Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 5, 2013, Pages

  Usui, Tatsuya ^a   Okada, Muneyoshi ^a   Hara, Yukio ^a   Yamawaki, Hideyuki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Hypertension; Inflammation; Reactive oxygen species; Signal transduction; Vasoconstriction

Indexed keywords

1 BENZYL 3 CETYL 2 METHYLIMIDAZOLIUM IODIDE; 7 AMINO 1 CYCLOPROPYL 3 ETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D] PYRIMIDINE 6 CARBOXAMIDE; A 484954; ACETYLCHOLINE; ELONGATION FACTOR 2 KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NH 125; NORADRENALIN; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART RATE; HUMAN; HUMAN CELL; HYPERTENSION; INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SUPERIOR MESENTERIC ARTERY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; WESTERN BLOTTING;

HYPERTENSION; INFLAMMATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELONGATION FACTOR 2 KINASE; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION; IMIDAZOLES; MALE; MAP KINASE KINASE 4; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1; VASCULITIS;

EID: 84883427428     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00373.2013     Document Type: Article

References (43)

1. Amoureux S, Lorgis L, Sicard P, Girard C, Rochette L, Vergely C. Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension. Fundam Clin Pharmacol 26: 227-234, 2012.
2. Arora S, Yang JM, Kinzy TG, Utsumi R, Okamoto T, Kitayama T, Ortiz PA, Hait WN. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res 63: 6894-6899, 2003.
3. Arora S, Yang JM, Utsumi R, Okamoto T, Kitayama T, Hait WN. P-glycoprotein mediates resistance to histidine kinase inhibitors. Mol Pharmacol 66: 460-467, 2004.
4. Bagaglio DM, Cheng EH, Gorelick FS, Mitsui K, Nairn AC, Hait WN. Phosphorylation of elongation factor 2 in normal and malignant rat glial cells. Cancer Res 53: 2260-2264, 1993.
5. Bagaglio DM, Hait WN. Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells. Cell Growth Differ 5: 1403-1408, 1994.
6. Bucher B, Travo P, Stoclet JC. Smooth muscle cell hypertrophy and hyperplasia in the thoracic aorta of spontaneously hypertensive rats. Cell Biol Int Rep 8: 567-577, 1984.
7. 2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells. Biochem Biophys Res Commun 180: 1372-1376, 1991.
8. Ceolotto G, Gallo A, Papparella I, Franco L, Murphy E, Iori E, Pagnin E, Fadini GP, Albiero M, Semplicini A, Avogaro A. Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism. Arterioscler Thromb Vasc Biol 27: 2627-2633, 2007.
9. Chen Z, Gopalakrishnan SM, Bui MH, Soni NB, Warrior U, Johnson EF, Donnelly JB, Glaser KB. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem 286: 43951-43958, 2011.
10. Cheng EH, Gorelick FS, Czernik AJ, Bagaglio DM, Hait WN. Calmodulin-dependent protein kinases in rat glioblastoma. Cell Growth Differ 6: 615-621, 1995.
11. Daniel EE, Kwan CY, Lee RM, Smeda J. Early structural changes in precapillary vessels in hypertension and their relationship to functional changes. J Cardiovasc Pharmacol 6, Suppl 4: S671-S682, 1984.
12. Glowinska B, Urban M, Peczynska J, Florys B. Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes. Metabolism 54: 1020-1026, 2005.
13. Hait WN, Wu H, Jin S, Yang JM. Elongation factor-2 kinase: its role in protein synthesis and autophagy. Autophagy 2: 294-296, 2006.
14. House SJ, Ginnan RG, Armstrong SE, Singer HA. Calcium/calmodulin-dependent protein kinase II-δ isoform regulation of vascular smooth muscle cell proliferation. Am J Physiol Cell Physiol 292: C2276-C2287, 2007.
15. Jozwiak J, Jozwiak S, Grzela T, Lazarczyk M. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular Med 7: 287-296, 2005.
16. Knebel A, Haydon CE, Morrice N, Cohen P. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and-insensitive pathways. Biochem J 367: 525-532, 2002.
17. Koeners MP, Braam B, Joles JA. Perinatal inhibition of NF-kappaB has long-term antihypertensive effects in spontaneously hypertensive rats. J Hypertens 29: 1160-1166, 2011.
18. Lee HM, Kim HJ, Won KJ, Choi WS, Park SH, Song H, Park PJ, Park TK, Lee CK, Kim B. Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells. J Vasc Res 45: 259-268, 2008.
19. Li H, Li W, Gupta AK, Mohler PJ, Anderson ME, Grumbach IM. Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy. Am J Physiol Heart Circ Physiol 298: H688-H698, 2010.
20. Li L, Yi-Ming W, Li ZZ, Zhao L, Yu YS, Li DJ, Xia CY, Liu JG, Su DF. Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats. Pharmacol Res 58: 196-201, 2008.
21. 2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21. J Biol Chem 286: 7990-7999, 2011.
22. Liang CJ, Wang SH, Chen YH, Chang SS, Hwang TL, Leu YL, Tseng YC, Li CY, Chen YL. Viscolin reduces VCAM-1 expression in TNFalpha-treated endothelial cells via the JNK/NF-kappaB and ROS pathway. Free Radic Biol Med 51: 1337-1346, 2011.
23. Luscher TF. [Hypertension and vascular diseases: molecular and cellular mechanisms]. Schweiz Med Wochenschr 125: 270-282, 1995.
24. 2-dependent regulation of vascular smooth muscle cell polarization and migration. Am J Physiol Cell Physiol 294: C1465-C1475, 2008.
25. Morita T, Okada M, Hara Y, Yamawaki H. Mechanisms underlying impairment of endothlium-dependent relaxation by fetal bovine serum in organ-cultured rat mesenteric artery. Eur J Pharmacol 668: 401-406, 2011.
26. Mukohda M, Okada M, Hara Y, Yamawaki H. Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats. J Pharmacol Sci 120: 26-35, 2012.
27. Orr AW, Hastings NE, Blackman BR, Wamhoff BR. Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res 47: 168-180, 2010.
28. Paravicini TM, Touyz RM. Redox signaling in hypertension. Cardiovasc Res 71: 247-258, 2006.
29. Parissis JT, Venetsanou KF, Mentzikof DG, Kalantzi MV, Georgopoulou MV, Chrisopoulos N, Karas SM. Plasma levels of soluble cellular adhesion molecules in patients with arterial hypertension. Correlations with plasma endothelin-1. Eur J Intern Med 12: 350-356, 2001.
30. Parmer TG, Ward MD, Yurkow EJ, Vyas VH, Kearney TJ, Hait WN. Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer. Br J Cancer 79: 59-64, 1999.
31. Pavur KS, Petrov AN, Ryazanov AG. Mapping the functional domains of elongation factor-2 kinase. Biochemistry 39: 12216-12224, 2000.
32. Pyr Dit Ruys S, Wang X, Smith EM, Herinckx G, Hussain N, Rider MH, Vertommen D, Proud CG. Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J 442: 681-692, 2012.
33. Ryazanov AG, Shestakova EA, Natapov PG. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature 334: 170-173, 1988.
34. Smith EM, Proud CG. cdc2-Cyclin B regulates eEF2 kinase activity in a cell cycle-and amino acid-dependent manner. EMBO J 27: 1005-1016, 2008.
35. Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A. Treatment with the cytochrome P450 omega-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. Br J Pharmacol 168: 1878-1888, 2013.
36. Usui T, Okada M, Hara Y, Yamawaki H. Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats. Hypertension 60: 1031-1039, 2012.
37. Usui T, Okada M, Hara Y, Yamawaki H. Exploring calmodulin-related proteins, which mediate development of hypertension, in vascular tissues of spontaneous hypertensive rats. Biochem Biophys Res Commun 405: 47-51, 2011.
38. Usui T, Okada M, Mizuno W, Oda M, Ide N, Morita T, Hara Y, Yamawaki H. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. Am J Physiol Heart Circ Physiol 302: H1894-H1904, 2012.
39. Usui T, Yamawaki H, Kamibayashi M, Okada M, Hara Y. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci 113: 182-191, 2010.
40. 2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells. J Pharmacol Sci 113: 214-223, 2010.
41. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 20: 4370-4379, 2001.
42. Wu H, Yang JM, Jin S, Zhang H, Hait WN. Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 66: 3015-3023, 2006.
43. Wu H, Zhu H, Liu DX, Niu TK, Ren X, Patel R, Hait WN, Yang JM. Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res 69: 2453-2460, 2009.