Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 308, Issue 9, 2015, Pages G757-G766

  Sun, Qian ^a   Zhong, Wei ^a   Zhang, Wenliang ^a   Li, Qiong ^a   Sun, Xiuhua ^a   Tan, Xiaobing ^a   Sun, Xinguo ^a   Dong, Daoyin ^a   Zhou, Zhanxiang ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

Alcoholic liver disease; Apoptosis; Endoplasmic reticulum; Mitochondria; Zinc

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 4; ALCOHOL; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CYTOCHROME C; INITIATION FACTOR 2ALPHA; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZRT IRT LIKE PROTEIN 13; ANTIOXIDANT; ATF4 PROTEIN, RAT; CARRIER PROTEIN; CASP3 PROTEIN, RAT; CATION TRANSPORT PROTEIN; CHELATING AGENT; DDIT3 PROTEIN, RAT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; REACTIVE OXYGEN METABOLITE; SLC30A4 PROTEIN, RAT; ZIP8 PROTEIN, RAT;

ALCOHOL INTOXICATION; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME RELEASE; HISTOPATHOLOGY; LIVER CELL; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UPREGULATION; WEIGHT CHANGE; WISTAR RAT; ZINC DEFICIENCY; ANIMAL; BLOOD; DEFICIENCY; DEFICIENCY DISEASES; DISEASE MODEL; DRUG EFFECTS; LIVER; LIVER DISEASES, ALCOHOLIC; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TIME; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CHELATING AGENTS; DEFICIENCY DISEASES; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ETHANOL; EUKARYOTIC INITIATION FACTOR-2; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PHOSPHORYLATION; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; ZINC;

EID: 84930915068     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00442.2014     Document Type: Article

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