Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 23, 2015, Pages 7255-7260

  Qi, Qi ^a   Li, Dean Y ^b   Luo, Hongbo R ^c   Guan, Kun Liang ^d   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer progression; Netrin 1; YAP

Indexed keywords

LARGE TUMOR SUPPRESSOR KINASE 1; LARGE TUMOR SUPPRESSOR KINASE 2; MAMMALIAN STE20 LIKE PROTEIN KINASE 1; MAMMALIAN STE20 LIKE PROTEIN KINASE 2; NETRIN 1; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1A; PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG; UNCOORDINATED 5 HOMOLOG B PROTEIN; YES ASSOCIATED PROTEIN; NERVE GROWTH FACTOR; NETRIN-1; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; GENE INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARCINOGENESIS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; HUMANS; NERVE GROWTH FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84931291928     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505917112     Document Type: Article

References (31)

1. Pan D (2010) The hippo signaling pathway in development and cancer. Dev Cell 19(4):491-505.
2. Zhao B, Lei QY, Guan KL (2008) The Hippo-YAP pathway: New connections between regulation of organ size and cancer. Curr Opin Cell Biol 20(6):638-646.
3. Overholtzer M, et al. (2006) Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 103(33):12405-12410.
4. Camargo FD, et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17(23):2054-2060.
5. Steinhardt AA, et al. (2008) Expression of Yes-associated protein in common solid tumors. Hum Pathol 39(11):1582-1589.
6. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL (2010) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev 24(1):72-85.
7. Serafini T, et al. (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78(3):409-424.
8. Mehlen P, et al. (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395(6704):801-804.
9. Bernet A, et al. (2007) Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 133(6):1840-1848.
10. Dumartin L, et al. (2010) Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Gastroenterology 138(4):1595-1606, 1606.e1-8.
11. Mazelin L, et al. (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431(7004):80-84.
12. Rodrigues S, De Wever O, Bruyneel E, Rooney RJ, Gespach C (2007) Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis. Oncogene 26(38):5615-5625.
13. Mehlen P, Guenebeaud C (2010) Netrin-1 and its dependence receptors as original targets for cancer therapy. Curr Opin Oncol 22(1):46-54.
14. Feng X, et al. (2014) Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 25(6):831-845.
15. Chan SW, et al. (2011) Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem 286(9):7018-7026.
16. Royer C, et al. (2014) ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. PLoS ONE 9(10):e111384.
17. Kolupaeva V, Janssens V (2013) PP1 and PP2A phosphatases-Cooperating partners in modulating retinoblastoma protein activation. FEBS J 280(2):627-643.
18. Guenebeaud C, et al. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell 40(6):863-876.
19. Wang P, et al. (2011) PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE 6(9):e24288.
20. Lai Wing Sun K, Correia JP, Kennedy TE (2011) Netrins: Versatile extracellular cues with diverse functions. Development 138(11):2153-2169.
21. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20(11):2715-2722.
22. Tang X, et al. (2008) Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol 10(6):698-706.
23. He K, Jang SW, Joshi J, Yoo MH, Ye K (2011) Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Mol Biol Cell 22(11):1943-1954.
24. Forcet C, et al. (2002) Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417(6887):443-447.
25. Cai H, Xu Y (2013) The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. Cell Commun Signal 11(1):31.
26. Geetha T, Langlais P, Caruso M, Yi Z (2012) Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway. J Endocrinol 214(3):437-443.
27. Monick MM, et al. (2006) Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1. J Immunol 177(3):1636-1645.
28. Gordon M, et al. (2013) The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS ONE 8(10):e75483.
29. Crose LE, et al. (2014) Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. J Clin Invest 124(1):285-296.
30. Avruch J, et al. (2009) Rassf family of tumor suppressor polypeptides. J Biol Chem 284(17):11001-11005.
31. Park J, et al. (2010) Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem 285(45):35029-35038.