Cachexia and sarcopenia: Mechanisms and potential targets for intervention

Current Opinion in Pharmacology

Volumn 22, Issue , 2015, Pages 100-106

  Argilés, Josep M ^a   Busquets, Silvia ^a   Stemmler, Britta ^b   López Soriano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BSA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR ANTAGONIST; BETA HYDROXY BETA METHYLBUTYRIC ACID; BUTYRIC ACID; CORTICOSTEROID; ESPINDOLOL; GESTAGEN; INTERLEUKIN 6; LEUCINE; SELECTIVE ANDROGEN RECEPTOR ANTAGONIST; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANOREXIA; CACHEXIA; DIET SUPPLEMENTATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEREDITY; HUMAN; HYPERMETABOLISM; MUSCLE ATROPHY; MUSCLE FUNCTION; MUSCLE STRENGTH; NONHUMAN; NUTRITIONAL STATUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RESISTANCE TRAINING; REVIEW; SARCOPENIA; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ADIPOSE TISSUE; AGING; ANIMAL; COMPLICATION; INFLAMMATION; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPOSE TISSUE; AGING; ANIMALS; CACHEXIA; HUMANS; INFLAMMATION; MUSCLE, SKELETAL; NEOPLASMS; OXIDATIVE STRESS; SARCOPENIA;

EID: 84930819525     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.04.003     Document Type: Review

References (49)

1. W.J. Evans, J.E. Morley, J. Argiles, C. Bales, V. Baracos, D. Guttridge, A. Jatoi, K. Kalantar-Zadeh, H. Lochs, and G. Mantovani Cachexia: a new definition Clin Nutr 27 2008 793 799
2. J.M. Argilés, S.D. Anker, W.J. Evans, J.E. Morley, K.C.H. Fearon, F. Strasser, M. Muscaritoli, and V.E. Baracos Consensus on cachexia definitions J Am Med Dir Assoc 11 2010 229 230
3. K. Fearon, F. Strasser, S.D. Anker, I. Bosaeus, E. Bruera, R.L. Fainsinger, A. Jatoi, C. Loprinzi, N. MacDonald, and G. Mantovani Definition and classification of cancer cachexia: an international consensus Lancet Oncol 12 2011 489 495
4. M. Muscaritoli, S.D. Anker, J. Argiles, Z. Aversa, J.M. Bauer, G. Biolo, Y. Boirie, I. Bosaeus, T. Cederholm, and P. Costelli Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics" Clin Nutr 29 2010 154 159
5. A.J. Cruz-Jentoft, J.P. Baeyens, J.M. Bauer, Y. Boirie, T. Cederholm, F. Landi, F.C. Martin, J.-P. Michel, Y. Rolland, and S.M. Schneider Sarcopenia: European consensus on definition and diagnosis: report of the European Working Grop on Sarcopenia in Older People Age Ageing 39 2010 412 423
6. J.E. Morley, A.M. Abbatecola, J.M. Argiles, V. Baracos, J. Bauer, S. Bhasin, T. Cederholm, A.J.S. Coats, S.R. Cummings, and W.J. Evans Sarcopenia with limited mobility: an international consensus J Am Med Dir Assoc 12 2011 403 409
7. C.M.M. Prado, J.R. Lieffers, L.J. McCargar, T. Reiman, M.B. Sawyer, L. Martin, and V.E. Baracos Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study Lancet Oncol 9 2008 629 635
8. G. Biolo, T. Cederholm, and M. Muscaritoli Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia Clin Nutr 33 2014 737 748
9. R. Sambasivan, and S. Tajbakhsh Adult skeletal muscle stem cells Results Probl Cell Differ 56 2015 191 213
10. J.M. Argilés, S. Busquets, B. Stemmler, and F.J. López-Soriano Cancer cachexia: understanding the molecular basis Nat Rev Cancer 14 2014 754 762
11. D.A. Rivas, S.J. Lessard, N.P. Rice, M.S. Lustgarten, K. So, L.J. Goodyear, L.D. Parnell, and R.A. Fielding Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling FASEB J 2014 10.1096/fj.14-254490
12. N. Tardif, J. Salles, C. Guillet, J. Tordjman, S. Reggio, J.-F. Landrier, C. Giraudet, V. Patrac, J. Bertrand-Michel, and C. Migne Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation Aging Cell 13 2014 1001 1011
13. A.M. Shum, T. Mahendradatta, R.J. Taylor, A.B. Painter, M.M. Moore, M. Tsoli, T.C. Tan, S.J. Clarke, G.R. Robertson, and P. Polly Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting Aging (Albany NY) 4 2012 133 143
14. C.M. Julienne, J.-F. Dumas, C. Goupille, M. Pinault, C. Berri, A. Collin, S. Tesseraud, C. Couet, and S. Servais Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency J Cachexia Sarcopenia Muscle 3 2012 265 275
15. D. Sanchís, S. Busquets, B. Alvarez, D. Ricquier, F.J. López-Soriano, and J.M. Argilés Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model FEBS Lett 436 1998 415 418
16. C. Constantinou, C.C. Fontes de Oliveira, D. Mintzopoulos, S. Busquets, J. He, M. Kesarwani, M. Mindrinos, L.G. Rahme, J.M. Argilés, and A.A. Tzika Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia Int J Mol Med 27 2011 15 24
17. A.A. Tzika, C.C. Fontes-Oliveira, A.A. Shestov, C. Constantinou, N. Psychogios, V. Righi, D. Mintzopoulos, S. Busquets, F.J. Lopez-Soriano, and S. Milot Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model Int J Oncol 43 2013 886 894
18. D. Antunes, A.I. Padrão, E. Maciel, D. Santinha, P. Oliveira, R. Vitorino, D. Moreira-Gonçalves, B. Colaço, M.J. Pires, and C. Nunes Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting Biochim Biophys Acta 1841 2014 896 905
19. X. Wang, A.M. Pickrell, T.A. Zimmers, and C.T. Moraes Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia PLoS One 7 2012 e33426
20. F. Okada Inflammation and free radicals in tumor development and progression Redox Rep 7 2002 357 368
21. J.M. Argilés, C.C. Fontes-Oliveira, G. Fuster, E. Ametller, M. Figueras, M. Olivan, F.J. Lopez-Soriano, X. Qu, J. Demuth, and P. Stevens Patterns of gene expression in muscle and fat in tumor-bearing rats: effects of CRF2R agonist on cachexia Muscle Nerve 42 2010 936 949
22. N. Fortunati, R. Manti, N. Birocco, M. Pugliese, E. Brignardello, L. Ciuffreda, M.G. Catalano, M. Aragno, and G. Boccuzzi Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients Oncol Rep 18 2007 1521 1527
23. A.I. Padrão, P. Oliveira, R. Vitorino, B. Colaço, M.J. Pires, M. Márquez, E. Castellanos, M.J. Neuparth, C. Teixeira, and C. Costa Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity Int J Biochem Cell Biol 45 2013 1399 1409
24. V. Romanello, and M. Sandri Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles J Mol Cell Cardiol 55 2013 64 72
25. S. Venkatesh, J. Lee, K. Singh, I. Lee, and C.K. Suzuki Multitasking in the mitochondrion by the ATP-dependent Lon protease Biochim Biophys Acta 1823 2012 56 66
26. A.R. Konopka, and K. Sreekumaran Nair Mitochondrial and skeletal muscle health with advancing age Mol Cell Endocrinol 379 2013 19 29
27. R.T. Hepple Mitochondrial involvement and impact in aging skeletal muscle Front Aging Neurosci 6 2014 211
28. M.R. Beltran Valls, D.J. Wilkinson, M.V. Narici, K. Smith, B.E. Phillips, D. Caporossi, and P.J. Atherton Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia J Gerontol A: Biol Sci Med Sci 70 2015 174 181 10.1093/gerona/glu007
29. V.B. Vays, C.M. Eldarov, I.M. Vangely, N.G. Kolosova, L.E. Bakeeva, and V.P. Skulachev Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure [Internet] Aging (Albany, NY) 6 2014 140 148
30. G. Gouspillou, I. Bourdel-Marchasson, R. Rouland, G. Calmettes, M. Biran, V. Deschodt-Arsac, S. Miraux, E. Thiaudiere, P. Pasdois, and D. Detaille Mitochondrial energetics is impaired in vivo in aged skeletal muscle Aging Cell 13 2014 39 48
31. G. Gouspillou, N. Sgarioto, S. Kapchinsky, F. Purves-Smith, B. Norris, C.H. Pion, S. Barbat-Artigas, F. Lemieux, T. Taivassalo, and J.A. Morais Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans FASEB J 28 2014 1621 1633
32. J.M. Argilés, S. Busquets, and F.J. López-Soriano The role of uncoupling proteins in pathophysiological states Biochem Biophys Res Commun 293 2002 1145 1152
33. J.M. Argilés, C.C. Fontes-Oliveira, M. Toledo, F.J. López-Soriano, and S. Busquets Cachexia: a problem of energetic inefficiency J Cachexia Sarcopenia Muscle 5 2014 279 286 10.1007/s13539-014-0154-x
34. B. Szczesny, G. Olah, D.K. Walker, E. Volpi, B.B. Rasmussen, C. Szabo, and S. Mitra Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage PLoS One 8 2013 e75201
35. P. Puigserver, J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C.Y. Zhang, S. Krauss, V.K. Mootha, B.B. Lowell, and B.M. Spiegelman Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1 Mol Cell 8 2001 971 982
36. J.P. White, M.J. Puppa, S. Sato, S. Gao, R.L. Price, J.W. Baynes, M.C. Kostek, L.E. Matesic, and J.A. Carson IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse Skelet Muscle 2 2012 14
37. K.A. Baltgalvis, F.G. Berger, M.M.O. Pena, J.M. Davis, S.J. Muga, and J.A. Carson Interleukin-6 and cachexia in ApcMin/+ mice Am J Physiol Regul Integr Comp Physiol 294 2008 R393 R401
38. J.D. Walston, A.M. Matteini, C. Nievergelt, L.A. Lange, D.M. Fallin, N. Barzilai, E. Ziv, L. Pawlikowska, P. Kwok, and S.R. Cummings Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults Exp Gerontol 44 2009 350 355
39. J.M. Argilés, S. Busquets, A. Felipe, and F.J. López-Soriano Muscle wasting in cancer and ageing: cachexia versus sarcopenia Adv. Gerontol. [Uspekhi Gerontol./Ross. Akad. Nauk. Gerontol. Obs.] 18 2006 39 54
40. M. Michaud, L. Balardy, G. Moulis, C. Gaudin, C. Peyrot, B. Vellas, M. Cesari, and F. Nourhashemi Proinflammatory cytokines, aging, and age-related diseases J Am Med Dir Assoc 14 2013 877 882
41. M.D. Grounds Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling Biogerontology 3 2002 19 24
42. H. Wakabayashi, and K. Sakuma Comprehensive approach to sarcopenia treatment Curr Clin Pharmacol 9 2014 171 180
43. A.J. Cruz-Jentoft, F. Landi, S.M. Schneider, C. Zuniga, H. Arai, Y. Boirie, L.-K. Chen, R.A. Fielding, F.C. Martin, and J.-P. Michel Prevalence of and interventions for sarcopenia in ageing adults: a systematic review Report of the International Sarcopenia Initiative (EWGSOP and IWGS) Age Ageing 43 2014 748 759
44. K. Sakuma, and A. Yamaguchi Novel intriguing strategies attenuating to sarcopenia J Aging Res 2012 2012 251217
45. A. Wagatsuma, and K. Sakuma Vitamin D signaling in myogenesis: potential for treatment of sarcopenia Biomed Res Int 2014 2014 121254
46. K. Tanaka, I. Kanazawa, T. Yamaguchi, S. Yano, H. Kaji, and T. Sugimoto Active vitamin D possesses beneficial effects on the interaction between muscle and bone Biochem Biophys Res Commun 450 2014 482 487
47. J.M. Argilés, A. Anguera, and B. Stemmler A new look at an old drug for the treatment of cancer cachexia: megestrol acetate Clin Nutr 32 2013 319 324
48. N. Ebner, L. Steinbeck, W. Doehner, S.D. Anker, and S. von Haehling Highlights from the 7th Cachexia Conference: muscle wasting pathophysiological detection and novel treatment strategies J Cachexia Sarcopenia Muscle 5 2014 27 34
49. J.M. Argilés, S. Busquets, F.J. López-Soriano, P. Costelli, and F. Penna Are there any benefits of exercise training in cancer cachexia? J Cachexia Sarcopenia Muscle 3 2012 73 76