-
1
-
-
84875551472
-
Broadly neutralizing antiviral antibodies
-
Corti D, Lanzavecchia A. 2013. Broadly neutralizing antiviral antibodies. Annu Rev Immunol 31:705-742. http://dx.doi.org/10.1146/annurev-immunol-032712-095916.
-
(2013)
Annu Rev Immunol
, vol.31
, pp. 705-742
-
-
Corti, D.1
Lanzavecchia, A.2
-
2
-
-
84921847141
-
Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies
-
Lee PS, Wilson IA. 2015. Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies. Curr Top Microbiol Immunol 386:323-341. http://dx.doi.org/10.1007/82_2014_413.
-
(2015)
Curr Top Microbiol Immunol
, vol.386
, pp. 323-341
-
-
Lee, P.S.1
Wilson, I.A.2
-
3
-
-
0019890491
-
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution
-
Wilson IA, Skehel JJ, Wiley DC. 1981. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289: 366-373. http://dx.doi.org/10.1038/289366a0.
-
(1981)
Nature
, vol.289
, pp. 366-373
-
-
Wilson, I.A.1
Skehel, J.J.2
Wiley, D.C.3
-
4
-
-
84873403163
-
Structure and receptor binding properties of a pandemic H1N1 virus hemagglutinin
-
Yang H, Carney P, Stevens J. 2010. Structure and receptor binding properties of a pandemic H1N1 virus hemagglutinin. PLoS Curr 2:RRN1152. http://dx.doi.org/10.1371/currents.RRN1152.
-
(2010)
PLoS Curr
, vol.2
-
-
Yang, H.1
Carney, P.2
Stevens, J.3
-
5
-
-
77957816428
-
Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus
-
Zhang W, Qi J, Shi Y, Li Q, Gao F, Sun Y, Lu X, Lu Q, Vavricka CJ, Liu D, Yan J, Gao GF. 2010. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell 1:459-467. http://dx.doi.org/10.1007/s13238-010-0059-1.
-
(2010)
Protein Cell
, vol.1
, pp. 459-467
-
-
Zhang, W.1
Qi, J.2
Shi, Y.3
Li, Q.4
Gao, F.5
Sun, Y.6
Lu, X.7
Lu, Q.8
Vavricka, C.J.9
Liu, D.10
Yan, J.11
Gao, G.F.12
-
6
-
-
84856875534
-
Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic
-
Xu R, McBride R, Nycholat CM, Paulson JC, Wilson IA. 2012. Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. J Virol 86:982-990. http://dx.doi.org/10.1128/JVI.06322-11.
-
(2012)
J Virol
, vol.86
, pp. 982-990
-
-
Xu, R.1
McBride, R.2
Nycholat, C.M.3
Paulson, J.C.4
Wilson, I.A.5
-
7
-
-
79952702297
-
Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain
-
Farnsworth A, Cyr TD, Li C, Wang J, Li X. 2011. Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain. Vaccine 29:1529-1533. http://dx.doi.org/10.1016/j.vaccine.2010.12.120.
-
(2011)
Vaccine
, vol.29
, pp. 1529-1533
-
-
Farnsworth, A.1
Cyr, T.D.2
Li, C.3
Wang, J.4
Li, X.5
-
8
-
-
84887277978
-
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus
-
McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Chen L, Srivatsan S, Zheng A, Zhou T, Graepel KW, Kumar A, Moin S, Boyington JC, Chuang GY, Soto C, Baxa U, Bakker AQ, Spits H, Beaumont T, Zheng Z, Xia N, Ko SY, Todd JP, Rao S, Graham BS, Kwong PD. 2013. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science 342:592-598. http://dx.doi.org/10.1126/science.1243283.
-
(2013)
Science
, vol.342
, pp. 592-598
-
-
McLellan, J.S.1
Chen, M.2
Joyce, M.G.3
Sastry, M.4
Stewart-Jones, G.B.5
Yang, Y.6
Zhang, B.7
Chen, L.8
Srivatsan, S.9
Zheng, A.10
Zhou, T.11
Graepel, K.W.12
Kumar, A.13
Moin, S.14
Boyington, J.C.15
Chuang, G.Y.16
Soto, C.17
Baxa, U.18
Bakker, A.Q.19
Spits, H.20
Beaumont, T.21
Zheng, Z.22
Xia, N.23
Ko, S.Y.24
Todd, J.P.25
Rao, S.26
Graham, B.S.27
Kwong, P.D.28
more..
-
9
-
-
84884678235
-
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
-
Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Pena AT, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, van Gils MJ, King CR, Wilson IA, Ward AB, Klasse PJ, Moore JP. 2013. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog 9:e1003618. http://dx.doi.org/10.1371/journal.ppat.1003618.
-
(2013)
PLoS Pathog
, vol.9
-
-
Sanders, R.W.1
Derking, R.2
Cupo, A.3
Julien, J.P.4
Yasmeen, A.5
de Val, N.6
Kim, H.J.7
Blattner, C.8
de la Pena, A.T.9
Korzun, J.10
Golabek, M.11
de Los Reyes, K.12
Ketas, T.J.13
van Gils, M.J.14
King, C.R.15
Wilson, I.A.16
Ward, A.B.17
Klasse, P.J.18
Moore, J.P.19
-
10
-
-
34547770260
-
Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge
-
Lee JK, Prussia A, Snyder JP, Plemper RK. 2007. Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge. J Virol 81:8821-8826. http://dx.doi.org/10.1128/JVI.00754-07.
-
(2007)
J Virol
, vol.81
, pp. 8821-8826
-
-
Lee, J.K.1
Prussia, A.2
Snyder, J.P.3
Plemper, R.K.4
-
11
-
-
84866953140
-
Cross-neutralization of influenza A viruses mediated by a single antibody loop
-
Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. 2012. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature 489:526-532. http://dx.doi.org/10.1038/nature11414.
-
(2012)
Nature
, vol.489
, pp. 526-532
-
-
Ekiert, D.C.1
Kashyap, A.K.2
Steel, J.3
Rubrum, A.4
Bhabha, G.5
Khayat, R.6
Lee, J.H.7
Dillon, M.A.8
O'Neil, R.E.9
Faynboym, A.M.10
Horowitz, M.11
Horowitz, L.12
Ward, A.B.13
Palese, P.14
Webby, R.15
Lerner, R.A.16
Bhatt, R.R.17
Wilson, I.A.18
-
12
-
-
0024818499
-
Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis
-
Sowdhamini R, Srinivasan N, Shoichet B, Santi DV, Ramakrishnan C, Balaram P. 1989. Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis. Protein Eng 3:95-103.
-
(1989)
Protein Eng
, vol.3
, pp. 95-103
-
-
Sowdhamini, R.1
Srinivasan, N.2
Shoichet, B.3
Santi, D.V.4
Ramakrishnan, C.5
Balaram, P.6
-
13
-
-
80051635697
-
A highly conserved neutralizing epitope on group 2 influenza A viruses
-
Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, Poon LL, Peiris M, Koudstaal W, Wilson IA, Goudsmit J. 2011. A highly conserved neutralizing epitope on group 2 influenza A viruses. Science 333:843-850. http://dx.doi.org/10.1126/science.1204839.
-
(2011)
Science
, vol.333
, pp. 843-850
-
-
Ekiert, D.C.1
Friesen, R.H.2
Bhabha, G.3
Kwaks, T.4
Jongeneelen, M.5
Yu, W.6
Ophorst, C.7
Cox, F.8
Korse, H.J.9
Brandenburg, B.10
Vogels, R.11
Brakenhoff, J.P.12
Kompier, R.13
Koldijk, M.H.14
Cornelissen, L.A.15
Poon, L.L.16
Peiris, M.17
Koudstaal, W.18
Wilson, I.A.19
Goudsmit, J.20
more..
-
14
-
-
84886314094
-
Antibody recognition of the pandemic H1N1 influenza virus hemagglutinin receptor binding site
-
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Jr, Ward AB, Wilson IA. 2013. Antibody recognition of the pandemic H1N1 influenza virus hemagglutinin receptor binding site. J Virol 87:12471-12480. http://dx.doi.org/10.1128/JVI.01388-13.
-
(2013)
J Virol
, vol.87
, pp. 12471-12480
-
-
Hong, M.1
Lee, P.S.2
Hoffman, R.M.3
Zhu, X.4
Krause, J.C.5
Laursen, N.S.6
Yoon, S.I.7
Song, L.8
Tussey, L.9
Crowe, J.E.10
Ward, A.B.11
Wilson, I.A.12
-
15
-
-
64849114224
-
Antibody recognition of a highly conserved influenza virus epitope
-
Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. 2009. Antibody recognition of a highly conserved influenza virus epitope. Science 324:246-251. http://dx.doi.org/10.1126/science.1171491.
-
(2009)
Science
, vol.324
, pp. 246-251
-
-
Ekiert, D.C.1
Bhabha, G.2
Elsliger, M.A.3
Friesen, R.H.4
Jongeneelen, M.5
Throsby, M.6
Goudsmit, J.7
Wilson, I.A.8
-
16
-
-
84866122029
-
Highly conserved protective epitopes on influenza B viruses
-
Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin O, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. 2012. Highly conserved protective epitopes on influenza B viruses. Science 337:1343-1348. http://dx.doi.org/10.1126/science.1222908.
-
(2012)
Science
, vol.337
, pp. 1343-1348
-
-
Dreyfus, C.1
Laursen, N.S.2
Kwaks, T.3
Zuijdgeest, D.4
Khayat, R.5
Ekiert, D.C.6
Lee, J.H.7
Metlagel, Z.8
Bujny, M.V.9
Jongeneelen, M.10
van der Vlugt, R.11
Lamrani, M.12
Korse, H.J.13
Geelen, E.14
Sahin, O.15
Sieuwerts, M.16
Brakenhoff, J.P.17
Vogels, R.18
Li, O.T.19
Poon, L.L.20
Peiris, M.21
Koudstaal, W.22
Ward, A.B.23
Wilson, I.A.24
Goudsmit, J.25
Friesen, R.H.26
more..
-
17
-
-
84891910969
-
A common solution to group 2 influenza virus neutralization
-
Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA. 2014. A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci USA 111:445-450. http://dx.doi.org/10.1073/pnas.1319058110.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 445-450
-
-
Friesen, R.H.1
Lee, P.S.2
Stoop, E.J.3
Hoffman, R.M.4
Ekiert, D.C.5
Bhabha, G.6
Yu, W.7
Juraszek, J.8
Koudstaal, W.9
Jongeneelen, M.10
Korse, H.J.11
Ophorst, C.12
Brinkman-van der Linden, E.C.13
Throsby, M.14
Kwakkenbos, M.J.15
Bakker, A.Q.16
Beaumont, T.17
Spits, H.18
Kwaks, T.19
Vogels, R.20
Ward, A.B.21
Goudsmit, J.22
Wilson, I.A.23
more..
-
18
-
-
84911404794
-
Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus
-
Lee PS, Ohshima N, Stanfield RL, Yu W, Iba Y, Okuno Y, Kurosawa Y, Wilson IA. 2014. Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nat Commun 5:3614. http://dx.doi.org/10.1093/emboj/21.5.865.
-
(2014)
Nat Commun
, vol.5
, pp. 3614
-
-
Lee, P.S.1
Ohshima, N.2
Stanfield, R.L.3
Yu, W.4
Iba, Y.5
Okuno, Y.6
Kurosawa, Y.7
Wilson, I.A.8
-
19
-
-
0036500549
-
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes
-
Ha Y, Stevens DJ, Skehel JJ, Wiley DC. 2002. H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes. EMBO J 21:865-875. http://dx.doi.org/10.1093/emboj/21.5.865.
-
(2002)
EMBO J
, vol.21
, pp. 865-875
-
-
Ha, Y.1
Stevens, D.J.2
Skehel, J.J.3
Wiley, D.C.4
-
20
-
-
3142574848
-
H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes
-
Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ. 2004. H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes. Virology 325:287-296. http://dx.doi.org/10.1016/j.virol.2004.04.040.
-
(2004)
Virology
, vol.325
, pp. 287-296
-
-
Russell, R.J.1
Gamblin, S.J.2
Haire, L.F.3
Stevens, D.J.4
Xiao, B.5
Ha, Y.6
Skehel, J.J.7
-
21
-
-
0026560161
-
Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity
-
Godley L, Pfeifer J, Steinhauer D, Ely B, Shaw G, Kaufmann R, Suchanek E, Pabo C, Skehel JJ, Wiley DC, Wharton S. 1992. Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity. Cell 68:635-645. http://dx.doi.org/10.1016/0092-8674(92)90140-8.
-
(1992)
Cell
, vol.68
, pp. 635-645
-
-
Godley, L.1
Pfeifer, J.2
Steinhauer, D.3
Ely, B.4
Shaw, G.5
Kaufmann, R.6
Suchanek, E.7
Pabo, C.8
Skehel, J.J.9
Wiley, D.C.10
Wharton, S.11
-
22
-
-
0028023726
-
Structure of influenza haemagglutinin at the pH of membrane fusion
-
Bullough PA, Hughson FM, Skehel JJ, Wiley DC. 1994. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371:37-43. http://dx.doi.org/10.1038/371037a0.
-
(1994)
Nature
, vol.371
, pp. 37-43
-
-
Bullough, P.A.1
Hughson, F.M.2
Skehel, J.J.3
Wiley, D.C.4
-
23
-
-
79955373167
-
Structural characterization of an early fusion intermediate of influenza virus hemagglutinin
-
Xu R, Wilson IA. 2011. Structural characterization of an early fusion intermediate of influenza virus hemagglutinin. J Virol 85:5172-5182. http://dx.doi.org/10.1128/JVI.02430-10.
-
(2011)
J Virol
, vol.85
, pp. 5172-5182
-
-
Xu, R.1
Wilson, I.A.2
-
24
-
-
84892615764
-
Mechanisms of hemagglutinin targeted influenza virus neutralization
-
Brandenburg B, Koudstaal W, Goudsmit J, Klaren V, Tang C, Bujny MV, Korse HJ, Kwaks T, Otterstrom JJ, Juraszek J, van Oijen AM, Vogels R, Friesen RH. 2013. Mechanisms of hemagglutinin targeted influenza virus neutralization. PLoS One 8:e80034. http://dx.doi.org/10.1371/journal.pone.0080034.
-
(2013)
PLoS One
, vol.8
-
-
Brandenburg, B.1
Koudstaal, W.2
Goudsmit, J.3
Klaren, V.4
Tang, C.5
Bujny, M.V.6
Korse, H.J.7
Kwaks, T.8
Otterstrom, J.J.9
Juraszek, J.10
van Oijen, A.M.11
Vogels, R.12
Friesen, R.H.13
-
25
-
-
79952140653
-
Influenza virus vaccine based on the conserved hemagglutinin stalk domain
-
Steel J, Lowen AC, Wang TT, Yondola M, Gao Q, Haye K, Garcia-Sastre A, Palese P. 2010. Influenza virus vaccine based on the conserved hemagglutinin stalk domain. mBio 1:e00018-10. http://dx.doi.org/10.1073/pnas.1007465107.
-
(2010)
mBio
, vol.1
-
-
Steel, J.1
Lowen, A.C.2
Wang, T.T.3
Yondola, M.4
Gao, Q.5
Haye, K.6
Garcia-Sastre, A.7
Palese, P.8
-
26
-
-
77956379133
-
Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge
-
Bommakanti G, Citron MP, Hepler RW, Callahan C, Heidecker GJ, Najar TA, Lu X, Joyce JG, Shiver JW, Casimiro DR, ter Meulen J, Liang X, Varadarajan R. 2010. Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge. Proc Natl Acad Sci USA 107:13701-13706. http://dx.doi.org/10.1073/pnas.1007465107.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13701-13706
-
-
Bommakanti, G.1
Citron, M.P.2
Hepler, R.W.3
Callahan, C.4
Heidecker, G.J.5
Najar, T.A.6
Lu, X.7
Joyce, J.G.8
Shiver, J.W.9
Casimiro, D.R.10
ter Meulen, J.11
Liang, X.12
Varadarajan, R.13
-
27
-
-
84870656355
-
Design of Escherichia coli-expressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge
-
Bommakanti G, Lu X, Citron MP, Najar TA, Heidecker GJ, Ter Meulen J, Varadarajan R, Liang X. 2012. Design of Escherichia coli-expressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge. J Virol 86:13434-13444. http://dx.doi.org/10.1128/JVI.01429-12.
-
(2012)
J Virol
, vol.86
, pp. 13434-13444
-
-
Bommakanti, G.1
Lu, X.2
Citron, M.P.3
Najar, T.A.4
Heidecker, G.J.5
Ter Meulen, J.6
Varadarajan, R.7
Liang, X.8
-
28
-
-
84885953445
-
Influenza virus hemagglutinin stalk-based antibodies and vaccines
-
Krammer F, Palese P. 2013. Influenza virus hemagglutinin stalk-based antibodies and vaccines. Curr Opin Virol 3:521-530. http://dx.doi.org/10.1016/j.coviro.2013.07.007.
-
(2013)
Curr Opin Virol
, vol.3
, pp. 521-530
-
-
Krammer, F.1
Palese, P.2
-
29
-
-
84891912497
-
Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines
-
Lu Y, Welsh JP, Swartz JR. 2014. Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines. Proc Natl Acad Sci USA 111:125-130. http://dx.doi.org/10.1073/pnas.1308701110.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 125-130
-
-
Lu, Y.1
Welsh, J.P.2
Swartz, J.R.3
-
30
-
-
84903476533
-
Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection
-
Mallajosyula VV, Citron M, Ferrara F, Lu X, Callahan C, Heidecker GJ, Sarma SP, Flynn JA, Temperton NJ, Liang X, Varadarajan R. 2014. Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection. Proc Natl Acad Sci USA 111:E2514-E2523. http://dx.doi.org/10.1073/pnas.1402766111.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. E2514-E2523
-
-
Mallajosyula, V.V.1
Citron, M.2
Ferrara, F.3
Lu, X.4
Callahan, C.5
Heidecker, G.J.6
Sarma, S.P.7
Flynn, J.A.8
Temperton, N.J.9
Liang, X.10
Varadarajan, R.11
-
31
-
-
0029558245
-
A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation
-
Chen J, Wharton SA, Weissenhorn W, Calder LJ, Hughson FM, Skehel JJ, Wiley DC. 1995. A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation. Proc Natl Acad Sci USA 92:12205-12209. http://dx.doi.org/10.1073/pnas.92.26.12205.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 12205-12209
-
-
Chen, J.1
Wharton, S.A.2
Weissenhorn, W.3
Calder, L.J.4
Hughson, F.M.5
Skehel, J.J.6
Wiley, D.C.7
|