Recent advances in renal transplantation: Antibody-mediated rejection takes center stage

F1000Prime Reports

Volumn 7, Issue , 2015, Pages

  Pouliquen, Eric ^a,b,c   Koenig, Alice ^a,b,c   Chen, Chien Chia ^a,b,c   Sicard, Antoine ^a,b,c   Rabeyrin, Maud ^a   Morelon, Emmanuel ^a,b,c   Dubois, Valérie ^d   Thaunat, Olivier ^a,b,c  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LYON   (France)

^d ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; COMPLEMENT; ECULIZUMAB; HLA ANTIBODY; IMMUNOGLOBULIN; RITUXIMAB;

ACUTE GRAFT REJECTION; ALLOTRANSPLANTATION; ANTIBODY MEDIATED REJECTION; COMPLEMENT CLASSICAL PATHWAY; DISEASE COURSE; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL MONITORING; IMMUNOLOGIST; IMMUNOTHERAPY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NONHUMAN; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

EID: 84931291774     PISSN: None     EISSN: 20517599     Source Type: Journal    
DOI: 10.12703/P7-51     Document Type: Review

References (87)

1. Schieppati A, Remuzzi G: Chronic renal diseases as a public health problem: epidemiology, social, and economic implications. Kidney international. Supplement 2005:S7-S10.
2. Gorer PA: The antigenic basis of tumour transplantation. J Pathol 1938, 47:231-52.
3. Billingham RE, Medawar PB: The Technique of Free Skin Grafting in Mammals. Journal of Experimental Biology 1951, 28:385-402.
4. Benichou G, Yamada Y, Yun S, Lin C, Fray M, Tocco G: Immune recognition and rejection of allogeneic skin grafts. Immunotherapy 2011, 3:757-70.
5. Sellarés J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF: Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012, 12:388-99.
6. Patel R, Terasaki PI: Significance of the positive crossmatch test in kidney transplantation. The New England journal of medicine 1969, 280:735-9.
7. Jeannet M, Pinn VW, Flax MH, Winn HJ, Russell PS: Humoral antibodies in renal allotransplantation in man. The New England journal of medicine 1970, 282:111-7.
8. Hall JG, Smith ME, Edwards PA, Shooter KV: The low concentration of macroglobulin antibodies in peripheral lymph. Immunology 1969, 16:773-8.
9. Russell PS, Chase CM, Winn HJ, Colvin RB: Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. Journal of immunology (Baltimore, Md.: 1950) 1994, 152:5135-41.
10. Thaunat O, Louedec L, Dai J, Bellier F, Groyer E, Delignat S, Gaston A, Caligiuri G, Joly E, Plissonnier D, Michel J, Nicoletti A: Direct and indirect effects of alloantibodies link neointimal and medial remodeling in graft arteriosclerosis. Arteriosclerosis, thrombosis, and vascular biology 2006, 26:2359-65.
11. Hill GS, Nochy D, Bruneval P, Duong van Huyen JP, Glotz D, Suberbielle C, Zuber J, Anglicheau D, Empana J, Legendre C, Loupy A: Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation. Journal of the American Society of Nephrology: JASN 2011, 22:975-83.
12. Smith RN, Kawai T, Boskovic S, Nadazdin O, Sachs DH, Cosimi AB, Colvin RB: Chronic antibody mediated rejection of renal allografts: pathological, serological and immunologic features in nonhuman primates. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006, 6:1790-8.
13. Thaunat O: Humoral immunity in chronic allograft rejection: puzzle pieces come together. Transplant immunology 2012, 26:101-6.
14. Tan JC, Wadia PP, Coram M, Grumet FC, Kambham N, Miller K, Pereira S, Vayntrub T, Miklos DB: H-Y antibody development associates with acute rejection in female patients with male kidney transplants. Transplantation 2008, 86:75-81.
15. Thaunat O, Graff-Dubois S, Fabien N, Duthey A, Attuil-Audenis V, Nicoletti A, Patey N, Morelon E: A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney international 2012, 81:207-19.
16. Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel TK, Miklos DB, Sarwal MM, Butte AJ: Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:4148-53.
17. Dragun D, Catar R, Philippe A: Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance. Current opinion in organ transplantation 2013, 18:430-5.
18. Jackson AM, Sigdel TK, Delville M, Hsieh S, Dai H, Bagnasco S, Montgomery RA, Sarwal MM: Endothelial Cell Antibodies Associated with Novel Targets and Increased Rejection. Journal of the American Society of Nephrology: JASN 2014.
19. Dragun D, Müller DN, Bräsen JH, Fritsche L, Nieminen-Kelhä M, Dechend R, Kintscher U, Rudolph B, Hoebeke J, Eckert D, Mazak I, Plehm R, Schönemann C, Unger T, Budde K, Neumayer H, Luft FC, Wallukat G: Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. The New England journal of medicine 2005, 352:558-69.
20. Taniguchi M, Rebellato LM, Cai J, Hopfield J, Briley KP, Haisch CE, Catrou PG, Bolin P, Parker K, Kendrick WT, Kendrick SA, Harland RC, Terasaki PI: Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013, 13:2577-89.
21. Conlon TM, Saeb-Parsy K, Cole JL, Motallebzadeh R, Qureshi MS, Rehakova S, Negus MC, Callaghan CJ, Bolton EM, Bradley JA, Pettigrew GJ: Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. Journal of immunology (Baltimore, Md.: 1950) 2012, 188:2643-52.
22. Lakkis FG, Arakelov A, Konieczny BT, Inoue Y: Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nature medicine 2000, 6:686-8.
23. Thaunat O, Patey N, Caligiuri G, Gautreau C, Mamani-Matsuda M, Mekki Y, Dieu-Nosjean M, Eberl G, Ecochard R, Michel J, Graff-Dubois S, Nicoletti A: Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. Journal of immunology (Baltimore, Md.: 1950) 2010, 185:717-28.
24. Thaunat O, Nicoletti A: Lymphoid neogenesis in chronic rejection. Current opinion in organ transplantation 2008, 13:16-9.
25. Thaunat O, Graff-Dubois S, Brouard S, Gautreau C, Varthaman A, Fabien N, Field A, Louedec L, Dai J, Joly E, Morelon E, Soulillou J, Michel J, Nicoletti A: Immune responses elicited in tertiary lymphoid tissues display distinctive features. PloS one 2010, 5:e11398.
26. Thaunat O: Pathophysiologic significance of B-cell clusters in chronically rejected grafts. Transplantation 2011, 92:121-6.
27. Roumenina LT, Zuber J, Frémeaux-Bacchi V: Physiological and therapeutic complement regulators in kidney transplantation. Current opinion in organ transplantation 2013, 18:421-9.
28. Hirohashi T, Uehara S, Chase CM, DellaPelle P, Madsen JC, Russell PS, Colvin RB: Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010, 10:510-7.
29. Loupy A, Suberbielle-Boissel C, Hill GS, Lefaucheur C, Anglicheau D, Zuber J, Martinez F, Thervet E, Méjean A, Charron D, Duong van Huyen JP, Bruneval P, Legendre C, Nochy D: Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009, 9:2561-70.
30. Hirohashi T, Chase CM, Della Pelle P, Sebastian D, Alessandrini A, Madsen JC, Russell PS, Colvin RB: A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012, 12:313-21.
31. Hidalgo LG, Sis B, Sellares J, Campbell PM, Mengel M, Einecke G, Chang J, Halloran PF: NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010, 10:1812-22.
32. Bachelet T, Couzi L, Pitard V, Sicard X, Rigothier C, Lepreux S, Moreau J, Taupin J, Merville P, Déchanet-Merville J: Cytomegalovirus-responsive gd T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions. Journal of the American Society of Nephrology: JASN 2014, 25:2471-82.
33. Zhang X, Reed EF: Effect of antibodies on endothelium. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009, 9:2459-65.
34. Mauiyyedi S, Pelle PD, Saidman S, Collins AB, Pascual M, Tolkoff-Rubin NE, Williams WW, Cosimi AA, Schneeberger EE, Colvin RB: Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. Journal of the American Society of Nephrology: JASN 2001, 12:574-82.
35. Regele H, Böhmig GA, Habicht A, Gollowitzer D, Schillinger M, Rockenschaub S, Watschinger B, Kerjaschki D, Exner M: Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection. Journal of the American Society of Nephrology: JASN 2002, 13:2371-80.
36. Loupy A, Jordan SC: Transplantation: Donor-specific HLA antibodies and renal allograft failure. Nature reviews. Nephrology 2013, 9:130-1.
37. Heilman RL, Nijim A, Desmarteau YM, Khamash H, Pando MJ, Smith ML, Chakkera HA, Huskey J, Valdez R, Reddy KS: De Novo Donor-Specific Human Leukocyte Antigen Antibodies Early After Kidney Transplantation. Transplantation 2014.
38. Lefaucheur C, Loupy A, Hill GS, Andrade J, Nochy D, Antoine C, Gautreau C, Charron D, Glotz D, Suberbielle-Boissel C: Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. Journal of the American Society of Nephrology: JASN 2010, 21:1398-406.
39. Heinemann FM, Roth I, Rebmann V, Arnold M, Witzke O, Wilde B, Spriewald BM, Grosse-Wilde H: Immunoglobulin isotype-specific characterization of anti-human leukocyte antigen antibodies eluted from explanted renal allografts. Human immunology 2007, 68:500-6.
40. Hönger G, Hopfer H, Arnold M, Spriewald BM, Schaub S, Amico P: Pretransplant IgG subclasses of donor-specific human leukocyte antigen antibodies and development of antibody-mediated rejection. Transplantation 2011, 92:41-7.
41. Wahrmann M, Exner M, Schillinger M, Haidbauer B, Regele H, Körmöczi GF, Hörl WH, Böhmig GA: Pivotal role of complement-fixing HLA alloantibodies in presensitized kidney allograft recipients. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006, 6:1033-41.
42. Cicciarelli JC, Kasahara N, Lemp NA, Adamson R, Dembitsky W, Browne B, Steinberg S: Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients. Clinical transplants 2013:413-22.
43. Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA: The impact of glycosylation on the biological function and structure of human immunoglobulins. Annual review of immunology 2007, 25:21-50.
44. Raju TS: Terminal sugars of Fc glycans influence antibody effector functions of IgGs. Current opinion in immunology 2008, 20:471-8.
45. Thaunat O, Legendre C, Morelon E, Kreis H, Mamzer-Bruneel M: To biopsy or not to biopsy? Should we screen the histology of stable renal grafts? Transplantation 2007, 84:671-6.
46. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, Campbell PM, Cascalho M, Collins AB, Demetris AJ, Drachenberg CB, Gibson IW, Grimm PC, Haas M, Lerut E, Liapis H, Mannon RB, Marcus PB, Mengel M, Mihatsch MJ, Nankivell BJ, Nickeleit V, Papadimitriou JC, Platt JL, Randhawa P, Roberts I, Salinas-Madriga L, Salomon DR, Seron D, Sheaff M et al.: Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007, 7:518-26.
47. Feucht HE, Schneeberger H, Hillebrand G, Burkhardt K, Weiss M, Riethmüller G, Land W, Albert E: Capillary deposition of C4d complement fragment and early renal graft loss. Kidney international 1993, 43:1333-8.
48. Rahimi S, Qian Z, Layton J, Fox-Talbot K, Baldwin WM, Wasowska BA: Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004, 4:326-34.
49. Loupy A, Hill GS, Suberbielle C, Charron D, Anglicheau D, Zuber J, Timsit MO, Duong JP, Bruneval P, Vernerey D, Empana JP, Jouven X, Nochy D, Legendre CH: Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA). American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011, 11:56-65.
50. Sis B, Jhangri GS, Bunnag S, Allanach K, Kaplan B, Halloran PF: Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009, 9:2312-23.
51. Haas M, Sis B, Racusen LC, Solez K, Glotz D, Colvin RB, Castro MCR, David, DSR, David-Neto E, Bagnasco SM, Cendales LC, Cornell LD, Demetris AJ, Drachenberg CB, Farver CF, Farris AB, Gibson IW, Kraus E, Liapis H, Loupy A, Nickeleit V, Randhawa P, Rodriguez ER, Rush D, Smith RN, Tan CD, Wallace WD, Mengel M: Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014, 14:272-83.
52. Gebel HM, Bray RA: Laboratory assessment of HLA antibodies circa 2006: making sense of sensitivity. Transplantation Reviews 2006, 20:189-94.
53. Garovoy MR, Rheinschmidt MA: Flow cytometry analysis: a high technology crossmatch technique facilitating transplantation. Transplant Proc 1983, 15:1939-44.
54. Kao KJ, Scornik JC, Small SJ: Enzyme-linked immunoassay for anti-HLA antibodies-an alternative to panel studies by lymphocytotoxicity. Transplantation 1993, 55:192-6.
55. Pei R, Lee J, Shih N, Chen M, Terasaki PI: Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003, 75:43-9.
56. Gebel HM, Bray RA: HLA antibody detection with solid phase assays: great expectations or expectations too great? American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014, 14:1964-75.
57. Guidicelli G, Anies G, Bachelet T, Dubois V, Moreau J, Merville P, Couzi L, Taupin J: The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patients. Transplant immunology 2013, 29:17-21.
58. Süsal C, Ovens J, Mahmoud K, Döhler B, Scherer S, Ruhenstroth A, Tran TH, Heinold A, Opelz G: No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a Collaborative Transplant Study report. Transplantation 2011, 91:883-7.
59. Bachelet T, Couzi L, Lepreux S, Legeret M, Pariscoat G, Guidicelli G, Merville P, Taupin J: Kidney intragraft donor-specific antibodies as determinant of antibody-mediated lesions and poor graft outcome. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013, 13:2855-64.
60. Loupy A, Lefaucheur C, Vernerey D, Chang J, Hidalgo LG, Beuscart T, Verine J, Aubert O, Dubleumortier S, Duong van Huyen, Jean-Paul, Jouven X, Glotz D, Legendre C, Halloran PF: Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection. Journal of the American Society of Nephrology: JASN 2014, 25:2267-77.
61. Lefaucheur C, Nochy D, Hill GS, Suberbielle-Boissel C, Antoine C, Charron D, Glotz D: Determinants of poor graft outcome in patients with antibody-mediated acute rejection. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007, 7:832-41.
62. Sicard A, Ducreux S, Rabeyrin M, Couzi L, McGregor B, Badet L, Scoazec JY, Bachelet T, Lepreux S, Visentin J, Merville P, Fremeaux-Bacchi V, Morelon E, Taupin J, Dubois V, Thaunat O: Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss. Journal of the American Society of Nephrology: JASN 2015, 26:457-67.
63. Loupy A, Lefaucheur C, Vernerey D, Prugger C, Duong van Huyen, Jean-Paul, Mooney N, Suberbielle C, Frémeaux-Bacchi V, Méjean A, Desgrandchamps F, Anglicheau D, Nochy D, Charron D, Empana J, Delahousse M, Legendre C, Glotz D, Hill GS, Zeevi A, Jouven X: Complement-binding anti-HLA antibodies and kidney-allograft survival. The New England journal of medicine 2013, 369:1215-26.
64. Bartel G, Wahrmann M, Schwaiger E, Kikić Ž, Winzer C, Hörl WH, Mühlbacher F, Hoke M, Zlabinger GJ, Regele H, Böhmig GA: Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients. Transplant international: official journal of the European Society for Organ Transplantation 2013, 26:121-30.
65. Diebolder CA, Beurskens FJ, de Jong, Rob N, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck Albert JR, van de Winkel, Jan GJ, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren, Paul WHI: Complement is activated by IgG hexamers assembled at the cell surface. Science (New York, NY) 2014, 343:1260-3.
66. Zand MS, Vo T, Huggins J, Felgar R, Liesveld J, Pellegrin T, Bozorgzadeh A, Sanz I, Briggs BJ: Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways. Transplantation 2005, 79:1507-15.
67. Kazatchkine MD, Kaveri SV: Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. The New England journal of medicine 2001, 345:747-55.
68. Lefaucheur C, Nochy D, Andrade J, Verine J, Gautreau C, Charron D, Hill GS, Glotz D, Suberbielle-Boissel C: Comparison of combination Plasmapheresis/IVIg/anti-CD20 versus high-dose IVIg in the treatment of antibody-mediated rejection. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009, 9:1099-107.
69. Böhmig GA, Wahrmann M, Regele H, Exner M, Robl B, Derfler K, Soliman T, Bauer P, Müllner M, Druml W: Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007, 7:117-21.
70. Gupta G, Abu Jawdeh, Bassam G, Racusen LC, Bhasin B, Arend LJ, Trollinger B, Kraus E, Rabb H, Zachary AA, Montgomery RA, Alachkar N: Late antibody-mediated rejection in renal allografts: outcome after conventional and novel therapies. Transplantation 2014, 97:1240-6.
71. Faguer S, Kamar N, Guilbeaud-Frugier C, Fort M, Modesto A, Mari A, Ribes D, Cointault O, Lavayssière L, Guitard J, Durand D, Rostaing L: Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 2007, 83:1277-80.
72. An GH, Yun J, Hong YA, Khvan M, Chung BH, Choi BS, Park CW, Choi YJ, Kim Y, Yang CW: The effect of combination therapy with rituximab and intravenous immunoglobulin on the progression of chronic antibody mediated rejection in renal transplant recipients. Journal of immunology research 2014, 2014:828732.
73. Sautenet B, Blancho G, Buchler M, Morelon E, Toupance O, Barrou B, Ducloux D, Hurault de Ligny B, Moulin B, Le Gouge A, Lebranchu Y: One Year Results of the Effects of Rituximab on Acute Humoral Rejection in Renal Transplantation: RITUX ERAH, a Multicenter Randomized Placebo Controlled Trial [abstract]. Presented at 2013 American Transplant Congress: 18-22 May 2013, Seattle, WA.
74. Kamar N, Milioto O, Puissant-Lubrano B, Esposito L, Pierre MC, Mohamed AO, Lavayssière L, Cointault O, Ribes D, Cardeau I, Nogier MB, Durand D, Abbal M, Blancher A, Rostaing L: Incidence and predictive factors for infectious disease after rituximab therapy in kidney-transplant patients. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010, 10:89-98.
75. Hychko G, Mirhosseini A, Parhizgar A, Ghahramani N: A Systematic Review and Meta-Analysis of Rituximab in Antibody-mediated Renal Allograft Rejection. International journal of organ transplantation medicine 2011, 2:51-6.
76. Tillou X, Poirier N, Le Bas-Bernardet S, Hervouet J, Minault D, Renaudin K, Vistoli F, Karam G, Daha M, Soulillou JP, Blancho G: Recombinant human C1-inhibitor prevents acute antibody-mediated rejection in alloimmunized baboons. Kidney international 2010, 78:152-9.
77. Zuraw BL, Busse PJ, White M, Jacobs J, Lumry W, Baker J, Craig T, Grant JA, Hurewitz D, Bielory L, Cartwright WE, Koleilat M, Ryan W, Schaefer O, Manning M, Patel P, Bernstein JA, Friedman RA, Wilkinson R, Tanner D, Kohler G, Gunther G, Levy R, McClellan J, Redhead J, Guss D, Heyman E, Blumenstein BA, Kalfus I, Frank MM: Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. The New England journal of medicine 2010, 363:513-22.
78. Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu C, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L: The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. The New England journal of medicine 2006, 355:1233-43.
79. Zuber J, Le Quintrec M, Krid S, Bertoye C, Gueutin V, Lahoche A, Heyne N, Ardissino G, Chatelet V, Noël L, Hourmant M, Niaudet P, Frémeaux-Bacchi V, Rondeau E, Legendre C, Loirat C: Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012, 12:3337-54.
80. Barnett A, Nicholas R, Asgari E, Chowdhury P, Sacks SH, Dorling A, Mamode N: The use of eculizumab in renal transplantation. Clinical transplantation 2013, 27:E216-29.
81. Stegall MD, Diwan T, Raghavaiah S, Cornell LD, Burns J, Dean PG, Cosio FG, Gandhi MJ, Kremers W, Gloor JM: Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011, 11:2405-13.
82. Perry DK, Burns JM, Pollinger HS, Amiot BP, Gloor JM, Gores GJ, Stegall MD: Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009, 9:201-9.
83. Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, Roy-Chaudhury P, Govil A, Mogilishetty G, Rike AH, Cardi M, Wadih G, Tevar A, Woodle ES: Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation 2008, 86:1754-61.
84. Liefeldt L, Brakemeier S, Glander P, Waiser J, Lachmann N, Schönemann C, Zukunft B, Illigens P, Schmidt D, Wu K, Rudolph B, Neumayer H, Budde K: Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012, 12:1192-8.
85. Serre J, Michonneau D, Bachy E, Noël L, Dubois V, Suberbielle C, Kreis H, Legendre C, Mamzer-Bruneel M, Morelon E, Thaunat O: Maintaining calcineurin inhibition after the diagnosis of posttransplant lymphoproliferative disorder improves renal graft survival. Kidney international 2014, 85:182-90.
86. Chesneau M, Michel L, Degauque N, Brouard S: Regulatory B cells and tolerance in transplantation: from animal models to human. Frontiers in immunology 2013, 4:497.
87. Zeng Q, Ng Y, Singh T, Jiang K, Sheriff KA, Ippolito R, Zahalka S, Li Q, Randhawa P, Hoffman RA, Ramaswami B, Lund FE, Chalasani G: B cells mediate chronic allograft rejection independently of antibody production. The Journal of clinical investigation 2014, 124:1052-6.