Neutrophil to lymphocyte ratio is related to stent thrombosis and high mortality in patients with acute myocardial infarction

Angiology

Volumn 66, Issue 6, 2015, Pages 545-552

  Ayça, Burak ^a   Akln, Fatih ^b   Celik, Omer ^c   Sahin, Irfan ^a   Yildiz, S Sezai ^a   Avci, I Ilker ^a   Gulsen, Kamil ^d   Okuyan, Ertugrul ^a   Dinckal, M Hakan ^a  

^a Ba cilar Education and Research Hospital   (Turkey)

^b Mu la Sltkl Kocman University Faculty of Science   (Turkey)

^c Istanbul Mehmet Akif Ersoy Cardiovascular Surgery Education and Research Hospital   (Turkey)

^d NEAR EAST UNIVERSITY   (Turkey)

Author keywords

mortality; neutrophil to lymphocyte ratio; ST segment elevation myocardial infarction; stent thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; CLOPIDOGREL; CREATINE KINASE MB; CREATININE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRASUGREL; TRIACYLGLYCEROL; TROPONIN I;

ADULT; ARTICLE; CARDIAC PATIENT; CARDIOGENIC SHOCK; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; CORONARY RISK; DIAGNOSTIC TEST ACCURACY STUDY; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPH; ECHOCARDIOGRAPHY; FEMALE; HEART ARREST; HEART LEFT VENTRICLE EJECTION FRACTION; HEMATOLOGY ANALYZER; HIGH VOLUME HOSPITAL; HOSPITALIZATION; HUMAN; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; PERCUTANEOUS CORONARY INTERVENTION; PREDICTION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SMOKING; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; THROMBUS ASPIRATION; ADVERSE EFFECTS; AGED; AREA UNDER THE CURVE; BLOOD; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; CORONARY THROMBOSIS; DEVICES; EPIDEMIOLOGY; IMMUNOLOGY; LYMPHOCYTE; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NEUTROPHIL; ODDS RATIO; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; RISK; RISK FACTOR; STATISTICAL MODEL; STENT; TIME; TREATMENT OUTCOME; TURKEY;

ADULT; AGED; AREA UNDER CURVE; CHI-SQUARE DISTRIBUTION; CORONARY THROMBOSIS; FEMALE; HOSPITALS, HIGH-VOLUME; HUMANS; LOGISTIC MODELS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NEUTROPHILS; ODDS RATIO; PERCUTANEOUS CORONARY INTERVENTION; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; ROC CURVE; STENTS; TIME FACTORS; TREATMENT OUTCOME; TURKEY;

EID: 84931076774     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319714542997     Document Type: Article

References (40)

1. D'Ascenzo F, Bollati M, Clementi F, et al. Incidence and predictors of coronary stent thrombosis: evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thromboses. Int J Cardiol. 2013 ; 167 ((2)). 575-584
2. Niccoli G, Montone RA, Ferrante G, Crea F. The evolving role of inflammatory biomarkers in risk assessment after stent implantation. J Am Coll Cardiol. 2010 ; 56 ((22)). 1783-1793
3. Park DW, Yun SC, Lee JY, et al. C-reactive protein and the risk of stent thrombosis and cardiovascular events after drug-eluting stent implantation. Circulation. 2009 ; 120 ((20)). 1987-1995
4. Schoos MM, Kelbæk H, Kofoed KF, et al. Usefulness of preprocedure high-sensitivity C-reactive protein to predict death, recurrent myocardial infarction, and stent thrombosis according to stent type in patients with ST-segment elevation myocardial infarction randomized to bare metal or drug-eluting stenting during primary percutaneous coronary intervention. Am J Cardiol. 2011 ; 107 ((11)). 1597-1603
5. Zahorec R. Ratio of neutrophil to lymphocyte counts - rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001 ; 102 ((1)). 5-14
6. Açar G, Fidan S, Uslu ZA, et al. Relationship of neutrophil-lymphocyte ratio with the presence, severity, and extent of coronary atherosclerosis detected by coronary computed tomography angiography [published online February 19, 2014]. Angiology. 2014 ;:
7. Azab B, Chainani V, Shah N, McGinn JT. Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study. Angiology. 2013 ; 64 ((6)). 456-465
8. Arbel Y, Finkelstein A, Halkin A, et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis. 2012 ; 225 ((2)). 456-460
9. Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol. 2010 ; 106 ((4)). 470-476
10. Shen XH, Chen Q, Shi Y, Li HW. Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Chin Med J (Engl). 2010 ; 123 ((23)). 3438-3443
11. Ciçek G, Açlkgoz SK, Bozbay M, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Angiology. 2015 ; 66 ((5)). 441-447
12. Sahin DY, Elbasan Z, Gür M, et al. Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction. Angiology. 2013 ; 64 ((6)). 423-429
13. Duffy BK, Gurm HS, Rajagopa lV, Gupta R, EllisS G, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol. 2006 ; 97 ((7)). 993-996
14. Azab B, Shariff MA, Bachir R, Nabagiez JP, McGinn JT. Elevated preoperative neutrophil/lymphocyte ratio as a predictor of increased long-term survival in minimal invasive coronary artery bypass surgery compared to sternotomy. J Cardiothorac Surg. 2013 ; 8: 193
15. Akpek M, Kaya MG, Lam YY, et al. Relation of neutrophil/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol. 2012 ; 110 ((5)). 621-627
16. Chia S, Nagurney JT, Brown DF, et al. Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for st-elevation myocardial infarction. Am J Cardiol. 2009 ; 103 ((3)). 333-337
17. Kaya A, Kaya Y, Topçu S, et al. Neutrophil-to-lymphocyte ratio predicts contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention. Angiology. 2014 ; 65 ((1)). 51-56
18. Sibbing D, Braun S, Jawansky S, et al. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thromb Haemost. 2008 ; 99 ((1)). 121-126
19. Horne BD, Anderson JL, John JM, Weaver A, Bair TL. Inter mountain heart collaborative study group. which white blood cell subtypes predict increased cardiovascular risk?. J Am Coll Cardiol. 2005 ; 45 ((10)). 1638-1643
20. Yarnell JW, Patterson CC, Sweetnam PM, Lowe GD. Haemostatic/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies. Eur Heart J. 2004 ; 25 ((12)). 1049-1056
21. Meyer-Sabellek W, Brasch H. Atherosclerosis, inflammation, leukocyte function and the effect of statins. J Hypertens. 2006 ; 24 ((12)). 2349-2351
22. Bian C, Wu Y, Shi Y, et al. Predictive value of the relative lymphocyte count in coronary heart disease. Heart Vessels. 2010 ; 25 ((6)). 469-473
23. Grau AJ, Boddy AW, Dukovic DA, Buggle F, Lichy C. Leukocyte count as an independent predictor of recurrent ischemic events. Stroke. 2004 ; 35 ((5)). 1147-1152
24. Cooper HA, Exner DV, Waclawiw MA, Domanski MJ. White blood cell count and mortality in patients with ischemic and non- ischemic leftventricular systolic dysfunction (an analysis of the studies of left ventricular dysfunction [SOLVD]). Am J Cardiol. 1999 ; 84 ((3)). 252-257
25. Spark JI, Sarveswaran J, Blest N, Charalabidis P, Asthana S. An elevated neutrophil-lymphocyte ratio independently predicts mortality in chronic critical limb ischemia. J Vasc Surg. 2010 ; 52 ((3)). 632-636
26. Ott I, Neumann FJ, Gawaz M, Schmitt M, Schömig A. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation. 1996 ; 94 ((6)). 1239-1246
27. Siminiak T, Flores NA, Sheridan DJ. Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular injury. Eur Heart J. 1995 ; 16 ((2)). 160-170
28. Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997 ; 79 ((6)). 812-814
29. Nebeker JR, Virmani R, Bennett CL, et al. Hypersensitivity cases associated with drug-eluting coronary stents: A review of available cases from the research on adverse drug events and reports (radar) project. J Am Coll Cardiol. 2006 ; 47 ((1)). 175-181
30. Virmani R, Guagliumi G, Farb A, et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: Should we be cautious?. Circulation. 2004 ; 109 ((6)). 701-705
31. Kotani J, Awata M, Nanto S, et al. Incomplete neointimal coverage of sirolimus-eluting stents: Angioscopic findings. J Am Coll Cardiol. 2006 ; 47 ((10)). 2108-2111
32. Nakazawa G, Finn AV, Joner M, et al. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug eluting stent placement for acute myocardial infarction patients: An autopsy study. Circulation. 2008 ; 118 ((11)). 1138-1145
33. Finn AV, Joner M, Nakazawa G, et al. Pathological correlates of late drug-eluting stent thrombosis: Strut coverage as a marker of endothelialization. Circulation. 2007 ; 115 ((18)). 2435-2441
34. Bisoendial RJ, Kastelein JJ, Levels JH, et al. Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res. 2005 ; 96 ((7)). 714-716
35. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol. 1999 ; 19 ((4)). 972-978
36. Tesfamariam B, DeFelice AF. Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol. 2007 ; 46 ((4)). 229-237
37. Smits PC, Hofma S, Togni M, et al. Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial. Lancet. 2013 ; 381 ((9867)). 651-660
38. Mehilli J, Kastrati A, Wessely R, et al. Intracoronary stenting and angiographic restenosis - test equivalence between 2 drug-eluting stents (ISAR-TEST) trial investigators randomized trial of a nonpolymer-based rapamycin-eluting stent versus a polymer-based paclitaxel-eluting stent for the reduction of late lumen loss. Circulation. 2006 ; 113 ((2)). 273-279
39. Tamai H, Igaki K, Kyo E, et al. Initial and 6-month results of biodegradable poly-l-lactic acid coronary stents in humans. Circulation. 2000 ; 102 ((4)). 399-404
40. Erbel R, Di Mario C, Bartunek J, et al. Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial PROGRESS-AMS (Clinical performance and angiographic results of coronary stenting with absorbable metal stents) investigators. Lancet. 2007 ; 369 ((9576)). 1869-1875