Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 308, Issue 10, 2015, Pages H1298-H1305

  Kameshima, Satoshi ^a   Kazama, Kyosuke ^a   Okada, Muneyoshi ^a   Yamawaki, Hideyuki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Eukaryotic elongation factor 2 kinase; Matrix metalloproteinase; Pulmonary hypertension; Reactive oxygen species; Vascular remodeling

Indexed keywords

A 484954; ELONGATION FACTOR 2 KINASE; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCROTALINE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; UNCLASSIFIED DRUG; A-484954; EEF2K PROTEIN, RAT; MMP2 PROTEIN, RAT; OXIDOREDUCTASE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VIVO STUDY; LUNG ARTERY PRESSURE; MALE; MONOCROTALINE-INDUCED PULMONARY HYPERTENSION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; VASCULAR REMODELING; VASCULAR RESISTANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; HYPERTENSION, PULMONARY; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; ELONGATION FACTOR 2 KINASE; HYPERTENSION, PULMONARY; MALE; MATRIX METALLOPROTEINASE 2; MONOCROTALINE; NADH, NADPH OXIDOREDUCTASES; PYRIDINES; PYRIMIDINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; VASCULAR REMODELING;

EID: 84930827547     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00864.2014     Document Type: Article

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