Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NACl diet with/without aldosterone infusion

American Journal of Physiology - Renal Physiology

Volumn 300, Issue 3, 2011, Pages

  Zhang, Yue ^a,b   Listhrop, Raelene ^c   Ecelbarger, Carolyn M ^c   Kishore, Bellamkonda K ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arginine vasopressin; Extracellular nucleotides; Purinergic signaling; Urinary concentration

Indexed keywords

8 ISOPROSTANE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; ARGIPRESSIN; BUMETANIDE; COMPLEMENTARY DNA; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROSTAGLANDIN E2; PURINERGIC P2Y2 RECEPTOR; RECEPTOR SUBUNIT; RNA; SODIUM CHLORIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG INFUSION; KIDNEY; KIDNEY CONCENTRATING CAPACITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC MINIPUMP; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SODIUM EXCRETION; SODIUM TRANSPORT; WESTERN BLOTTING; WILD TYPE;

EID: 79954498884     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00549.2010     Document Type: Article

References (54)

1. Audigé A, Yu ZR, Frey BM, Uehlinger DE, Frey FJ, Vogt B. Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephritic syndrome. Clin Sci 104: 389-395, 2003.
2. Bailey MA, Imbert-Teboul M, Turner C, Marsy S, Srai K, Burnstock G, Unwin RJ. Axial distribution and characterization of basolateral P2Y receptors along the rat renal tubule. Kidney Int 58: 1893-1901, 2000.
3. 12,14 prostaglandin J2 Arthritis Res Ther 7: R1325-R1337, 2005.
4. Briet M, Schiffrin EL. Aldosterone: effects on the kidney and cardiovascular system. Nature Rev Nephrol 6: 261-273, 2010.
5. Cabral PD, Silva GB, Baigorria ST, Juncos LA, Juncos LI, García NH. 8-Iso-prostaglandin-F2α stimulates chloride transport in thick ascending limbs: role of cAMP and protein kinase A. Am J Physiol Renal Physiol 299: F1396-F1400, 2010.
6. Churchill PC, Ellis VR. Purinergic P2y receptors stimulate renin secretion by rat renal cortical slices. J Pharmacol Exp Ther 266: 160-163, 1993.
7. Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR. Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl~ transport. J Biol Chem 274: 26461-26468, 1999.
8. da Silva CG, Specht A, Wegiel B, Ferran C, Kaczmarek E. Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation 119: 871-879, 2009.
9. Djelidi S, Fay M, Cluzeaud F, Escoubet B, Eugene E, Capurro C, Bonvalet JP, Farman N, Blot-Chabaud M. Transcriptional regulation of sodium transport by vasopressin in renal cells. J Biol Chem 272: 32919-32924, 1997.
10. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279: F46-F53, 2000.
11. Ecelbarger CA, Kim GH, Wade JB, Knepper MA. Regulation of the abundance of renal sodium transporters and channels by vasopressin. Expt Nephrol 171: 227-234, 2001.
12. Ecelbarger CA, Yu S, Lee AJ, Weinstein LS, Knepper MA. Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the Gsa gene. Am J Physiol Renal Physiol 277: F235-F244, 1999.
13. Farjah M, Roxas BP, Geenen DL, Danziger RS. Dietary salt regulates renal SGK1 abundance. Relevence to salt sensitivity in the Dahl rat. Hypertension 41: 874-878, 2003.
14. Fernandez-Llama P, Ecelbarger CA, Ware JA, Andrews P, Lee AJ, Turner R, Nielsen S, Knepper MA. Cyclooxygenase inhibitors increase Na-K-2Cl cotransporter abundance in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 277: F219-F226, 1999.
15. Greenberg SS, Zhao X, Wang JF, Hua L, Ouyang J. cAMP and purinergic P2y receptors upregulate and enhance inducible NO synthase mRNA and protein in vivo. Am J Physiol Lung Cell Mol Physiol 273: L967-L979, 1997.
16. Homolya L, Watt WC, Lazarowski ER, Koller BH, Boucher RC. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y2 receptor (-/-) mice. J Biol Chem 274: 26454-26460, 1999.
17. Jia Z, Zhang A, Zhang H, Dong Z, Yang T. Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion. Circ Res 99: 1243-1251, 2006.
18. Katada J, Meguro T, Saito H, Ohashi A, Anzai T, Ogawa S, Yo-shikawa T. Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction. Circulation 111: 2157-2164, 2005.
19. Kim JS, Choi KC, Jeong MH, Kim SW, Oh Y, Lee J. Increased expression of sodium transporters in rats chronically inhibited of nitric oxide synthesis. J Korean Med Sci 21: 1-4, 2006.
20. Kishore BK, Nelson RD, Miller RL, Carlson NG, Kohan DE. P2Y2 receptors and water transport in the kidney. Purinergic Signalling 5: 491-499, 2009.
21. Knepper MA, Im GH, Masilamani S. Renal tubule sodium transporter abundance profiling in rat kidney. Response to aldosterone and variations in NaCl intake. Ann NY Acad Sci 986: 562-569, 2003.
22. Kunzelmann K, Bachhuber T, Reeger R, Markovich D, Sun J, Schreiber R. Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2. FASEB J 19: 142-143, 2005.
23. Leipziger J. Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol 284: F419-F432, 2003.
24. Listhrop R, Nelson RD, Ecelbarger CA, Kohan DE, Kishore BK. Genetic deletion of P2Y2 receptor (P2Y2-R) alters the protein abundances of proximal tubular and thick ascending limb sodium transporters (Abstract). FASEB J 21: 1328A, 2007.
25. Listhrop R, Zhang Y, Charlotte H, Kamerath CD, Ecelbarger CM, Kishore BK. Altered expression of renal sodium transporters/channels in P2Y2 receptor knockout mice fed high or low salt diet (Abstract). J Am Soc Nephrol 19: 352A, 2008.
26. Manolopoulou J, Bielohuby M, Caton SJ, Gomez-Sanchez CE, Renner-Mueller I, Wolf E, Lichtenauer UD, Beuschlein F, Hoeflich A, Bidlingmaier M. A highly sensitive immunofluorometric assay for the measurement of aldosterone in small sample volumes: validation in mouse serum. J Endocrinol 196: 215-224, 2008.
27. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA. Aldo-sterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
28. Masilamani S, Wang X, Kim GH, Brooks H, Nielsen J, Nielsen S, Nakamura K, Stokes JB, Knepper MA. Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction. Am J Physiol Renal Physiol 283: F648-F657, 2002.
29. Mo J, Fisher MJ. Uridine nucleotide-induced stimulation of gluconeo-genesis in isolated rat proximal tubules. Naunyn Schmiedebergs Arch Pharmacol 366: 151-157, 2002.
30. + channel. Proc Australian Physiol Soc 40: 63-70, 2009.
31. + channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem 283: 36599-36607, 2008.
32. Prætorius HA, Leipiziger J. Intrarenal purinergic signaling in the control of renal tubular transport. Annu Rev Physiol 72: 377-393, 2010.
33. Praticò D, Lawson JA, Rokach J, FitzGerald GA. The isoprostanes in biology and medicine. Trends Endocrinol Metab 12: 243-247, 2001.
34. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisted. FASEB J 22: 659-661, 2007.
35. Riazi S, Khan O, Tiwari S, Hu X, Ecelbarger CA. Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) in the obese Zucker rat. Am J Nephrol 26: 245-257, 2006.
36. + and water reabsorption. FASEB J 21: 3717-3726, 2007.
37. Schwiebert EM, Kishore BK. Extracellular nucleotide signaling along the renal epithelium. Am J Physiol Renal Physiol 280: F945-F963, 2001.
38. Shirley DG, Bailey MA, Unwin RJ. In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption. Am J Physiol Renal Physiol 288: F1243-F1248, 2005.
39. Song J, Hu X, Shi M, Knepper MA, Ecelbarger CA. Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure. Am J Physiol Renal Physiol 287: F1204-F1212, 2004.
40. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyk O. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol 21: 1903-1911, 2010.
41. Stoos BA, Carretero OA, Garvin JL. Endothelial-derived nitric oxide inhibits sodium transport by affecting apical membrane channels in cultured collecting duct cells. J Am Soc Nephrol 4: 1855-1860, 1994.
42. Sun R, Carlson NG, Hemmert AC, Kishore BK. P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am J Physiol Renal Physiol 289: F585-F591, 2005.
43. Sun R, Miller RL, Hemmert AC, Zhang P, Shi H, Nelson RD, Kishore BK. Chronic dDAVP infusion in rats decreases the expression of P2Y2 receptor in inner medulla and P2Y2 receptor-mediated PGE2 by IMCD. Am J Physiol Renal Physiol 289: F768-F776, 2005.
44. Takeda M, Kobayashi M, Endou H. Establishment of a mouse clonal early proximal tubule cell line and outer medullary collecting duct cells expressing P2 purinoceptors. Biochem Mol Biol Int 44: 657-664, 1998.
45. Tiwari S, Packer RK, Song J, Sugimura Y, Hu X, Verbalis JG, Ecelbarger CA. Increased renal a-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. Am J Physiol Renal Physiol 291: F49-F57, 2006.
46. Vallon V. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol 294: F10-F27, 2008.
47. Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, Knepper MA. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest 108: 215-222, 2001.
48. Welch BD, Carlson NG, Shi H, Myatt L, Kishore BK. P2Y2 receptor-stimulated release of prostaglandin E2 by rat medullary collecting duct preparations. Am J Physiol Renal Physiol 285: F711-F721, 2003.
49. Wildman SSP, Kang ESK, King BF. EnaC, renal sodium excretion and extracellular ATP. Purnergic Signalling 5: 481-489, 2009.
50. Wildman SSP, Marks JM, Turner CM, Yew-Booth L, Peppiatt-Wildman CM, King BF, Shirley DG, Wang W, Unwin RJ. Sodium-dependent regulation of renal amiloride-sensitive currents by apical P2 receptors. J Am Soc Nephrol 19: 731-742, 2008.
51. Zhang Y, Kohan DE, Kamerath CD, Kishore BK. Effect of aldosterone in a background of high sodium diet in P2Y2 receptor knockout mice (Abstract). J Am Soc Nephrol 19: 584A, 2008.
52. Zhang Y, Kohan DE, Nelson RD, Carlson NG, Kishore BK. Potential involvement of P2Y2 receptor in diuresis of postobstructive uropathy in rats. Am J Physiol Renal Physiol 298: F634-F642, 2010.
53. Zhang Y, Nelson RD, Carlson NG, Kamerath CD, Kohan DE, Kishore BK. Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus. Am J Physiol Renal Physiol 296: F1194-F1201, 2009.
54. Zhang Y, Sands JM, Kohan DE, Nelson RD, Martin CF, Carlson NG, Kamerath CD, Ge Y, Klein JD, Kishore BK. Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol 295: F1715-F1724, 2008.