SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 15, 2015, Pages 2948-2952

Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents

(7) Yadav, Rammohan R a,b Sharma, Sadhana a,b Joshi, Prashant a,b Wani, Abubakar a,b Vishwakarma, Ram A a,b Kumar, Ajay a Bharate, Sandip B a,b

a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE (India)

b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR (India)

Author keywords

Alzheimer's disease; Dyrk1A; Dyrk2; Meridianins; Neuroprotection

Indexed keywords

4 [5 BROMO 1 [2 NITRO 4 (TRIFLUOROMETHYL)PHENYLSULFONYL]1H INDOL 3 YL]PYRIMIDIN 2 AMINE; ALKALOID DERIVATIVE; GLUTAMIC ACID; MERIDIANIN DERIVATIVE; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; [3(2 AMINOPYRIMIDIN 4 YL) 5 BROMO 1H INDOL 1 YL](MORPHOLINO)METHANONE; DYRK KINASE; INDOLE ALKALOID; INDOLE DERIVATIVE; MERIDIANIN G; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE;

ARTICLE; BINDING SITE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; HUMANS; INDOLE ALKALOIDS; INDOLES; MODELS, MOLECULAR; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930927950 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.05.034 Document Type: Article

Times cited : (34)

References (26)

1
- 43049142654
- M. Varjosalo, M. Björklund, F. Cheng, H. Syvänen, T. Kivioja, S. Kilpinen, Z. Sun, O. Kallioniemi, H.G. Stunnenberg, W.W. He, P. Ojala, and J. Taipale Cell 133 2008 537
- (2008) Cell , vol.133 , pp. 537
- Varjosalo, M.¹ Björklund, M.² Cheng, F.³ Syvänen, H.⁴ Kivioja, T.⁵ Kilpinen, S.⁶ Sun, Z.⁷ Kallioniemi, O.⁸ Stunnenberg, H.G.⁹ He, W.W.¹⁰ Ojala, P.¹¹ Taipale, J.¹²

2
- 35348942303
- S.L. Sherman, E.G. Allen, L.H. Bean, and S.B. Freeman Ment. Retard. Dev. Disabil. Res. Rev. 13 2007 221
- (2007) Ment. Retard. Dev. Disabil. Res. Rev. , vol.13 , pp. 221
- Sherman, S.L.¹ Allen, E.G.² Bean, L.H.³ Freeman, S.B.⁴

3
- 0028341315
- J.R. Korenberg, X.N. Chen, R. Schipper, Z. Sun, R. Gonsky, S. Gerwehr, N. Carpenter, C. Daumer, P. Dignan, and C. Disteche Proc. Natl. Acad. Sci. U.S.A. 91 1994 4997
- (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 4997
- Korenberg, J.R.¹ Chen, X.N.² Schipper, R.³ Sun, Z.⁴ Gonsky, R.⁵ Gerwehr, S.⁶ Carpenter, N.⁷ Daumer, C.⁸ Dignan, P.⁹ Disteche, C.¹⁰

4
- 0042025827
- L. Nadel Genes Brain Behav. 2 2003 156
- (2003) Genes Brain Behav. , vol.2 , pp. 156
- Nadel, L.¹

5
- 36849075621
- S.-R. Ryoo, H.K. Jeong, C. Radnaabazar, J.-J. Yoo, H.-J. Cho, H.-W. Lee, I.-S. Kim, Y.-H. Cheon, Y.S. Ahn, S.-H. Chung, and W.-J. Song J. Biol. Chem. 282 2007 34850
- (2007) J. Biol. Chem. , vol.282 , pp. 34850
- Ryoo, S.-R.¹ Jeong, H.K.² Radnaabazar, C.³ Yoo, J.-J.⁴ Cho, H.-J.⁵ Lee, H.-W.⁶ Kim, I.-S.⁷ Cheon, Y.-H.⁸ Ahn, Y.S.⁹ Chung, S.-H.¹⁰ Song, W.-J.¹¹

6
- 79951946396
- T. Adayev, J. Wegiel, and Y.-W. Hwang Arch. Biochem. Biophys. 507 2011 212
- (2011) Arch. Biochem. Biophys. , vol.507 , pp. 212
- Adayev, T.¹ Wegiel, J.² Hwang, Y.-W.³

7
- 36549040859
- J. Bain, L. Plater, M. Elliott, N. Shpiro, C.J. Hastie, H. McLauchlan, I. Klevernic, J.S.C. Arthur, D.R. Alessi, and P. Cohen Biochem. J. 408 2007 297
- (2007) Biochem. J. , vol.408 , pp. 297
- Bain, J.¹ Plater, L.² Elliott, M.³ Shpiro, N.⁴ Hastie, C.J.⁵ McLauchlan, H.⁶ Klevernic, I.⁷ Arthur, J.S.C.⁸ Alessi, D.R.⁹ Cohen, P.¹⁰

8
- 70349947061
- N. Göckler, G. Jofre, C. Papadopoulos, U. Soppa, F.J. Tejedor, and W. Becker FEBS J. 276 2009 6324
- (2009) FEBS J. , vol.276 , pp. 6324
- Göckler, N.¹ Jofre, G.² Papadopoulos, C.³ Soppa, U.⁴ Tejedor, F.J.⁵ Becker, W.⁶

9
- 33749317531
- T. Adayev, M.-C. Chen-Hwang, N. Murakami, J. Wegiel, and Y.-W. Hwang Biochemistry 45 2006 12011
- (2006) Biochemistry , vol.45 , pp. 12011
- Adayev, T.¹ Chen-Hwang, M.-C.² Murakami, N.³ Wegiel, J.⁴ Hwang, Y.-W.⁵

10
- 0037392942
- J. Bain, H. McLauchlan, M. Elliott, and P. Cohen Biochem. J. 371 2003 199
- (2003) Biochem. J. , vol.371 , pp. 199
- Bain, J.¹ McLauchlan, H.² Elliott, M.³ Cohen, P.⁴

11
- 79951954356
- Y. Ogawa, Y. Nonaka, T. Goto, E. Ohnishi, T. Hiramatsu, I. Kii, M. Yoshida, T. Ikura, H. Onogi, H. Shibuya, T. Hosoya, N. Ito, and M. Hagiwara Nat. Commun. 1 2010 1
- (2010) Nat. Commun. , vol.1 , pp. 1
- Ogawa, Y.¹ Nonaka, Y.² Goto, T.³ Ohnishi, E.⁴ Hiramatsu, T.⁵ Kii, I.⁶ Yoshida, M.⁷ Ikura, T.⁸ Onogi, H.⁹ Shibuya, H.¹⁰ Hosoya, T.¹¹ Ito, N.¹² Hagiwara, M.¹³

12
- 79959406830
- M. Debdab, F. Carreaux, S. Renault, M. Soundararajan, O. Fedorov, P. Filippakopoulos, O. Lozach, L. Babault, T. Tahtouh, B. Baratte, Y. Ogawa, M. Hagiwara, A. Eisenreich, U. Rauch, S. Knapp, L. Meijer, and J.-P. Bazureau J. Med. Chem. 54 2011 4172
- (2011) J. Med. Chem. , vol.54 , pp. 4172
- Debdab, M.¹ Carreaux, F.² Renault, S.³ Soundararajan, M.⁴ Fedorov, O.⁵ Filippakopoulos, P.⁶ Lozach, O.⁷ Babault, L.⁸ Tahtouh, T.⁹ Baratte, B.¹⁰ Ogawa, Y.¹¹ Hagiwara, M.¹² Eisenreich, A.¹³ Rauch, U.¹⁴ Knapp, S.¹⁵ Meijer, L.¹⁶ Bazureau, J.-P.¹⁷

13
- 84868530112
- T. Tahtouh, J.M. Elkins, P. Filippakopoulos, M. Soundararajan, G. Burgy, E. Durieu, C. Cochet, R.S. Schmid, D.C. Lo, F. Delhommel, A.E. Oberholzer, L.H. Pearl, F. Carreaux, J.-P. Bazureau, S. Knapp, and L. Meijer J. Med. Chem. 55 2012 9312
- (2012) J. Med. Chem. , vol.55 , pp. 9312
- Tahtouh, T.¹ Elkins, J.M.² Filippakopoulos, P.³ Soundararajan, M.⁴ Burgy, G.⁵ Durieu, E.⁶ Cochet, C.⁷ Schmid, R.S.⁸ Lo, D.C.⁹ Delhommel, F.¹⁰ Oberholzer, A.E.¹¹ Pearl, L.H.¹² Carreaux, F.¹³ Bazureau, J.-P.¹⁴ Knapp, S.¹⁵ Meijer, L.¹⁶

14
- 79960196093
- F. Giraud, G. Alves, E. Debiton, L. Nauton, V. Théry, E. Durieu, Y. Ferandin, O. Lozach, L. Meijer, F. Anizon, E. Pereira, and P. Moreau J. Med. Chem. 54 2011 4474
- (2011) J. Med. Chem. , vol.54 , pp. 4474
- Giraud, F.¹ Alves, G.² Debiton, E.³ Nauton, L.⁴ Théry, V.⁵ Durieu, E.⁶ Ferandin, Y.⁷ Lozach, O.⁸ Meijer, L.⁹ Anizon, F.¹⁰ Pereira, E.¹¹ Moreau, P.¹²

15
- 84890511580
- S. Gourdain, J. Dairou, C. Denhez, L.C. Bui, F. Rodrigues-Lima, N. Janel, J.M. Delabar, K. Cariou, and R.H. Dodd J. Med. Chem. 56 2013 9569
- (2013) J. Med. Chem. , vol.56 , pp. 9569
- Gourdain, S.¹ Dairou, J.² Denhez, C.³ Bui, L.C.⁴ Rodrigues-Lima, F.⁵ Janel, N.⁶ Delabar, J.M.⁷ Cariou, K.⁸ Dodd, R.H.⁹

16
- 77954213722
- G.D. Cuny, M. Robin, N.P. Ulyanova, D. Patnaik, V. Pique, G. Casano, J.-F. Liu, X. Lin, J. Xian, M.A. Glicksman, R.L. Stein, and J.M.G. Higgins Bioorg. Med. Chem. Lett. 20 2010 3491
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3491
- Cuny, G.D.¹ Robin, M.² Ulyanova, N.P.³ Patnaik, D.⁴ Pique, V.⁵ Casano, G.⁶ Liu, J.-F.⁷ Lin, X.⁸ Xian, J.⁹ Glicksman, M.A.¹⁰ Stein, R.L.¹¹ Higgins, J.M.G.¹²

17
- 84899847151
- C. Schmitt, D. Kail, M. Mariano, M. Empting, N. Weber, T. Paul, R.W. Hartmann, and M. Engel PLoS ONE 9 2014 e87851
- (2014) PLoS ONE , vol.9 , pp. e87851
- Schmitt, C.¹ Kail, D.² Mariano, M.³ Empting, M.⁴ Weber, N.⁵ Paul, T.⁶ Hartmann, R.W.⁷ Engel, M.⁸

18
- 0000338886
- L.H. Franco, E.B.D.K. Joffe, L. Puricelli, M. Tatian, A.M. Seldes, and J.A. Palermo J. Nat. Prod. 61 1998 1130
- (1998) J. Nat. Prod. , vol.61 , pp. 1130
- Franco, L.H.¹ Joffe, E.B.D.K.² Puricelli, L.³ Tatian, M.⁴ Seldes, A.M.⁵ Palermo, J.A.⁶

19
- 34548577508
- A.M. Seldes, M.F. Brasco, L.H. Franco, and J.A. Palermo Nat. Prod. Res. 21 2007 555
- (2007) Nat. Prod. Res. , vol.21 , pp. 555
- Seldes, A.M.¹ Brasco, M.F.² Franco, L.H.³ Palermo, J.A.⁴

20
- 1542509425
- M. Gompel, M. Leost, E.B. De Kier Joffe, L. Puricelli, L.H. Franco, J. Palermo, and L. Meijer Bioorg. Med. Chem. Lett. 14 2004 1703
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1703
- Gompel, M.¹ Leost, M.² De Kier Joffe, E.B.³ Puricelli, L.⁴ Franco, L.H.⁵ Palermo, J.⁶ Meijer, L.⁷

21
- 53749085771
- E. Rossignol, E. Debiton, D. Fabbro, P. Moreau, M. Prudhomme, and F. Anizon Anticancer Drugs 19 2008 789
- (2008) Anticancer Drugs , vol.19 , pp. 789
- Rossignol, E.¹ Debiton, E.² Fabbro, D.³ Moreau, P.⁴ Prudhomme, M.⁵ Anizon, F.⁶

22
- 66449124044
- R. Akue-Gedu, E. Debiton, Y. Ferandin, L. Meijer, M. Prudhomme, F. Anizon, and P. Moreau Bioorg. Med. Chem. 17 2009 4420
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 4420
- Akue-Gedu, R.¹ Debiton, E.² Ferandin, Y.³ Meijer, L.⁴ Prudhomme, M.⁵ Anizon, F.⁶ Moreau, P.⁷

23
- 36749074458
- G. Simon, H. Couthan-Gourves, J.P. Haelters, B. Corbel, N. Kervarec, F. Michaud, and L. Meijer J. Heterocycl. Chem. 44 2007 793
- (2007) J. Heterocycl. Chem. , vol.44 , pp. 793
- Simon, G.¹ Couthan-Gourves, H.² Haelters, J.P.³ Corbel, B.⁴ Kervarec, N.⁵ Michaud, F.⁶ Meijer, L.⁷

24
- 84878795566
- S.B. Bharate, R.R. Yadav, S.I. Khan, B.L. Tekwani, M.R. Jacob, I.A. Khan, and R.A. Vishwakarma Med. Chem. Commun. 4 2013 1042
- (2013) Med. Chem. Commun. , vol.4 , pp. 1042
- Bharate, S.B.¹ Yadav, R.R.² Khan, S.I.³ Tekwani, B.L.⁴ Jacob, M.R.⁵ Khan, I.A.⁶ Vishwakarma, R.A.⁷

25
- 85018121728
- 24 The synthesis of meridianin sulfonamides 29a-ad is as follows: To the solution of meridianin G (18) or meridianin C (19) in dichloromethane (5 ml) was added DMAP (0.05 equiv), aryl sulfonyl chloride (1.1 equiv) and N,N-diisopropylethylamine (1.5 equiv). The mixture was stirred at room temperature for 20 h. Reaction was then quenched by the addition of 10% HCl.
- + (543.9740).

26
- 84899026191
- A. Bahl, P. Joshi, S. Bharate, and H. Chopra Med. Chem. Res. 23 2014 1925
- (2014) Med. Chem. Res. , vol.23 , pp. 1925
- Bahl, A.¹ Joshi, P.² Bharate, S.³ Chopra, H.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.