Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction

Angiology

Volumn 64, Issue 6, 2013, Pages 423-429

  Şahin, Durmuş Yildiray ^a   Elbasan, Zafer ^a   Gür, Mustafa ^a   Yildiz, Ali ^b   Akpinar, Onur ^c   Icen, Yahya Kemal ^a   Turkoglu, Caner ^a   Tekin, Kamuran ^a   Kuloglu, Osman ^a   Çayli, Murat ^a  

^a ADANA NUMUNE EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b HARRAN UNIVERSITY   (Turkey)

^c BSK Metropark Hospital   (Turkey)

Author keywords

lymphocyte; myocardial infarction; neutrophil

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDIABETIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATINE KINASE MB; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TROPONIN; URIC ACID;

ADULT; AGE; ARTICLE; BODY MASS; CARDIAC PATIENT; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DISEASE SEVERITY; EOSINOPHIL COUNT; FAMILY HISTORY; FEMALE; GLUCOSE BLOOD LEVEL; HEART EJECTION FRACTION; HEART RATE; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NEUTROPHIL COUNT; PERCUTANEOUS CORONARY INTERVENTION; PREDICTION; PROSPECTIVE STUDY; SMOKING; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; SYNTAX SCORE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

LYMPHOCYTE; MYOCARDIAL INFARCTION; NEUTROPHIL;

ADULT; AGED; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; LINEAR MODELS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NEUTROPHILS; PERCUTANEOUS CORONARY INTERVENTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84881248200     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319712453305     Document Type: Article

References (40)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999 ; 340 (2). 115-126
2. Libby P.. What have we learned about the biology of atherosclerosis? The role of inflammation. Am J Cardiol. 2001 ; 88 (7B). 3J - 6J
3. Gurm HS, Bhatt DL, Lincoff AM, et al. Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials. Heart. 2003 ; 89 (10). 1200-1204
4. Gurm HS, Bhatt DL, Gupta R, Ellis SG, Topol EJ, Lauer MS. Preprocedural white blood cell count and death after percutaneous coronary intervention. Am Heart J. 2003 ; 146 (4). 692-698
5. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005 ; 15 (4). 266-271
6. Horne BD, Anderson JL, John JM, et al. Intermountain Heart Collaborative Study Group. Which white blood cell subtypes predict increased cardiovascular risk?. J Am Coll Cardiol. 2005 ; 45 (10). 1638-1643
7. Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta. 2008 ; 395 (1-2). 27-31
8. Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol. 2008 ; 101 (6). 747-752
9. Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005 ; 1 (2). 219-227
10. Capodanno D, Di Salvo ME, Cincotta G, Miano M, Tamburino C, Tamburino C. Usefulness of the SYNTAX score for predicting clinical outcome after percutaneous coronary intervention of unprotected left main coronary artery disease. Circ Cardiovasc Interv. 2009 ; 2 (4). 302-308
11. Capodanno D, Capranzano P, Di Salvo ME, et al. Usefulness of SYNTAX score to select patients with left main coronary artery disease to be treated with coronary artery bypass graft. JACC Cardiovasc Interv. 2009 ; 2 (8). 731-738
12. Valgimigli M, Serruys PW, Tsuchida K, et al. Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Am J Cardiol. 2007 ; 99 (8). 1072-1081
13. Wykrzykowska JJ, Garg S, Girasis C, et al. Value of the SYNTAX score (SX) for risk assessment in the "all-comers" population of the randomized multicenter LEADERS Trial. J Am Coll Cardiol. 2010 ; 56 (4). 272-277
14. Girasis C, Garg S, Räber L, et al. SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutaneous coronary interventions: a substudy of SIRolimus-eluting stent compared with pacliTAXel-eluting stent for coronary revascularization (SIRTAX) trial. Eur Heart J. 2011 ; 32 (24). 3115-3127
15. Myocardial infarction redefined: a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J. 2000 ; 21 (18). 1502-1513
16. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989 ; 2 (5). 358-367
17. Serruys PW, Onuma Y, Garg S, et al. Assessment of the SYNTAX score in the Syntax study. EuroIntervention. 2009 ; 5 (1). 50-56
18. Hoffman M, Blum A, Baruch R, Kaplan E, Benjamin M. Leukocytes and coronary heart disease. Atherosclerosis. 2004 ; 172 (1). 1-6
19. Ott I, Neumann FJ, Gawaz M, Schmitt M, Schömig A. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation. 1996 ; 94 (6). 1239-1246
20. Maxwell SRJ, Lip GYH. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol. 1997 ; 58 (2). 95-117
21. Furman MI, Becker RC, Yarzebski J, Savegeau J, Gore JM, Goldberg RJ. Effect of elevated leukocyte count on in-hospital mortality following acute myocardial infarction. Am J Cardiol. 1996 ; 78 (8). 945-948
22. Kirtane AJ, Bui A, Murphy SA, Barron HV, Gibson CM. Association of peripheral neutrophilia with adverse angiographic outcomes in ST elevation myocardial infarction. Am J Cardiol. 2004 ; 93 (5). 532-536
23. Avanzas P, Quiles J, Lopez de Sa E, et al. Neutrophil count and infarct size in patients with acute myocardial infarction. Int J Cardiol. 2004 ; 97 (1). 155-156
24. Fiarresga AJ, Ferreira RC, Feliciano J, et al. Prognostic value of neutrophil response in the era of acute myocardial infarction mechanical reperfusion. Rev Port Cardiol. 2004 ; 23 (11). 1387-1396
25. Eriksson EE, Xie X, Werr J, Thoren P, Lindbom L. Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins. FASEB J. 2001 ; 15 (7). 1149-1157
26. Naruko T, Ueda M, Haze K, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation. 2002 ; 106 (23). 2894-2900
27. Sarma J, Laan CA, Alam S, Jha A, Fox KA, Dransfield I. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation. 2002 ; 105 (18). 2166-2171
28. Barron H, Cannon C, Murphy S, Braunwald E, Gibson CM. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction: a thrombolysis in myocardial infarction 10 substudy. Circulation. 2000 ; 102 (19). 2329-2334
29. Pelizzon G, Dixon S, Stone G, et al. Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction (The Stent PAMI Trial). Am J Cardiol. 2003 ; 91 (6). 729-731
30. Siminiak T, Flores N, Sheridan D. Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular injury. Eur Heart J. 1995 ; 16 (2). 160-170
31. Ducloux D, Challier B, Saas P, Tiberghien P, Chalopin JM. CD4 cell lymphopenia and atherosclerosis in renal transplant recipients. J Am Soc Nephrol. 2003 ; 14 (3). 767-772
32. Onsrud M, Thorsby E.. Influence of in vivo hydrocortisone on some human blood lymphocyte subpopulations. I. Effect on natural killer cell activity. Scand J Immunol. 1981 ; 13 (6). 573-579
33. Thomson SP, Gibbons RJ, Smars PA, et al. Incremental value of the leukocyte differential and the rapid creatine kinase-MB isoenzyme for the early diagnosis of myocardial infarction. Ann Intern Med. 1995 ; 122 (5). 335-341
34. Sabatine MS, Morrow DA, Cannon CP, et al. Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes. A TACTICS-TIMI 18 Substudy. J Am Coll Cardiol. 2002 ; 40 (10). 1761-1768
35. Avramakis G, Papadimitraki E, Papakonstandinou D, et al. Platelets and white blood cell subpopulations among patients with myocardial infarction and unstable angina. Platelets. 2007 ; 18 (1). 16-23
36. Bickel C, Rupprecht HJ, Blankenberg S, et al. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. Am J Cardiol. 2002 ; 89 (1). 12-17
37. Lazzeri C, Valente S, Chiostri M, Sori A, Bernardo P, Gensini GF. Gensini uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience. Int J Cardiol. 2010 ; 138 (2). 206-209
38. Gur M, Yilmaz R, Demirbag R, Aksoy N. Relation of serum uric acid levels with the presence and severity of angiographic coronary artery disease. Angiology. 2008 ; 59 (2). 166-171
39. Wheeler JG, Juzwishin KD, Eiriksdottir G, Gudnason V, Danesh J. Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis. PLoS Med. 2005 ; 2 (3). e76
40. Duran M, Kalay N, Akpek M, et al. High levels of serum uric acid predict severity of coronary artery disease in patients with acute coronary syndrome [published online November 21]. Angiology. 2011 ;: