Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model

Journal of Controlled Release

Volumn 207, Issue , 2015, Pages 101-111

  Ekdawi, Sandra N ^a   Stewart, James M P ^b   Dunne, Michael ^a   Stapleton, Shawn ^c,d   Mitsakakis, Nicholas ^a   Dou, Yannan N ^a   Jaffray, David A ^b,c,d,e   Allen, Christine ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d PRINCESS MARGARET HOSPITAL   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Computed tomography; Intratumoral distribution; Liposome; Nanomedicine; Optical microscopy; Tumor accumulation

Indexed keywords

BIOLOGICAL MATERIALS; BLOOD VESSELS; COMPUTERIZED TOMOGRAPHY; DRUG DELIVERY; ENZYME INHIBITION; FLUORESCENCE; FLUORESCENCE MICROSCOPY; INFRARED DEVICES; LIPOSOMES; MEDICAL NANOTECHNOLOGY; OPTICAL DATA STORAGE; OPTICAL MICROSCOPY; TISSUE; TOMOGRAPHY;

HETEROGENEOUS DISTRIBUTIONS; INTRATUMORAL DISTRIBUTION; IODINATED CONTRAST AGENTS; LIPOSOME-BASED DRUG FORMULATIONS; NEAR-INFRARED FLUORESCENCE; TUMOR ACCUMULATION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT MODELS;

TUMORS;

IOHEXOL; LIPOSOME; CONTRAST MEDIUM; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG UPTAKE; FEMALE; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; MOUSE; NANOMEDICINE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; SPATIOTEMPORAL ANALYSIS; TUMOR LOCALIZATION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANIMAL; BLOOD FLOW; CANCER TRANSPLANTATION; CHEMISTRY; FLUORESCENCE IMAGING; HUMAN; METABOLISM; MICROCIRCULATION; PROCEDURES; RADIOGRAPHY; SCID MOUSE; SCINTIGRAPHY; TISSUE DISTRIBUTION; UTERINE CERVIX TUMOR; VASCULARIZATION; XENOGRAFT;

ANIMALS; CONTRAST MEDIA; FEMALE; HETEROGRAFTS; HUMANS; IOHEXOL; LIPIDS; LIPOSOMES; MICE, SCID; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; OPTICAL IMAGING; PERFUSION IMAGING; REGIONAL BLOOD FLOW; TISSUE DISTRIBUTION; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MICROENVIRONMENT; UTERINE CERVICAL NEOPLASMS;

EID: 84927592712     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.006     Document Type: Article

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