Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism

Molecular Biology of the Cell

Volumn 26, Issue 12, 2015, Pages 2298-2310

  Helenius, Terhi O ^a   Misiorek, Julia O ^a   Nyström, Joel H ^a   Fortelius, Lina E ^a   Habtezion, Aida ^b   Liao, Jian ^c   Asghar, M Nadeem ^a   Zhang, Haiyan ^b   Azhar, Salman ^b   Omary, M Bishr ^d,e   Toivola, Diana M ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Applied Biomics Inc   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COA SYNTHASE 2; 3 HYDROXYBUTYRIC ACID; ACETIC ACID; BUTYRIC ACID; CYTOKERATIN 8; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOBUTYRIC ACID; KETONE BODY; MONOCARBOXYLATE TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; COTRANSPORTER; HMGCS2 PROTEIN, MOUSE; KRT8 PROTEIN, MOUSE; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; BACTERIUM; CELL ULTRASTRUCTURE; CLOSTRIDIUM; COLON FLORA; COLONOCYTE; CONTROLLED STUDY; DESCENDING COLON; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DIETARY FIBER; DOWN REGULATION; ENERGY METABOLISM; ENZYME ACTIVITY; FECES; FEMALE; FIRMICUTES; GENE INACTIVATION; HOMEOSTASIS; INFLAMMATION; INTESTINE CELL; KETOGENESIS; KETOGENIC DIET; LIVER; MALE; MICROBIAL POPULATION DYNAMICS; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SMALL INTESTINE; STARVATION; ANIMAL; BIOSYNTHESIS; COLON; CYTOLOGY; GENE DELETION; GENETICS; INTESTINE MUCOSA; METABOLISM;

MUS;

ANIMALS; COLON; DOWN-REGULATION; ENERGY METABOLISM; FEMALE; GENE DELETION; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; INTESTINAL MUCOSA; KERATIN-8; KETONE BODIES; MALE; MICE; MONOCARBOXYLIC ACID TRANSPORTERS; PPAR ALPHA; SYMPORTERS;

EID: 84930885868     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-02-0736     Document Type: Article

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