Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 6, 2015, Pages F639-F649

  Liu, Wei Jing ^a   Xu, Bi Hua ^a   Ye, Lin ^a   Liang, Dong ^a   Wu, Hong Luan ^a   Zheng, Yuan Yuan ^a   Deng, Jian Kun ^a   Li, Benyi ^a   Liu, Hua Feng ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Lysosomal dysfunction; Lysosomal membrane permeabilization; Tubular epithelial cells; Urinary proteins

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN L; HYDROLASE; KIDNEY INJURY MOLECULE 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OVALBUMIN;

ACIDIFICATION; ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE EPITHELIUM; LYSOSOME MEMBRANE; MALE; MEMBRANE PERMEABILITY; NEPHROTIC SYNDROME; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN URINE LEVEL; PROTEINURIA; SUPERNATANT; YOUNG ADULT; ADOLESCENT; CELL LINE; EPITHELIUM CELL; INTRACELLULAR MEMBRANE; KIDNEY TUBULE; LYSOSOME; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; PHYSIOLOGY; ULTRASTRUCTURE;

ADOLESCENT; ADULT; CATHEPSINS; CELL LINE; EPITHELIAL CELLS; FEMALE; HUMANS; INTRACELLULAR MEMBRANES; KIDNEY TUBULES; LYSOSOMES; MALE; OVALBUMIN; OXIDATIVE STRESS; PERMEABILITY; PROTEINURIA; YOUNG ADULT;

EID: 84930884517     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00383.2014     Document Type: Article

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