PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells

FEBS Letters

Volumn 589, Issue 9, 2015, Pages 1033-1039

  Shin, Miyoung ^a   Lee, Kyung Eun ^b   Yang, Eun Gyeong ^b   Jeon, Hyesung ^b,c   Song, Hyun Kyu ^a  

^a Korea University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

EGFR dephosphorylation; ER PM contact; PEA 15; pERK1 2; PTP1B; Triple negative breast cancer cells

Indexed keywords

CALCIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEA15 PROTEIN, HUMAN; PHOSPHOPROTEIN; SIGNAL PEPTIDE;

CELL MEMBRANE; CELL SURVIVAL; CONFOCAL MICROSCOPY; CYTOPLASM; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRIPLE NEGATIVE BREAST CANCER; TUMOR CELL LINE;

CALCIUM; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CYTOPLASM; ENDOPLASMIC RETICULUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROSCOPY, CONFOCAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84930983435     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.03.009     Document Type: Article

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