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Volumn 100, Issue , 2015, Pages 89-97

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

(9) Eldehna, Wagdy M a Fares, Mohamed a Ibrahim, Hany S a Aly, Mohamed H b,c Zada, Suher c Ali, Mamdouh M d Abou Seri, Sahar M e Abdel Aziz, Hatem A d,f Abou El Ella, Dalal A g

a Egyptian Russian University (Egypt)

b The British University in Egypt (Egypt)

c The American University in Cairo (Egypt)

d NATIONAL RESEARCH CENTRE (Egypt)

e CAIRO UNIVERSITY (Egypt)

f KING SAUD UNIVERSITY (Saudi Arabia)

g Ain Shams University (Egypt)

Author keywords

Design; Docking; HepG2; Urea; VEGFR 2

Indexed keywords

1 (3 CHLOROPHENYL) 3 (4 ((2 OXOINDOLIN 3 YLIDENE) AMINO)PHENYL)UREA; 1 (3 CHLOROPHENYL) 3 (4 ((5 FLUORO 2 OXOINDOLIN 3 YLIDENE)AMINO)PHENYL)UREA; 1 (4 ((2 OXOINDOLIN 3 YLIDENE)AMINO)PHENYL) 3 PHENYLUREA; 1 (4 ((5 CHLORO 2 OXOINDOLIN 3 YLIDENE)AMINO) PHENYL) 3 (4 CHLOROPHENYL)UREA; 1 (4 ((5 CHLORO 2 OXOINDOLIN 3 YLIDENE)AMINO) PHENYL) 3 (4 FLUOROPHENYL)UREA; 1 (4 ((5 FLUORO 2 OXOINDOLIN 3 YLIDENE)AMINO) PHENYL) 3 (3 (TRIFLUOROMETHYL)PHENYL)UREA; 1 (4 ((5 FLUORO 2 OXOINDOLIN 3 YLIDENE)AMINO) PHENYL) 3 (4 METHOXYPHENYL)UREA; 1 (4 CHLOROPHENYL) 3 (4 ((2 OXOINDOLIN 3 YLIDENE) AMINO)PHENYL)UREA; 1 (4 CYANOPHENYL) 3 (4 ((2 OXOINDOLIN 3 YLIDENE) AMINO)PHENYL)UREA; 4 (3 (4 ((5 CHLORO 2 OXOINDOLIN 3 YLIDENE)AMINO) PHENYL)UREIDO)BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; DOXORUBICIN; INDOLINE UREA DERIVATIVE; SORAFENIB; UNCLASSIFIED DRUG; UREA DERIVATIVE; VASCULOTROPIN RECEPTOR 2; INDOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; UREA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HUMANS; INDOLES; LIVER NEOPLASMS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84931281941 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2015.05.040 Document Type: Article

Times cited : (55)

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