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Volumn 3, Issue 7, 2006, Pages 387-395

Drug Insight: Clopidogrel nonresponsiveness

Author keywords

Clopidogrel; Nonresponsiveness,P2y12 receptors blockers; Platelets; Response variability

Indexed keywords

3 [7 [2 (3,4 DIFLUOROPHENYL)CYCLOPROPYLAMINO] 5 PROPYLTHIO 1,2,3 TRIAZOLO[4,5 D]PYRIMIDIN 3 YL] 5 HYDROXYMETHOXY 1,2 CYCLOPENTANEDIOL; ACETYLSALICYLIC ACID; ATORVASTATIN; CANGRELOR; CLOPIDOGREL; CYTOCHROME P450 3A4; ERYTHROMYCIN; HYPERICUM PERFORATUM EXTRACT; PRASUGREL; PURINE P2Y12 RECEPTOR; RECEPTOR BLOCKING AGENT; RIFAMPICIN; UNCLASSIFIED DRUG;

EID: 33745562145     PISSN: 17434297     EISSN: 17434300     Source Type: Journal    
DOI: 10.1038/ncpcardio0602     Document Type: Review
Times cited : (116)

References (60)
  • 1
    • 4043166369 scopus 로고    scopus 로고
    • Platelet activation in myocardial ischemic syndromes
    • Gurbel PA et al. (2004) Platelet activation in myocardial ischemic syndromes. Expert Rev Cardiovasc Ther 2: 535-545
    • (2004) Expert Rev Cardiovasc Ther , vol.2 , pp. 535-545
    • Gurbel, P.A.1
  • 2
    • 27744444421 scopus 로고    scopus 로고
    • Resistance to antiplatelet drugs: Current status and future research
    • Tantry US et al. (2005) Resistance to antiplatelet drugs: Current status and future research. Expert Opin Pharmacother 6: 2027-2045
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 2027-2045
    • Tantry, U.S.1
  • 5
    • 13244264932 scopus 로고    scopus 로고
    • Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets
    • Dorsam RT et al. (2004) Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets. J Thromb Haemost 2: 804-812
    • (2004) J Thromb Haemost , vol.2 , pp. 804-812
    • Dorsam, R.T.1
  • 6
    • 20444503923 scopus 로고    scopus 로고
    • 12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk
    • 12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk. Thromb Haemost 93: 1128-1136
    • (2005) Thromb Haemost , vol.93 , pp. 1128-1136
    • van der Meijden, P.E.1
  • 7
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 ligand (CD40L) - Subcellular localization, regulation of expression, and inhibition by clopidogrel
    • Hermann A et al. (2001) Platelet CD40 ligand (CD40L) - subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets 12: 74-82
    • (2001) Platelets , vol.12 , pp. 74-82
    • Hermann, A.1
  • 8
    • 2542488125 scopus 로고    scopus 로고
    • Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome
    • Xiao Z and Theroux P (2004) Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 43: 1982-1988
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1982-1988
    • Xiao, Z.1    Theroux, P.2
  • 9
    • 14844295052 scopus 로고    scopus 로고
    • Platelet microparticles and soluble P selectin in peripheral artery disease: Relationship to extent of disease and platelet activation markers
    • Tan KT et al. (2005) Platelet microparticles and soluble P selectin in peripheral artery disease: Relationship to extent of disease and platelet activation markers. Ann Med 37: 61-66
    • (2005) Ann Med , vol.37 , pp. 61-66
    • Tan, K.T.1
  • 10
    • 23244459498 scopus 로고    scopus 로고
    • Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury
    • Wang K et al. (2005) Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol 25: 1584-1589
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1584-1589
    • Wang, K.1
  • 11
    • 6944237687 scopus 로고    scopus 로고
    • Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy
    • McFadden EP et al. (2004) Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy. Lancet 364: 1519-1521
    • (2004) Lancet , vol.364 , pp. 1519-1521
    • McFadden, E.P.1
  • 12
    • 0028083293 scopus 로고
    • The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A
    • Savi P et al. (1994) The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A. Thromb Haemost 72: 313-317
    • (1994) Thromb Haemost , vol.72 , pp. 313-317
    • Savi, P.1
  • 13
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC et al. (2004) Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 109: 166-171
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1
  • 14
    • 0037588974 scopus 로고    scopus 로고
    • 12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270
    • 12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood 101: 3908-3914
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1
  • 15
    • 4644289299 scopus 로고    scopus 로고
    • Platelet-active drugs: The relationships among dose, effectiveness, and side effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Patrono C et al. (2004) Platelet-active drugs: The relationships among dose, effectiveness, and side effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (Suppl): S234S-S264S
    • (2004) Chest , vol.126 , Issue.SUPPL.
    • Patrono, C.1
  • 16
    • 33646561025 scopus 로고    scopus 로고
    • The effect of clopidogrel with and without eptifibatide on tumor necrosis factor-α and C-reactive protein release after elective stenting: Results of the CLEAR PLATELETS-Ib study
    • in press
    • Gurbel PA et al. The effect of clopidogrel with and without eptifibatide on tumor necrosis factor-α and C-reactive protein release after elective stenting: Results of the CLEAR PLATELETS-Ib study. J Am Coll Cardiol, in press
    • J Am Coll Cardiol
    • Gurbel, P.A.1
  • 17
    • 26844522121 scopus 로고    scopus 로고
    • Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromes
    • Di Nisio M et al. (2005) Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromes. J Am Coll Cardiol 46: 1582-1583
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1582-1583
    • Di Nisio, M.1
  • 18
    • 27644536235 scopus 로고    scopus 로고
    • Platelet reactivity in patients and recurrent events post-stenting: Results of the PREPARE POST-STENTING Study
    • Gurbel PA et al. (2005) Platelet reactivity in patients and recurrent events post-stenting: Results of the PREPARE POST-STENTING Study. J Am Coll Cardiol 46: 1820-1826
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1820-1826
    • Gurbel, P.A.1
  • 19
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA et al. (2003) Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 107: 2908-2913
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1
  • 20
    • 18144371221 scopus 로고    scopus 로고
    • The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting
    • Gurbel PA et al. (2005) The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol 45: 1392-1396
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1392-1396
    • Gurbel, P.A.1
  • 21
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
    • Yusuf S et al.; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345: 494-502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1
  • 22
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • CREDO Investigators
    • Steinhubl SR et al.; CREDO Investigators (2002) Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288: 2411-2420
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1
  • 23
    • 23644437489 scopus 로고    scopus 로고
    • Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug
    • Labarthe B et al. (2005) Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug. J Am Coll Cardiol 46: 638-645
    • (2005) J Am Coll Cardiol , vol.46 , pp. 638-645
    • Labarthe, B.1
  • 24
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S et al. (2004) Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 109: 3171-3175
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1
  • 25
    • 27644465874 scopus 로고    scopus 로고
    • Clopidogrel effect on platelet reactivity in patients with stent thrombosis: Results of the CREST Study
    • Gurbel PA et al. (2005) Clopidogrel effect on platelet reactivity in patients with stent thrombosis: Results of the CREST Study. J Am Coll Cardiol 46: 1827-1832
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1827-1832
    • Gurbel, P.A.1
  • 26
    • 20344394411 scopus 로고    scopus 로고
    • Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: A case-control study
    • Ajzenberg N et al. (2005) Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: A case-control study. J Am Coll Cardiol 45: 1753-1756
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1753-1756
    • Ajzenberg, N.1
  • 27
    • 0038354521 scopus 로고    scopus 로고
    • Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation
    • Barragan P et al. (2003) Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv 59: 295-302
    • (2003) Catheter Cardiovasc Interv , vol.59 , pp. 295-302
    • Barragan, P.1
  • 28
    • 14944378655 scopus 로고    scopus 로고
    • Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: Results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study
    • Gurbel PA et al. (2005) Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: Results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation 111: 1153-1159
    • (2005) Circulation , vol.111 , pp. 1153-1159
    • Gurbel, P.A.1
  • 29
    • 11144357878 scopus 로고    scopus 로고
    • Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions
    • Lepantalo A et al. (2004) Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions. Eur Heart J 25: 476-483
    • (2004) Eur Heart J , vol.25 , pp. 476-483
    • Lepantalo, A.1
  • 30
    • 33745581274 scopus 로고    scopus 로고
    • Correlation between platelet response units measured with a point-of-care test and ADP-induced platelet aggregation assessed with conventional optical aggregometry
    • [abstract #P2936] Presented at the European Society of Cardiology: 2005 September 3-7; Stockholm, Sweden
    • von Beckerath N et al. (2005) Correlation between platelet response units measured with a point-of-care test and ADP-induced platelet aggregation assessed with conventional optical aggregometry [abstract #P2936]. Presented at the European Society of Cardiology: 2005 September 3-7; Stockholm, Sweden
    • (2005)
    • von Beckerath, N.1
  • 31
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • Aleil B et al. (2005) Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 3: 85-92
    • (2005) J Thromb Haemost , vol.3 , pp. 85-92
    • Aleil, B.1
  • 32
    • 8344231455 scopus 로고    scopus 로고
    • Aspirin and clopidogrel: Efficacy, safety, and the issue of drug resistance
    • Cattaneo M (2004) Aspirin and clopidogrel: Efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol 24: 1980-1987
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1980-1987
    • Cattaneo, M.1
  • 33
    • 0036379817 scopus 로고    scopus 로고
    • Individual variations of platelet inhibition after loading doses of clopidogrel
    • Jaremo P et al. (2002) Individual variations of platelet inhibition after loading doses of clopidogrel. J Intern Med 252: 233-238
    • (2002) J Intern Med , vol.252 , pp. 233-238
    • Jaremo, P.1
  • 34
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Muller I et al. (2003) Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost 89: 783-787
    • (2003) Thromb Haemost , vol.89 , pp. 783-787
    • Muller, I.1
  • 35
    • 1242315475 scopus 로고    scopus 로고
    • Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization
    • Mobley JE et al. (2004) Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization. Am J Cardiol 93: 456-458
    • (2004) Am J Cardiol , vol.93 , pp. 456-458
    • Mobley, J.E.1
  • 36
    • 11844256436 scopus 로고    scopus 로고
    • Variability in platelet responsiveness to clopidogrel among 544 individuals
    • Serebruany VL et al. (2005) Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 45: 246-251
    • (2005) J Am Coll Cardiol , vol.45 , pp. 246-251
    • Serebruany, V.L.1
  • 37
    • 9644281092 scopus 로고    scopus 로고
    • Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting
    • Angiolillo DJ et al. (2005) Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting. Thromb Res 115: 101-108
    • (2005) Thromb Res , vol.115 , pp. 101-108
    • Angiolillo, D.J.1
  • 38
    • 4444353174 scopus 로고    scopus 로고
    • Pharmacokinetics of clopidogrel after administration of a high loading dose
    • Taubert D et al. (2004) Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost 92: 311-316
    • (2004) Thromb Haemost , vol.92 , pp. 311-316
    • Taubert, D.1
  • 39
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial
    • von Beckerath N et al. (2005) Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation 112: 2946-2950
    • (2005) Circulation , vol.112 , pp. 2946-2950
    • von Beckerath, N.1
  • 40
    • 16844368927 scopus 로고    scopus 로고
    • A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite
    • von Beckerath N et al. (2005) A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite. Thromb Haemost 93: 789-791
    • (2005) Thromb Haemost , vol.93 , pp. 789-791
    • von Beckerath, N.1
  • 41
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction
    • Lau WC et al. (2003) Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction. Circulation 107: 32-37
    • (2003) Circulation , vol.107 , pp. 32-37
    • Lau, W.C.1
  • 42
    • 0042780283 scopus 로고    scopus 로고
    • Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial
    • Saw J et al. (2003) Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation 108: 921-924
    • (2003) Circulation , vol.108 , pp. 921-924
    • Saw, J.1
  • 43
    • 0042848535 scopus 로고    scopus 로고
    • Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies
    • MITRA PLUS Study Group
    • Wienbergen H et al.; MITRA PLUS Study Group (2003) Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies. Am J Cardiol 92: 285-288
    • (2003) Am J Cardiol , vol.92 , pp. 285-288
    • Wienbergen, H.1
  • 44
    • 7544244139 scopus 로고    scopus 로고
    • Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting
    • Gorchakova O et al. Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting. Eur Heart J 25: 1898-1902
    • Eur Heart J , vol.25 , pp. 1898-1902
    • Gorchakova, O.1
  • 45
    • 4444244344 scopus 로고    scopus 로고
    • Clopidogrel did not inhibit platelet function early after coronary bypass surgery: A prospective randomized trial
    • Lim E et al. (2004) Clopidogrel did not inhibit platelet function early after coronary bypass surgery: A prospective randomized trial. J Thorac Cardiovasc Surg 128: 432-435
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 432-435
    • Lim, E.1
  • 46
    • 13244274961 scopus 로고    scopus 로고
    • Platelet activation in type 2 diabetes mellitus
    • Ferroni P et al. (2004) Platelet activation in type 2 diabetes mellitus. J Thromb Haemost 2: 1282-1291
    • (2004) J Thromb Haemost , vol.2 , pp. 1282-1291
    • Ferroni, P.1
  • 47
    • 23644433510 scopus 로고    scopus 로고
    • Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment
    • Angiolillo DJ et al. (2005) Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 54: 2430-2435
    • (2005) Diabetes , vol.54 , pp. 2430-2435
    • Angiolillo, D.J.1
  • 48
    • 11144355993 scopus 로고    scopus 로고
    • Platelet aggregation according to body mass index in patients undergoing coronary stenting: Should clopidogrel loading-dose be weight adjusted?
    • Angiolillo DJ et al. (2004) Platelet aggregation according to body mass index in patients undergoing coronary stenting: Should clopidogrel loading-dose be weight adjusted? J Invasive Cardiol 16: 169-174
    • (2004) J Invasive Cardiol , vol.16 , pp. 169-174
    • Angiolillo, D.J.1
  • 49
    • 0034496491 scopus 로고    scopus 로고
    • Genetics of platelet receptor single-nucleotide polymorphisms: Clinical implications in thrombosis
    • Beer JH et al. (2000) Genetics of platelet receptor single-nucleotide polymorphisms: Clinical implications in thrombosis. Ann Med 32: 10-14
    • (2000) Ann Med , vol.32 , pp. 10-14
    • Beer, J.H.1
  • 50
    • 0346365089 scopus 로고    scopus 로고
    • 12 H2 haplotype is associated with peripheral arterial disease: A case-control study
    • 12 H2 haplotype is associated with peripheral arterial disease: A case-control study. Circulation 108: 2971-2973
    • (2003) Circulation , vol.108 , pp. 2971-2973
    • Fontana, P.1
  • 51
    • 17444429227 scopus 로고    scopus 로고
    • P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose
    • von Beckerath N et al. (2005) P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 16: 199-204
    • (2005) Blood Coagul Fibrinolysis , vol.16 , pp. 199-204
    • von Beckerath, N.1
  • 52
    • 9644281093 scopus 로고    scopus 로고
    • The difference between clopidogrel responsiveness and posttreatment platelet reactivity
    • Samara WM et al. (2005) The difference between clopidogrel responsiveness and posttreatment platelet reactivity. Thromb Res 115: 89-94
    • (2005) Thromb Res , vol.115 , pp. 89-94
    • Samara, W.M.1
  • 53
    • 85081149726 scopus 로고    scopus 로고
    • What is the best measure of thrombotic risks - Pretreatment platelet aggregation, clopidogrel responsiveness, or posttreatment platelet aggregation?
    • Tantry US et al. (2005) What is the best measure of thrombotic risks - pretreatment platelet aggregation, clopidogrel responsiveness, or posttreatment platelet aggregation? Catheter Cardiovasc Interv 66: 597-598
    • (2005) Catheter Cardiovasc Interv , vol.66 , pp. 597-598
    • Tantry, U.S.1
  • 54
    • 4944261759 scopus 로고    scopus 로고
    • Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy
    • Kastrati A et al. (2004) Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy. Circulation 110: 1916-1919
    • (2004) Circulation , vol.110 , pp. 1916-1919
    • Kastrati, A.1
  • 55
    • 33644872364 scopus 로고    scopus 로고
    • ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention - Summary article: A report of American Collage of Cardiology/American Heart Association Task Force on Practice Guidelines
    • (ACC/AHA/SCAI Writing Committee to update the 2001 Guidelines for Percutaneous Coronary Intervention)
    • Smith SC Jr et al. (2006) ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention - summary article: A report of American Collage of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to update the 2001 Guidelines for Percutaneous Coronary Intervention). Circulation 113: 156-175
    • (2006) Circulation , vol.113 , pp. 156-175
    • Smith Jr., S.C.1
  • 56
    • 33646261670 scopus 로고    scopus 로고
    • 12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • 12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin. Eur Heart J 27: 1038-1047
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1
  • 57
    • 33344464928 scopus 로고    scopus 로고
    • 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial
    • 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial. Am Heart J 151: 689.e1-689.e10
    • (2006) Am Heart J , vol.151
    • Greenbaum, A.B.1
  • 58
    • 21644448736 scopus 로고    scopus 로고
    • 12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • JUMBO-TIMI 26 Investigators
    • 12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation 111: 3366-3373
    • (2005) Circulation , vol.111 , pp. 3366-3373
    • Wiviott, S.D.1
  • 59
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348: 1329-1339
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 60
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL et al. (2006) Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354: 1706-1717
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.