Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 5, 2015, Pages 2960-2963

  Chan, Liana C ^a,b   Basuino, Li ^a   Diep, Binh ^a   Hamilton, Stephanie ^a   Chatterjee, Som S ^a   Chambers, Henry F ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CEFTAROLINE; CEFTOBIPROLE; GDPP PROTEIN; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2; PENICILLIN BINDING PROTEIN 2A; PENICILLIN BINDING PROTEIN 4; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CEPHALOSPORIN DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM MUTANT; GENE MUTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE;

ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS;

EID: 84931267031     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05004-14     Document Type: Article

References (20)

1. Chambers HF. 1988. Methicillin-resistant staphylococci. Clin Microbiol Rev 1:173-186.
2. Fuda C, Suvorov M, Vakulenko SB, Mobashery S. 2004. The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J Biol Chem 279:40802-40806. http://dx.doi.org/10.1074/jbc.M403589200.
3. Lovering AL, Gretes MC, Safadi SS, Danel F, de Castro L, Page MG, Strynadka NC. 2012. Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole. J Biol Chem 287:32096-32102. http://dx.doi.org/10.1074/jbc.M112.355644.
4. Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-Lopez C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA. 2013. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proc Natl Acad Sci USA 110:16808-16813. http://dx.doi.org/10.1073/pnas.1300118110.
5. Garrison MW, Kawamura NM, Wen MM. 2012. Ceftaroline fosamil: a new cephalosporin active against resistant Gram-positive organisms including MRSA. Expert Rev Anti Infect Ther 10:1087-1103. http://dx.doi.org/10.1586/eri.12.112.
6. Anderson SD, Gums JG. 2008. Ceftobiprole: an extended-spectrum antimethicillin-resistant Staphylococcus aureus cephalosporin. Ann Pharmacother 42:806-816. http://dx.doi.org/10.1345/aph.1L016.
7. Barbour A, Derendorf H. 2010. Resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole. Ther Clin Risk Manag 6:485-495.
8. Chambers HF. 2006. Ceftobiprole: in-vivo profile of a bactericidal cephalosporin. Clin Microbiol Infect 12(Suppl s2):17-22. http://dx.doi.org/10.1111/j.1469-0691.2006.01404.x.
9. Bazan JA, Martin SI. 2010. Ceftaroline fosamil: a novel broad-spectrum cephalosporin. Drugs Today (Barc) 46:743-755. http://dx.doi.org/10.1358/dot.2010.46.10.1519172.
10. Bush K. 2012. Improving known classes of antibiotics: an optimistic approach for the future. Curr Opin Pharmacol 12:527-534. http://dx.doi.org/10.1016/j.coph.2012.06.003.
11. Banerjee R, Gretes M, Basuino L, Strynadka N, Chambers HF. 2008. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 52:2089-2096. http://dx.doi.org/10.1128/AAC.01403-07.
12. Katayama Y, Ito T, Hiramatsu K. 2000. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 44:1549-1555. http://dx.doi.org/10.1128/AAC.44.6.1549-1555.2000.
13. Katayama Y, Zhang HZ, Chambers HF. 2003. Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics. Microb Drug Resist 9:329-336. http://dx.doi.org/10.1089/107662903322762752.
14. Katayama Y, Robinson DA, Enright MC, Chambers HF. 2005. Genetic background affects stability of mecA in Staphylococcus aureus. J Clin Microbiol 43:2380-2383. http://dx.doi.org/10.1128/JCM.43.5.2380-2383.2005.
15. CLSI. 2012. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 9th ed. CLSI document M07-A9. Clinical and Laboratory Standards Institute, Wayne, PA.
16. Banerjee R, Gretes M, Harlem C, Basuino L, Chambers HF. 2010. A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level beta-lactam resistance contains mutations in three genes. Antimicrob Agents Chemother 54:4900-4902. http://dx.doi.org/10.1128/AAC.00594-10.
17. Alm RA, McLaughlin RE, Kos VN, Sader HS, Iaconis JP, Lahiri SD. 2014. Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective. J Antimicrob Chemother 69:2065-2075. http://dx.doi.org/10.1093/jac/dku114.
18. Long SW, Olsen RJ, Mehta SC, Palzkill TG, Cernoch PL, Perez KK, Musick WL, Rosato AE, Musser JM. 2014. PBP2a mutations causing high-level ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother 58:6668-6674. http://dx.doi.org/10.1128/AAC.03622-14.
19. Lim D, Strynadka NC. 2002. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Nat Struct Biol 9:870-876. http://dx.doi.org/10.1038/nsb858.
20. Mendes RE, Tsakris A, Sader HS, Jones RN, Biek D, McGhee P, Appelbaum PC, Kosowska-Shick K. 2012. Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline. J Antimicrob Chemother 67:1321-1324. http://dx.doi.org/10.1093/jac/dks069.