Invest Drugs 21: 755–761.
    • (2012) Expert Opin Invest Drugs , vol.21 , pp. 755-761
    • Pribble, P.1    Edelman, M.2
  • 46
    • 0024440701 scopus 로고
    • Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA
    • Ratnam M. Marquardt H. Duhring J. Freisheim J. (1989) Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry 28: 8249–8254.
    • (1989) Biochemistry , vol.28 , pp. 8249-8254
    • Ratnam, M.1    Marquardt, H.2    Duhring, J.3    Freisheim, J.4
  • 47
    • 84898963005 scopus 로고    scopus 로고
    • Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs
    • Reddy J. Dorton R. Bloomfield A. Nelson M. Vetzel M. Guan J. et al. (2014) Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs. Clin Cancer Res 20: 2104–2114.
    • (2014) Clin Cancer Res , vol.20 , pp. 2104-2114
    • Reddy, J.1    Dorton, R.2    Bloomfield, A.3    Nelson, M.4    Vetzel, M.5    Guan, J.6
  • 48
    • 34249321972 scopus 로고    scopus 로고
    • Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate
    • Reddy J. Dorton R. Westrick E. Dawson A. Smith T. Xu L. et al. (2007) Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res 67: 4434–4442.
    • (2007) Cancer Res , vol.67 , pp. 4434-4442
    • Reddy, J.1    Dorton, R.2    Westrick, E.3    Dawson, A.4    Smith, T.5    Xu, L.6
  • 49
    • 0028301752 scopus 로고
    • Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
    • Ross J. Chaudhuri P. Ratnam M. (1994) Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 73: 2432–2443.
    • (1994) Cancer , vol.73 , pp. 2432-2443
    • Ross, J.1    Chaudhuri, P.2    Ratnam, M.3
  • 50
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: what does it promise in tissue-targeted therapeutics?
    • Salazar M. Ratnam M. (2007) The folate receptor: what does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev 26: 141–152.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 141-152
    • Salazar, M.1    Ratnam, M.2
  • 51
    • 0028206803 scopus 로고
    • Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity
    • Shen F. Ross J. Wang X. Ratnam M. (1994) Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry 33: 1209–1215.
    • (1994) Biochemistry , vol.33 , pp. 1209-1215
    • Shen, F.1    Ross, J.2    Wang, X.3    Ratnam, M.4
  • 52
    • 40649096363 scopus 로고    scopus 로고
    • Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
    • Shia J. Klimstra D. Nitzkorski J. Low P. Gonen M. Landmann R. et al. (2008) Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance. Hum Pathol 39: 498–505.
    • (2008) Hum Pathol , vol.39 , pp. 498-505
    • Shia, J.1    Klimstra, D.2    Nitzkorski, J.3    Low, P.4    Gonen, M.5    Landmann, R.6
  • 53
    • 0034722715 scopus 로고    scopus 로고
    • Identification of two putative novel folate receptor genes in humans and mouse
    • Spiegelstein O. Eudy J. Finnell R. (2000) Identification of two putative novel folate receptor genes in humans and mouse. Gene 258: 117–125.
    • (2000) Gene , vol.258 , pp. 117-125
    • Spiegelstein, O.1    Eudy, J.2    Finnell, R.3
  • 54
    • 77951494873 scopus 로고    scopus 로고
    • Targeted cancer therapies in the twenty-first century: lessons from imatinib
    • Stegmeier F. Warmuth M. Sellers W. Dorsch M. (2010) Targeted cancer therapies in the twenty-first century: lessons from imatinib. Clin Pharmacol Ther 87: 543–552.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 543-552
    • Stegmeier, F.1    Warmuth, M.2    Sellers, W.3    Dorsch, M.4
  • 55
    • 84881095514 scopus 로고    scopus 로고
    • Erlotinib resistance in lung cancer: current progress and future perspectives
    • Tang J. Salama R. Gadgeel S. Sarkar F. Ahmad A. (2013) Erlotinib resistance in lung cancer: current progress and future perspectives. Front Pharmacol 4: 15.
    • (2013) Front Pharmacol , vol.4 , pp. 15
    • Tang, J.1    Salama, R.2    Gadgeel, S.3    Sarkar, F.4    Ahmad, A.5
  • 56
    • 84865243485 scopus 로고    scopus 로고
    • Overcoming resistance to antiangiogenic therapies
    • Tejpar S. Prenen H. Mazzone M. (2012) Overcoming resistance to antiangiogenic therapies. Oncologist 17: 1039–1050.
    • (2012) Oncologist , vol.17 , pp. 1039-1050
    • Tejpar, S.1    Prenen, H.2    Mazzone, M.3
  • 57
    • 84864274164 scopus 로고    scopus 로고
    • Clinical translation of folate receptor-targeted therapeutics
    • Teng L. Xie J. Teng L. Lee R. (2012) Clinical translation of folate receptor-targeted therapeutics. Expert Opin Drug Deliv 9:901–908.
    • (2012) Expert Opin Drug Deliv , vol.9 , pp. 901-908
    • Teng, L.1    Teng, L.2    Xie, J.3    Lee, R.4
  • 59
    • 84862209448 scopus 로고    scopus 로고
    • A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells
    • Tian Y. Wu G. Xing J. Tang J. Zhang Y. Huang Z. et al. (2012) A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells. BMC Immunol 13: 30.
    • (2012) BMC Immunol , vol.13 , pp. 30
    • Tian, Y.1    Wu, G.2    Xing, J.3    Tang, J.4    Zhang, Y.5    Huang, Z.6
  • 61
    • 0031944910 scopus 로고    scopus 로고
    • Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer
    • Toffoli G. Russo A. Gallo A. Cernigoi C. Miotti S. Sorio R. et al. (1998) Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer. Int J Cancer 79: 121–126.
    • (1998) Int J Cancer , vol.79 , pp. 121-126
    • Toffoli, G.1    Russo, A.2    Gallo, A.3    Cernigoi, C.4    Miotti, S.5    Sorio, R.6
  • 62
    • 84904278154 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of weekly fartetuzumab with carboplatin / taxane in subjects with platinum-sensitive ovarian cancer in first relapse
    • Vergote I. Armstrong D. Scambia G. Fujiwara K. Gorbunova V. Schweizer C. et al. (2013) Double-blind, placebo-controlled study of weekly fartetuzumab with carboplatin / taxane in subjects with platinum-sensitive ovarian cancer in first relapse. Int J Gynecol Cancer 23(Suppl. 1): 11.
    • (2013) Int J Gynecol Cancer , vol.23 , pp. 11
    • Vergote, I.1    Armstrong, D.2    Scambia, G.3    Fujiwara, K.4    Gorbunova, V.5    Schweizer, C.6
  • 63
    • 84863946983 scopus 로고    scopus 로고
    • Engineering folate-drug conjugates to target cancer: from chemistry to clinic
    • Vlahov I. Leamon C. (2012) Engineering folate-drug conjugates to target cancer: from chemistry to clinic. Bioconjug Chem 23: 1357–1369.
    • (2012) Bioconjug Chem , vol.23 , pp. 1357-1369
    • Vlahov, I.1    Leamon, C.2
  • 64
    • 33747349484 scopus 로고    scopus 로고
    • Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
    • Vlahov I. Santhapuram H. Kleindl P. Howard S. Stanford K. Leamon C. (2006) Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorg Med Chem Lett 16: 5093–5096.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 5093-5096
    • Vlahov, I.1    Santhapuram, H.2    Kleindl, P.3    Howard, S.4    Stanford, K.5    Leamon, C.6
  • 65
    • 0026752798 scopus 로고
    • Distribution of the folate receptor GP 38 in normal and malignant cell lines and tissues
    • Weitman S. Lark R. Coney L. Fort D. Frasca V. Zurawski V. Jr et al. (1992 a) Distribution of the folate receptor GP 38 in normal and malignant cell lines and tissues. Cancer Res 52: 3396–3401.
    • (1992) Cancer Res , vol.52 , pp. 3396-3401
    • Weitman, S.1    Lark, R.2    Coney, L.3    Fort, D.4    Frasca, V.5    Zurawski, V.6
  • 66
    • 0026476410 scopus 로고
    • Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis
    • Weitman S. Weinberg A. Coney L. Zurawski V. Jennings D. Kamen B. (1992 b) Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis. Cancer Res 52: 6708–6711.
    • (1992) Cancer Res , vol.52 , pp. 6708-6711
    • Weitman, S.1    Weinberg, A.2    Coney, L.3    Zurawski, V.4    Jennings, D.5    Kamen, B.6
  • 67
    • 0029118446 scopus 로고
    • Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity
    • Westerhof G. Schornagel J. Kathmann I. Jackman A. Rosowsky A. Forsch R. et al. (1995) Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Mol Pharmacol 48: 459–471.
    • (1995) Mol Pharmacol , vol.48 , pp. 459-471
    • Westerhof, G.1    Schornagel, J.2    Kathmann, I.3    Jackman, A.4    Rosowsky, A.5    Forsch, R.6
  • 68
    • 63249102414 scopus 로고    scopus 로고
    • A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis
    • Zhao R. Min S. Wang Y. Campanella E. Low P. Goldman I. (2009) A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. J Biol Chem 284: 4267–4274.
    • (2009) J Biol Chem , vol.284 , pp. 4267-4274
    • Zhao, R.1    Min, S.2    Wang, Y.3    Campanella, E.4    Low, P.5    Goldman, I.6


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