ANG II modulation of cardiac growth and remodeling in immature fetal sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 308, Issue 11, 2015, Pages R965-R972

  Sandgren, Jeremy ^a   Scholz, Thomas D ^a   Segar, Jeffrey L ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cardiomyocyte; Heart; Hyperplasia; Hypertrophy

Indexed keywords

ANGIOTENSIN II; CYCLIN B1; CYCLIN E1; CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; NITROPRUSSIDE SODIUM; PROTEIN P21; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN E; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FETUS; HEART AFTERLOAD; HEART DEVELOPMENT; HEART DISEASE; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART REMODELING; HEART WEIGHT; IMMATURITY; NONHUMAN; PRIORITY JOURNAL; SHEEP; ANIMAL; BLOOD PRESSURE; CARDIOMEGALY; CELL DIFFERENTIATION; CELL ENLARGEMENT; CELL PROLIFERATION; CELL SIZE; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG EFFECTS; FETUS HEART; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; HYPERPLASIA; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIME;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOMARKERS; BLOOD PRESSURE; CARDIOMEGALY; CELL DIFFERENTIATION; CELL ENLARGEMENT; CELL PROLIFERATION; CELL SIZE; CYCLIN B1; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FETAL HEART; GESTATIONAL AGE; HYPERPLASIA; HYPERTENSION; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; NITROPRUSSIDE; PROLIFERATING CELL NUCLEAR ANTIGEN; SHEEP; SIGNAL TRANSDUCTION; TIME FACTORS; VASODILATOR AGENTS;

EID: 84930898311     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00034.2015     Document Type: Article

References (42)

1. Barbera A, Giraud GD, Reller MD, Maylie J, Morton MJ, Thornburg KL. Right ventricular systolic pressure load alters myocyte maturation in fetal sheep. Am J Physiol Regul Integr Comp Physiol 279: R1157–R1164, 2000.
2. Booth LC, Malpas SC, Barrett CJ, Guild SJ, Gunn AJ, Bennet L. Is baroreflex control of sympathetic activity and heart rate active in the preterm fetal sheep? Am J Physiol Regul Integr Comp Physiol 296: R603–R609, 2009.
3. Booz GW, Day JN, Baker KM. Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr-705 dephosphorylation. Basic Res Cardiol 98: 33–38, 2003.
4. Botting KJ, McMillen IC, Forbes H, Nyengaard JR, Morrison JL. Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes. J Am Heart Assoc 3: 2014.
5. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol 293: H620–H627, 2007.
6. Chattergoon NN, Giraud GD, Louey S, Stork P, Fowden AL, Thornburg KL. Thyroid hormone drives fetal cardiomyocyte maturation. FASEB J 26: 397–408, 2012.
7. Davis JP, Vo XT, Sulakhe PV. Altered responsiveness of guanylyl cyclase to nitric oxide following treatment of cardiomyocytes with Snitroso- D,L-acetylpenicillamine and sodium nitroprusside. Biochem Biophys Res Commun 238: 351–356, 1997.
8. Dostal DE, Baker KM. Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Am J Hypertens 5: 276–280, 1992.
9. Flogel U, Merx MW, Godecke A, Decking UK, Schrader J. Myoglobin: A scavenger of bioactive NO. Proc Natl Acad Sci USA 98: 735–740, 2001.
10. Giraud GD, Louey S, Jonker S, Schultz J, Thornburg KL. Cortisol stimulates cell cycle activity in the cardiomyocyte of the sheep fetus. Endocrinology 147: 3643–3649, 2006.
11. Goutsouliak V, Rabkin SW. Angiotensin II-induced inositol phosphate generation is mediated through tyrosine kinase pathways in cardiomyocytes. Cell Signal 9: 505–512, 1997.
12. Grieve DJ, Byrne JA, Siva A, Layland J, Johar S, Cave AC, Shah AM. Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload. J Am Coll Cardiol 47: 817–826, 2006.
13. Hammond J, Balligand JL. Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: from contractility to remodeling. J Mol Cell Cardiol 52: 330–340, 2012.
14. Hata JA, Williams ML, Koch WJ. Genetic manipulation of myocardial _-adrenergic receptor activation and desensitization. J Mol Cell Cardiol 37: 11–21, 2004.
15. Ismay MJ, Lumbers ER, Stevens AD. The action of angiotensin II on the baroreflex response of the conscious ewe and the conscious fetus. J Physiol 288: 467–479, 1979.
16. Jonker SS, Faber JJ, Anderson DF, Thornburg KL, Louey S, Giraud GD. Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension. Am J Physiol Regul Integr Comp Physiol 292: R913–R919, 2007.
17. Jonker SS, Scholz TD, Segar JL. The effect of adrenalectomy on the cardiac response to subacute fetal anemia. Can J Physiol Pharmacol 89: 79–88, 2011.
18. Jonker SS, Scholz TD, Segar JL. Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep after chronic anemia. Pediatr Res 69: 485–490, 2011.
19. Jonker SS, Zhang L, Louey S, Giraud GD, Thornburg KL, Faber JJ. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J Appl Physiol 102: 1130–1142, 2007.
20. Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension 25: 1252–1259, 1995.
21. Li G, Bae S, Zhang L. Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart. Am J Physiol Heart Circ Physiol 286: H1712–H1719, 2004.
22. Li G, Xiao Y, Estrella JL, Ducsay CA, Gilbert RD, Zhang L. Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat. J Soc Gynecol Investig 10: 265–274, 2003.
23. Lin Y, Wang LN, Xi YH, Li HZ, Xiao FG, Zhao YJ, Tian Y, Yang BF, Xu CQ. L-arginine inhibits isoproterenol-induced cardiac hypertrophy through nitric oxide and polyamine pathways. Basic Clin Pharmacol Toxicol 103: 124–130, 2008.
24. Loyer X, Heymes C, Samuel JL. Constitutive nitric oxide synthases in the heart from hypertrophy to failure. Clin Exp Pharmacol Physiol 35: 483–488, 2008.
25. Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, Takagahara S, Turner JH, Kozasa T, Kobayashi H, Sato Y, Kawanishi T, Inoue R, Nagao T, Kurose H. G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem 280: 18, 434–18, 441, 2005.
26. Norris AW, Bahr TM, Scholz TD, Peterson ES, Volk KA, Segar JL. Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep. Pediatr Res 75: 689–696, 2014.
27. Olson AK, Protheroe KN, Scholz TD, Segar JL. The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. J Soc Gynecol Investig 13: 157–165, 2006.
28. Olson AK, Protheroe KN, Scholz TD, Segar JL. The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. J Soc Gynecol Invest 13: 157–165, 2006.
29. Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, Hori S, Ogawa S. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res 81: 611–617, 1997.
30. Rockman HA, Wachhorst SP, Mao L, Ross JJ. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. Am J Physiol Heart Circ Physiol 266: H2468–H2475, 1994.
31. Ruetten H, Dimmeler S, Gehring D, Ihling C, Zeiher AM. Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload. Cardiovasc Res 66: 444–453, 2005.
32. Sadoshima JI, Izumo S. Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Circ Res 73: 424–438, 1993.
33. Samson F, Bonnet N, Heimburger M, Rucker-Martin C, Levitsky DO, Mazmanian GM, Mercadier JJ, Serraf A. Left ventricular alterations in a model of fetal left ventricular overload. Pediatr Res 48: 43–49, 2000.
34. Schluter KD, Wenzel S. Angiotensin II: a hormone involved in and contributing to pro-hypertrophic cardiac networks and target of antihypertrophic cross-talks. Pharmacol Ther 119: 311–325, 2008.
35. Schunkert H, Sadoshima J, Cornelius T, Kagaya Y, Weinberg EO, Izumo S, Riegger G, Lorell BH. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res 76: 489–497, 1995.
36. Segar JL, Dalshaug GB, Bedell KA, Smith OM, Scholz TD. Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep. Am J Physiol Regul Integr Comp Physiol 281: R2037–R2047, 2001.
37. Segar JL, Volk KA, Lipman MH, Scholz TD. Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart. Exp Physiol 98: 722–733, 2013.
38. Smolich JJ, Walker AM, Campbell GR, Adamson TM. Left and right ventricular myocardial morphometry in fetal, neonatal, and adult sheep. Am J Physiol Heart Circ Physiol 257: H1–H9, 1989.
39. Sundgren NC, Giraud GD, Stork PJ, Maylie JG, Thornburg KL. Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes. J Physiol 548: 881–891, 2003.
40. Unno N, Wong CH, Jenkins SL, Wentworth RA, Ding XY, Li C, Robertson SS, Smotherman WP, Nathanielsz PW. Blood pressure and heart rate in the ovine fetus: ontogenic changes and effects of fetal adrenalectomy. Am J Physiol Heart Circ Physiol 276: H248–H256, 1999.
41. Wassink G, Bennet L, Booth LC, Jensen EC, Wibbens B, Dean JM, Gunn AJ. The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol (1985) 103: 1311–1317, 2007.
42. Wenzel S, Rohde C, Wingerning S, Roth J, Kojda G, Schluter KD. Lack of endothelial nitric oxide synthase-derived nitric oxide formation favors hypertrophy in adult ventricular cardiomyocytes. Hypertension 49: 193–200, 2007.