Transplantation: Donor-specific HLA antibodies and renal allograft failure

Nature Reviews Nephrology

Volumn 9, Issue 3, 2013, Pages 130-131

  Loupy, Alexandre ^a   Jordan, Stanley C ^b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIBODY; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; RITUXIMAB;

ANTIBODY BLOOD LEVEL; COMPLEMENT DEPENDENT CYTOTOXICITY; FLOW CYTOMETRY; GRAFT FAILURE; GRAFT RECIPIENT; HUMAN; IMMUNOASSAY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT FAILURE; KIDNEY DONOR; KIDNEY FAILURE; META ANALYSIS (TOPIC); PLASMAPHERESIS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; STRATIFICATION; SYSTEMATIC REVIEW (TOPIC);

CYTOTOXICITY TESTS, IMMUNOLOGIC; DESENSITIZATION, IMMUNOLOGIC; FLOW CYTOMETRY; GRAFT REJECTION; HLA ANTIGENS; HUMANS; ISOANTIGENS; KIDNEY TRANSPLANTATION;

EID: 84874663214     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2013.18     Document Type: Review

References (10)

1. Mohan, S. et al. Donor-specific antibodies adversely affect kidney allograft outcomes. J. Am. Soc. Nephrol. 12, 2061-2071 (2012).
2. Einecke, G. et al. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am. J. Transplant. 9, 2520-2531 (2009).
3. Gaston, R. S. et al. Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure. Transplantation 90, 68-74 (2010).
4. Sellares, J. et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am. J. Transplant. 12, 388-399 (2012).
5. Colvin, R. B. Antibody-mediated renal allograft rejection: diagnosis and pathogenesis. J. Am. Soc. Nephrol. 18, 1046-1056 (2007).
6. Vo, A. A. et al. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N. Engl. J. Med. 359, 242-251 (2008).
7. Lefaucheur, C. et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. J. Am. Soc. Nephrol. 21, 1398-1406 (2010).
8. Lefaucheur, C. et al. Antibody-mediated vascular rejection of kidney allografts: a population-based study. Lancet 381, 313-319 (2013).
9. Lai, C. H. et al. Antibody testing strategies for deceased donor kidney transplantation after immunomodulatory therapy. Transplantation 92, 48-53 (2011).
10. Chin, C. et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients. J. Heart Lung Transplant. 30, 158-163 (2011).