Regulation of the ryanodine receptor by anti-apoptotic Bcl-2 is independent of its BH3-domain-binding properties

Biochemical and Biophysical Research Communications

Volumn 463, Issue 3, 2015, Pages 174-179

  Vervliet, Tim ^a   Lemmens, Irma ^b   Welkenhuyzen, Kirsten ^a   Tavernier, Jan ^b   Parys, Jan B ^a   Bultynck, Geert ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

ABT 199; B cell lymphoma 2; BH3 mimetic; Hydrophobic cleft; P2A; Ryanodine receptors

Indexed keywords

BH3 PROTEIN; CALCIUM; CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PROTEIN BCL 2; RYANODINE RECEPTOR; VENETOCLAX; 4-(4-((2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL)METHYL)PIPERAZIN-1-YL)-N-((3-NITRO-4-((TETRAHYDRO-2H-PYRAN-4-YLMETHYL)AMINO)PHENYL)SULFONYL)-2-(1H-PYRROLO(2,3-B)PYRIDIN-5-YLOXY)BENZAMIDE; FUSED HETEROCYCLIC RINGS; PROTEIN BINDING; SULFONAMIDE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HYDROPHOBICITY; MEASUREMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMISTRY; HEK293 CELL LINE; METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE;

BICYCLO COMPOUNDS, HETEROCYCLIC; CALCIUM SIGNALING; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PROTEIN BINDING; PROTEIN INTERACTION MAPS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SULFONAMIDES;

EID: 84930925557     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.131     Document Type: Article

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