Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

Multiple Sclerosis Journal

Volumn 19, Issue 14, 2013, Pages 1938-1942

  Fenoglio, Chiara ^a   Ridolfi, Elisa ^a   Cantoni, Claudia ^a,b   De Riz, Milena ^a   Bonsi, Rossana ^a   Serpente, Maria ^a   Villa, Chiara ^a   Pietroboni, Anna M ^a   Naismith, Robert T ^b   Alvarez, Enrique ^b   Parks, Becky J ^b   Bresolin, Nereo ^b   Cross, Anne H ^b   Piccio, Laura M ^b   Galimberti, Daniela ^a   Scarpini, Elio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biomarkers; demyelination; microRNA; Multiple sclerosis; serum

Indexed keywords

MICRORNA; MICRORNA 15B; MICRORNA 223; MICRORNA 23A; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; MALE; MULTIPLE SCLEROSIS; PATHOGENESIS; RNA ANALYSIS; SERUM;

BIOMARKERS; DEMYELINATION; MICRORNA; MULTIPLE SCLEROSIS; SERUM;

ADULT; CASE-CONTROL STUDIES; DISABILITY EVALUATION; DOWN-REGULATION; FEMALE; GENETIC MARKERS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PREDICTIVE VALUE OF TESTS;

EID: 84888616452     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458513485654     Document Type: Article

References (11)

1. Sawcer S, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 ; 476: 214-219
2. Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 2004 ; 116: 281-297
3. Fenoglio C, Ridolfi E, Galimberti D, et al. MicroRNAs as active players in the pathogenesis of multiple sclerosis. Int J Mol Sci. 2012 ; 13: 13227-13239
4. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for MS. Ann Neurol. 2001 ; 50: 121-127
5. Mitchell PS, Parkin RK, Kroh EM. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2009 ; 105: 10513-10518
6. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 ; 25: 402-408
7. Siegel SR, Mackenzie J, Chaplin G, et al. Circulating microRNAs involved in multiple sclerosis. Mol Biol Rep. 2012 ; 39: 6219-6225
8. Haghikia A, Haghikia A, Hellwig K, et al. Regulated microRNAs in the CSF of patients with multiple sclerosis: A case-control study. Neurology. 2012 ; 79: 2166-2170
9. Osman A. MicroRNAs in health and disease - basic science and clinical applications. Clin Lab. 2012 ; 58: 393-402
10. Hoy AM, Buck AH. Extracellular small RNAs: What, where, why?. Biochem Soc Trans. 2012 ; 40: 886-890
11. Geekiyanage H, Jicha GA, Nelson PT, et al. Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease. Exp Neurol. 2012 ; 235: 491-496