메뉴 건너뛰기




Volumn 2, Issue 1, 2015, Pages 43-55

Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; MICRORNA 103; MICRORNA 18A; MICRORNA 20B; MICRORNA 29A; MICRORNA 326; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NATALIZUMAB; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

EID: 84930935659     PISSN: None     EISSN: 23289503     Source Type: Journal    
DOI: 10.1002/acn3.152     Document Type: Article
Times cited : (72)

References (56)
  • 1
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet 2002;9313:1221-1231.
    • (2002) Lancet , vol.9313 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 2
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
    • Hohlfeld R, Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci USA 2004;101:14599-14606.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 3
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005;23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 4
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    • Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 2005;9:485-495.
    • (2005) Trends Immunol , vol.9 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 5
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992;6364:63-66.
    • (1992) Nature , vol.6364 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3
  • 6
    • 0027529932 scopus 로고
    • Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
    • Baron JL. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 1993;1:57-68.
    • (1993) J Exp Med , vol.1 , pp. 57-68
    • Baron, J.L.1
  • 7
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006;9:899-910.
    • (2006) N Engl J Med , vol.9 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 8
    • 79955833670 scopus 로고    scopus 로고
    • Sustained improvement in Expanded Disability Status Scale as a new efficacy measure of neurological change in multiple sclerosis: treatment effects with natalizumab in patients with relapsing multiple sclerosis
    • Phillips JT, Giovannoni G, Lublin FD, et al. Sustained improvement in Expanded Disability Status Scale as a new efficacy measure of neurological change in multiple sclerosis: treatment effects with natalizumab in patients with relapsing multiple sclerosis. Mult Scler 2011;8:970-979.
    • (2011) Mult Scler , vol.8 , pp. 970-979
    • Phillips, J.T.1    Giovannoni, G.2    Lublin, F.D.3
  • 9
    • 84862521049 scopus 로고    scopus 로고
    • Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS
    • Weinstock-Guttman B, Galetta SL, Giovannoni G, et al. Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS. J Neurol 2012;5:898-905.
    • (2012) J Neurol , vol.5 , pp. 898-905
    • Weinstock-Guttman, B.1    Galetta, S.L.2    Giovannoni, G.3
  • 10
    • 84896422979 scopus 로고    scopus 로고
    • Natalizumab in clinical practice: managing the risks, enjoying the benefits
    • Aktas O. Natalizumab in clinical practice: managing the risks, enjoying the benefits. J Neurol Neurosurg Psychiatry 2014;85:1181.
    • (2014) J Neurol Neurosurg Psychiatry , vol.85 , pp. 1181
    • Aktas, O.1
  • 11
    • 34247854822 scopus 로고    scopus 로고
    • Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases
    • Stüve O, Bennett JL. Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases. CNS Drug Rev 2007;1:79-95.
    • (2007) CNS Drug Rev , vol.1 , pp. 79-95
    • Stüve, O.1    Bennett, J.L.2
  • 12
    • 0035052096 scopus 로고    scopus 로고
    • Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis
    • Theien BE, Vanderlugt CL, Eagar TN, et al. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest 2001;8:995-1006.
    • (2001) J Clin Invest , vol.8 , pp. 995-1006
    • Theien, B.E.1    Vanderlugt, C.L.2    Eagar, T.N.3
  • 13
    • 0344305462 scopus 로고    scopus 로고
    • Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE
    • Theien BE, Vanderlugt CL, Nickerson-Nutter C, et al. Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE. Blood 2003;13:4464-4471.
    • (2003) Blood , vol.13 , pp. 4464-4471
    • Theien, B.E.1    Vanderlugt, C.L.2    Nickerson-Nutter, C.3
  • 14
    • 3342901590 scopus 로고    scopus 로고
    • VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
    • Mittelbrunn M, Molina A, Escribese MM, et al. VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc Natl Acad Sci USA 2004;30:11058-11063.
    • (2004) Proc Natl Acad Sci USA , vol.30 , pp. 11058-11063
    • Mittelbrunn, M.1    Molina, A.2    Escribese, M.M.3
  • 15
    • 33646347357 scopus 로고    scopus 로고
    • Natalizumab effects on immune cell responses in multiple sclerosis
    • Niino M, Bodner C, Simard M, et al. Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol 2006;5:748-754.
    • (2006) Ann Neurol , vol.5 , pp. 748-754
    • Niino, M.1    Bodner, C.2    Simard, M.3
  • 16
    • 84888261112 scopus 로고    scopus 로고
    • Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis
    • Warnke C, Mausberg AK, Stettner M, et al. Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis. Neurology 2013;16:1400-1408.
    • (2013) Neurology , vol.16 , pp. 1400-1408
    • Warnke, C.1    Mausberg, A.K.2    Stettner, M.3
  • 17
    • 39849089879 scopus 로고    scopus 로고
    • Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients
    • Lindberg RLP, Achtnichts L, Hoffmann F, et al. Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients. J Neuroimmunol 2008;194:153-164.
    • (2008) J Neuroimmunol , vol.194 , pp. 153-164
    • Lindberg, R.L.P.1    Achtnichts, L.2    Hoffmann, F.3
  • 18
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs genomics, biogenesis, mechanism, and function
    • Bartel D. MicroRNAs genomics, biogenesis, mechanism, and function. Cell 2004;2:281-297.
    • (2004) Cell , vol.2 , pp. 281-297
    • Bartel, D.1
  • 19
    • 47849125676 scopus 로고    scopus 로고
    • MicroRNAs: new regulators of immune cell development and function
    • Baltimore D, Boldin MP, O'Connell RM, et al. MicroRNAs: new regulators of immune cell development and function. Nat Immunol 2008;8:839-845.
    • (2008) Nat Immunol , vol.8 , pp. 839-845
    • Baltimore, D.1    Boldin, M.P.2    O'Connell, R.M.3
  • 20
    • 67651113615 scopus 로고    scopus 로고
    • Differential micro RNA expression in PBMC from multiple sclerosis patients
    • Otaegui D, Baranzini SE, Armañanzas R, et al. Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One 2009;7:e6309.
    • (2009) PLoS One , vol.7 , pp. e6309
    • Otaegui, D.1    Baranzini, S.E.2    Armañanzas, R.3
  • 21
    • 77149132365 scopus 로고    scopus 로고
    • Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls
    • Keller A, Leidinger P, Lange J, et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One 2009;10:e7440.
    • (2009) PLoS One , vol.10 , pp. e7440
    • Keller, A.1    Leidinger, P.2    Lange, J.3
  • 22
    • 77749260581 scopus 로고    scopus 로고
    • Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients
    • Lindberg RLP, Hoffmann F, Mehling M, et al. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur J Immunol 2010;3:888-898.
    • (2010) Eur J Immunol , vol.3 , pp. 888-898
    • Lindberg, R.L.P.1    Hoffmann, F.2    Mehling, M.3
  • 23
    • 70449716915 scopus 로고    scopus 로고
    • MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
    • Du C, Liu C, Kang J, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol 2009;12:1252-1259.
    • (2009) Nat Immunol , vol.12 , pp. 1252-1259
    • Du, C.1    Liu, C.2    Kang, J.3
  • 24
    • 77957888270 scopus 로고    scopus 로고
    • MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood
    • Cox MB, Cairns MJ, Gandhi KS, et al. MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood. PLoS One 2010;8:e12132.
    • (2010) PLoS One , vol.8 , pp. e12132
    • Cox, M.B.1    Cairns, M.J.2    Gandhi, K.S.3
  • 25
    • 77956343824 scopus 로고    scopus 로고
    • Altered miRNA expression in T regulatory cells in course of multiple sclerosis
    • de Santis G, Ferracin M, Biondani A, et al. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol 2010;1-2:165-171.
    • (2010) J Neuroimmunol , vol.1-2 , pp. 165-171
    • de Santis, G.1    Ferracin, M.2    Biondani, A.3
  • 26
    • 80052853319 scopus 로고    scopus 로고
    • Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis
    • Waschbisch A, Atiya M, Linker RA, et al. Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis. PLoS One 2011;9:e24604.
    • (2011) PLoS One , vol.9 , pp. e24604
    • Waschbisch, A.1    Atiya, M.2    Linker, R.A.3
  • 27
    • 83755186512 scopus 로고    scopus 로고
    • Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity
    • Guerau-de-Arellano M, Smith KM, Godlewski J, et al. Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain 2011;12:3578-3589.
    • (2011) Brain , vol.12 , pp. 3578-3589
    • Guerau-de-Arellano, M.1    Smith, K.M.2    Godlewski, J.3
  • 28
    • 84881245624 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers for disease staging in multiple sclerosis
    • Gandhi R, Healy B, Gholipour T, et al. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol 2013;6:729-740.
    • (2013) Ann Neurol , vol.6 , pp. 729-740
    • Gandhi, R.1    Healy, B.2    Gholipour, T.3
  • 29
    • 84888616452 scopus 로고    scopus 로고
    • Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
    • Fenoglio C, Ridolfi E, Cantoni C, et al. Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. Mult Scler 2013;14:1938-1942.
    • (2013) Mult Scler , vol.14 , pp. 1938-1942
    • Fenoglio, C.1    Ridolfi, E.2    Cantoni, C.3
  • 30
    • 84888604525 scopus 로고    scopus 로고
    • Differential microRNA expression in blood in multiple sclerosis
    • Sondergaard HB, Hesse D, Krakauer M, et al. Differential microRNA expression in blood in multiple sclerosis. Mult Scler 2013;14:1849-1857.
    • (2013) Mult Scler , vol.14 , pp. 1849-1857
    • Sondergaard, H.B.1    Hesse, D.2    Krakauer, M.3
  • 31
    • 84881264271 scopus 로고    scopus 로고
    • MicroRNA expression changes during interferon-beta treatment in the peripheral blood of multiple sclerosis patients
    • Hecker M, Thamilarasan M, Koczan D, et al. MicroRNA expression changes during interferon-beta treatment in the peripheral blood of multiple sclerosis patients. Int J Mol Sci 2013;8:16087-16110.
    • (2013) Int J Mol Sci , vol.8 , pp. 16087-16110
    • Hecker, M.1    Thamilarasan, M.2    Koczan, D.3
  • 32
    • 84895733395 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing
    • Keller A, Leidinger P, Steinmeyer F, et al. Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing. Mult Scler 2014;3:295-303.
    • (2014) Mult Scler , vol.3 , pp. 295-303
    • Keller, A.1    Leidinger, P.2    Steinmeyer, F.3
  • 33
    • 72649095061 scopus 로고    scopus 로고
    • MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
    • Junker A, Krumbholz M, Eisele S, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009;12:3342-3352.
    • (2009) Brain , vol.12 , pp. 3342-3352
    • Junker, A.1    Krumbholz, M.2    Eisele, S.3
  • 34
    • 84860196299 scopus 로고    scopus 로고
    • MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions
    • Lescher J, Paap F, Schultz V, et al. MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions. J Neuroimmunol 2012;1-2:27-33.
    • (2012) J Neuroimmunol , vol.1-2 , pp. 27-33
    • Lescher, J.1    Paap, F.2    Schultz, V.3
  • 35
    • 84871297324 scopus 로고    scopus 로고
    • Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study
    • Haghikia A, Haghikia A, Hellwig K, et al. Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study. Neurology 2012;22:2166-2170.
    • (2012) Neurology , vol.22 , pp. 2166-2170
    • Haghikia, A.1    Haghikia, A.2    Hellwig, K.3
  • 36
    • 56649115875 scopus 로고    scopus 로고
    • Microfluidic-based enzymatic on-chip labeling of miRNAs
    • Vorwerk S, Ganter K, Cheng Y, et al. Microfluidic-based enzymatic on-chip labeling of miRNAs. N Biotechnol 2008;25:142-149.
    • (2008) N Biotechnol , vol.25 , pp. 142-149
    • Vorwerk, S.1    Ganter, K.2    Cheng, Y.3
  • 37
    • 34547602163 scopus 로고    scopus 로고
    • GeneTrail - advanced gene set enrichment analysis
    • Backes C, Keller A, Kuentzer J, et al. GeneTrail - advanced gene set enrichment analysis. Nucleic Acids Res 2007;35:W186-W192.
    • (2007) Nucleic Acids Res , vol.35 , pp. W186-W192
    • Backes, C.1    Keller, A.2    Kuentzer, J.3
  • 38
    • 23144431724 scopus 로고    scopus 로고
    • P-Match: transcription factor binding site search by combining patterns and weight matrices
    • Chekmenev DS, Haid C, Kel AE. P-Match: transcription factor binding site search by combining patterns and weight matrices. Nucleic Acids Res 2005;33(suppl 2):W432-W437.
    • (2005) Nucleic Acids Res , vol.33 , pp. W432-W437
    • Chekmenev, D.S.1    Haid, C.2    Kel, A.E.3
  • 39
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • Betel D, Koppal A, Agius P, et al. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010;8:R90.
    • (2010) Genome Biol , vol.8 , pp. R90
    • Betel, D.1    Koppal, A.2    Agius, P.3
  • 40
    • 78349297865 scopus 로고    scopus 로고
    • Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation
    • Huehnchen P, Prozorovski T, Klaissle P, et al. Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation. Glia 2011;1:132-142.
    • (2011) Glia , vol.1 , pp. 132-142
    • Huehnchen, P.1    Prozorovski, T.2    Klaissle, P.3
  • 41
    • 39749143354 scopus 로고    scopus 로고
    • Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    • Ventura A, Young AG, Winslow MM, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008;5:875-886.
    • (2008) Cell , vol.5 , pp. 875-886
    • Ventura, A.1    Young, A.G.2    Winslow, M.M.3
  • 42
    • 84856808348 scopus 로고    scopus 로고
    • Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis
    • Baker D, Amor S. Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis. J Neuroimmunol 2012;1-2:78-83.
    • (2012) J Neuroimmunol , vol.1-2 , pp. 78-83
    • Baker, D.1    Amor, S.2
  • 43
    • 84881423363 scopus 로고    scopus 로고
    • microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis
    • de Kouchkovsky D, Esensten JH, Rosenthal WL, et al. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J Immunol 2013;4:1594-1605.
    • (2013) J Immunol , vol.4 , pp. 1594-1605
    • de Kouchkovsky, D.1    Esensten, J.H.2    Rosenthal, W.L.3
  • 44
    • 84864812650 scopus 로고    scopus 로고
    • miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis
    • Smith KM, Guerau-de-Arellano M, Costinean S, et al. miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis. J Immunol 2012;4:1567-1576.
    • (2012) J Immunol , vol.4 , pp. 1567-1576
    • Smith, K.M.1    Guerau-de-Arellano, M.2    Costinean, S.3
  • 45
    • 77952507643 scopus 로고    scopus 로고
    • miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells
    • Cascio S, D'Andrea A, Ferla R, et al. miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol 2010;1:242-249.
    • (2010) J Cell Physiol , vol.1 , pp. 242-249
    • Cascio, S.1    D'Andrea, A.2    Ferla, R.3
  • 46
    • 70449602451 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    • Lei Z, Li B, Yang Z, et al. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One 2009;10:e7629.
    • (2009) PLoS One , vol.10 , pp. e7629
    • Lei, Z.1    Li, B.2    Yang, Z.3
  • 47
    • 84902193953 scopus 로고    scopus 로고
    • miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3
    • Zhu E, Wang X, Zheng B, et al. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3. J Immunol 2014;192:5599-5609.
    • (2014) J Immunol , vol.192 , pp. 5599-5609
    • Zhu, E.1    Wang, X.2    Zheng, B.3
  • 48
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;7359:214-219.
    • (2011) Nature , vol.7359 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3
  • 49
    • 84871922920 scopus 로고    scopus 로고
    • Epigenetic changes in patients with multiple sclerosis
    • Koch MW, Metz LM, Kovalchuk O. Epigenetic changes in patients with multiple sclerosis. Nat Rev Neurol 2013;1:35-43.
    • (2013) Nat Rev Neurol , vol.1 , pp. 35-43
    • Koch, M.W.1    Metz, L.M.2    Kovalchuk, O.3
  • 50
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krützfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;7068:685-689.
    • (2005) Nature , vol.7068 , pp. 685-689
    • Krützfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 51
    • 84861674736 scopus 로고    scopus 로고
    • Altered microRNA expression in B lymphocytes in multiple sclerosis: towards a better understanding of treatment effects
    • Sievers C, Meira M, Hoffmann F, et al. Altered microRNA expression in B lymphocytes in multiple sclerosis: towards a better understanding of treatment effects. Clin Immunol 2012;1:70-79.
    • (2012) Clin Immunol , vol.1 , pp. 70-79
    • Sievers, C.1    Meira, M.2    Hoffmann, F.3
  • 52
    • 41949102707 scopus 로고    scopus 로고
    • miRiad roles for the miR-17-92 cluster in development and disease
    • Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008;2:217-222.
    • (2008) Cell , vol.2 , pp. 217-222
    • Mendell, J.T.1
  • 53
    • 60649108674 scopus 로고    scopus 로고
    • VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
    • Argaw AT, Gurfein BT, Zhang Y, et al. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci USA 2009;6:1977-1982.
    • (2009) Proc Natl Acad Sci USA , vol.6 , pp. 1977-1982
    • Argaw, A.T.1    Gurfein, B.T.2    Zhang, Y.3
  • 54
    • 37749021324 scopus 로고    scopus 로고
    • Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
    • Harris TJ, Grosso JF, Yen H, et al. Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol 2007;7:4313-4317.
    • (2007) J Immunol , vol.7 , pp. 4313-4317
    • Harris, T.J.1    Grosso, J.F.2    Yen, H.3
  • 55
    • 44649191160 scopus 로고    scopus 로고
    • T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76
    • Nguyen K, Sylvain NR, Bunnell SC. T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 2008;6:810-821.
    • (2008) Immunity , vol.6 , pp. 810-821
    • Nguyen, K.1    Sylvain, N.R.2    Bunnell, S.C.3
  • 56
    • 28444499085 scopus 로고    scopus 로고
    • Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis
    • Steinman L, Zamvil SS. Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends Immunol 2005;11:565-571.
    • (2005) Trends Immunol , vol.11 , pp. 565-571
    • Steinman, L.1    Zamvil, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.