Netrin-1 Mediates Early Events in Pancreatic Adenocarcinoma Progression, Acting on Tumor and Endothelial Cells

Gastroenterology

Volumn 138, Issue 4, 2010, Pages

  Dumartin, Laurent ^a,b   Quemener, Cathy ^a,b   Laklai, Hanane ^a   Herbert, John ^c   Bicknell, Roy ^c   Bousquet, Corinne ^a   Pyronnet, Stéphane ^a   Castronovo, Vincent ^d   Schilling, Martin K ^e   Bikfalvi, Andreas ^a,b   Hagedorn, Martin ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e SAARLAND UNIVERSITY   (Germany)

Author keywords

Angiogenesis; Chick Embryo; Endothelial Cell; Microarray; Pancreatic Ductal Adenocarcinoma

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; GENE PRODUCT; NETRIN 1; SMALL INTERFERING RNA;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER CELL; CANCER GRAFT; CANCER GROWTH; CANCER INVASION; CELL ADHESION; CELL INTERACTION; CELL INVASION; CELL SPECIFICITY; CHORIOALLANTOIS; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PANCREAS ADENOCARCINOMA; PANCREAS DUCTAL ADENOCARCINOMA; PLACENTA CIRCULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA; UPREGULATION;

EID: 77949828629     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.12.061     Document Type: Article

References (47)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43-66
2. Bardeesy N., and DePinho R.A. Pancreatic cancer biology and genetics. Nat Rev Cancer 2 (2002) 897-909
3. Keleg S., Buchler P., Ludwig R., Buchler M.W., and Friess H. Invasion and metastasis in pancreatic cancer. Mol Cancer 2 (2003) 14
4. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
5. Mehlen P., and Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer 6 (2006) 449-458
6. Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 (2001) 375-379
7. Pekarik V., Bourikas D., Miglino N., Joset P., Preiswerk S., and Stoeckli E.T. Screening for gene function in chicken embryo using RNAi and electroporation. Nat Biotechnol 21 (2003) 93-96
8. Hagedorn M., Javerzat S., Gilges D., et al. Accessing key steps of human tumor progression in vivo by using an avian embryo model. Proc Natl Acad Sci U S A 102 (2005) 1643-1648
9. Delloye-Bourgeois C., Fitamant J., Paradisi A., et al. Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med 206 (2009) 833-847
10. Paradisi A., Maisse C., Coissieux M.M., et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A 106 (2009) 17146-17151
11. Fitamant J., Guenebeaud C., Coissieux M.M., et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A 105 (2008) 4850-4855
12. Castets M., Coissieux M.M., Delloye-Bourgeois C., et al. Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Dev Cell 16 (2009) 614-620
13. Saidi A., Javerzat S., Bellahcene A., et al. Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma. Int J Cancer 122 (2008) 2187-2198
14. Herbert J.M., Stekel D., Sanderson S., Heath V.L., and Bicknell R. A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes. BMC Genomics 9 (2008) 153
15. Koshiba T., Hosotani R., Wada M., et al. Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma. Cancer 82 (1998) 642-650
16. Cohenuram M., and Saif M.W. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future. JOP 8 (2007) 4-15
17. Yang A.D., Camp E.R., Fan F., et al. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res 66 (2006) 46-51
18. Frolov A., Schuller K., Tzeng C.W., et al. ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib. Cancer Biol Ther 6 (2007) 548-554
19. Matouk I.J., DeGroot N., Mezan S., et al. The H19 non-coding RNA is essential for human tumor growth. PLoS ONE 2 (2007) e845
20. Lu X., Le Noble F., Yuan L., et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432 (2004) 179-186
21. Wilson B.D., Ii M., Park K.W., et al. Netrins promote developmental and therapeutic angiogenesis. Science 313 (2006) 640-644
22. De Breuck S., Lardon J., Rooman I., and Bouwens L. Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 46 (2003) 926-933
23. Mazelin L., Bernet A., Bonod-Bidaud C., et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431 (2004) 80-84
24. Duxbury M.S., Ito H., Zinner M.J., Ashley S.W., and Whang E.E. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene 23 (2004) 465-473
25. Li M., Zhang Y., Feurino L.W., et al. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci 99 (2008) 733-737
26. Crnogorac-Jurcevic T., Efthimiou E., Capelli P., et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 20 (2001) 7437-7446
27. Gesierich S., Paret C., Hildebrand D., et al. Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res 11 (2005) 2840-2852
28. Jaskiewicz K., Nalecz A., Rzepko R., and Sledzinski Z. Immunocytes and activated stellate cells in pancreatic fibrogenesis. Pancreas 26 (2003) 239-242
29. Iacobuzio-Donahue C.A., Ryu B., Hruban R.H., and Kern S.E. Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol 160 (2002) 91-99
30. Tessier-Lavigne M., and Goodman C.S. The molecular biology of axon guidance. Science 274 (1996) 1123-1133
31. Mehlen P., Rabizadeh S., Snipas S.J., Assa-Munt N., Salvesen G.S., and Bredesen D.E. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395 (1998) 801-804
32. Mehlen P., and Bredesen D.E. The dependence receptor hypothesis. Apoptosis 9 (2004) 37-49
33. Yilmaz A., Kliche S., Mayr-Beyrle U., Fellbrich G., and Waltenberger J. p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival. Biochem Biophys Res Commun 306 (2003) 730-736
34. Yebra M., Montgomery A.M., Diaferia G.R., et al. Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell 5 (2003) 695-707
35. Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 4 (2004) 978-987
36. Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., and Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell 133 (2008) 1241-1254
37. Hruban R.H., Adsay N.V., Albores-Saavedra J., et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66 (2006) 95-106
38. Crnogorac-Jurcevic T., Efthimiou E., Nielsen T., et al. Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene 21 (2002) 4587-4594
39. Stacker S.A., Caesar C., Baldwin M.E., et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 7 (2001) 186-191
40. Yonemura Y., Endo Y., Tabata K., et al. Role of VEGF-C and VEGF-D in lymphangiogenesis in gastric cancer. Int J Clin Oncol 10 (2005) 318-327
41. Delloye-Bourgeois C., Brambilla E., Coissieux M.M., et al. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J Natl Cancer Inst 101 (2009) 237-247
42. Schneider G., Hamacher R., Eser S., Friess H., Schmid R.M., and Saur D. Molecular biology of pancreatic cancer-new aspects and targets. Anticancer Res 28 (2008) 1541-1550
43. Ly N.P., Komatsuzaki K., Fraser I.P., et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A 102 (2005) 14729-14734
44. Bouvree K., Larrivee B., Lv X., et al. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. Dev Biol 318 (2008) 172-183
45. Larrivee B., Freitas C., Trombe M., et al. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev 21 (2007) 2433-2447
46. Link B.C., Reichelt U., Schreiber M., et al. Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 14 (2007) 2591-2599
47. Wang W., Reeves W.B., and Ramesh G. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Am J Physiol Renal Physiol 296 (2009) F723-F729