The Predictive Value of Platelet Function Point-of-Care Tests for Postoperative Blood Loss and Transfusion in Routine Cardiac Surgery: A Systematic Review

Thoracic and Cardiovascular Surgeon

Volumn 63, Issue 1, 2015, Pages 2-20

  Petricevic, Mate ^a   Kopjar, Tomislav ^a   Biocina, Bojan ^a   Milicic, Davor ^b   Kolic, Kresimir ^c   Boban, Marko ^d   Skoric, Bosko ^b   Lekic, Ante ^a   Gasparovic, Hrvoje ^a  

^a KBC Zagreb   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c UNIVERSITY OF SPLIT   (Croatia)

^d UNIVERSITY OF RIJEKA   (Croatia)

Author keywords

blood; blood transfusion; coagulation anticoagulation; coronary artery bypass grafts surgery

Indexed keywords

ASSAY; BLEEDING; BLOOD CLOTTING PARAMETERS; BLOOD TRANSFUSION; CORONARY ARTERY BYPASS GRAFT; EX VIVO STUDY; HUMAN; PERIOPERATIVE PERIOD; POINT OF CARE TESTING; POSTOPERATIVE HEMORRHAGE; PREDICTIVE VALUE; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; THROMBOCYTE FUNCTION; FORECASTING; HEART SURGERY; HOSPITAL INFORMATION SYSTEM; PHYSIOLOGIC MONITORING;

BLOOD TRANSFUSION; CARDIAC SURGICAL PROCEDURES; CORONARY ARTERY BYPASS; FORECASTING; HUMANS; MONITORING, PHYSIOLOGIC; PERIOPERATIVE PERIOD; PLATELET FUNCTION TESTS; POINT-OF-CARE SYSTEMS; POSTOPERATIVE HEMORRHAGE;

EID: 84930767108     PISSN: 01716425     EISSN: 14391902     Source Type: Journal    
DOI: 10.1055/s-0034-1378191     Document Type: Review

References (62)

1. Whitlock R., Crowther M. A., Ng H. J. Bleeding in cardiac surgery: its prevention and treatment-an evidence-based review. Crit Care Clin: 2005; 21 3 589 610
2. Christensen M. C., Dziewior F., Kempel A., von Heymann C. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth: 2012; 26 1 46 51
3. Dixon B., Santamaria J. D., Reid D., et al. The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME). Transfusion: 2013; 53 1 19 27
4. Biancari F., Mikkola R., Heikkinen J., Lahtinen J., Kettunen U., Juvonen T. Individual surgeon's impact on the risk of re-exploration for excessive bleeding after coronary artery bypass surgery. J Cardiothorac Vasc Anesth: 2012; 26 4 550 556
5. O'Donnell C. J., Larson M. G., Feng D., et al. Framingham Heart Study. Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation: 2001; 103 25 3051 3056
6. Ben-Dor I., Kleiman N. S., Lev E. Assessment, mechanisms, and clinical implication of variability in platelet response to aspirin and clopidogrel therapy. Am J Cardiol: 2009; 104 2 227 233
7. Mehta R. H., Roe M. T., Mulgund J., et al. Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery. J Am Coll Cardiol: 2006; 48 2 281 286
8. Spiess B. D., Tuman K. J., McCarthy R. J., DeLaria G. A., Schillo R., Ivankovich A. D. Thromboelastography as an indicator of post-cardiopulmonary bypass coagulopathies. J Clin Monit: 1987; 3 1 25 30
9. Ti L. K., Cheong K. F., Chen F. G. Prediction of excessive bleeding after coronary artery bypass graft surgery: the influence of timing and heparinase on thromboelastography. J Cardiothorac Vasc Anesth: 2002; 16 5 545 550
10. Velik-Salchner C., Maier S., Innerhofer P., et al. An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study. Anesth Analg: 2009; 108 6 1747 1754
11. Fitchett D., Mazer C. D., Eikelboom J., Verma S. Antiplatelet therapy and cardiac surgery: review of recent evidence and clinical implications. Can J Cardiol: 2013; 29 9 1042 1047
12. Smith P. K., Goodnough L. T., Levy J. H., et al. Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis. J Am Coll Cardiol: 2012; 60 5 388 396
13. Jernberg T., Payne C. D., Winters K. J., et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J: 2006; 27 10 1166 1173
14. Bhatt D. L., Stone G. W., Mahaffey K. W., et al. CHAMPION PHOENIX Investigators. Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med: 2013; 368 14 1303 1313
15. Angiolillo D. J., Firstenberg M. S., Price M. J., et al. BRIDGE Investigators. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. JAMA: 2012; 307 3 265 274
16. Casutt M., Konrad C., Schuepfer G. Effect of rivaroxaban on blood coagulation using the viscoelastic coagulation test ROTEM™ Anaesthesist: 2012; 61 11 948 953
17. Nascimento B., Rizoli S., Rubenfeld G., Lin Y., Callum J., Tien H. C. Design and preliminary results of a pilot randomized controlled trial on a 1:1:1 transfusion strategy: the trauma formula-driven versus laboratory-guided study. J Trauma: 2011; 71 5 01 S418 S426
18. Paparella D., Brister S. J., Buchanan M. R. Coagulation disorders of cardiopulmonary bypass: a review. Intensive Care Med: 2004; 30 10 1873 1881
19. Jackson G. N., Ashpole K. J., Yentis S. M. The TEG vs the ROTEM thromboelastography/thromboelastometry systems. Anaesthesia: 2009; 64 2 212 215
20. Nielsen V. G. A comparison of the Thrombelastograph and the ROTEM. Blood Coagul Fibrinolysis: 2007; 18 3 247 252
21. Seidel H., Rahman M. M., Scharf R. E. Monitoring of antiplatelet therapy. Current limitations, challenges, and perspectives. Hamostaseologie: 2011; 31 1 41 51
22. Poston R., Gu J., Manchio J., et al. Platelet function tests predict bleeding and thrombotic events after off-pump coronary bypass grafting. Eur J Cardiothorac Surg: 2005; 27 4 584 591
23. Carroll R. C., Chavez J. J., Snider C. C., Meyer D. S., Muenchen R. A. Correlation of perioperative platelet function and coagulation tests with bleeding after cardiopulmonary bypass surgery. J Lab Clin Med: 2006; 147 4 197 204
24. Preisman S., Kogan A., Itzkovsky K., Leikin G., Raanani E. Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgery. Eur J Cardiothorac Surg: 2010; 37 6 1367 1374
25. Kwak Y. L., Kim J. C., Choi Y. S., Yoo K. J., Song Y., Shim J. K. Clopidogrel responsiveness regardless of the discontinuation date predicts increased blood loss and transfusion requirement after off-pump coronary artery bypass graft surgery. J Am Coll Cardiol: 2010; 56 24 1994 2002
26. Weitzel N. S., Weitzel L. B., Epperson L. E., Karimpour-Ford A., Tran Z. V., Seres T. Platelet mapping as part of modified thromboelastography (TEG®) in patients undergoing cardiac surgery and cardiopulmonary bypass. Anaesthesia: 2012; 67 10 1158 1165
27. Mahla E., Suarez T. A., Bliden K. P., et al. Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG (TARGET-CABG) study. Circ Cardiovasc Interv: 2012; 5 2 261 269
28. Dunning J., Versteegh M., Fabbri A., et al. EACTS Audit and Guidelines Committee. Guideline on antiplatelet and anticoagulation management in cardiac surgery. Eur J Cardiothorac Surg: 2008; 34 1 73 92
29. Wright R. S., Anderson J. L., Adams C. D., et al. 2011 ACCF/AHA focused update of the Guidelines for the Management of Patients with Unstable Angina/Non-ST-Elevation Myocardial Infarction (updating the 2007 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol: 2011; 57 19 1920 1959
30. Despotis G. J., Levine V., Filos K. S., et al. Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. Anesthesiology: 1996; 85 6 1311 1323
31. Ereth M. H., Nuttall G. A., Klindworth J. T., et al. Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass? Anesth Analg: 1997; 85 2 259 264
32. Ereth M. H., Nuttall G. A., Santrach P. J., Klindworth J. T., Oliver W. C. Jr, Schaff H. V. The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. Anesthesiology: 1998; 88 4 962 969
33. Dietrich G. V., Schueck R., Menges T., Kiesenbauer N. P., Fruehauf A. C., Marquardt I. Comparison of four methods for the determination of platelet function in whole blood in cardiac surgery. Thromb Res: 1998; 89 6 295 301
34. Wahba A., Sander S., Birnbaum D. E. Are in-vitro platelet function tests useful in predicting blood loss following open heart surgery? Thorac Cardiovasc Surg: 1998; 46 4 228 231
35. Slaughter T. F., Sreeram G., Sharma A. D., El-Moalem H., East C. J., Greenberg C. S. Reversible shear-mediated platelet dysfunction during cardiac surgery as assessed by the PFA-100 platelet function analyzer. Blood Coagul Fibrinolysis: 2001; 12 2 85 93
36. Forestier F., Coiffic A., Mouton C., Ekouevi D., Chêne G., Janvier G. Platelet function point-of-care tests in post-bypass cardiac surgery: are they relevant? Br J Anaesth: 2002; 89 5 715 721
37. Fattorutto M., Pradier O., Schmartz D., Ickx B., Barvais L. Does the platelet function analyser (PFA-100) predict blood loss after cardiopulmonary bypass? Br J Anaesth: 2003; 90 5 692 693
38. Cammerer U., Dietrich W., Rampf T., Braun S. L., Richter J. A. The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery. Anesth Analg: 2003; 96 1 51 57 table of contents
39. Gerrah R., Brill A., Tshori S., Lubetsky A., Merin G., Varon D. Using cone and plate(let) analyzer to predict bleeding in cardiac surgery. Asian Cardiovasc Thorac Ann: 2006; 14 4 310 315
40. Solomon C., Hartmann J., Osthaus A., et al. Platelet concentrates transfusion in cardiac surgery in relation to preoperative point-of-care assessment of platelet adhesion and aggregation. Platelets: 2010; 21 3 221 228
41. Rahe-Meyer N., Winterhalter M., Boden A., et al. Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand: 2009; 53 2 168 175
42. Reece M. J., Klein A. A., Salviz E. A., et al. Near-patient platelet function testing in patients undergoing coronary artery surgery: a pilot study. Anaesthesia: 2011; 66 2 97 103
43. Metz C. E. Basic principles of ROC analysis. Semin Nucl Med: 1978; 8 4 283 298
44. Ranucci M., Baryshnikova E., Soro G., Ballotta A., De Benedetti D., Conti D.; Surgical and Clinical Outcome Research (SCORE) Group. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg: 2011; 91 1 123 129
45. Petricevic M., Biocina B., Milicic D., et al. Bleeding risk assessment using multiple electrode aggregometry in patients following coronary artery bypass surgery. J Thromb Thrombolysis: 2013; 35 1 31 40
46. Petricevic M., Biocina B., Milicic D., et al. Bleeding risk assessment using whole blood impedance aggregometry and rotational thromboelastometry in patients following cardiac surgery. J Thromb Thrombolysis: 2013; 36 4 514 526
47. Weber C. F., Görlinger K., Meininger D., et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology: 2012; 117 3 531 547
48. Schimmer C., Hamouda K., Sommer S. P., Özkur M., Hain J., Leyh R. The predictive value of multiple electrode platelet aggregometry (multiplate) in adult cardiac surgery. Thorac Cardiovasc Surg: 2013; 61 8 733 743
49. Di Dedda U., Ranucci M., Baryshnikova E., Castelvecchio S.; Surgical and Clinical Outcome Research Group. Thienopyridines resistance and recovery of platelet function after discontinuation of thienopyridines in cardiac surgery patients. Eur J Cardiothorac Surg: 2014; 45 1 165 170
50. Alström U., Granath F., Oldgren J., Ståhle E., Tydén H., Siegbahn A. Platelet inhibition assessed with VerifyNow, flow cytometry and PlateletMapping in patients undergoing heart surgery. Thromb Res: 2009; 124 5 572 577
51. Rosengart T. K., Romeiser J. L., White L. J., et al. Platelet activity measured by a rapid turnaround assay identifies coronary artery bypass grafting patients at increased risk for bleeding and transfusion complications after clopidogrel administration. J Thorac Cardiovasc Surg: 2013; 146 5 1259 1266, e1, discussion 1266
52. Petricevic M., Biocina B., Konosic S., Kopjar T., Kunac N., Gasparovic H. Assessment of platelet function by whole blood impedance aggregometry in coronary artery bypass grafting patients on acetylsalicylic acid treatment may prompt a switch to dual antiplatelet therapy. Heart Vessels: 2013; 28 1 57 65
53. Gurbel P. A., Tantry U. S. Drug insight: Clopidogrel nonresponsiveness. Nat Clin Pract Cardiovasc Med: 2006; 3 7 387 395
54. Lordkipanidzé M., Diodati J. G., Pharand C. Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: a look at the clinical and pharmacological evidence. Pharmacol Ther: 2009; 123 2 178 186
55. Sambu N., Warner T., Curzen N. Clopidogrel withdrawal: is there a rebound phenomenon? Thromb Haemost: 2011; 105 2 211 220
56. Görlinger K., Shore-Lesserson L., Dirkmann D., Hanke A. A., Rahe-Meyer N., Tanaka K. A. Management of hemorrhage in cardiothoracic surgery. J Cardiothorac Vasc Anesth: 2013; 27 (4, Suppl): S20 S34
57. Kim J. H., Newby L. K., Clare R. M., et al. Clopidogrel use and bleeding after coronary artery bypass graft surgery. Am Heart J: 2008; 156 5 886 892
58. Loor G., Vivacqua A., Sabik J. F. III., et al. Process improvement in cardiac surgery: development and implementation of a reoperation for bleeding checklist. J Thorac Cardiovasc Surg: 2013; 146 5 1028 1032
59. Rahe-Meyer N., Hanke A., Schmidt D. S., Hagl C., Pichlmaier M. Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: results from a randomized, placebo-controlled trial. J Thorac Cardiovasc Surg: 2013; 145 (3, Suppl): S178 S185
60. Girdauskas E., Kempfert J., Kuntze T., et al. Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. J Thorac Cardiovasc Surg: 2010; 140 5 1117 1124, e2
61. Hanke A. A., Herold U., Dirkmann D., Tsagakis K., Jakob H., Görlinger K. Thromboelastometry Based Early Goal-Directed Coagulation Management Reduces Blood Transfusion Requirements, Adverse Events, and Costs in Acute Type A Aortic Dissection: A Pilot Study. Transfus Med Hemother: 2012; 39 2 121 128
62. Lennon M. J., Gibbs N. M., Weightman W. M., et al. A comparison of Plateletworks and platelet aggregometry for the assessment of aspirin-related platelet dysfunction in cardiac surgical patients. J Cardiothorac Vasc Anesth: 2004; 18 136 140