Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease

Proteomics - Clinical Applications

Volumn 9, Issue 5-6, 2015, Pages 552-567

  Pocsfalvi, Gabriella ^a   Raj, Delfin A A ^a   Fiume, Immacolata ^a   Vilasi, Annalisa ^a   Trepiccione, Francesco ^b   Capasso, Giovambattista ^b  

^a CNR   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Ciliary signaling pathway; Extracellular vesicles; Kidney physiology; Polycystic kidney disease; Quantitative proteomics

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ALPHA GLUCOSIDASE; APOLIPOPROTEIN A1; AQUAPORIN 1; AQUAPORIN 2; CADHERIN 23; CALGRANULIN A; CALGRANULIN B; CD59 ANTIGEN; CD9 ANTIGEN; DIPEPTIDYL PEPTIDASE IV; ELONGATION FACTOR 2; EZRIN; GLUTATHIONE TRANSFERASE A3; GLUTATHIONE TRANSFERASE A5; GLYCOGEN SYNTHASE KINASE 3ALPHA; LIPOCORTIN 1; LIPOCORTIN 2; MACROPHAGE MIGRATION INHIBITION FACTOR; MEMBRANE METALLOENDOPEPTIDASE; MOESIN; MUCIN 1; PODOCALYXIN; PROSTATE STEM CELL ANTIGEN; PROTEOME; RADIXIN; TAMM HORSFALL GLYCOPROTEIN; UNINDEXED DRUG; UROPLAKIN 1A; UROPLAKIN 2; AQP2 PROTEIN, HUMAN; BENZAZEPINE DERIVATIVE; BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; TOLVAPTAN; VASOPRESSIN RECEPTOR ANTAGONIST;

ADULT; AGED; APICAL MEMBRANE; ARTICLE; CALCIUM BINDING; CALCIUM SIGNALING; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DOUBLE CUSHION ULTRACENTRIFUGATION; EXOSOME; FEMALE; HUMAN; HUMAN CELL; ISOBARIC TAGS FOR RELATIVE AND ABSOLUTE QUANTITATION; KIDNEY POLYCYSTIC DISEASE; MALE; MULTIDIMENSIONAL PROTEIN IDENTIFICATION TECHNOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; ULTRACENTRIFUGATION; URINALYSIS; WNT SIGNALING PATHWAY; CASE CONTROL STUDY; METABOLISM; MIDDLE AGED; POLYCYSTIC KIDNEY DISEASES; URINE; YOUNG ADULT;

ADULT; AGED; ANTIDIURETIC HORMONE RECEPTOR ANTAGONISTS; AQUAPORIN 2; BENZAZEPINES; BIOMARKERS; CALCIUM-BINDING PROTEINS; CASE-CONTROL STUDIES; EXTRACELLULAR VESICLES; HUMANS; MALE; MIDDLE AGED; POLYCYSTIC KIDNEY DISEASES; PROTEOME; WNT SIGNALING PATHWAY; YOUNG ADULT;

EID: 84930888362     PISSN: 18628346     EISSN: 18628354     Source Type: Journal    
DOI: 10.1002/prca.201400199     Document Type: Article

References (37)

1. Yoon, Y. J., Kim, O. Y., Gho, Y. S., Extracellular vesicles as emerging intercellular communicasomes. BMB Rep. 2014, 47, 531-539.
2. György, B., Szabó, T., Pásztói, M., Pál, Z. et al., Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 2011, 68, 2667-2688.
3. Yuana, Y., Sturk, A., Nieuwland, R., Extracellular vesicles in physiological and pathological conditions. Blood Rev. 2013, 27, 31-39.
4. Choi, D. S., Kim, D. K., Kim, Y. K., Gho, Y. S., Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics 2013, 13, 1554-1571.
5. Buzas, E. I., Gyorgy, B., Nagy, G., Falus, A., Gay, S., Emerging role of extracellular vesicles in inflammatory diseases. Nat. Rev. Rheumatol. 2014, 10, 356-364.
6. Pocsfalvi, G., Stanly, C., Vilasi, A., Fiume, I. et al., Employing extracellular vesicles for non-invasive renal monitoring: a captivating prospect. World J. Clin. Urol. 2014, 3, 66-80.
7. Wang, Z., Hill, S., Luther, J. M., Hachey, D. L., Schey, K. L., Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Proteomics 2012, 12, 329-338.
8. Wallingford, J. B., Mitchell, B., Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev. 2011, 25, 201-213.
9. Ishikawa, H., Thompson, J., Yates, JR 3rd, John, R., Marshall, Wallace, F., Proteomic analysis of mammalian primary cilia. Curr. Biol. 2012, 22, 414-419.
10. Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I. et al., Characterization of PKD protein-positive exosome-like vesicles. J. Am. Soc. Nephrol. 2009, 20, 278-288.
11. Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A. et al., Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 299, G990-G999.
12. Street, J. M., Birkhoff, W., Menzies, R. I., Webb, D. J. et al., Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells. J. Physiol. 2011, 589, 6119-6127.
13. Winyard, P., Jenkins, D., Putative roles of cilia in polycystic kidney disease. Biochim. Biophys. Acta 2011, 1812, 1256-1262.
14. Torres, V. E., Chapman, A. B., Devuyst, O., Gansevoort, R. T. et al., Tolvaptan in patients with autosomal dominant polycystic kidney disease. N. Engl. J. Med. 2012, 367, 2407-2418.
15. Karp, N. A., Lilley, K. S., Investigating sample pooling strategies for DIGE experiments to address biological variability. Proteomics 2009, 9, 388-397.
16. Raj, D. A. A., Capasso, G., Fiume, I., Pocsfalvi, G., Procedura di isolamento e di purificazione degli esosomi urinari per la ricerca di biomarcatori proteici, patent deposited on 14 March 2011, Ufficio Italiano Brevetti e Marchi, NA2011A000012.
17. Raj, D. A., Fiume, I., Capasso, G., Pocsfalvi, G., A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes. Kidney Int. 2012, 81, 1263-1272.
18. Datta, A., Park, J. E., Li, X., Zhang, H. et al., Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics. J. Proteome Res. 2010, 9, 472-484.
19. Mathivanan, S., Simpson, R. J., ExoCarta: a compendium of exosomal proteins and RNA. Proteomics 2009, 9, 4997-5000.
20. Pisitkun, T., Shen, R.-F., Knepper, M. A., Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. USA 2004, 101, 13368-13373.
21. Grantham, J. J., Chapman, A. B., Torres, V. E., Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes. Clin. J. Am. Soc. Nephrol. 2006, 1, 148-157.
22. Reif, G. A., Yamaguchi, T., Nivens, E., Fujiki, H. et al., Tolvaptan inhibits ERK-dependent cell proliferation, Cl- secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. Am. J. Physiol. Renal Physiol. 2011, 301, F1005-F1013.
23. Torres, V. E., Vasopressin in chronic kidney disease: an elephant in the room? Kidney Int. 2009, 76, 925-928.
24. Irazabal, M. V., Torres, V. E., Hogan, M. C., Glockner, J. et al., Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease. Kidney Int. 2011, 80, 295-301.
25. Wu, C. C., MacCoss, M. J., Shotgun proteomics: tools for the analysis of complex biological systems. Curr. Opin. Mol. Ther. 2002, 4, 242-250.
26. Kim, D. K., Lee, J., Kim, S. R., Choi, D. S. et al., EVpedia: a community web portal for extracellular vesicles research. Bioinformatics 2014, 10, 933-939.
27. Roitbak, T., Ward, C. J., Harris, P. C., Bacallao, R. et al., A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol. Biol. Cell 2004, 15, 1334-1346.
28. Allen, E., Piontek, K. B., Garrett-Mayer, E., Garcia-Gonzalez, M. et al., Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors. Hum. Mol. Genet. 2006, 15, 11-21.
29. Nielsen, S., Renal aquaporins: an overview. BJU Int. 2002, 90, 1-6.
30. Jang, K.-J., Cho, H. S., Kang, D. H., Bae, W. G. et al., Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr. Biol. 2011, 3, 134-141.
31. Markoff, A., Gerke, V., Expression and functions of annexins in the kidney. Am. J. Physiol. Renal Physiol. 2005, 289, F949-956.
32. AbouAlaiwi, W. A., Ratnam, S., Booth, R. L., Shah, J. V., Nauli, S. M., Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum. Mol. Genet. 2011, 20, 354-367.
33. Tomas, A., Futter, C., Moss, S. E., Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. J. Cell Biol. 2004, 165, 813-822.
34. Benzing, T., Simons, M., Walz, G., Wnt signaling in polycystic kidney disease. J. Am. Soc. Nephrol. 2007, 18, 1389-1398.
35. Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., Caplan, M. J., Exosome release of beta-catenin: a novel mechanism that antagonizes Wnt signaling. J. Cell Biol. 2010, 190, 1079-1091.
36. Luyten, A., Su, X., Gondela, S., Chen, Y. et al., Aberrant regulation of planar cell polarity in polycystic kidney disease. J. Am. Soc. Nephrol. 2010, 21, 1521-1532.
37. Charron, A. J., Nakamura, S., Bacallao, R., Wandinger-Ness, A., Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells. J. Cell Biol. 2000, 149, 111-124.