A functional SNP in MIR124-1, a brain expressed miRNA gene, is associated with aggressiveness in a Colombian sample

European Psychiatry

Volumn 30, Issue 4, 2015, Pages 499-503

  Gonzalez Giraldo Y ^a   Camargo, A ^b   Lopez Leon S ^c   Adan, A ^d,e   Forero, D A ^a  

^a CENTRO DE INVESTIGACIONES   (Colombia)

^b UNIVERSIDAD DE CIENCIAS APLICADAS Y AMBIENTALES   (Colombia)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSITY OF BARCELONA   (Spain)

^e Institute for Brain Cognition and Behavior (IR3C)   (Spain)

Author keywords

Aggression; Endophenotypes; Latin America; NcRNAs; Psychiatric genetics; Violence

Indexed keywords

MICRORNA 124; MICRORNA; MIRN124 MICRORNA, HUMAN;

ADULT; AGGRESSIVENESS; ARTICLE; BARRATT IMPULSIVENESS SCALE; COLOMBIA; COLOMBIAN; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IMPULSIVENESS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; AGGRESSION; BRAIN CHEMISTRY; GENETIC ASSOCIATION STUDY; GENETIC POLYMORPHISM; GENETICS; PSYCHOLOGY; VIOLENCE; YOUNG ADULT;

ADULT; AGGRESSION; BRAIN CHEMISTRY; COLOMBIA; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MICRORNAS; POLYMORPHISM, GENETIC; SURVEYS AND QUESTIONNAIRES; VIOLENCE; YOUNG ADULT;

EID: 84930872325     PISSN: 09249338     EISSN: 17783585     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2015.03.002     Document Type: Article

References (47)

1. Alaerts M., Ceulemans S., Forero D., Moens L.N., De Zutter S., Heyrman L., et al. Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population. Am J Med Genet B Neuropsychiatr Genet 2009, 150B:585-592.
2. Anholt R.R., Mackay T.F. Genetics of aggression. Annu Rev Genet 2012, 46:145-164.
3. Bahi A., Dreyer J.L. Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption. Eur J Neurosci 2013, 38:2328-2337.
4. Bahi A., Chandrasekar V., Dreyer J.L. Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology 2014, 46:78-87.
5. Benitez B.A., Forero D.A., Arboleda G.H., Granados L.A., Yunis J.J., Fernandez W., et al. Exploration of genetic susceptibility factors for Parkinson's disease in a South American sample. J Genet 2010, 89:229-232.
6. Beskow L.M., Burke W., Merz J.F., Barr P.A., Terry S., Penchaszadeh V.B., et al. Informed consent for population-based research involving genetics. JAMA 2001, 286:2315-2321.
7. Bryant F.B., Smith B.D. Refining the architecture of aggression: a measurement model for the Buss-Perry Aggression Questionnaire. J Res Pers 2001, 35:138-167.
8. Buss A.H., Perry M. The aggression questionnaire. J Pers Soc Psychol 1992, 63:452.
9. Chandrasekar V., Dreyer J.L. microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. Mol Cell Neurosci 2009, 42:350-362.
10. El-Kordi A., Kastner A., Grube S., Klugmann M., Begemann M., Sperling S., et al. A single gene defect causing claustrophobia. Transl Psychiatry 2013, 3:e254.
11. Forero D.A., Arboleda G., Yunis J.J., Pardo R., Arboleda H. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients. J Neural Transm 2006, 113:1253-1262.
12. Forero D.A., van der Ven K., Callaerts P., Del-Favero J. miRNA genes and the brain: implications for psychiatric disorders. Hum Mutat 2010, 31:1195-1204.
13. Forero D.A., Velez-van-Meerbeke A., Deshpande S.N., Nicolini H., Perry G. Neuropsychiatric genetics in developing countries: current challenges. World J Psychiatry 2014, 4:69-71.
14. Forero D.A., Lopez-Leon S., Shin H.D., Park B.L., Kim D.J. Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. Drug Alcohol Depend 2015, 149:259-263.
15. Gallardo-Pujol D., Kramp U., Garcia-Forero C., Perez-Ramirez M., Andres-Pueyo A. Assessing aggressiveness quickly and efficiently: the Spanish adaptation of Aggression Questionnaire-refined version. Eur Psychiatry 2006, 21:487-494.
16. Gao F.B. Context-dependent functions of specific microRNAs in neuronal development. Neural Dev 2010, 5:25.
17. Gascon E., Lynch K., Ruan H., Almeida S., Verheyden J.M., Seeley W.W., et al. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med 2014, 20:1444-1451.
18. Gong Y., Wu C.N., Xu J., Feng G., Xing Q.H., Fu W., et al. Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets. Eur Neuropsychopharmacol 2013, 23:1182-1189.
19. Herbert H.K., Hyder A.A., Butchart A., Norton R. Global health: injuries and violence. Infect Dis Clin North Am 2011, 25:653-668. x.
20. Hernandez H.G., Tse M.Y., Pang S.C., Arboleda H., Forero D.A. Optimizing methodologies for PCR-based DNA methylation analysis. Biotechniques 2013, 55:181-197.
21. International HapMap C., Altshuler D.M., Gibbs R.A., Peltonen L., Altshuler D.M., Gibbs R.A., et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010, 467:52-58.
22. Jensen K.P., Covault J., Conner T.S., Tennen H., Kranzler H.R., Furneaux H.M. A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry 2009, 14:381-389.
23. Karolchik D., Barber G.P., Casper J., Clawson H., Cline M.S., Diekhans M., et al. The UCSC Genome Browser database: 2014 update. Nucleic Acids Res 2014, 42:D764-D770.
24. Kovacs-Nagy R., Elek Z., Szekely A., Nanasi T., Sasvari-Szekely M., Ronai Z. Association of aggression with a novel microRNA binding site polymorphism in the wolframin gene. Am J Med Genet B Neuropsychiatr Genet 2013, 162B:404-412.
25. Liang Y., Ridzon D., Wong L., Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 2007, 8:166.
26. Lozano R., Naghavi M., Foreman K., Lim S., Shibuya K., Aboyans V., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380:2095-2128.
27. Makeyev E.V., Zhang J., Carrasco M.A., Maniatis T. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 2007, 27:435-448.
28. Mann J.J., Arango V.A., Avenevoli S., Brent D.A., Champagne F.A., Clayton P., et al. Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry 2009, 65:556-563.
29. Miles D.R., Carey G. Genetic and environmental architecture of human aggression. J Pers Soc Psychol 1997, 72:207-217.
30. Morales L.C., Arboleda G., Rodriguez Y., Forero D.A., Ramirez N., Yunis J.J., et al. Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients. Am J Med Genet A 2009, 149A:2695-2699.
31. Murray C.J., Lopez A.D. Measuring the global burden of disease. N Engl J Med 2013, 369:448-457.
32. Murray C.J., Vos T., Lozano R., Naghavi M., Flaxman A.D., Michaud C., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380:2197-2223.
33. Ojeda D.A., Perea C.S., Nino C.L., Gutierrez R.M., Lopez-Leon S., Arboleda H., et al. A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales. Neurosci Lett 2013, 553:52-56.
34. Ojeda D.A., Perea C.S., Suarez A., Nino C.L., Gutierrez R.M., Lopez-Leon S., et al. Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample. Neurol Sci 2014, 35:41-47.
35. Ojeda D.A., Lopez-Leon S., Forero D.A. A novel cost-effective assay based on real-time PCR for COMT Val158Met genotyping. Biomarkers 2014, 19:567-570.
36. Orozco-Cabal L., Rodriguez M., Herin D.V., Gempeler J., Uribe M. Validity and reliability of the abbreviated Barratt Impulsiveness Scale in Spanish (BIS-15S). Rev Colomb Psiquiatr 2010, 39:93-109.
37. Patton G.C., Coffey C., Sawyer S.M., Viner R.M., Haller D.M., Bose K., et al. Global patterns of mortality in young people: a systematic analysis of population health data. Lancet 2009, 374:881-892.
38. Qi L., Hu Y., Zhan Y., Wang J., Wang B.B., Xia H.F., et al. A SNP site in pri-miR-124 changes mature miR-124 expression but no contribution to Alzheimer's disease in a Mongolian population. Neurosci Lett 2012, 515:1-6.
39. Sharan P., Gallo C., Gureje O., Lamberte E., Mari J.J., Mazzotti G., et al. Mental health research priorities in low- and middle-income countries of Africa, Asia, Latin America and the Caribbean. Br J Psychiatry 2009, 195:354-363.
40. Siever L.J. Neurobiology of aggression and violence. Am J Psychiatry 2008, 165:429-442.
41. Smarr K.L., Keefer A.L. Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Arthritis Care Res 2011, 63(Suppl. 11):S454-S466.
42. Sole X., Guino E., Valls J., Iniesta R., Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 2006, 22:1928-1929.
43. Spinella M. Normative data and a short form of the Barratt Impulsiveness Scale. Int J Neurosci 2007, 117:359-368.
44. Strazisar M., Cammaerts S., van der Ven K., Forero D.A., Lenaerts A.S., Nordin A., et al. MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets. Mol Psychiatry 2014, [Epub ahead of print]. 10.1038/mp.2014.53.
45. Vassos E., Collier D.A., Fazel S. Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry 2014, 19:471-477.
46. Vlachos I.S., Paraskevopoulou M.D., Karagkouni D., Georgakilas G., Vergoulis T., Kanellos I., et al. DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions. Nucleic Acids Res 2015, 43:D153-D159.
47. Yang L., Zhang R., Li M., Wu X., Wang J., Huang L., et al. A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance. PloS One 2014, 9:e107065.