-
1
-
-
84891854386
-
Precedent: A randomized phase ii trial comparing vintafolide (ec145) and pegylated liposomal doxorubicin (pld) in combination versus pld alone in patients with platinum-resistant ovarian cancer
-
Naumann RW, Coleman RL, Burger RA, Sausville EA, Kutarska E, Ghamande SA, et al. PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. J Clin Oncol 2013;31:4400-6.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4400-4406
-
-
Naumann, R.W.1
Coleman, R.L.2
Burger, R.A.3
Sausville, E.A.4
Kutarska, E.5
Ghamande, S.A.6
-
2
-
-
80052413192
-
Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: Patterns and significance
-
D'Angelica M, Ammori J, Gonen M, Klimstra DS, Low PS, Murphy L, et al. Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: patterns and significance. Mod Pathol 2011;24: 1221-8.
-
(2011)
Mod Pathol
, vol.24
, pp. 1221-1228
-
-
D'Angelica, M.1
Ammori, J.2
Gonen, M.3
Klimstra, D.S.4
Low, P.S.5
Murphy, L.6
-
3
-
-
0030910859
-
Overexpression of folate binding protein in ovarian cancers
-
Toffoli G, Cernigoi C, Russo A, Gallo A, Bagnoli M, Boiocchi M. Overexpression of folate binding protein in ovarian cancers. Int J Cancer 1997;74:193-8.
-
(1997)
Int J Cancer
, vol.74
, pp. 193-198
-
-
Toffoli, G.1
Cernigoi, C.2
Russo, A.3
Gallo, A.4
Bagnoli, M.5
Boiocchi, M.6
-
4
-
-
0028301752
-
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines
-
Ross JF, Chaudhuri PK, Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 1994;73:2432-43.
-
(1994)
Physiologic and clinical implications. Cancer
, vol.73
, pp. 2432-2443
-
-
Ross, J.F.1
Chaudhuri, P.K.2
Ratnam, M.3
-
5
-
-
0026752798
-
Distribution of the folate receptor gp38 in normal and malignant cell lines and tissues
-
Weitman SD, Lark RH, Coney LR, Fort DW, Frasca V, Zurawski VR Jr, et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992;52:3396-401.
-
(1992)
Cancer Res
, vol.52
, pp. 3396-3401
-
-
Weitman, S.D.1
Lark, R.H.2
Coney, L.R.3
Fort, D.W.4
Frasca, V.5
Zurawski Jr., V.R.6
-
6
-
-
34547108108
-
Folate receptor overexpression is associated with poor outcome in breast cancer
-
Hartmann LC, Keeney GL, Lingle WL, Christianson TJ, Varghese B, Hillman D, et al. Folate receptor overexpression is associated with poor outcome in breast cancer. Int J Cancer 2007;121:938-42.
-
(2007)
Int J Cancer
, vol.121
, pp. 938-942
-
-
Hartmann, L.C.1
Keeney, G.L.2
Lingle, W.L.3
Christianson, T.J.4
Varghese, B.5
Hillman, D.6
-
7
-
-
58149158183
-
Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue
-
Markert S, Lassmann S, Gabriel B, Klar M, Werner M, Gitsch G, et al. Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue. Anticancer Res 2008;28:3567-72.
-
(2008)
Anticancer Res
, vol.28
, pp. 3567-3572
-
-
Markert, S.1
Lassmann, S.2
Gabriel, B.3
Klar, M.4
Werner, M.5
Gitsch, G.6
-
8
-
-
14644392093
-
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
-
Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, Leamon CP. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338: 284-93.
-
(2005)
Anal Biochem
, vol.338
, pp. 284-293
-
-
Parker, N.1
Turk, M.J.2
Westrick, E.3
Lewis, J.D.4
Low, P.S.5
Leamon, C.P.6
-
9
-
-
57349100779
-
Folate-targeted drug strategies for the treatment of cancer
-
Leamon CP. Folate-targeted drug strategies for the treatment of cancer. Curr Opin Investig Drugs 2008;9:1277-86.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1277-1286
-
-
Leamon, C.P.1
-
10
-
-
1942535110
-
Folate receptor-targeted drugs for cancer and inflammatory diseases
-
Low PS, Antony ACe. Folate receptor-targeted drugs for cancer and inflammatory diseases. Adv Drug Deliv Rev 2004;56:1055-231.
-
(2004)
Adv Drug Deliv Rev
, vol.56
, pp. 1055-1231
-
-
Low, P.S.1
Antony, A.C.2
-
11
-
-
18344386053
-
Targeting therapeutic and imaging agents to folate receptor-positive tumors
-
Reddy JA, Allagadda VM, Leamon CP. Targeting therapeutic and imaging agents to folate receptor-positive tumors. Curr Pharm Biotechnol 2005;6:131-50.
-
(2005)
Curr Pharm Biotechnol
, vol.6
, pp. 131-150
-
-
Reddy, J.A.1
Allagadda, V.M.2
Leamon, C.P.3
-
12
-
-
84967351229
-
Folate-mediated delivery of protein and peptide drugs into tumors
-
In: Torchilin V, editorLondon, UK: World Scientific/Imperial College Press
-
Reddy JA, Leamon CP, Low PS. Folate-mediated delivery of protein and peptide drugs into tumors. In:Torchilin V, editor. Delivery of protein and peptide drugs in cancer. London, UK: World Scientific/Imperial College Press; 2006. p. 183-204.
-
(2006)
Delivery of Protein and Peptide Drugs in Cancer
, pp. 183-1204
-
-
Reddy, J.A.1
Leamon, C.P.2
Low, P.S.3
-
13
-
-
83655178029
-
Folate receptor targeted cancer chemotherapy
-
In:JackmanAL LeamonCP editors London UK: Springer Science
-
Reddy JA, Leamon CP. Folate receptor targeted cancer chemotherapy. In:JackmanAL, LeamonCP, editors. Targeted drug strategies for cancer and inflammation. London, UK: Springer Science; 2011. p. 135-50.
-
(2011)
Targeted Drug Strategies for Cancer and Inflammation
, pp. 135-150
-
-
Reddy, J.A.1
Leamon, C.P.2
-
14
-
-
78751537219
-
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications
-
Leamon CP, Reddy JA, Klein PJ, Vlahov IR, Dorton R, Bloomfield A, et al. Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications. J Pharmacol Exp Ther 2010;336:336-43.
-
(2010)
J Pharmacol Exp Ther
, vol.336
, pp. 336-343
-
-
Leamon, C.P.1
Reddy, J.A.2
Klein, P.J.3
Vlahov, I.R.4
Dorton, R.5
Bloomfield, A.6
-
15
-
-
70350070854
-
In vivo structural activity and optimization studies of folate-tubulysin conjugates
-
Reddy JA, Dorton R, Dawson A, Vetzel M, Parker N, Nicoson JS, et al. In vivo structural activity and optimization studies of folate-tubulysin conjugates. Mol Pharm 2009;6:1518-25.
-
(2009)
Mol Pharm
, vol.6
, pp. 1518-1525
-
-
Reddy, J.A.1
Dorton, R.2
Dawson, A.3
Vetzel, M.4
Parker, N.5
Nicoson, J.S.6
-
16
-
-
57149087269
-
Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin b analogue
-
Leamon CP, Reddy JA, Vetzel M, Dorton R, Westrick E, Parker N, et al. Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue. Cancer Res 2008; 68:9839-44.
-
(2008)
Cancer Res
, vol.68
, pp. 9839-9844
-
-
Leamon, C.P.1
Reddy, J.A.2
Vetzel, M.3
Dorton, R.4
Westrick, E.5
Parker, N.6
-
17
-
-
34447128803
-
Folate receptor-specific antitumor activity of ec131, a folate- maytansinoid conjugate
-
Reddy JA, Westrick E, Santhapuram HK, Howard SJ, Miller ML, Vetzel M, et al. Folate receptor-specific antitumor activity of EC131, a folate- maytansinoid conjugate. Cancer Res 2007;67:6376-82.
-
(2007)
Cancer Res
, vol.67
, pp. 6376-6382
-
-
Reddy, J.A.1
Westrick, E.2
Santhapuram, H.K.3
Howard, S.J.4
Miller, M.L.5
Vetzel, M.6
-
18
-
-
34249321972
-
Preclinical evaluation of ec145, a folate-vinca alkaloid conjugate
-
Reddy JA, Dorton R, Westrick E, Dawson A, Smith T, Xu LC, et al. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res 2007;67:4434-42.
-
(2007)
Cancer Res
, vol.67
, pp. 4434-4442
-
-
Reddy, J.A.1
Dorton, R.2
Westrick, E.3
Dawson, A.4
Smith, T.5
Xu, L.C.6
-
19
-
-
34447131647
-
Comparative preclinical activity of the folate-targeted vinca alkaloid conjugatesec140 and ec145
-
Leamon CP, Reddy JA, Vlahov IR, Westrick E, Parker N, Nicoson JS, et al. Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugatesEC140 and EC145. Int J Cancer 2007;121:1585-92.
-
(2007)
Int J Cancer
, vol.121
, pp. 1585-1592
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
Westrick, E.4
Parker, N.5
Nicoson, J.S.6
-
20
-
-
35548957255
-
Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
-
Leamon CP, Reddy JA, Vlahov IR, Westrick E, Dawson A, Dorton R, et al. Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Mol Pharm 2007;4:659-67.
-
(2007)
Mol Pharm
, vol.4
, pp. 659-667
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
Westrick, E.4
Dawson, A.5
Dorton, R.6
-
21
-
-
71449112911
-
Clinical pharmacokinetics and exposure-toxicity relationship of a folate-vinca alkaloid conjugate ec145 in cancer patients
-
Li J, Sausville EA, Klein PJ, Morgenstern D, Leamon CP, Messmann RA, et al. Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients. J Clin Pharmacol 2009;49:1467-76.
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 1467-1476
-
-
Li, J.1
Sausville, E.A.2
Klein, P.J.3
Morgenstern, D.4
Leamon, C.P.5
Messmann, R.A.6
-
22
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
23
-
-
84869209094
-
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
-
Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 2012;18:1639-42.
-
(2012)
Nat Med
, vol.18
, pp. 1639-1642
-
-
Zhang, S.1
Liu, X.2
Bawa-Khalfe, T.3
Lu, L.S.4
Lyu, Y.L.5
Liu, L.F.6
-
24
-
-
84898984279
-
Ec-fv-02: A phase ii study of ec145 in patients with advanced ovarian cancer [abstract]
-
Oct 11-14; Belgrade, Serbia: ESGO; 2009. Abstract nr #A-171-0006-01181
-
Naumann RW, Morris R, Harb WA, Micha J, Sutton G, Dinh T, et al. EC-FV-02: a phase II study of EC145 in patients with advanced ovarian cancer [abstract]. In: Proceedings of the 16th International Meeting of European Society of Gynaecological Oncology; 2009 Oct 11-14; Belgrade, Serbia: ESGO; 2009. Abstract nr #A-171- 0006-01181.
-
(2009)
Proceedings of the 16th International Meeting of European Society of Gynaecological Oncology
-
-
Naumann, R.W.1
Morris, R.2
Harb, W.A.3
Micha, J.4
Sutton, G.5
Dinh, T.6
-
25
-
-
33747349484
-
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: Ec145, a folic acid conjugate of desacetylvinblastine monohydrazide
-
Vlahov IR, Santhapuram HK, Kleindl PJ, Howard SJ, Stanford KM, Leamon CP. Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorg Med Chem Lett 2006; 16:5093-6.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5093-5096
-
-
Vlahov, I.R.1
Santhapuram, H.K.2
Kleindl, P.J.3
Howard, S.J.4
Stanford, K.M.5
Leamon, C.P.6
-
26
-
-
0032947768
-
Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin
-
Go RS, Adjei AA. Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin. J Clin Oncol 1999;17:409-22.
-
(1999)
J Clin Oncol
, vol.17
, pp. 409-422
-
-
Go, R.S.1
Adjei, A.A.2
-
27
-
-
42249094731
-
Pharmaceutical management of ovarian cancer: Current status
-
Markman M. Pharmaceutical management of ovarian cancer: current status. Drugs 2008;68:771-89.
-
(2008)
Drugs
, vol.68
, pp. 771-789
-
-
Markman, M.1
-
29
-
-
67649380867
-
Current role and future aspects of topotecan in relapsed ovarian cancer
-
Sehouli J, Oskay-Ozcelik G. Current role and future aspects of topotecan in relapsed ovarian cancer. Curr Med Res Opin 2009; 25:639-51.
-
(2009)
Curr Med Res Opin
, vol.25
, pp. 639-6351
-
-
Sehouli, J.1
Oskay-Ozcelik, G.2
-
30
-
-
45849097227
-
Key role of topoisomerase i inhibitors in the treatment of recurrent and refractory epithelial ovarian carcinoma
-
Wethington SL, Wright JD, Herzog TJ. Key role of topoisomerase I inhibitors in the treatment of recurrent and refractory epithelial ovarian carcinoma. Expert Rev Anticancer Ther 2008;8:819-31.
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, pp. 819-831
-
-
Wethington, S.L.1
Wright, J.D.2
Herzog, T.J.3
-
31
-
-
0035060411
-
Phase ii study of vinorelbine in the treatment of platinumresistant ovarian carcinoma
-
Sorensen P, Hoyer M, Jakobsen A, Malmstrom H, Havsteen H, Bertelsen K. Phase II study of vinorelbine in the treatment of platinumresistant ovarian carcinoma. Gynecol Oncol 2001;81:58-62.
-
(2001)
Gynecol Oncol
, vol.81
, pp. 58-62
-
-
Sorensen, P.1
Hoyer, M.2
Jakobsen, A.3
Malmstrom, H.4
Havsteen, H.5
Bertelsen, K.6
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