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Volumn 108, Issue 4, 2011, Pages 1445-1450

Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA4 INTEGRIN; CASPASE; CYTOKERATIN 8; FOCAL ADHESION KINASE; PROTEIN ANTIBODY; SURVIVIN;

EID: 79952129489     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010833108     Document Type: Article
Times cited : (40)

References (51)
  • 1
    • 0036468732 scopus 로고    scopus 로고
    • 'Hard' and 'soft' principles defining the structure, functionand regulation of keratin intermediate filaments
    • Coulombe PA, Omary MB (2002) 'Hard' and 'soft' principles defining the structure, functionand regulation of keratin intermediate filaments. Curr Opin Cell Biol 14:110-122.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 110-122
    • Coulombe, P.A.1    Omary, M.B.2
  • 2
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
    • Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24. (Pubitemid 13215192)
    • (1982) Cell , vol.31 , Issue.1 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3
  • 5
    • 68849111162 scopus 로고    scopus 로고
    • Toward unraveling the complexity of simple epithelial keratins in human disease
    • Omary MB, Ku NO, Strnad P, Hanada S (2009) Toward unraveling the complexity of simple epithelial keratins in human disease. J Clin Invest 119:1794-1805.
    • (2009) J Clin Invest , vol.119 , pp. 1794-1805
    • Omary, M.B.1    Ku, N.O.2    Strnad, P.3    Hanada, S.4
  • 6
    • 0035942786 scopus 로고    scopus 로고
    • Keratin 8 mutations in patients with cryptogenic liver disease
    • DOI 10.1056/NEJM200105243442103
    • Ku NO, Gish R, Wright TL, Omary MB (2001) Keratin 8 mutations in patients with cryptogenic liver disease. N Engl J Med 344:1580-1587. (Pubitemid 32479910)
    • (2001) New England Journal of Medicine , vol.344 , Issue.21 , pp. 1580-1587
    • Ku, N.-O.1    Gish, R.2    Wright, T.L.3    Omary, M.B.4
  • 8
    • 77956157619 scopus 로고    scopus 로고
    • Keratin variants predispose to acute liver failure and adverse outcome: Race and ethnic associations
    • Acute Liver Failure Study Group
    • Strnad P, et al.; Acute Liver Failure Study Group (2010) Keratin variants predispose to acute liver failure and adverse outcome: Race and ethnic associations. Gastroenterology, 139:828-835, 835, e1-e3.
    • (2010) Gastroenterology , vol.139
    • Strnad, P.1
  • 9
    • 1642348652 scopus 로고    scopus 로고
    • Keratins modulate colonocyte electrolyte transport via protein mistargeting
    • DOI 10.1083/jcb.200308103
    • Toivola DM, Krishnan S, Binder HJ, Singh SK, Omary MB (2004) Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol 164:911-921. (Pubitemid 38366902)
    • (2004) Journal of Cell Biology , vol.164 , Issue.6 , pp. 911-921
    • Toivola, D.M.1    Krishnan, S.2    Binder, H.J.3    Singh, S.K.4    Omary, M.B.5
  • 10
    • 0028607055 scopus 로고
    • Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
    • Baribault H, Penner J, Iozzo RV, Wilson-Heiner M (1994) Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 8:2964-2973.
    • (1994) Genes Dev , vol.8 , pp. 2964-2973
    • Baribault, H.1    Penner, J.2    Iozzo, R.V.3    Wilson-Heiner, M.4
  • 11
    • 19444375279 scopus 로고    scopus 로고
    • Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
    • DOI 10.1242/jcs.02316
    • Habtezion A, Toivola DM, Butcher EC, Omary MB (2005) Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. J Cell Sci 118:1971-1980. (Pubitemid 40723840)
    • (2005) Journal of Cell Science , vol.118 , Issue.9 , pp. 1971-1980
    • Habtezion, A.1    Toivola, D.M.2    Butcher, E.C.3    Omary, M.B.4
  • 12
    • 65549107433 scopus 로고    scopus 로고
    • Keratin 18 provides resistance to Fas-mediated liver failure in mice
    • Leifeld L, et al. (2009) Keratin 18 provides resistance to Fas-mediated liver failure in mice. Eur J Clin Invest 39:481-488.
    • (2009) Eur J Clin Invest , vol.39 , pp. 481-488
    • Leifeld, L.1
  • 14
    • 2642684550 scopus 로고    scopus 로고
    • Lessons from keratin 18 knockout mice: Formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates
    • DOI 10.1083/jcb.140.6.1441
    • Magin TM, et al. (1998) Lessons from keratin 18 knockout mice: Formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol 140:1441-1451. (Pubitemid 28152992)
    • (1998) Journal of Cell Biology , vol.140 , Issue.6 , pp. 1441-1451
    • Magin, T.M.1    Schroder, R.2    Leitgeb, S.3    Wanninger, F.4    Zatloukal, K.5    Grund, C.6    Melton, D.W.7
  • 15
    • 34547222677 scopus 로고    scopus 로고
    • A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice
    • DOI 10.1016/j.yexcr.2007.05.019, PII S0014482707002285
    • Hesse M, et al. (2007) A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice. Exp Cell Res 313:3127-3140. (Pubitemid 47125884)
    • (2007) Experimental Cell Research , vol.313 , Issue.14 , pp. 3127-3140
    • Hesse, M.1    Grund, C.2    Herrmann, H.3    Brohl, D.4    Franz, T.5    Omary, M.B.6    Magin, T.M.7
  • 17
    • 34447256176 scopus 로고    scopus 로고
    • Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease
    • Tao GZ, et al. (2007) Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol 5:857-864.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 857-864
    • Tao, G.Z.1
  • 19
    • 0029739950 scopus 로고    scopus 로고
    • Control of adhesion-dependent cell survival by focal adhesion kinase
    • Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134:793-799. (Pubitemid 26269148)
    • (1996) Journal of Cell Biology , vol.134 , Issue.3 , pp. 793-799
    • Frisch, S.M.1    Vuori, K.2    Ruoslahti, E.3    Chan-Hui, P.-Y.4
  • 20
    • 0032102763 scopus 로고    scopus 로고
    • Structure and assembly of hemidesmosomes
    • DOI 10.1002/(SICI)1521-1878(199806)20:6<488::AID-BIES7>3.0.CO;2-I
    • Jones JC, Hopkinson SB, Goldfinger LE (1998) Structure and assembly of hemidesmosomes. Bioessays 20:488-494. (Pubitemid 28320611)
    • (1998) BioEssays , vol.20 , Issue.6 , pp. 488-494
    • Jones, J.C.R.1    Hopkinson, S.B.2    Goldfinger, L.E.3
  • 21
    • 0032908323 scopus 로고    scopus 로고
    • Structure and function of hemidesmosomes: More than simple adhesion complexes
    • DOI 10.1046/j.1523-1747.1999.00546.x
    • Borradori L, Sonnenberg A (1999) Structure and function of hemidesmosomes: More than simple adhesion complexes. J Invest Dermatol 112:411-418. (Pubitemid 29171928)
    • (1999) Journal of Investigative Dermatology , vol.112 , Issue.4 , pp. 411-418
    • Borradori, L.1    Sonnenberg, A.2
  • 23
    • 0029789008 scopus 로고    scopus 로고
    • Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant
    • Ku NO, et al. (1996) Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant. J Clin Invest 98:1034-1046.
    • (1996) J Clin Invest , vol.98 , pp. 1034-1046
    • Ku, N.O.1
  • 25
    • 0031836071 scopus 로고    scopus 로고
    • Protein phosphatase inhibition in normal and keratin 8/18 assembly- Incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity
    • DOI 10.1002/hep.510280117
    • Toivola DM, et al. (1998) Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity. Hepatology 28:116-128. (Pubitemid 28299993)
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 116-128
    • Toivola, D.M.1    Omary, M.B.2    Ku, N.-O.3    Peltola, O.4    Baribault, H.5    Eriksson, J.E.6
  • 26
    • 0035921430 scopus 로고    scopus 로고
    • Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation
    • DOI 10.1083/jcb.200102130
    • Gilbert S, Loranger A, Daigle N, Marceau N (2001) Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol 154:763-773. (Pubitemid 34292958)
    • (2001) Journal of Cell Biology , vol.154 , Issue.4 , pp. 763-773
    • Gilbert, S.1    Loranger, A.2    Daigle, N.3    Marceau, N.4
  • 27
    • 0034599872 scopus 로고    scopus 로고
    • Keratin-dependent, epithelial resistance to tumor necrosis factor- Induced apoptosis
    • DOI 10.1083/jcb.149.1.17
    • Caulin C, Ware CF, Magin TM, Oshima RG (2000) Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol 149:17-22. (Pubitemid 30196695)
    • (2000) Journal of Cell Biology , vol.149 , Issue.1 , pp. 17-22
    • Caulin, C.1    Ware, C.F.2    Magin, T.M.3    Oshima, R.G.4
  • 29
    • 33745628320 scopus 로고    scopus 로고
    • A disease- and phosphorylation-related nonmechanical function for keratin 8
    • Ku NO, Omary MB (2006) A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol 174:115-125.
    • (2006) J Cell Biol , vol.174 , pp. 115-125
    • Ku, N.O.1    Omary, M.B.2
  • 30
    • 44149085177 scopus 로고    scopus 로고
    • Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation
    • Tao GZ, et al. (2008) Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation. J Pathol 215:164-174.
    • (2008) J Pathol , vol.215 , pp. 164-174
    • Tao, G.Z.1
  • 31
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts P, et al. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274-282.
    • (1993) Cell , vol.75 , pp. 274-282
    • Mombaerts, P.1
  • 32
    • 34447120194 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic survivin: Molecular mechanism, prognostic, and therapeutic potential
    • DOI 10.1158/0008-5472.CAN-07-0494
    • Stauber RH, Mann W, Knauer SK (2007) Nuclear and cytoplasmic survivin: Molecular mechanism, prognostic, and therapeutic potential. Cancer Res 67:5999-6002. (Pubitemid 47037475)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 5999-6002
    • Stauber, R.H.1    Mann, W.2    Knauer, S.K.3
  • 33
    • 69749094996 scopus 로고    scopus 로고
    • Survivin as a global target of intrinsic tumor suppression networks
    • Guha M, Altieri DC (2009) Survivin as a global target of intrinsic tumor suppression networks. Cell Cycle 8:2708-2710.
    • (2009) Cell Cycle , vol.8 , pp. 2708-2710
    • Guha, M.1    Altieri, D.C.2
  • 34
    • 33845979791 scopus 로고    scopus 로고
    • Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis
    • DOI 10.1634/stemcells.2006-0165
    • Marconi A, et al. (2007) Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis. Stem Cells 25:149-155. (Pubitemid 46052985)
    • (2007) Stem Cells , vol.25 , Issue.1 , pp. 149-155
    • Marconi, A.1    Dallaglio, K.2    Lotti, R.3    Vaschieri, C.4    Truzzi, F.5    Fantini, F.6    Pincelli, C.7
  • 35
    • 0033558439 scopus 로고    scopus 로고
    • Integrins and human intestinal cell functions
    • Beaulieu JF (1999) Integrins and human intestinal cell functions. Front Biosci 4:D310-D321.
    • (1999) Front Biosci , vol.4
    • Beaulieu, J.F.1
  • 36
    • 0033554485 scopus 로고    scopus 로고
    • The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway
    • DOI 10.1006/bbrc.1999.1496
    • Tang K, Nie D, Cai Y, Honn KV (1999) The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway. Biochem Biophys Res Commun 264:127-132. (Pubitemid 29500475)
    • (1999) Biochemical and Biophysical Research Communications , vol.264 , Issue.1 , pp. 127-132
    • Tang, K.1    Nie, D.2    Cai, Y.3    Honn, K.V.4
  • 37
    • 5644298698 scopus 로고    scopus 로고
    • Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase
    • DOI 10.1158/0008-5472.CAN-04-1809
    • Gilcrease MZ, Zhou X, Welch K (2004) Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase. Cancer Res 64:7395-7398. (Pubitemid 39372079)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7395-7398
    • Gilcrease, M.Z.1    Zhou, X.2    Welch, K.3
  • 38
    • 0035253607 scopus 로고    scopus 로고
    • PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3- kinase/Akt-dependent and -independent pathways
    • Weng L, Brown J, Eng C (2001) PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 10:237-242. (Pubitemid 32123982)
    • (2001) Human Molecular Genetics , vol.10 , Issue.3 , pp. 237-242
    • Weng, L.-P.1    Brown, J.L.2    Eng, C.3
  • 39
    • 0035110609 scopus 로고    scopus 로고
    • Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia
    • Ameen NA, Figueroa Y, Salas PJ (2001) Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia. J Cell Sci 114:563-575. (Pubitemid 32186113)
    • (2001) Journal of Cell Science , vol.114 , Issue.3 , pp. 563-575
    • Ameen, N.A.1    Figueroa, Y.2    Salas, P.J.I.3
  • 40
    • 0034735577 scopus 로고    scopus 로고
    • Cytokeratins 8 and 19 in the mouse placental development
    • Tamai Y, et al. (2000) Cytokeratins 8 and 19 in the mouse placental development. J Cell Biol 151:563-572.
    • (2000) J Cell Biol , vol.151 , pp. 563-572
    • Tamai, Y.1
  • 41
    • 0034596918 scopus 로고    scopus 로고
    • Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
    • Hesse M, Franz T, Tamai Y, Taketo MM, Magin TM (2000) Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. EMBO J 19:5060-5070.
    • (2000) EMBO J , vol.19 , pp. 5060-5070
    • Hesse, M.1    Franz, T.2    Tamai, Y.3    Taketo, M.M.4    Magin, T.M.5
  • 42
    • 0037847551 scopus 로고    scopus 로고
    • Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury
    • DOI 10.1053/jhep.2003.50181
    • Ku NO, Soetikno RM, Omary MB (2003) Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology 37:1006-1014. (Pubitemid 36538677)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1006-1014
    • Ku, N.-O.1    Soetikno, R.M.2    Omary, M.B.3
  • 43
    • 37549036729 scopus 로고    scopus 로고
    • Survivin, cancer networks and pathway-directed drug discovery
    • Altieri DC (2008) Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 8:61-70.
    • (2008) Nat Rev Cancer , vol.8 , pp. 61-70
    • Altieri, D.C.1
  • 44
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • DOI 10.1016/j.cell.2004.07.002, PII S0092867404006610
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118:229-241. (Pubitemid 38962578)
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 45
    • 55049110418 scopus 로고    scopus 로고
    • No longer an innocent bystander: Epithelial toll-like receptor signaling in the development of mucosal inflammation
    • Gribar SC, Richardson WM, Sodhi CP, Hackam DJ (2008) No longer an innocent bystander: Epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med 14:645-659.
    • (2008) Mol Med , vol.14 , pp. 645-659
    • Gribar, S.C.1    Richardson, W.M.2    Sodhi, C.P.3    Hackam, D.J.4
  • 46
    • 4043138038 scopus 로고    scopus 로고
    • Microflora of the gastrointestinal tract: A review
    • Hao WL, Lee YK (2004) Microflora of the gastrointestinal tract: A review. Methods Mol Biol 268:491-502.
    • (2004) Methods Mol Biol , vol.268 , pp. 491-502
    • Hao, W.L.1    Lee, Y.K.2
  • 47
    • 23344449020 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    • DOI 10.1111/j.0105-2896.2005.00291.x
    • Elson CO, et al. (2005) Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 206:260-276. (Pubitemid 41105175)
    • (2005) Immunological Reviews , vol.206 , pp. 260-276
    • Elson, C.O.1    Cong, Y.2    McCracken, V.J.3    Dimmitt, R.A.4    Lorenz, R.G.5    Weaver, C.T.6
  • 49
    • 2342434472 scopus 로고    scopus 로고
    • Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation
    • Zhong B, et al. (2004) Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. J Cell Sci 117:1709-1719.
    • (2004) J Cell Sci , vol.117 , pp. 1709-1719
    • Zhong, B.1
  • 51
    • 14244253371 scopus 로고    scopus 로고
    • Studying simple epithelial keratins in cells and tissues
    • Ku NO, et al. (2004) Studying simple epithelial keratins in cells and tissues. Methods Cell Biol 78:489-517.
    • (2004) Methods Cell Biol , vol.78 , pp. 489-517
    • Ku, N.O.1


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