The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

Journal of Controlled Release

Volumn 211, Issue , 2015, Pages 163-170

  Stapleton, Shawn ^a,b,e   Milosevic, Michael ^a,b   Tannock, Ian F ^a,b   Allen, Christine ^c   Jaffray, David A ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Blood flow; Drug delivery; Interstitial fluid pressure; Intra tumoral heterogeneity; Liposomes; Nanomedicine; Transport

Indexed keywords

COMPUTERIZED TOMOGRAPHY; DRUG DELIVERY; LIPOSOMES; MEDICAL NANOTECHNOLOGY; MICROCIRCULATION; NONINVASIVE MEDICAL PROCEDURES; PATIENT TREATMENT; ROBOTICS; TRANSPORT PROPERTIES;

BLOOD FLOW; INTERACTIVE EFFECT; INTERSTITIAL FLUID PRESSURES; INTRA-TUMORAL HETEROGENEITY; NONINVASIVE METHODS; RADIAL DISTRIBUTIONS; TRANSPORT; VASCULAR PERMEABILITY;

TUMORS;

IOHEXOL; LIPOSOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER TRANSPLANTATION; COMPUTED TOMOGRAPHY SCANNER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; FEMALE; INTERSTITIAL FLUID; MAXIMUM PLASMA CONCENTRATION; MICRO-COMPUTED TOMOGRAPHY; MICROCIRCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCINTIGRAPHY; ANIMAL; CAPILLARY PERMEABILITY; EXTRACELLULAR FLUID; METABOLISM; PHYSIOLOGY; PRESSURE; SCID MOUSE; TUMOR MICROENVIRONMENT;

ANIMALS; CAPILLARY PERMEABILITY; EXTRACELLULAR FLUID; FEMALE; LIPOSOMES; MICE; MICE, SCID; MICROCIRCULATION; PRESSURE; TUMOR MICROENVIRONMENT;

EID: 84931275207     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.06.008     Document Type: Article

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