Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1)

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 12, 2015, Pages F1398-F1408

  Zhang, Yue ^a,b   Robson, Simon C ^c,d   Morris, Kaiya L ^a,b   Heiney, Kristina M ^a,b   Dwyer, Karen M ^e   Kishore, Bellamkonda K ^a,b   Ecelbarger, Carolyn M ^f,g  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g GEORGETOWN UNIVERSITY   (United States)

Author keywords

Aldosterone; Ectonucleotidases; Extracellular nucleotides; Nucleoside triphosphate diphosphohydrolase 1; Purinergic receptors; Sodium transporters

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; CD39 ANTIGEN; EPITHELIAL SODIUM CHANNEL; SODIUM; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; APYRASE; LEUKOCYTE ANTIGEN;

ALDOSTERONE URINE LEVEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HIGH SODIUM INTAKE; HOMEOSTASIS; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; MOUSE; NATRIURESIS; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SODIUM BLOOD LEVEL; SODIUM HOMEOSTASIS; SODIUM RESTRICTION; TRANSGENIC MOUSE; URINE VOLUME; WESTERN BLOTTING; WILD TYPE MOUSE; ANIMAL; BLOOD; BLOOD PRESSURE; HUMAN; METABOLISM; PHYSIOLOGY; PROCEDURES;

ALDOSTERONE; ANIMALS; ANTIGENS, CD; APYRASE; BLOOD PRESSURE; DIET, SODIUM-RESTRICTED; EPITHELIAL SODIUM CHANNELS; HUMANS; MICE; NATRIURESIS; SODIUM; SODIUM CHLORIDE SYMPORTERS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84931072934     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00125.2014     Document Type: Article

References (39)

1. Deaglio S, Robson SC. Ectonucleotidases as regulators of purinergic signaling in thromobosis, inflammation, and immunity. Adv Pharmacol 61: 301-332, 2011.
2. Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ. Thromboregulatory manifestations in human CD transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest 113: 1440-1446, 2004.
3. Kaczmarek E, Bakker JP, Clarke DN, Csizmadia E, Kocher O, Veves A, Tecilazich F, O'Donnell CP, Ferran C, Malhotra A. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. PLoS One 8: e70559, 2013.
4. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14522-14557, 1998.
5. Kishore BK, Chou CL, Knepper MA. Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 269: F863-F869, 1995.
6. Kishore BK, Isaac J, Fausther M, Tripp SR, Shi H, Gill PS, Braun N, Zimmermann H, Sévigny J, Robson SC. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Renal Physiol 288: F1032-F1043, 2005.
7. Kishore BK, Nelson RD, Miller RL, Carlson NG, Kohan DE. P2Y2 receptors and water transport in the kidney. Purinergic Signal 5: 491-499, 2009.
8. Kishore BK, Zhang Y, Gevorgyan H, Kohan DE, Schiedel AC, Müller CE, Peti-Peterdi J. Cellular localization of adenine receptors in the rat kidney and their functional significance in the inner medullary collecting duct. Am J Physiol Renal Physiol 305: F298-F305, 2013.
9. Kukulsko F, Lévesque SA, Sévigny J. Impact of ectoenzymes on p2 and p1 receptor signaling. Adv Pharmacol 61: 263-299, 2011.
10. Lazarowski ER, Sesma JI, Seminario-Vidal L, Kreda SM. Molecular mechanisms of purine and pyrimidine nucleotide release. Adv Pharmacol 61: 221-261, 2011.
11. Leipziger J. Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol 284: F419-F432, 2003.
12. Longhi MS, Robson SC, Bernstein SH, Serra S, Deaglio S. Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med 91: 165-172, 2013.
13. Marques RD, Prætorius HA, Leipziger J. P2Y2 receptor knock-out mice display normal NaCl absorption in medullary thick ascending limb. Front Physiol 4: 280, 2013.
14. Masilamani S, Kim GH, Wade JB, Knepper MA. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
15. McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol 298: R851-R861, 2010.
16. Mizumoto N, Kumamoto T, Robson SC, Sevigny J, Matsue H, Enjyoji K, Takashima A. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nature Med 8: 358-365, 2002.
17. Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J. Tubulogelomerular feedback and renin secretion in NTPDase1/CD39-deficient mice. Am J Physiol Renal Physiol 294: F965-F970, 2008.
18. + channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem 283: 36599-36607, 2008.
19. Prætorius H, Leipziger J. Intrarenal purinergic signaling in the control or renal tubular transport. Annu Rev Physiol 72: 377-393, 2010.
20. Rajagopal M, Kathapalia PP, Widdicombe JH, Pao AA. Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol 303: F483-F491, 2012.
21. Rajagopal M, Pao AC. Adenosine activates A2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells. Hypertension 55: 1123-1128, 2010.
22. Riazi S, Khan O, Hu X, Ecelbarger CA. Aldosterone infusion with high-NaCl diet increases blood pressure in obese but not lean Zucker rats. Am J Physiol Renal Physiol 291: F597-F605, 2006.
23. + and water reabsorption. FASEB J 21: 3717-3726, 2007.
24. Schetinger MR, Morsch VM, Bonan CD, Wyse AT. NTPDase and 5=-nucleotidase activities in physiological and disease conditions: new perspectives for human health. Biofactors 32: 77-98, 2007.
25. Shirley DG, Bailey MA, Unwin RJ. In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption. Am J Physiol Renal Physiol 288: F1243-F1248, 2005.
26. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol 21: 1903-1911, 2010.
27. + channel. Curr Opin Nephrol Hypertens 21: 52-60, 2012.
28. Vallon V. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol 294: F10-F27, 2008.
29. Vallon V, Rieg T. Regulation of renal transport mechanisms. Am J Physiol Renal Physiol 301: F463-F475, 2011.
30. Vekaria RM, Shirley DG, Sévigny J, Unwin RJ. Immunolocalization of ectonucleotidases along the rat nephron. Am J Physiol Renal Physiol 290: F550-F560, 2006.
31. Velazquez H, Bartiss A, Bernstein P, Ellison DH. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am J Physiol Renal Fluid Electrolyte Physiol 270: F211-F219, 1996.
32. Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, Knepper MA. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest 108: 215-222, 2001.
33. Wildman SS, Marks J, Turner CM, Yew-booth L, Peppiat-Wildman CM, King BF, Shirley DG, Wang W, Unwin RJ. Sodium-dependent regulation of renal amiloride-sensitive currents by apical P2 receptors. J Am Soc Nephrol 19: 731-742, 2008.
34. Yegutkin GG. Nucleotide-and nucleoside-converting ectoenzymes: Important modulators of purinergic signaling cascade. Biochim Biophys Acta 1783: 673-694, 2008.
35. Zhang Y, Li L, Kohan DE, Ecelbarger CM, Kishore BK. Attenuation of lithium-induced natriuresis and kaliuresis in P2Y2 receptor knockout mice. Am J Physiol Renal Physiol 305: F407-F416, 2013.
36. Zhang Y, Listhrop R, Ecelbarger CM, Kishore BK. Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed high-NaCl diet with/without aldosterone infusion. Am J Physiol Renal Physiol 300: F567-F668, 2011.
37. Zhang Y, Morris KL, Sparrow SK, Dwyer KM, Enjyoji K, Robson SC, Kishore BK. Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1. Am J Physiol Renal Physiol 303: F420-F430, 2012.
38. Zhang Y, Robson SC, Morris KL, Dwyer KM, Kishore BK, Ecelbarger CM. Impaired aldosterone escape in transgenic mice over-expressing human CD39: role of altered sodium transporter regulation (Abstract). J Am Soc Nephrol 23: 498A-499A, 2012.
39. Zhang Y, Sands JM, Kohan DE, Nelson RD, Martin CF, Carlson NG, Kamerath CD, Ge Y, Klein JD, Kishore BK. Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol 295: F1715-F1724, 2008.