In vitro inhibitory activities of six gypenosides on human liver cancer cell line HepG2 and possible role of HIF-1α pathway in them

Chemico-Biological Interactions

Volumn 238, Issue , 2015, Pages 48-54

  Shi, Lin ^a,b   Pi, Yuzhen ^a   Luo, Cheng ^c   Zhang, Chunhong ^a   Tan, Dehong ^a   Meng, Xianjun ^a  

^a SHENYANG AGRICULTURAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^c TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cytotoxic activity; Gynostemma pentaphyllum; Gypenosides; HepG2; HIF 1

Indexed keywords

19 OXO 3BETA,20 DIHYDROXYDAMMAR 24 EN 21 OCI ACID 21,23 LACTONE 3 O (ALPHA LEVO RHAMNOPYRANOSYL(1-2)) (BETA DEXTRO XYLOPARANOSYL(1-3)) ALPHA LEVO ARABINOPYRANOSIDE; 3 BETA,20 DIHYDROXYDAMMAR 24 ENE 21 OIC ACID 21,23 LACTONE 3 O (ALPHA LEVO RHAMNOPYRANOSYL(1-2)) (BETA DEXTRO XYLOPYRANOSYL(1-3)) BETA DEXTRO GLUCOPYRANOSIDE; 3 BETA,20,21 TRIHYDROXYDAMMAR 24 ENE 3 O (ALPHA LEVO RHAMNOPYRANOSYL(1-2)) (BETA DEXTRO XYLOPYRANOSYL(1-3)) BETA DEXTRO GLUCOPYRANOSYL 21 O BETA DEXTRO GLUCOPYRANOSIDE; GYPENOSIDE; GYPENOSIDE XLIX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; O N BUTYL 19 OXO 3BETA,20XI,21 TRIHYDROXY 21,23 EPOXYDAMMAR 24 ENE 3 O (ALPHA LEVO RHAMNOPYRANOSYL (1-2)) (BETA DEXTRO XYLOPYRANOSYL (1-3)) ALPHA LEVO ARABINOPYRANOSIDE; O N BUTYL 3BETA,20XI,21 TRIHYDROXY 21,23 EPOXYDAMMAR 24 ENE 3 O (ALPHA LEVO RHAMNOPYRANOSYL (1-2)) (BETA DEXTRO XYLOPYRANOSYL (1-3)) BETA DEXTRO GLUCOPYRANOSIDE; UNCLASSIFIED DRUG; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL HYPOXIA; CELL MIGRATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; FUNCTIONAL FOOD; GYNOSTEMMA PENTAPHYLLUM; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CANCER; LIVER PROTECTION; PHYTOCHEMISTRY; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TUMOR INVASION; CELL MOTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETICS; GYNOSTEMMA; METABOLISM; PLANT;

GYNOSTEMMA PENTAPHYLLUM;

CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; GYNOSTEMMA; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84931260343     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.06.004     Document Type: Article

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