Regulation of adipose tissue inflammation and insulin resistance by MAPK phosphatase 5

Journal of Biological Chemistry

Volumn 290, Issue 24, 2015, Pages 14875-14883

  Zhang, Yongliang ^a,b   Nguyen, Thang ^c   Tang, Peng ^a,b   Kennedy, Norman J ^d   Jiao, Huipeng ^a,b   Zhang, Mingliang ^e   Reynolds, Joseph M ^f,l   Jaeschke, Anja ^g   Martin Orozco, Natalia ^f   Chung, Yeonseok ^f   He, Wei Min ^h   Wang, Chen ^e   Jia, Weiping ^e   Ge, Baoxue ⁱ   Davis, Roger J ^d   Flavell, Richard A ^j   Dongk, Chen ^k  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e Shanghai Clinical Center of Diabetes   (China)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^h TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

ⁱ SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^j YALE UNIVERSITY   (United States)

^k TSINGHUA UNIVERSITY   (China)

^l ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CHEMICAL ACTIVATION; GLUCOSE; HEALTH RISKS; INSULIN; MACROPHAGES; MAMMALS; METABOLISM; PATHOLOGY; PHOSPHATASES;

ADIPOSE TISSUE; AKT ACTIVATION; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; MACROPHAGE INFILTRATIONS; METABOLIC DISORDERS; TYPE-2 DIABETES; WHITE ADIPOSE TISSUES;

TISSUE;

MAPK PHOSPHATASE 5; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; PROTEIN KINASE B; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; GLUCOSE;

ADIPOSE TISSUE; ADIPOSE TISSUE INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GLUCOSE INTOLERANCE; INFLAMMATION; INFLAMMATORY INFILTRATE; INNATE IMMUNITY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE; WILD TYPE; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY;

MUS;

ADIPOSE TISSUE; ANIMALS; GLUCOSE; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES;

EID: 84931287683     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.660969     Document Type: Article

References (40)

1. Tilg, H., and Moschen, A. R. (2008) Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 14, 222-231
2. Bastard, J. P., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., and Feve, B. (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17, 4-12
3. Blüher, M. (2009) Adipose tissue dysfunction in obesity. Exp. Clin. Endocrinol. Diabetes 117, 241-250
4. Hotamisligil, G. S. (2006) Inflammation and metabolic disorders. Nature 444, 860-867
5. Rosen, E. D., and Spiegelman, B. M. (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853
6. Qatanani, M., and Lazar, M. A. (2007) Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev. 21, 1443-1455
7. Olefsky, J. M., and Glass, C. K. (2010) Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246
8. Christodoulides, C., Lagathu, C., Sethi, J. K., and Vidal-Puig, A. (2009) Adipogenesis and WNT signalling. Trends Endocrinol. Metab. 20, 16-24
9. Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., and Hotamisligil, G. S. (2002) A central role for JNK in obesity and insulin resistance. Nature 420, 333-336
10. Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., and Shoelson, S. E. (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. 11, 183-190
11. Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z. W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., and Karin, M. (2005) IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198
12. Uysal, K. T., Wiesbrock, S. M., Marino, M. W., and Hotamisligil, G. S. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389, 610-614
13. Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pagès, G., Pouysségur, J., Le Marchand-Brustel, Y., and Binétruy, B. (2005) The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54, 402-411
14. Jeffrey, K. L., Camps, M., Rommel, C., and Mackay, C. R. (2007) Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat. Rev. Drug. Discov. 6, 391-403
15. Zhang, Y., and Dong, C. (2007) Regulatory mechanisms of mitogen-activated kinase signaling. Cell Mol. Life Sci. 64, 2771-2789
16. Zhang, Y., Blattman, J. N., Kennedy, N. J., Duong, J., Nguyen, T., Wang, Y., Davis, R. J., Greenberg, P. D., Flavell, R. A., and Dong, C. (2004) Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 430, 793-797
17. Theodosiou, A., Smith, A., Gillieron, C., Arkinstall, S., and Ashworth, A. (1999) MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. Oncogene 18, 6981-6988
18. Tanoue, T., Moriguchi, T., and Nishida, E. (1999) Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J. Biol. Chem. 274, 19949-19956
19. Park, K. W., Halperin, D. S., and Tontonoz, P. (2008) Before they were fat: adipocyte progenitors. Cell Metab. 8, 454-457
20. Gesta, S., Tseng, Y. H., and Kahn, C. R. (2007) Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256
21. Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., and Ferrante, A. W., Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808
22. Bachmanov, A. A., Reed, D. R., Tordoff, M. G., Price, R. A., and Beauchamp, G. K. (2001) Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice. Physiol. Behav. 72, 603-613
23. Loncar, D., Afzelius, B. A., and Cannon, B. (1988) Epididymal white adipose tissue after cold stress in rats. I. Nonmitochondrial changes. J. Ultrastruct. Mol. Struct Res. 101, 109-122
24. Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K., and Kasuga, M. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116, 1494-1505
25. Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., and Chen, H. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830
26. Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., and Lee, C. H. (2008) Adipocyte-derived Th2 cytokines and myeloid PPARδ regulate macrophage polarization and insulin sensitivity. Cell Metab. 7, 485-495
27. Furuhashi, M., Fucho, R., Görgün, C. Z., Tuncman, G., Cao, H., and Hotamisligil, G. S. (2008) Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J. Clin. Invest. 118, 2640-2650
28. Lumeng, C. N., Bodzin, J. L., and Saltiel, A. R. (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184
29. Montague, C. T., and O'Rahilly, S. (2000) The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49, 883-888
30. Gabriely, I., Ma, X. H., Yang, X. M., Atzmon, G., Rajala, M. W., Berg, A. H., Scherer, P., Rossetti, L., and Barzilai, N. (2002) Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51, 2951-2958
31. Barzilai, N., She, L., Liu, B. Q., Vuguin, P., Cohen, P., Wang, J., and Rossetti, L. (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98
32. Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., Mamane, Y., Mancini, J. A., Nawrocki, A. R., Lazarowski, E., Olefsky, J. M., and Kim, J. J. (2012) GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J. Immunol. 189, 1992-1999
33. Stolarczyk, E., Vong, C. T., Perucha, E., Jackson, I., Cawthorne, M. A., Wargent, E. T., Powell, N., Canavan, J. B., Lord, G. M., and Howard, J. K. (2013) Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet. Cell Metab. 17, 520-533
34. Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., and Olefsky, J. M. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-698
35. Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A., and Davis, R. J. (2013) JNK expression by macrophages promotes obesityinduced insulin resistance and inflammation. Science 339, 218-222
36. Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J. L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., and Karin, M. (2007) JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386-397
37. Pettus, L. H., and Wurz, R. P. (2008) Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008. Curr. Top Med. Chem. 8, 1452-1467
38. Koistinen, H. A., Chibalin, A. V., and Zierath, J. R. (2003) Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients. Diabetologia 46, 1324-1328
39. Lim, J. H., Lee, H. J., Ho Jung, M., and Song, J. (2009) Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cell Signal 21, 169-177
40. Sumara, G., Formentini, I., Collins, S., Sumara, I., Windak, R., Bodenmiller, B., Ramracheya, R., Caille, D., Jiang, H., Platt, K. A., Meda, P., Aebersold, R., Rorsman, P., and Ricci, R. (2009) Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis. Cell 136, 235-248