Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage

Osteoarthritis and Cartilage

Volumn 23, Issue 7, 2015, Pages 1214-1220

  Kobayashi, T ^a   Papaioannou, G ^a   Mirzamohammadi, F ^a   Kozhemyakina, E ^a   Zhang, M ^a,b   Blelloch, R ^c   Chong, M W ^d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Articular cartilage; Chondrocyte; Drosha; MicroRNA; Osteoarthritis; Prg4

Indexed keywords

CRE RECOMBINASE; MICRORNA; PROTEIN DGCR8; PROTEIN DROSHA; RIBONUCLEASE III; TAMOXIFEN; UNCLASSIFIED DRUG; DGCR8 PROTEIN, MOUSE; DROSHA PROTEIN, MOUSE; RNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE DEFECT; BONE DEVELOPMENT; BONE EROSION; CARTILAGE CELL; CELL DEATH; CHONDROPATHY; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; GENE DELETION; GENE FUNCTION; GENETIC ANALYSIS; GROWTH PLATE; MALE; MOUSE; MOUSE MODEL; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SYNTHESIS; SEX DIFFERENCE; TRANSGENIC MOUSE; ANIMAL; BONE DYSPLASIA; CHONDROCYTE; DEFICIENCY; ENZYMOLOGY; EPIPHYSIS PLATE; EXPERIMENTAL ARTHRITIS; GENETICS; KNOCKOUT MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BONE DISEASES, DEVELOPMENTAL; CARTILAGE, ARTICULAR; CELL DEATH; CHONDROCYTES; FEMALE; GENE DELETION; GROWTH PLATE; MALE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICRORNAS; OSTEOARTHRITIS; RIBONUCLEASE III; RNA-BINDING PROTEINS; TAMOXIFEN;

EID: 84930820168     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.02.015     Document Type: Article

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